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  1. Article: Carotenoids in orange carrots mitigate non-alcoholic fatty liver disease progression.

    Balbuena, Emilio / Cheng, Junrui / Eroglu, Abdulkerim

    Frontiers in nutrition

    2022  Volume 9, Page(s) 987103

    Abstract: Background: Carotenoids are abundant in colored fruits and vegetables. Non-alcoholic fatty liver disease (NAFLD) is a global burden and risk factor for end-stage hepatic diseases. This study aims to compare the anti-NAFLD efficacy between carotenoid- ... ...

    Abstract Background: Carotenoids are abundant in colored fruits and vegetables. Non-alcoholic fatty liver disease (NAFLD) is a global burden and risk factor for end-stage hepatic diseases. This study aims to compare the anti-NAFLD efficacy between carotenoid-rich and carotenoid-deficient vegetables.
    Materials and methods: Male C57BL/6J mice were randomized to one of four experimental diets for 15 weeks (
    Results: We observed that carotenoids in the orange carrots reduced HFD-induced weight gain, better than white carrots. Histological and triglyceride (TG) analyses revealed significantly decreased HFD-induced hepatic lipid deposition and TG content in the HFD + WC group, which was further reduced in the HFD + OC group. Western blot analysis demonstrated inconsistent changes of fatty acid synthesis-related proteins but significantly improved ACOX-1 and CPT-II, indicating that orange carrot carotenoids had the potential to inhibit NAFLD by improving β-oxidation. Further investigation showed significantly higher mRNA and protein levels of PPARα and its transcription factor activity.
    Conclusion: Carotenoid-rich foods may display more potent efficacy in mitigating NAFLD than those with low carotenoid levels.
    Language English
    Publishing date 2022-09-26
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2776676-7
    ISSN 2296-861X
    ISSN 2296-861X
    DOI 10.3389/fnut.2022.987103
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Carotenoids in Health as Studied by Omics-Related Endpoints.

    Bohn, Torsten / Balbuena, Emilio / Ulus, Hande / Iddir, Mohammed / Wang, Genan / Crook, Nathan / Eroglu, Abdulkerim

    Advances in nutrition (Bethesda, Md.)

    2023  Volume 14, Issue 6, Page(s) 1538–1578

    Abstract: Carotenoids have been associated with risk reduction for several chronic diseases, including the association of their dietary intake/circulating levels with reduced incidence of obesity, type 2 diabetes, certain types of cancer, and even lower total ... ...

    Abstract Carotenoids have been associated with risk reduction for several chronic diseases, including the association of their dietary intake/circulating levels with reduced incidence of obesity, type 2 diabetes, certain types of cancer, and even lower total mortality. In addition to some carotenoids constituting vitamin A precursors, they are implicated in potential antioxidant effects and pathways related to inflammation and oxidative stress, including transcription factors such as nuclear factor κB and nuclear factor erythroid 2-related factor 2. Carotenoids and metabolites may also interact with nuclear receptors, mainly retinoic acid receptor/retinoid X receptor and peroxisome proliferator-activated receptors, which play a role in the immune system and cellular differentiation. Therefore, a large number of downstream targets are likely influenced by carotenoids, including but not limited to genes and proteins implicated in oxidative stress and inflammation, antioxidation, and cellular differentiation processes. Furthermore, recent studies also propose an association between carotenoid intake and gut microbiota. While all these endpoints could be individually assessed, a more complete/integrative way to determine a multitude of health-related aspects of carotenoids includes (multi)omics-related techniques, especially transcriptomics, proteomics, lipidomics, and metabolomics, as well as metagenomics, measured in a variety of biospecimens including plasma, urine, stool, white blood cells, or other tissue cellular extracts. In this review, we highlight the use of omics technologies to assess health-related effects of carotenoids in mammalian organisms and models.
    MeSH term(s) Animals ; Humans ; Carotenoids/metabolism ; Diabetes Mellitus, Type 2 ; Inflammation ; Antioxidants/pharmacology ; Lutein ; Mammals/metabolism
    Chemical Substances Carotenoids (36-88-4) ; Antioxidants ; Lutein (X72A60C9MT)
    Language English
    Publishing date 2023-09-09
    Publishing country United States
    Document type Journal Article ; Review ; Research Support, Non-U.S. Gov't
    ZDB-ID 2583634-1
    ISSN 2156-5376 ; 2156-5376
    ISSN (online) 2156-5376
    ISSN 2156-5376
    DOI 10.1016/j.advnut.2023.09.002
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article: The Role of β-Carotene in Colonic Inflammation and Intestinal Barrier Integrity.

    Cheng, Junrui / Balbuena, Emilio / Miller, Baxter / Eroglu, Abdulkerim

    Frontiers in nutrition

    2021  Volume 8, Page(s) 723480

    Abstract: Background: ...

    Abstract Background:
    Language English
    Publishing date 2021-09-27
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2776676-7
    ISSN 2296-861X
    ISSN 2296-861X
    DOI 10.3389/fnut.2021.723480
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article: Lycopene Protects against Smoking-Induced Lung Cancer by Inducing Base Excision Repair.

    Cheng, Junrui / Miller, Baxter / Balbuena, Emilio / Eroglu, Abdulkerim

    Antioxidants (Basel, Switzerland)

    2020  Volume 9, Issue 7

    Abstract: Background: Oxidative stress plays a critical role in lung cancer progression. Carotenoids are efficient antioxidants. The objective of this study was to explore the efficacy of all-trans retinoic acid (ATRA) and carotenoids in cigarette smoke-induced ... ...

    Abstract Background: Oxidative stress plays a critical role in lung cancer progression. Carotenoids are efficient antioxidants. The objective of this study was to explore the efficacy of all-trans retinoic acid (ATRA) and carotenoids in cigarette smoke-induced oxidative stress within A549 human lung cancer epithelial cells.
    Methods: A549 cells were pretreated with 1-nM, 10-nM, 100-nM, 1-μM and 10-μM ATRA, β-carotene (BC) and lycopene for 24 h, followed by exposure to cigarette smoke using a smoking chamber.
    Results: The OxyBlot analysis showed that smoking significantly increased oxidative stress, which was inhibited by lycopene at 1 nM and 10 nM (
    Conclusions: Lycopene treatment at a lower dosage could inhibit smoke-induced oxidative stress and promote genome stability. These novel findings will shed light on the molecular mechanism of lycopene action against lung cancer.
    Language English
    Publishing date 2020-07-21
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2704216-9
    ISSN 2076-3921
    ISSN 2076-3921
    DOI 10.3390/antiox9070643
    Database MEDical Literature Analysis and Retrieval System OnLINE

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