LIVIVO - Search results -

Search results

Result 1 - 10 of total 34

Search options

Book ; Online: Lettere 1935-1972

Dessì, Giuseppe / Falqui, Enrico / Baldi, Alberto

Con una raccolta di racconti dispersi

(Moderna/Comparata)

2015

Series title	Moderna/Comparata
Keywords	linguistics ; Historical & comparative linguistics ; Literature & literary studies ; Literature: history & criticism
Language	0\|i
Size	1 electronic resource (254 pages)
Publisher	Firenze University Press
Publishing place	Florence
Document type	Book ; Online
Note	Italian ; Open Access
HBZ-ID	HT021609521
ISBN	9788866557722 ; 8866557722
Database	ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

Order via subito

This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

Inter-library loan at ZB MED

Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

Article ; Online: Le raffigurazioni di sé, esplicite e occulte, della camorra napoletana. Stereotipi estetici, magico-religiosi e artistici della comunicazione criminale

BALDI, Alberto

DADA Rivista di Antropologia post-globale, Vol VI, Iss 2, Pp 119-

2016 Volume 138

Abstract: Since its origins in the nineteenth century, the camorra has somewhat always taken care of its looks, as we would say nowadays. Its image has always been found between the need to move towards the occult dimension, in the shadow, and the necessity to ... ...

Abstract	Since its origins in the nineteenth century, the camorra has somewhat always taken care of its looks, as we would say nowadays. Its image has always been found between the need to move towards the occult dimension, in the shadow, and the necessity to affirm itself explicitly, to make its power apparent, and celebrate itself in the eyes of the Neapolitan urban proletariat, working class and even aristocracy: a social context to exploit or to do business with. The channels activated to outwardly underline the exercise of an absolutist will, grounded on violence, omertà and revenge are manifold. The first medium used to achieve this goal is the criminal’s body itself: through the use of some details or codified tattoos, together with a bombastic clothing style, the human body underlines the affiliation to the men of honour. The camorra shows very precociously a capacity to identify those media that can magnify and brilliantly perpetuate its own image: from animation and theatre to popular songs and cinema.
Keywords	Camorra ; honour ; tattoo ; popular song ; popular theatre ; Anthropology ; GN1-890 ; Ethnology. Social and cultural anthropology ; GN301-674 ; Philosophy. Psychology. Religion ; B ; Social sciences (General) ; H1-99
Subject code	700
Language	German
Publishing date	2016-12-01T00:00:00Z
Publisher	Antonio L. Palmisano
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

Full text online

Full text

Inter-library loan at ZB MED

Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

Article: Pharmacodynamic study of the 7,8-dihydroxy-4-methylcoumarin-induced selective cytotoxicity toward U-937 leukemic cells versus mature monocytes: Cytoplasmic p21Cⁱᵖ¹/ᵂᴬF¹ as resistance factor

Vázquez, Ramiro / Riveiro, María Eugenia / Mondillo, Carolina / Perazzo, Juan Carlos / Vermeulen, Mónica / Baldi, Alberto / Davio, Carlos / Shayo, Carina

Biochemical Pharmacology. 2013 July 15, v. 86, no. 2

2013

Abstract: The development of tumor-selective drugs with low systemic toxicity has always been a major challenge in cancer treatment. Our group previously identified the 7,8-dihydroxy-4-methylcoumarin (DHMC) as a potential chemotherapeutic agent due to its potent, ... ...

Abstract	The development of tumor-selective drugs with low systemic toxicity has always been a major challenge in cancer treatment. Our group previously identified the 7,8-dihydroxy-4-methylcoumarin (DHMC) as a potential chemotherapeutic agent due to its potent, selective anti-proliferative and apoptosis-inducing effects on several cancer cell lines over peripheral blood mononuclear cells. However, there are still no published reports that can explain such selectivity of action. Herein, we addressed this question by using the U-937 promonocytic leukemia cell line, which can be forced to differentiate into a monocyte-like phenotype in vitro. U-937 cells differentiation is dependent on the nuclear expression of p21Cⁱᵖ¹/ᵂᴬF¹, a protein that is absent in immature U-937 cells but present in both the nucleus and the cytoplasm of normal DHMC-resistant monocytes. Considering that induction of differentiation rendered U-937 cells resistant to DHMC, we evaluated the possible causal role of cytoplasmic p21Cⁱᵖ¹/ᵂᴬF¹ in the onset of such resistance by employing U-937 cells stably transfected with a ZnCl₂-inducible p21Cⁱᵖ¹/ᵂᴬF¹ variant lacking the nuclear localization signal (U-937/CB6-ΔNLS-p21 cells). Expression of cytoplasmic p21Cⁱᵖ¹/ᵂᴬF¹ did not induce differentiation of the cells but turned them resistant to DHMC through inhibition of JNK, a crucial mediator of DHMC-induced apoptosis in U-937 cells. Sub-acute toxicity evaluation of DHMC in Balb/c mice indicated that DHMC administered intraperitoneally at doses up to 100mg/kg induced no systemic damage. Collectively, our results explain for the first time the selective cytotoxicity of DHMC for tumor cells over normal monocytes, and encourage further in vivo studies on this compound as potential anti-leukemic agent.
Keywords	apoptosis ; cytoplasm ; cytotoxicity ; drugs ; in vivo studies ; leukemia ; mice ; monocytes ; nuclear localization signals ; phenotype
Language	English
Dates of publication	2013-0715
Size	p. 210-221.
Publishing place	Elsevier Inc.
Document type	Article
ZDB-ID	208787-x
ISSN	1873-2968 ; 0006-2952
ISSN (online)	1873-2968
ISSN	0006-2952
DOI	10.1016/j.bcp.2013.04.021
Database	NAL-Catalogue (AGRICOLA)

In stock of ZB MED Cologne/Königswinter

Zs.A 19: Show issues

Location:
Je nach Verfügbarkeit (siehe Angabe bei Bestand)
bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
Jg. 1995 - 2021: Lesesall (1.OG)
ab Jg. 2022: Lesesaal (EG)

Order via subito

Details ▾
- See ZB MED holdings
- Order with fees

Article ; Online: In vitro endothelial cell response to ionic dissolution products from boron-doped bioactive glass in the SiO

Haro Durand, Luis A / Góngora, Adrián / Porto López, José M / Boccaccini, Aldo R / Zago, M Paola / Baldi, Alberto / Gorustovich, Alejandro

Journal of materials chemistry. B

2014 Volume 2, Issue 43, Page(s) 7620–7630

Abstract: As it has been established that boron (B) may perform functions in angiogenesis and osteogenesis, the controlled and localized release of B ions from bioactive glasses (BGs) is expected to provide a promising therapeutic alternative for regenerative ... ...

Abstract	As it has been established that boron (B) may perform functions in angiogenesis and osteogenesis, the controlled and localized release of B ions from bioactive glasses (BGs) is expected to provide a promising therapeutic alternative for regenerative medicine of vascularized tissues, such as bone. The aim of this study was to assess the in vitro angiogenic effects of the ionic dissolution products (IDPs) from BGs in the SiO
Language	English
Publishing date	2014-10-08
Publishing country	England
Document type	Journal Article
ZDB-ID	2702241-9
ISSN	2050-7518 ; 2050-750X
ISSN (online)	2050-7518
ISSN	2050-750X
DOI	10.1039/c4tb01043d
Database	MEDical Literature Analysis and Retrieval System OnLINE

Order via subito

Article ; Online: Histamine H2 receptor trafficking: role of arrestin, dynamin, and clathrin in histamine H2 receptor internalization.

Fernandez, Natalia / Monczor, Federico / Baldi, Alberto / Davio, Carlos / Shayo, Carina

Molecular pharmacology

2008 Volume 74, Issue 4, Page(s) 1109–1118

Abstract: Agonist-induced internalization of G protein-coupled receptors (GPCRs) has been implicated in receptor desensitization, resensitization, and down-regulation. In the present study, we sought to establish whether the histamine H2 receptor (H2r) agonist ... ...

Abstract	Agonist-induced internalization of G protein-coupled receptors (GPCRs) has been implicated in receptor desensitization, resensitization, and down-regulation. In the present study, we sought to establish whether the histamine H2 receptor (H2r) agonist amthamine, besides promoting receptor desensitization, induced H2r internalization. We further studied the mechanisms involved and its potential role in receptor resensitization. In COS7 transfected cells, amthamine induced H2r time-dependent internalization, showing 70% of receptor endocytosis after 60-min exposure to amthamine. Agonist removal led to the rapid recovery of resensitized receptors to the cell surface. Similar results were obtained in the presence of cycloheximide, an inhibitor of protein synthesis. Treatment with okadaic acid, an inhibitor of the protein phosphatase 2A (PP2A) family of phosphatases, reduced the recovery of both H2r membrane sites and cAMP response. Arrestin 3 but not arrestin 2 overexpression reduced both H2r membrane sites and H2r-evoked cAMP response. Receptor cotransfection with dominant-negative mutants for arrestin, dynamin, Eps15 (a component of the clathrin-mediated endocytosis machinery), or RNA interference against arrestin 3 abolished both H2r internalization and resensitization. Similar results were obtained in U937 cells endogenously expressing H2r. Our findings suggest that amthamine-induced H2r internalization is crucial for H2r resensitization, processes independent of H2r de novo synthesis but dependent on PP2A-mediated dephosphorylation. Although we do not provide direct evidence for H2r interaction with beta-arrestin, dynamin, and/or clathrin, our results support their involvement in H2r endocytosis. The rapid receptor recycling to the cell surface and the specific involvement of arrestin 3 in receptor internalization further suggest that the H2r belongs to class A GPCRs.
MeSH term(s)	Animals ; Arrestin/metabolism ; COS Cells ; Cercopithecus aethiops ; Clathrin/metabolism ; Dynamins/metabolism ; Endocytosis ; Histamine Agonists/pharmacology ; History ; Humans ; Receptors, Histamine H2/drug effects ; Receptors, Histamine H2/genetics ; Receptors, Histamine H2/metabolism ; Receptors, Histamine H2/physiology ; Thiazoles/pharmacology ; Time Factors ; Transfection ; U937 Cells
Chemical Substances	Arrestin ; Clathrin ; Histamine Agonists ; Receptors, Histamine H2 ; Thiazoles ; amthamine (142437-67-0) ; Dynamins (EC 3.6.5.5)
Language	English
Publishing date	2008-10
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	124034-1
ISSN	1521-0111 ; 0026-895X
ISSN (online)	1521-0111
ISSN	0026-895X
DOI	10.1124/mol.108.045336
Database	MEDical Literature Analysis and Retrieval System OnLINE

In stock of ZB MED Cologne/Königswinter

Zs.A 525: Show issues

Location:
Je nach Verfügbarkeit (siehe Angabe bei Bestand)
bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
Jg. 1995 - 2021: Lesesall (1.OG)
ab Jg. 2022: Lesesaal (EG)

Order via subito

Details ▾
- See ZB MED holdings
- Order with fees

Article: In Vitro Human Umbilical Vein Endothelial Cells Response to Ionic Dissolution Products from Lithium-Containing 45S5 Bioactive Glass.

Haro Durand, Luis A / Vargas, Gabriela E / Vera-Mesones, Rosa / Baldi, Alberto / Zago, María P / Fanovich, María A / Boccaccini, Aldo R / Gorustovich, Alejandro

Materials (Basel, Switzerland)

2017 Volume 10, Issue 7

Abstract: Since lithium (Li⁺) plays roles in angiogenesis, the localized and controlled release of Li⁺ ions from bioactive glasses (BGs) represents a promising alternative therapy for the regeneration and repair of tissues with a high degree of vascularization. ... ...

Abstract	Since lithium (Li⁺) plays roles in angiogenesis, the localized and controlled release of Li⁺ ions from bioactive glasses (BGs) represents a promising alternative therapy for the regeneration and repair of tissues with a high degree of vascularization. Here, microparticles from a base 45S5 BG composition containing (wt %) 45% SiO₂, 24.5% Na₂O, 24.5% CaO, and 6% P₂O₅, in which Na₂O was partially substituted by 5% Li₂O (45S5.5Li), were obtained. The results demonstrate that human umbilical vein endothelial cells (HUVECs) have greater migratory and proliferative response and ability to form tubules in vitro after stimulation with the ionic dissolution products (IDPs) of the 45S5.5Li BG. The results also show the activation of the canonical Wnt/β-catenin pathway and the increase in expression of proangiogenic cytokines insulin like growth factor 1 (IGF1) and transforming growth factor beta (TGFβ). We conclude that the IDPs of 45S5.5Li BG would act as useful inorganic agents to improve tissue repair and regeneration, ultimately stimulating HUVECs behavior in the absence of exogenous growth factors.
Language	English
Publishing date	2017-07-03
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2487261-1
ISSN	1996-1944
ISSN	1996-1944
DOI	10.3390/ma10070740
Database	MEDical Literature Analysis and Retrieval System OnLINE

Order via subito

Article: In vitro endothelial cell response to ionic dissolution products from boron-doped bioactive glass in the SiO2–CaO–P2O5–Na2O system

Haro Durand, Luis A / Baldi, Alberto / Boccaccini, Aldo R / Góngora, Adrián / Gorustovich, Alejandro / Porto López, José M / Zago, M. Paola

Journal of materials chemistry B. 2014 Oct. 15, v. 2, no. 43

2014

Abstract	As it has been established that boron (B) may perform functions in angiogenesis and osteogenesis, the controlled and localized release of B ions from bioactive glasses (BGs) is expected to provide a promising therapeutic alternative for regenerative medicine of vascularized tissues, such as bone. The aim of this study was to assess the in vitro angiogenic effects of the ionic dissolution products (IDPs) from BGs in the SiO2–CaO–Na2O–P2O5 (45S5) system and of those from 45S5 BG doped with 2 wt% B2O3 (45S5.2B). The results show, for the first time, the IDPs from 45S5.2B BG stimulated human umbilical vein endothelial cell (HUVEC) proliferation and migration that were associated with phosphorylation of extracellular signal-related kinase (ERK) 1/2, focal adhesion kinase (FAK) and p38 protein. It was also shown that IDPs from 45S5.2B BG could enhance in vitro HUVEC tubule formation and secretion of interleukin 6 (IL6) and the basic fibroblast growth factor (bFGF). The effects observed are attributed to the presence of B in the IDPs. These findings are relevant to bone tissue engineering and regeneration because the IDPs from 45S5.2B BG may act as inexpensive inorganic angiogenic agents providing a convenient alternative to the application of conventional angiogenic growth factors.
Keywords	angiogenesis ; bone formation ; bones ; boron ; calcium ; fibroblast growth factor 2 ; glass ; human umbilical vein endothelial cells ; interleukin-6 ; ions ; mitogen-activated protein kinase ; non-specific protein-tyrosine kinase ; phosphates ; phosphorylation ; secretion ; silica ; sodium ; therapeutics ; tissue engineering
Language	English
Dates of publication	2014-1015
Size	p. 7620-7630.
Publishing place	The Royal Society of Chemistry
Document type	Article
ZDB-ID	2702241-9
ISSN	2050-7518 ; 2050-750X
ISSN (online)	2050-7518
ISSN	2050-750X
DOI	10.1039/c4tb01043d
Database	NAL-Catalogue (AGRICOLA)

Order via subito

Article ; Online: Pharmacodynamic study of the 7,8-dihydroxy-4-methylcoumarin-induced selective cytotoxicity toward U-937 leukemic cells versus mature monocytes: cytoplasmic p21(Cip1/WAF1) as resistance factor.

Vázquez, Ramiro / Riveiro, María Eugenia / Mondillo, Carolina / Perazzo, Juan Carlos / Vermeulen, Mónica / Baldi, Alberto / Davio, Carlos / Shayo, Carina

Biochemical pharmacology

2013 Volume 86, Issue 2, Page(s) 210–221

Abstract	The development of tumor-selective drugs with low systemic toxicity has always been a major challenge in cancer treatment. Our group previously identified the 7,8-dihydroxy-4-methylcoumarin (DHMC) as a potential chemotherapeutic agent due to its potent, selective anti-proliferative and apoptosis-inducing effects on several cancer cell lines over peripheral blood mononuclear cells. However, there are still no published reports that can explain such selectivity of action. Herein, we addressed this question by using the U-937 promonocytic leukemia cell line, which can be forced to differentiate into a monocyte-like phenotype in vitro. U-937 cells differentiation is dependent on the nuclear expression of p21(Cip1/WAF1), a protein that is absent in immature U-937 cells but present in both the nucleus and the cytoplasm of normal DHMC-resistant monocytes. Considering that induction of differentiation rendered U-937 cells resistant to DHMC, we evaluated the possible causal role of cytoplasmic p21(Cip1/WAF1) in the onset of such resistance by employing U-937 cells stably transfected with a ZnCl2-inducible p21(Cip1/WAF1) variant lacking the nuclear localization signal (U-937/CB6-ΔNLS-p21 cells). Expression of cytoplasmic p21(Cip1/WAF1) did not induce differentiation of the cells but turned them resistant to DHMC through inhibition of JNK, a crucial mediator of DHMC-induced apoptosis in U-937 cells. Sub-acute toxicity evaluation of DHMC in Balb/c mice indicated that DHMC administered intraperitoneally at doses up to 100mg/kg induced no systemic damage. Collectively, our results explain for the first time the selective cytotoxicity of DHMC for tumor cells over normal monocytes, and encourage further in vivo studies on this compound as potential anti-leukemic agent.
MeSH term(s)	Animals ; Blotting, Western ; Chemotaxis, Leukocyte ; Coumarins/pharmacology ; Cyclin-Dependent Kinase Inhibitor p21/physiology ; Fluorescent Antibody Technique, Indirect ; Humans ; Male ; Mice ; Mice, Inbred BALB C ; Monocytes/drug effects ; U937 Cells
Chemical Substances	7,8-dihydroxy-4-methylcoumarin ; CDKN1A protein, human ; Coumarins ; Cyclin-Dependent Kinase Inhibitor p21
Language	English
Publishing date	2013-07-15
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	208787-x
ISSN	1873-2968 ; 0006-2952
ISSN (online)	1873-2968
ISSN	0006-2952
DOI	10.1016/j.bcp.2013.04.021
Database	MEDical Literature Analysis and Retrieval System OnLINE

In stock of ZB MED Cologne/Königswinter

Zs.A 19: Show issues

Location:
Je nach Verfügbarkeit (siehe Angabe bei Bestand)
bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
Jg. 1995 - 2021: Lesesall (1.OG)
ab Jg. 2022: Lesesaal (EG)

Order via subito

Details ▾
- See ZB MED holdings
- Order with fees

Article ; Online: Cross-desensitization and cointernalization of H1 and H2 histamine receptors reveal new insights into histamine signal integration.

Alonso, Natalia / Fernandez, Natalia / Notcovich, Cintia / Monczor, Federico / Simaan, May / Baldi, Alberto / Gutkind, J Silvio / Davio, Carlos / Shayo, Carina

Molecular pharmacology

2013 Volume 83, Issue 5, Page(s) 1087–1098

Abstract: G protein-coupled receptor signaling does not result from sequential activation of a linear pathway of proteins/enzymes, but rather from complex interactions of multiple, branched signaling routes, i.e., signaling networks. In this work we present an ... ...

Abstract	G protein-coupled receptor signaling does not result from sequential activation of a linear pathway of proteins/enzymes, but rather from complex interactions of multiple, branched signaling routes, i.e., signaling networks. In this work we present an exhaustive study of the cross-talk between H1 and H2 histamine receptors (H1R and H2R) in U937 cells and Chinese hamster ovary-transfected cells. By desensitization assays we demonstrated the existence of a crossdesensitization between both receptors independent of protein kinase A or C. H1R-agonist stimulation inhibited cell proliferation and induced apoptosis in U937 cells following treatment of 48 hours. H1R-induced antiproliferative and apoptotic response was inhibited by an H2R agonist suggesting that the cross-talk between both receptors modifies their function. Binding and confocal microscopy studies revealed cointernalization of both receptors upon treatment with the agonists. To evaluate potential heterodimerization of the receptors, sensitized emission fluorescence resonance energy transfer experiments were performed in human embryonic kidney 293T cells using H1R-cyan fluorescent protein and H2R-yellow fluorescent protein. To our knowledge these findings may represent the first demonstration of agonist-induced heterodimerization of the H1R and H2R. In addition, we also show that the inhibition of the internalization process did not prevent receptor crossdesensitization, which was mediated by G protein-coupled receptor kinase 2. Our study provides new insights into the complex signaling network mediated by histamine and further knowledge for the rational use of its ligands.
MeSH term(s)	Animals ; Apoptosis/drug effects ; Apoptosis/physiology ; CHO Cells ; Cell Line ; Cell Line, Tumor ; Cell Proliferation/drug effects ; Cricetinae ; Cyclic AMP-Dependent Protein Kinases/metabolism ; G-Protein-Coupled Receptor Kinase 2/metabolism ; HEK293 Cells ; Histamine/metabolism ; Histamine Agonists/pharmacology ; Humans ; Protein Kinase C/metabolism ; Receptors, Histamine H1/metabolism ; Receptors, Histamine H2/metabolism ; Signal Transduction ; U937 Cells
Chemical Substances	Histamine Agonists ; Receptors, Histamine H1 ; Receptors, Histamine H2 ; Histamine (820484N8I3) ; Cyclic AMP-Dependent Protein Kinases (EC 2.7.11.11) ; Protein Kinase C (EC 2.7.11.13) ; G-Protein-Coupled Receptor Kinase 2 (EC 2.7.11.16)
Language	English
Publishing date	2013-03-05
Publishing country	United States
Document type	Journal Article ; Research Support, N.I.H., Intramural ; Research Support, Non-U.S. Gov't
ZDB-ID	124034-1
ISSN	1521-0111 ; 0026-895X
ISSN (online)	1521-0111
ISSN	0026-895X
DOI	10.1124/mol.112.083394
Database	MEDical Literature Analysis and Retrieval System OnLINE

In stock of ZB MED Cologne/Königswinter

Zs.A 525: Show issues

Location:
Je nach Verfügbarkeit (siehe Angabe bei Bestand)
bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
Jg. 1995 - 2021: Lesesall (1.OG)
ab Jg. 2022: Lesesaal (EG)

Order via subito

Details ▾
- See ZB MED holdings
- Order with fees

Article ; Online: FGFR3 Down-Regulation is Involved in bacillus Calmette-Guérin Induced Bladder Tumor Growth Inhibition.

Langle, Yanina V / Belgorosky, Denise / Prack McCormick, Bárbara / Sahores, Ana / Góngora, Adrián / Baldi, Alberto / Lanari, Claudia / Lamb, Caroline / Eiján, Ana M

The Journal of urology

2016 Volume 195, Issue 1, Page(s) 188–197

Abstract: Purpose: Bacillus Calmette-Guérin is the standard treatment for patients with nonmuscle invasive high histological grade bladder cancer. Previously we found that bacillus Calmette-Guérin induces murine bladder cancer MB49 cell death in vitro and in vivo, ...

Abstract	Purpose: Bacillus Calmette-Guérin is the standard treatment for patients with nonmuscle invasive high histological grade bladder cancer. Previously we found that bacillus Calmette-Guérin induces murine bladder cancer MB49 cell death in vitro and in vivo, generating tissue remodeling, which involves the release of fibroblast growth factor (FGF)-2. Materials and methods: We studied the effect of bacillus Calmette-Guérin treatment on FGF-2 and FGF receptor (FGFR) expression in bladder cancer. Results: In vitro FGF-2 increased MB49 cell proliferation but did not reverse bacillus Calmette-Guérin induced cell death. Increased FGF-2 expression was detected after bacillus Calmette-Guérin treatment. Moreover MB49 cells expressed high FGFR3 levels, which decreased after treatment. Similar results were observed in human T24 bladder cancer cells. In vivo MB49 tumors expressed higher FGFR3 levels than normal urothelium. Tumor FGFR3 decreased after treatment and correlated with tumor growth inhibition in response to bacillus Calmette-Guérin. In a pilot bioassay using 11 human bladder tumors treated ex vivo with bacillus Calmette-Guérin we found a subgroup of 41% of patients in whom FGFR3 was decreased after treatment. Conclusions: Based on bladder cancer murine model results we infer that down-regulation of FGFR3 is a predictive marker of a good response to bacillus Calmette-Guérin therapy. The decrease in FGFR3 in response to bacillus Calmette-Guérin occurred not only in a murine model but also in a human bladder cancer cell line and in some patient samples. More patients and increased followup are needed to establish the predictive role of FGFR3 as a marker in human bladder cancer.
MeSH term(s)	Adjuvants, Immunologic/therapeutic use ; Animals ; BCG Vaccine/therapeutic use ; Cell Proliferation ; Cells, Cultured ; Down-Regulation ; Humans ; Mice ; Receptor, Fibroblast Growth Factor, Type 3/biosynthesis ; Urinary Bladder Neoplasms/drug therapy ; Urinary Bladder Neoplasms/metabolism ; Urinary Bladder Neoplasms/pathology
Chemical Substances	Adjuvants, Immunologic ; BCG Vaccine ; FGFR3 protein, human (EC 2.7.10.1) ; Receptor, Fibroblast Growth Factor, Type 3 (EC 2.7.10.1)
Language	English
Publishing date	2016-01
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	3176-8
ISSN	1527-3792 ; 0022-5347
ISSN (online)	1527-3792
ISSN	0022-5347
DOI	10.1016/j.juro.2015.06.093
Database	MEDical Literature Analysis and Retrieval System OnLINE

In stock of ZB MED Cologne/Königswinter

Ui VI Zs.91: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular ab Jg. 2022: Lesesaal (EG)
Zs.MO 331: Show issues

Order via subito

Details ▾
- See ZB MED holdings
- Order with fees

To top

More links

Kategorien

Order via subito

Inter-library loan at ZB MED

Full text online

More links

Kategorien

Inter-library loan at ZB MED

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

More links

Kategorien

Order via subito

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

More links

Kategorien

Order via subito

More links

Kategorien

Order via subito

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito