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Article ; Online: Smartphone and video games overuse effects on hand joints: time for screening interventions?

Megna, M / Gisonni, P / Balato, N

Journal of the European Academy of Dermatology and Venereology : JEADV

2018 Volume 32, Issue 12, Page(s) e457–e458

MeSH term(s)	Behavior, Addictive ; Hand Joints ; Smartphone ; Ultrasonography ; Video Games
Language	English
Publishing date	2018-05-27
Publishing country	England
Document type	Letter ; Comment
ZDB-ID	1128828-0
ISSN	1468-3083 ; 0926-9959
ISSN (online)	1468-3083
ISSN	0926-9959
DOI	10.1111/jdv.15056
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Zs.A 3492: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (2.OG) ab Jg. 2022: Lesesaal (EG)
Zs.MO 413: Show issues

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Article ; Online: Real-life effectiveness of biological drugs on psoriatic difficult-to-treat body regions: scalp, palmoplantar area and lower limbs.

Megna, M / Cirillo, T / Balato, A / Balato, N / Gallo, L

Journal of the European Academy of Dermatology and Venereology : JEADV

2018 Volume 33, Issue 1, Page(s) e22–e23

MeSH term(s)	Adolescent ; Adult ; Aged ; Aged, 80 and over ; Biological Products/therapeutic use ; Female ; Foot/pathology ; Hand/pathology ; Humans ; Leg/pathology ; Male ; Middle Aged ; Psoriasis/drug therapy ; Psoriasis/pathology ; Scalp/pathology ; Young Adult
Chemical Substances	Biological Products
Language	English
Publishing date	2018-06-26
Publishing country	England
Document type	Letter
ZDB-ID	1128828-0
ISSN	1468-3083 ; 0926-9959
ISSN (online)	1468-3083
ISSN	0926-9959
DOI	10.1111/jdv.15119
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Zs.A 3492: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (2.OG) ab Jg. 2022: Lesesaal (EG)
Zs.MO 413: Show issues

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Article ; Online: Psoriasis in a cohort of patients with common variable immunodeficiency.

Megna, M / Pecoraro, A / Balato, N / Villani, A / Crescenzi, L / Balato, A / Spadaro, G

The British journal of dermatology

2019 Volume 180, Issue 4, Page(s) 935–936

MeSH term(s)	Adult ; Common Variable Immunodeficiency/complications ; Common Variable Immunodeficiency/drug therapy ; Common Variable Immunodeficiency/immunology ; Female ; Humans ; Immunoglobulins, Intravenous/administration & dosage ; Male ; Middle Aged ; Prospective Studies ; Psoriasis/diagnosis ; Psoriasis/epidemiology ; Psoriasis/immunology
Chemical Substances	Immunoglobulins, Intravenous
Language	English
Publishing date	2019-02-25
Publishing country	England
Document type	Letter ; Observational Study
ZDB-ID	80076-4
ISSN	1365-2133 ; 0007-0963
ISSN (online)	1365-2133
ISSN	0007-0963
DOI	10.1111/bjd.17408
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Ui VI Zs.23: Show issues

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Article ; Online: A Familial Novel Putative-Pathogenic Mutation Identified in Plaque-Psoriasis by a Multigene Panel Analysis.

Nunziato, Marcella / Balato, Anna / Ruocco, Anna / D'Argenio, Valeria / Di Caprio, Roberta / Balato, Nicola / Ayala, Fabio / Salvatore, Francesco

International journal of molecular sciences

2023 Volume 24, Issue 5

Abstract: Psoriasis is a chronic multifactorial skin disorder with an immune basis. It is characterized by patches of skin that are usually red, flaky and crusty, and that often release silvery scales. The patches appear predominantly on the elbows, knees, scalp ... ...

Abstract	Psoriasis is a chronic multifactorial skin disorder with an immune basis. It is characterized by patches of skin that are usually red, flaky and crusty, and that often release silvery scales. The patches appear predominantly on the elbows, knees, scalp and lower back, although they may also appear on other body areas and severity may be variable. The majority of patients (about 90%) present small patches known as "plaque psoriasis". The roles of environmental triggers such as stress, mechanical trauma and streptococcal infections are well described in psoriasis onset, but much effort is still needed to unravel the genetic component. The principal aim of this study was to use a next-generation sequencing technologies-based approach together with a 96 customized multigene panel in the attempt to determine if there are germline alterations that can explain the onset of the disease, and thus to find associations between genotypes and phenotypes. To this aim, we analyzed a family in which the mother showed mild psoriasis, and her 31-year-old daughter had suffered from psoriasis for several years, whereas an unaffected sister served as a negative control. We found variants already associated directly to psoriasis in the
MeSH term(s)	Adult ; Female ; Humans ; Genetic Predisposition to Disease ; Mutation ; Phenotype ; Psoriasis/etiology ; Psoriasis/genetics ; Streptococcal Infections/complications
Chemical Substances	TRAF3IP2 protein, human
Language	English
Publishing date	2023-03-01
Publishing country	Switzerland
Document type	Case Reports
ZDB-ID	2019364-6
ISSN	1422-0067 ; 1422-0067 ; 1661-6596
ISSN (online)	1422-0067
ISSN	1422-0067 ; 1661-6596
DOI	10.3390/ijms24054743
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Article: Adult Atopic Dermatitis: Less Certainty, More Challenges.

Megna, M / Patruno, C / Balato, A / Napolitano, M / Balato, N

Journal of investigational allergology & clinical immunology

2017 Volume 27, Issue 4, Page(s) 276–277

MeSH term(s)	Adult ; Dermatitis, Atopic ; Humans
Language	English
Publishing date	2017
Publishing country	Spain
Document type	Journal Article
ZDB-ID	1128657-x
ISSN	1018-9068
ISSN	1018-9068
DOI	10.18176/jiaci.0155
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Zs.A 3487: Show issues

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Article ; Online: A case of erythrodermic psoriasis successfully treated with ixekizumab.

Megna, Matteo / Gallo, Lucia / Balato, Nicola / Balato, Anna

Dermatologic therapy

2019 Volume 32, Issue 2, Page(s) e12825

Abstract: Erythrodermic psoriasis (EP) is the most severe form of psoriasis, resulting in significant morbidity and mortality. International guidelines on EP treatment are lacking, with most of the biologic drugs being used basing on case reports or small case ... ...

Abstract	Erythrodermic psoriasis (EP) is the most severe form of psoriasis, resulting in significant morbidity and mortality. International guidelines on EP treatment are lacking, with most of the biologic drugs being used basing on case reports or small case series. Ixekizumab, a fully human anti-interleukin (IL)-17A monoclonal antibody, is approved for moderate to severe plaque psoriasis while its use in EP is off label. However, two studies conducted on eight Japanese EP patients have showed ixekizumab as an efficacious and well tolerated therapy up to 24 and 52 weeks, respectively. To date, no case reports on Caucasian patients have been described. We report the case of a 66-year-old Caucasian female with EP successfully treated with ixekizumab, reaching PASI 100 after only 6 weeks of therapy and still maintaining this response at week 24. Our case report suggests ixekizumab as a highly efficacious treatment in EP, presenting also a very rapid action which leads to complete resolution of the disease after 6 weeks. Further studies are warrant to confirm our data, with controlled trials specifically dedicated to EP being strictly needed in order to verify the role and efficacy of the new biologics in EP.
MeSH term(s)	Aged ; Antibodies, Monoclonal, Humanized/therapeutic use ; Dermatitis, Exfoliative/drug therapy ; Dermatitis, Exfoliative/pathology ; Dermatologic Agents/therapeutic use ; Female ; Humans ; Interleukin-17/immunology ; Psoriasis/drug therapy ; Psoriasis/pathology ; Treatment Outcome
Chemical Substances	Antibodies, Monoclonal, Humanized ; Dermatologic Agents ; IL17A protein, human ; Interleukin-17 ; ixekizumab (BTY153760O)
Language	English
Publishing date	2019-01-31
Publishing country	United States
Document type	Case Reports ; Journal Article
ZDB-ID	1354801-3
ISSN	1529-8019 ; 1396-0296
ISSN (online)	1529-8019
ISSN	1396-0296
DOI	10.1111/dth.12825
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Zs.A 5181: Show issues

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Article ; Online: Rational ideation and empiric validation of an innovative digital dermographic tester.

Lembo, C / Patruno, C / Balato, N / Ayala, F / Balato, A / Lembo, S

Clinical and experimental dermatology

2018 Volume 43, Issue 3, Page(s) 268–273

Abstract: Background: Dermographism is a condition characterized by a weal response to a combination of pressure and traction on skin surface, and its diagnosis is based on medical history, clinical criteria and provocation test. The Dermographic Tester: Aim: ... ...

Abstract	Background: Dermographism is a condition characterized by a weal response to a combination of pressure and traction on skin surface, and its diagnosis is based on medical history, clinical criteria and provocation test. The Dermographic Tester Aim: To validate the effectiveness and accuracy of the DDT. Methods: We tested the DDT on 213 participants purposely sampled to obtain three groups, each with a different pattern of reaction to mechanical stimuli. Based on anamnestic, diagnostic and symptomatic criteria, patients were divided into dermographic urticaria (DU), spontaneous urticaria (SU) and healthy control (HC) groups. The DDT was used to apply 12 levels of pressure to the skin surface, and a frequency distribution of positive reactions was displayed for each group. Results: A force of 36-40 g/mm Conclusions: The DDT was found to be capable of differentiating patients with DU patients from those with SU and from HCs, and was able to precisely identify the weal elicitation threshold.
MeSH term(s)	Adolescent ; Adult ; Aged ; Child ; Female ; Humans ; Male ; Middle Aged ; Pressure/adverse effects ; Sensitivity and Specificity ; Skin/pathology ; Skin Tests/instrumentation ; Surveys and Questionnaires ; Urticaria/diagnosis ; Urticaria/etiology ; Young Adult
Language	English
Publishing date	2018-04
Publishing country	England
Document type	Journal Article ; Validation Studies
ZDB-ID	195504-4
ISSN	1365-2230 ; 0307-6938
ISSN (online)	1365-2230
ISSN	0307-6938
DOI	10.1111/ced.13314
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Zs.A 1278: Show issues

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Article ; Online: Letter to the editor submitted in response to "psoriasis in pregnancy: case series and literature review of data concerning exposure during pregnancy to ustekinumab".

Megna, Matteo / Villani, Alessia / Balato, Nicola / Balato, Anna

The Journal of dermatological treatment

2018 Volume 30, Issue 3, Page(s) 309

MeSH term(s)	Dermatologic Agents ; Female ; Humans ; Pregnancy ; Psoriasis ; Ustekinumab
Chemical Substances	Dermatologic Agents ; Ustekinumab (FU77B4U5Z0)
Language	English
Publishing date	2018-09-03
Publishing country	England
Document type	Letter ; Comment
ZDB-ID	1036299-x
ISSN	1471-1753 ; 0954-6634
ISSN (online)	1471-1753
ISSN	0954-6634
DOI	10.1080/09546634.2018.1508818
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Zs.A 2627: Show issues

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Article ; Online: Psoriatic arthritis onset in psoriatic patients receiving UV phototherapy in Italy.

Balato, Anna / Caiazzo, Giuseppina / Balato, Nicola / Napolitano, Maddalena

Giornale italiano di dermatologia e venereologia : organo ufficiale, Societa italiana di dermatologia e sifilografia

2018 Volume 155, Issue 6, Page(s) 733–738

Abstract: Background: Psoriasis is a chronic, recurrent, and immune-mediated inflammatory disease that affects 2-3% of the world population. A substantial proportion of patients with psoriasis, approximately 40%, develop a form of inflammatory arthritis known as ... ...

Abstract	Background: Psoriasis is a chronic, recurrent, and immune-mediated inflammatory disease that affects 2-3% of the world population. A substantial proportion of patients with psoriasis, approximately 40%, develop a form of inflammatory arthritis known as psoriatic arthritis (PsA), the arthritis follows the development of psoriasis, and it will develop simultaneously or possibly before the appearance of skin lesions. The presence of PsA indicates a need for more active intervention rather than purely topical therapies or UV-based therapies. The aim of this multicenter, retrospective, epidemiological study was to estimate the incidence of PsA in psoriatic patients receiving UV treatment as monotherapy. Methods: A retrospective epidemiological study was performed in 8 dermatological reference center, located throughout Italy (2 from Northern, 3 from Center, 3 from Southern); a period of 1 year was considered. Data from the overall study population including 326 patients with a diagnosis of psoriasis were analyzed. Furthermore, data coming from follow-up visits, including screening for PsA onset through specific questionnaires were analyzed. Results: PsA screening was positive in 27 patients (8.3%), whereas PsA diagnosis was confirmed by a rheumatologist in only 22/27 (81.5%) being therefore found in 22/326 (6.7%). Patients diagnosed with PsA had a statistically significantly higher abdominal circumference (96±15.3 vs. 88.9±18.3, P=0.048) and more commonly presented a positive past medical history for phototherapy (90.9% vs. 57.6% P=0.004). Conclusions: Our study showed that phototherapy is not able to prevent or slow down the risk of PsA development in psoriatic patients. PsA screening should be always carried out in those patients even if asymptomatic, especially in obese subjects which are at great risk to develop PsA due to their increased systemic inflammatory state.
MeSH term(s)	Adipose Tissue/metabolism ; Adult ; Alcohol Drinking/epidemiology ; Anti-Inflammatory Agents/therapeutic use ; Arthritis, Psoriatic/diagnosis ; Arthritis, Psoriatic/epidemiology ; Arthritis, Psoriatic/etiology ; Cardiovascular Diseases/epidemiology ; Comorbidity ; Cytokines/metabolism ; Female ; Humans ; Immunosuppressive Agents/therapeutic use ; Male ; Metabolic Syndrome/epidemiology ; Middle Aged ; Obesity/complications ; Psoriasis/drug therapy ; Psoriasis/radiotherapy ; Risk Factors ; Smoking/epidemiology ; Ultraviolet Therapy ; Waist Circumference
Chemical Substances	Anti-Inflammatory Agents ; Cytokines ; Immunosuppressive Agents
Language	English
Publishing date	2018-09-24
Publishing country	Italy
Document type	Journal Article ; Multicenter Study
ZDB-ID	604114-0
ISSN	1827-1820 ; 0026-4741 ; 0392-0488
ISSN (online)	1827-1820
ISSN	0026-4741 ; 0392-0488
DOI	10.23736/S0392-0488.18.06117-5
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Zs.B 119: Show issues

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Article ; Online: Guselkumab for the treatment of psoriasis.

Megna, Matteo / Balato, Anna / Raimondo, Annunziata / Balato, Nicola

Expert opinion on biological therapy

2018 Volume 18, Issue 4, Page(s) 459–468

Abstract: Introduction: Psoriasis is a chronic immune mediated disease in which the interplay of T cells and keratinocytes seems to play a key role. In this context, the interleukin (IL)-23/IL-17 axis is currently considered to be crucial in the pathogenesis of ... ...

Abstract	Introduction: Psoriasis is a chronic immune mediated disease in which the interplay of T cells and keratinocytes seems to play a key role. In this context, the interleukin (IL)-23/IL-17 axis is currently considered to be crucial in the pathogenesis of psoriasis and the selective inhibition of IL-23 may be viewed as an improvement of treatments blocking both IL-23 and IL-12, since its upstream actions. Areas covered: The authors performed a thorough and updated review on guselkumab, a fully human IgG1λ monoclonal antibody that blocks the p19 subunit of IL-23, analyzing efficacy and safety data from phase I, II and III trials. Expert opinion: Guselkumab represents a very promising therapy, providing an alternative mechanism of action with high efficacy and safety profiles, sustained total skin clearance, and rapid onset of effect also to psoriasis patients who previously failed or experienced an inadequate response to anti-TNF-α or anti-IL12/23. Guselkumab will definitively shift therapeutic goals of psoriasis management from PASI 75 to PASI 90 and 100 due to its exciting trials results, also favored by its increased treatment adherence due to its administering regimen (100 mg injection at week 0, 4 and then every 8 weeks).
MeSH term(s)	Antibodies, Monoclonal/adverse effects ; Antibodies, Monoclonal/chemistry ; Antibodies, Monoclonal/pharmacokinetics ; Antibodies, Monoclonal/therapeutic use ; Clinical Trials as Topic ; Half-Life ; Humans ; Interleukin-23/immunology ; Interleukin-23/metabolism ; Nasopharyngitis/etiology ; Psoriasis/drug therapy ; Treatment Outcome
Chemical Substances	Antibodies, Monoclonal ; Interleukin-23 ; guselkumab (089658A12D)
Language	English
Publishing date	2018-03-03
Publishing country	England
Document type	Journal Article ; Review
ZDB-ID	2052501-1
ISSN	1744-7682 ; 1471-2598
ISSN (online)	1744-7682
ISSN	1471-2598
DOI	10.1080/14712598.2018.1445223
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