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Article ; Online: The Role of Major Salivary Gland Ultrasound in the Diagnostic Workup of Sicca Syndrome: A Large Single-Centre Study.

Vallifuoco, Giulia / Falsetti, Paolo / Bardelli, Marco / Conticini, Edoardo / Gentileschi, Stefano / Baldi, Caterina / Al Khayyat, Suhel Gabriele / Cantarini, Luca / Frediani, Bruno

Tomography (Ann Arbor, Mich.)

2024 Volume 10, Issue 1, Page(s) 66–78

Abstract: 1) Objective: To determine the diagnostic accuracy of major salivary gland ultrasonography (SGUS) in primary Sjogren's syndrome (SS), we used the Outcome Measures in Rheumatology Clinical Trials (OMERACT) scoring system on a large single-centre cohort ... ...

Abstract	(1) Objective: To determine the diagnostic accuracy of major salivary gland ultrasonography (SGUS) in primary Sjogren's syndrome (SS), we used the Outcome Measures in Rheumatology Clinical Trials (OMERACT) scoring system on a large single-centre cohort of patients with sicca syndrome. (2) Method: We retrospectively collected the clinical, imaging and serological data of all the patients referred with a suspicion of SS who underwent SGUS and minor salivary glands biopsy. (3) Results: A total of 132 patients were included. The SGUS scores were correlated between the two sides (
MeSH term(s)	Humans ; Sjogren's Syndrome/diagnostic imaging ; Retrospective Studies ; Salivary Glands/diagnostic imaging ; Ultrasonography ; Fibrosis
Language	English
Publishing date	2024-01-08
Publishing country	Switzerland
Document type	Journal Article
ISSN	2379-139X
ISSN (online)	2379-139X
DOI	10.3390/tomography10010006
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Article: Superb microvascular imaging in giant cell arteritis.

Conticini, Edoardo / Falsetti, Paolo / Baldi, Caterina / Bardelli, Marco / Cantarini, Luca / Frediani, Bruno

Clinical and experimental rheumatology

2022 Volume 40, Issue 4, Page(s) 860–861

MeSH term(s)	Diagnostic Imaging ; Giant Cell Arteritis/diagnostic imaging ; Humans
Language	English
Publishing date	2022-04-27
Publishing country	Italy
Document type	Letter ; Comment
ZDB-ID	605886-3
ISSN	1593-098X ; 0392-856X
ISSN (online)	1593-098X
ISSN	0392-856X
DOI	10.55563/clinexprheumatol/ygcvaz
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Article ; Online: Routine color doppler ultrasonography for the early diagnosis of cranial giant cell arteritis relapses.

Conticini, Edoardo / Falsetti, Paolo / Baldi, Caterina / Fabiani, Claudia / Cantarini, Luca / Frediani, Bruno

Internal and emergency medicine

2022 Volume 17, Issue 8, Page(s) 2431–2435

MeSH term(s)	Humans ; Giant Cell Arteritis/diagnostic imaging ; Ultrasonography, Doppler, Color ; Recurrence ; Early Diagnosis ; Ultrasonography
Language	English
Publishing date	2022-09-26
Publishing country	Italy
Document type	Letter
ZDB-ID	2454173-4
ISSN	1970-9366 ; 1828-0447
ISSN (online)	1970-9366
ISSN	1828-0447
DOI	10.1007/s11739-022-03110-w
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Article ; Online: Diffuse Peripheral Enthesitis in Metabolic Syndrome: A Retrospective Clinical and Power Doppler Ultrasound Study.

Falsetti, Paolo / Conticini, Edoardo / Baldi, Caterina / Bardelli, Marco / Cantarini, Luca / Frediani, Bruno

Reumatologia clinica

2022 Volume 18, Issue 5, Page(s) 273–278

Abstract: Objectives: To investigate peripheral enthesitis with power Doppler ultrasound (PDUS) in patients presenting low back pain (LBP) and metabolic syndrome (MetS) in comparison with patients with only LBP, to correlate US scores with clinical-anthropometric ...

Abstract	Objectives: To investigate peripheral enthesitis with power Doppler ultrasound (PDUS) in patients presenting low back pain (LBP) and metabolic syndrome (MetS) in comparison with patients with only LBP, to correlate US scores with clinical-anthropometric characteristics, and to define any relationship between enthesitis and concurrent diffuse idiopathic hyperostosis syndrome (DISH). Methods: Sixty outpatients with LBP and MetS, evaluated with multi-site entheseal PDUS, scoring inflammatory and structural damage changes, were retrospectively analyzed. A group of 60 subjects with LBP, without MetS and evaluated with the same protocol, was analyzed as the control group. Results: Patients showed overweight (BMI 29.8) and low-grade inflammatory state (C-reactive protein [CRP] 0.58mg/dL, erythrosedimentation rate [ESR] 20.2mm/h). Enthesitis was demonstrated in 52 (86%) patients (17.6% entheses), and in 8 controls (13.3%) (p<.00001). PD signals (15% of patients) were associated with entheseal pain (p=.0138). US scores correlated with body mass index (BMI), pain, type 2 diabetes. In 28 (46%) patients a concurrent DISH was diagnosed, correlating with older age (p<.0001), CRP (p=.0428), ESR (p=.0069) and PDUS scores (p=.0312 inflammatory, p=.0071 structural). MetS had a strong association (OR 4.375, p=.0007) with concurrent DISH. Conclusions: Diffuse peripheral enthesitis is very common in MetS. Almost half of MetS patients can have a concurrent diagnosis of DISH; they are older, with higher inflammation, and higher PDUS enthesitis scores.
MeSH term(s)	Diabetes Mellitus, Type 2 ; Enthesopathy/diagnostic imaging ; Enthesopathy/etiology ; Humans ; Metabolic Syndrome/complications ; Metabolic Syndrome/diagnostic imaging ; Pain ; Retrospective Studies ; Ultrasonography, Doppler/methods
Language	English
Publishing date	2022-05-13
Publishing country	Spain
Document type	Journal Article
ISSN	2173-5743
ISSN (online)	2173-5743
DOI	10.1016/j.reumae.2020.12.005
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Article: Efficacy and Safety of Upadacitinib in Rheumatoid Arthritis: Real-Life Experience from a Prospective Longitudinal Multicentric Study.

Baldi, Caterina / Parisi, Simone / Falsetti, Paolo / Sota, Jurgen / Ditto, Maria Chiara / Capassoni, Marco / D'alessandro, Miriana / Conticini, Edoardo / Nacci, Francesca / Peroni, Clara Lisa / Cometi, Laura / Fusaro, Enrico / Frediani, Bruno / Guiducci, Serena

Journal of clinical medicine

2024 Volume 13, Issue 2

Abstract: Background: We provide the first prospective longitudinal multicenter experience on Upadacitinib efficacy and safety profile in Rheumatoid Arthritis (RA) in a real-life context, focusing on clinimetric and ultrasonographic (US) data.: Methods: RA ... ...

Abstract	Background: We provide the first prospective longitudinal multicenter experience on Upadacitinib efficacy and safety profile in Rheumatoid Arthritis (RA) in a real-life context, focusing on clinimetric and ultrasonographic (US) data. Methods: RA patients referred to three Italian tertiary Centers who started Upadacitinib were enrolled as per ACR/EULAR classification criteria and prospectively reviewed. The primary aim of this study was to assess changes in clinimetric and ultrasonographic scores through time (at baseline, after 1 month, 3 months, and 6 months from the beginning of the therapy). Secondary aims were to: (i) estimate the impact of biologic lines of treatment and concomitant therapies on response to therapy; (ii) explore changes in laboratory parameters; and (iii) find potential predictive factors associated with response to therapy. Results: Seventy-one patients (49 Females and 22 Males) were included. Clinimetric scores, including the Disease Activity Score (DAS28-CRP) and Simplified Clinical Disease Activity Index (SDAI), and US findings (synovial hypertrophy and power Doppler) significantly improved ( Conclusion: Our real-life experience confirms the efficacy of Upadacitinib in terms of clinical and ultrasonographic improvement, as well as displaying a good safety profile.
Language	English
Publishing date	2024-01-11
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2662592-1
ISSN	2077-0383
ISSN	2077-0383
DOI	10.3390/jcm13020401
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Article ; Online: Impact of age and cardiovascular risk factors on the incidence of adverse events in patients with rheumatoid arthritis treated with Janus Kinase inhibitors: data from a real-life multicentric cohort.

Gentileschi, Stefano / Gaggiano, Carla / Damiani, Arianna / Coccia, Carmela / Bernardini, Pamela / Cazzato, Massimiliano / D'Alessandro, Francesco / Vallifuoco, Giulia / Terribili, Riccardo / Bardelli, Marco / Baldi, Caterina / Cantarini, Luca / Mosca, Marta / Frediani, Bruno / Guiducci, Serena

Clinical and experimental medicine

2024 Volume 24, Issue 1, Page(s) 62

Abstract: Inhibiting Janus Kinases (JAK) is a crucial therapeutic strategy in rheumatoid arthritis (RA). However, the use of JAK inhibitors has recently raised serious safety concerns. The study aims to evaluate the safety profile of JAKi in patients with RA and ... ...

Abstract	Inhibiting Janus Kinases (JAK) is a crucial therapeutic strategy in rheumatoid arthritis (RA). However, the use of JAK inhibitors has recently raised serious safety concerns. The study aims to evaluate the safety profile of JAKi in patients with RA and identify potential risk factors (RFs) for adverse events (AEs). Data of RA patients treated with JAKi in three Italian centers from January 2017 to December 2022 were retrospectively analyzed. 182 subjects (F:117, 64.3%) underwent 193 treatment courses. 78.6% had at least one RF, including age ≥ 65 years, obesity, smoking habit, hypertension, dyslipidemia, hyperuricemia, diabetes, previous VTE or cancer, and severe mobility impairment. We identified 70 AEs (28/100 patients/year), among which 15 were serious (6/100 patients/year). A high disease activity was associated with AEs occurrence (p = 0.03 for CDAI at T0 and T6; p = 0.04 for SDAI at T0 and T6; p = 0.01 and p = 0.04 for DAS28ESR at T6 and T12, respectively). No significant differences in AEs occurrence were observed after stratification by JAKi molecules (p = 0.44), age groups (p = 0.08) nor presence of RFs (p > 0.05 for all of them). Neither the presence of any RFs, nor the cumulative number of RFs shown by the patient, nor age ≥ 65 did predict AEs occurrence. Although limited by the small sample size and the limited number of cardiovascular events, our data do not support the correlation between cardiovascular RFs-including age-and a higher incidence of AEs during JAKi therapy. The role of uncontrolled disease activity in AEs occurrence should by emphasized.
MeSH term(s)	Humans ; Aged ; Janus Kinase Inhibitors/adverse effects ; Cardiovascular Diseases/epidemiology ; Incidence ; Retrospective Studies ; Risk Factors ; Arthritis, Rheumatoid/drug therapy ; Heart Disease Risk Factors ; Antirheumatic Agents/adverse effects
Chemical Substances	Janus Kinase Inhibitors ; Antirheumatic Agents
Language	English
Publishing date	2024-03-30
Publishing country	Italy
Document type	Journal Article
ZDB-ID	2053018-3
ISSN	1591-9528 ; 1591-8890
ISSN (online)	1591-9528
ISSN	1591-8890
DOI	10.1007/s10238-024-01325-z
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Zs.A 5481: Show issues

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Article: Diagnostic accuracy of OGUS, Southend halo score and halo count in giant cell arteritis.

Conticini, Edoardo / Falsetti, Paolo / Al Khayyat, Suhel Gabriele / Grazzini, Silvia / Baldi, Caterina / Bellisai, Francesca / Gentileschi, Stefano / Bardelli, Marco / Fabiani, Claudia / Cantarini, Luca / Dasgupta, Bhaskar / Frediani, Bruno

Frontiers in medicine

2024 Volume 11, Page(s) 1320076

Abstract: Objectives: Ultrasound has a paramount role in the diagnostic assessment of giant cell arteritis (GCA); Southend halo score (HS), halo count (HC), and OMERACT GCA Ultrasonography Score (OGUS) are the first quantitative scores proposed in this setting. ... ...

Abstract	Objectives: Ultrasound has a paramount role in the diagnostic assessment of giant cell arteritis (GCA); Southend halo score (HS), halo count (HC), and OMERACT GCA Ultrasonography Score (OGUS) are the first quantitative scores proposed in this setting. The aim of this study was therefore to assess the diagnostic accuracy of these scores in a real-life scenario, as well as to evaluate their optimal cutoff, also with respect to disease extent, sex, and age. Methods: We retrospectively collected clinical, serological, and US findings of all patients referred for the first time to our vasculitis clinic in the suspicion of GCA. Results: A total of 79 patients were included, and a definite diagnosis of GCA was made in 43 patients. For OGUS, the ROC curve showed an optimal cut point of 0.81 (sensitivity 79.07% and specificity 97.22%). For HC and HS, the optimal cutoff values were > 1.5 (sensitivity 76.7% and specificity 97.2%) and > 14.5 (sensitivity 74.4% and specificity 97.2%), respectively. No relevant differences were assessed when patients were stratified according to disease extent, age, and sex. Compression sign (CS) was positive in 34 of 38 patients with cranial GCA and negative in all controls and LV-GCA. Conclusion: All three scores display good sensitivity and excellent specificity, although the cutoff was slightly different than proposed. In particular, for OGUS, a threshold of 0.81 could be employed for diagnostic purposes, although it was developed solely for monitoring. Due to its high sensitivity and specificity, CS should be always assessed in all patients referred with a suspicion of cranial GCA.
Language	English
Publishing date	2024-01-26
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2775999-4
ISSN	2296-858X
ISSN	2296-858X
DOI	10.3389/fmed.2024.1320076
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Article: High prevalence of ultrasound-defined enthesitis in patients with metabolic syndrome. Comment on: How normal is the enthesis by ultrasound in healthy subjects? Di Matteo et al.

Falsetti, Paolo / Conticini, Edoardo / Baldi, Caterina / Acciai, Caterina / Frediani, Bruno

Clinical and experimental rheumatology

2020 Volume 39, Issue 2, Page(s) 435–436

MeSH term(s)	Enthesopathy ; Healthy Volunteers ; Humans ; Metabolic Syndrome/diagnostic imaging ; Metabolic Syndrome/epidemiology ; Prevalence ; Ultrasonography
Language	English
Publishing date	2020-04-23
Publishing country	Italy
Document type	Letter ; Comment
ZDB-ID	605886-3
ISSN	1593-098X ; 0392-856X
ISSN (online)	1593-098X
ISSN	0392-856X
DOI	10.55563/clinexprheumatol/zm9e6u
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Zs.A 2002: Show issues

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Jg. 1995 - 2021: Lesesall (1.OG)
ab Jg. 2022: Lesesaal (EG)

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Article ; Online: Diffuse Peripheral Enthesitis in Metabolic Syndrome: A Retrospective Clinical and Power Doppler Ultrasound Study.

Falsetti, Paolo / Conticini, Edoardo / Baldi, Caterina / Bardelli, Marco / Cantarini, Luca / Frediani, Bruno

Reumatologia clinica

2021

Abstract	Objectives: To investigate peripheral enthesitis with power Doppler ultrasound (PDUS) in patients presenting low back pain (LBP) and metabolic syndrome (MetS) in comparison with patients with only LBP, to correlate US scores with clinical-anthropometric characteristics, and to define any relationship between enthesitis and concurrent diffuse idiopathic hyperostosis syndrome (DISH). Methods: Sixty outpatients with LBP and MetS, evaluated with multi-site entheseal PDUS, scoring inflammatory and structural damage changes, were retrospectively analyzed. A group of 60 subjects with LBP, without MetS and evaluated with the same protocol, was analyzed as the control group. Results: Patients showed overweight (BMI 29.8) and low-grade inflammatory state (C-reactive protein [CRP] 0.58mg/dL, erythrosedimentation rate [ESR] 20.2mm/h). Enthesitis was demonstrated in 52 (86%) patients (17.6% entheses), and in 8 controls (13.3%) (p<.00001). PD signals (15% of patients) were associated with entheseal pain (p=.0138). US scores correlated with body mass index (BMI), pain, type 2 diabetes. In 28 (46%) patients a concurrent DISH was diagnosed, correlating with older age (p<.0001), CRP (p=.0428), ESR (p=.0069) and PDUS scores (p=.0312 inflammatory, p=.0071 structural). MetS had a strong association (OR 4.375, p=.0007) with concurrent DISH. Conclusions: Diffuse peripheral enthesitis is very common in MetS. Almost half of MetS patients can have a concurrent diagnosis of DISH; they are older, with higher inflammation, and higher PDUS enthesitis scores.
Language	Spanish
Publishing date	2021-02-24
Publishing country	Spain
Document type	Journal Article
ISSN	2173-5743
ISSN (online)	2173-5743
DOI	10.1016/j.reuma.2020.12.005
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Article: Stem Cell Injection for Complex Refractory Perianal Fistulas in Crohn's Disease: A Single Center Initial Experience.

Colombo, Francesco / Cammarata, Francesco / Baldi, Caterina / Rizzetto, Francesco / Bondurri, Andrea / Carmagnola, Stefania / Gridavilla, Daniele / Maconi, Giovanni / Ardizzone, Sandro / Danelli, Piergiorgio

Frontiers in surgery

2022 Volume 9, Page(s) 834870

Abstract: From 30 to 70% of patients with Crohn's disease (CD) may develop perianal fistulas during their lifetime. The medical and surgical management of this complication is challenging, and its treatment still gives unsatisfactory results. However, recent ... ...

Abstract	From 30 to 70% of patients with Crohn's disease (CD) may develop perianal fistulas during their lifetime. The medical and surgical management of this complication is challenging, and its treatment still gives unsatisfactory results. However, recent studies on adipose-derived mesenchymal stem cells have proven their anti-inflammatory and immuno-modulatory potential, representing a new promising tool in the treatment of such stubborn disease. We report our initial experience with three patients who had recurrent perianal CD treated with local infiltration of stem cell darvadstrocel (Alofisel). All the patients had a long history of perianal disease refractory to multiple medical and surgical treatments. The preoperative workup included transperineal ultrasound (TP-US), pelvic MRI, and colonoscopy that ruled out active proctitis in all the patients. The post-treatment follow-up included clinical assessment at 1, 3, and 6 months with repeated MRI and TP-US at 6 months. At 6 months, 2 patients had a clinical response despite radiological persistence of fistula tracts, while one patient presented perianal fistula recurrence complicated by perianal abscess. Although our experience is limited to 3 patients and a short follow-up, our results confirm that darvadstrocel injection is a safe procedure, with a good clinical response in most of the patients, but that it apparently had no effect on the anatomical modification of the fistula tracts. Long-term results, with a rigorous assessment of anatomical lesions, are still needed to support the promising data of the literature.
Language	English
Publishing date	2022-02-07
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2773823-1
ISSN	2296-875X
ISSN	2296-875X
DOI	10.3389/fsurg.2022.834870
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