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Article: Ultrasound examination of coelomic viscera through the plastron in stranded green sea turtles (

Baldini, Mariella / Roque, Caroline Augusto / Marcon, Melissa / Maranho, Andrea

2019 Volume 9, Issue 1, Page(s) 38–43

Abstract: Many projects have been developed in the last years for the conservation of sea turtles. Young green turtles ( ...

Abstract	Many projects have been developed in the last years for the conservation of sea turtles. Young green turtles (
MeSH term(s)	Animals ; Brazil/epidemiology ; Feces/chemistry ; Foreign Bodies/epidemiology ; Foreign Bodies/etiology ; Foreign Bodies/veterinary ; Gastrointestinal Contents/diagnostic imaging ; Gastrointestinal Tract/diagnostic imaging ; Turtles ; Ultrasonography/veterinary
Language	English
Publishing date	2019-02-18
Publishing country	Libya
Document type	Journal Article
ZDB-ID	2651664-0
ISSN	2218-6050 ; 2226-4485
ISSN (online)	2218-6050
ISSN	2226-4485
DOI	10.4314/ovj.v9i1.7
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Article ; Online: Post-Stroke Detection of Subclinical Paroxysmal Atrial Fibrillation in Patients With Embolic Stroke of Undetermined Source in the Real World Practice: The Empoli ESUS Atrial Fibrillation (E 2 AF) Study.

Grifoni, Elisa / Baldini, Giulia / Baldini, Mariella / Pinto, Gabriele / Micheletti, Irene / Madonia, Elisa M / Cosentino, Eleonora / Bartolozzi, Maria L / Bertini, Elisabetta / Dei, Alessandro / Signorini, Ira / Giannoni, Sara / Del Rosso, Attilio / Prisco, Domenico / Guidi, Leonello / Masotti, Luca

The neurologist

2023 Volume 28, Issue 1, Page(s) 25–31

Abstract: Background: Subclinical paroxysmal atrial fibrillation (AF) is one of the main occult causative mechanisms of embolic stroke of undetermined source (ESUS). Aim of this study was to identify AF predictors, and to develop a score to predict the ... ...

Abstract	Background: Subclinical paroxysmal atrial fibrillation (AF) is one of the main occult causative mechanisms of embolic stroke of undetermined source (ESUS). Aim of this study was to identify AF predictors, and to develop a score to predict the probability of AF detection in ESUS. Methods: We retrospectively analyzed ESUS patients undergoing 2-week external electrocardiographic monitoring. Patients with and without AF detection were compared. On the basis of multivariate analysis, predictors of AF were identified and used to develop a predictive score, which was then compared with other existing literature scores. Results: Eighty-two patients, 48 females, mean age±SD 72±10 years, were included. In 36 patients (43.9%) AF was detected. The frequency of age 75 years or above and arterial hypertension, and the median CHA 2 DS 2 -VASc score were significantly higher in patients with AF compared with those without. National Institutes of Health Stroke Scale (NIHSS) score ≥8 was the only independent variable associated with AF detection. We derived the Empoli ESUS-AF (E 2 AF) score (NIHSS ≥8 5 points, arterial hypertension 3 points, age 75 years or above 2 points, age 65 to 74 years 1 point, history of coronary/peripheral artery disease 1 point, left atrial enlargement 1 point, posterior lesion 1 point, cortical or cortical-subcortical lesion 1 point), whose predictive power in detecting AF was good (area under the curve: 0.746, 95% confidence interval: 0.638-0.836) and higher than that of CHA 2 DS 2 -VASc and other scores. Conclusions: In our study NIHSS score ≥8 was the only independent predictor of post-ESUS-AF detection. The E 2 AF score appears to have a good predictive power for detecting AF. External validations are required.
MeSH term(s)	Aged ; Female ; Humans ; Atrial Fibrillation/complications ; Atrial Fibrillation/diagnosis ; Embolic Stroke/complications ; Hypertension/complications ; Hypertension/diagnosis ; Retrospective Studies ; Risk Factors ; Stroke/complications ; Stroke/diagnosis ; Male
Language	English
Publishing date	2023-01-01
Publishing country	United States
Document type	Journal Article
ZDB-ID	1361380-7
ISSN	2331-2637 ; 1074-7931
ISSN (online)	2331-2637
ISSN	1074-7931
DOI	10.1097/NRL.0000000000000440
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Article ; Online: Validation of Empoli Embolic Stroke of Undetermined Source Atrial Fibrillation (E 2 AF) Score for Detecting Atrial Fibrillation in Patients With Embolic Stroke of Undetermined Source.

Masotti, Luca / Grifoni, Elisa / Baglini, Alessia / Sivieri, Irene / Mannini, Marianna / Iandoli, Gina / Madonia, Elisa Maria / Cosentino, Eleonora / Micheletti, Irene / Signorini, Ira / Cioni, Elisa / Sansone, Teresa / Pelagalli, Giulia / Baldini, Mariella / Giannoni, Sara / Bertini, Elisabetta / Di Donato, Ilaria

The neurologist

2023 Volume 28, Issue 6, Page(s) 426–428

MeSH term(s)	Humans ; Atrial Fibrillation/complications ; Atrial Fibrillation/diagnosis ; Embolic Stroke ; Heart Atria ; Stroke/complications ; Stroke/diagnosis ; Risk Factors
Language	English
Publishing date	2023-11-01
Publishing country	United States
Document type	Journal Article
ZDB-ID	1361380-7
ISSN	2331-2637 ; 1074-7931
ISSN (online)	2331-2637
ISSN	1074-7931
DOI	10.1097/NRL.0000000000000497
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Article ; Online: Posterior reversible encephalopathy syndrome in a complicated autoimmune background: differential diagnosis and etiological hypothesis.

Bartolini, Emanuele / Baldini, Mariella / Ricci, Giulia

Acta neurologica Belgica

2013 Volume 113, Issue 2, Page(s) 191–193

MeSH term(s)	Adult ; Autoimmune Diseases/diagnosis ; Autoimmune Diseases/immunology ; Brain/immunology ; Brain/pathology ; Diagnosis, Differential ; Female ; Humans ; Magnetic Resonance Imaging/methods ; Posterior Leukoencephalopathy Syndrome/diagnosis ; Posterior Leukoencephalopathy Syndrome/etiology ; Posterior Leukoencephalopathy Syndrome/immunology
Language	English
Publishing date	2013-06
Publishing country	Italy
Document type	Case Reports ; Letter
ZDB-ID	127315-2
ISSN	2240-2993 ; 0300-9009
ISSN (online)	2240-2993
ISSN	0300-9009
DOI	10.1007/s13760-012-0105-2
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Article ; Online: Impulsivity traits and awareness of motor intention in Parkinson's disease: a proof-of-concept study.

Giovannelli, Fabio / Menichetti, Chiara / Kiferle, Lorenzo / Raglione, Laura Maria / Brotini, Stefania / Vanni, Paola / Bacci, Duccio / Baldini, Mariella / Borgheresi, Alessandra / Del Bene, Alessandra / Grassi, Enrico / Guidi, Leonello / Toscani, Lucia / Volpi, Gino / Palumbo, Pasquale / Viggiano, Maria Pia / Cincotta, Massimo

Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology

2021 Volume 43, Issue 1, Page(s) 335–340

Abstract: Introduction: In patients with Parkinson's disease (PD), impulsivity is still a matter of investigation. It has been hypothesized that impulsive personality traits may favour impulse control disorder (ICD) onset during dopaminergic therapy. In healthy ... ...

Abstract	Introduction: In patients with Parkinson's disease (PD), impulsivity is still a matter of investigation. It has been hypothesized that impulsive personality traits may favour impulse control disorder (ICD) onset during dopaminergic therapy. In healthy subjects, a relationship between the awareness of motor intention and impulsive personality traits assessed by the Barratt impulsivity scale (BIS-11) has been reported. The aim of this study was to evaluate the relationship between the awareness of voluntary action and impulsivity traits in PD. Methods: Twenty-eight PD patients (stages I-III on the Hoehn and Yahr scale) underwent an impulsivity trait assessment by the BIS-11 scale and a task based on the Libet's clock. Participants were requested to perform a self-initiated movement and report the time they first feel their intention to move (W-judgement) or the time of the actual movement (M-judgement). Results: In patients with higher BIS-11 scores, the time lag between the W-judgement and the actual movement was significantly lower than in patients with lower BIS-11. No difference emerged in the M-judgement. Conclusion: Data suggest that also in PD patients, the impulsive personality trait is related to a "delayed" awareness of motor intention and therefore to a shorter interval to allow a conscious "veto" of the impending action. Characterization of the temporal profile of awareness of motor intention could prove useful in identifying PD patients at risk of developing ICDs during dopaminergic treatment.
MeSH term(s)	Humans ; Impulsive Behavior ; Intention ; Judgment ; Movement ; Parkinson Disease/drug therapy
Language	English
Publishing date	2021-05-28
Publishing country	Italy
Document type	Journal Article
ZDB-ID	2016546-8
ISSN	1590-3478 ; 1590-1874
ISSN (online)	1590-3478
ISSN	1590-1874
DOI	10.1007/s10072-021-05325-9
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Article ; Online: Predictive Factors for Hemorrhagic Transformation in Acute Ischemic Stroke in the REAL-World Clinical Practice.

Grifoni, Elisa / Bini, Chiara / Signorini, Ira / Cosentino, Eleonora / Micheletti, Irene / Dei, Alessandro / Pinto, Gabriele / Madonia, Elisa Maria / Sivieri, Irene / Mannini, Marianna / Baldini, Mariella / Bertini, Elisabetta / Giannoni, Sara / Bartolozzi, Maria Letizia / Guidi, Leonello / Bartalucci, Paola / Vanni, Simone / Segneri, Antonio / Pratesi, Alessandra /

Giordano, Antonio / Dainelli, Francesca / Maggi, Francesca / Romagnoli, Mario / Cioni, Elisa / Cioffi, Elisa / Pelagalli, Giulia / Mattaliano, Chiara / Schipani, Elena / Murgida, Giuseppe Salvatore / Di Martino, Stefania / Sisti, Eleonora / Cozzi, Andrea / Francolini, Valentina / Masotti, Luca

The neurologist

2023 Volume 28, Issue 3, Page(s) 150–156

Abstract: Background: Few data exists on predictive factors of hemorrhagic transformation (HT) in real-world acute ischemic stroke patients. The aims of this study were: (i) to identify predictive variables of HT (ii) to develop a score for predicting HT.: ... ...

Abstract	Background: Few data exists on predictive factors of hemorrhagic transformation (HT) in real-world acute ischemic stroke patients. The aims of this study were: (i) to identify predictive variables of HT (ii) to develop a score for predicting HT. Methods: We retrospectively analyzed the clinical, radiographic, and laboratory data of patients with acute ischemic stroke consecutively admitted to our Stroke Unit along two years. Patients with HT were compared with those without HT. A multivariate logistic regression analysis was performed to identify independent predictors of HT on CT scan at 24 hours to develop a practical score. Results: The study population consisted of 564 patients with mean age 77.5±11.8 years. Fifty-two patients (9.2%) showed HT on brain CT at 24 hours (4.9% symptomatic). NIHSS score ≥8 at Stroke Unit admission (3 points), cardioembolic etiology (2 points), acute revascularization by systemic thrombolysis and/or mechanical thrombectomy (1 point), history of previous TIA/stroke (1 point), and major vessel occlusion (1 point) were found independent risk factors of HT and were included in the score (Hemorrhagic Transformation Empoli score (HTE)). The predictive power of HTE score was good with an AUC of 0.785 (95% CI: 0.749-0.818). Compared with 5 HT predictive scores proposed in the literature (THRIVE, SPAN-100, MSS, GRASPS, SITS-SIC), the HTE score significantly better predicted HT. Conclusions: NIHSS score ≥8 at Stroke Unit admission, cardioembolism, urgent revascularization, previous TIA/stroke, and major vessel occlusion were independent predictors of HT. The HTE score has a good predictive power for HT. Prospective studies are warranted.
MeSH term(s)	Humans ; Aged ; Aged, 80 and over ; Brain Ischemia/complications ; Brain Ischemia/diagnostic imaging ; Ischemic Stroke/complications ; Ischemic Stroke/diagnostic imaging ; Retrospective Studies ; Ischemic Attack, Transient ; Stroke/complications ; Stroke/diagnostic imaging ; Risk Factors
Language	English
Publishing date	2023-05-01
Publishing country	United States
Document type	Journal Article
ZDB-ID	1361380-7
ISSN	2331-2637 ; 1074-7931
ISSN (online)	2331-2637
ISSN	1074-7931
DOI	10.1097/NRL.0000000000000462
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Article ; Online: Epilepsy after neuroimaging normalization in a woman with tacrolimus-related posterior reversible encephalopathy syndrome.

Baldini, Mariella / Bartolini, Emanuele / Gori, Sara / Bonanni, Enrica / Cosottini, Mirco / Iudice, Alfonso / Murri, Luigi

Epilepsy & behavior : E&B

2010 Volume 17, Issue 4, Page(s) 558–560

Abstract: Posterior reversible encephalopathy syndrome (PRES) is known to occur after solid organ transplantation, and is caused by immunosuppressive agents such as tacrolimus. PRES onset usually occurs within the first 2months after liver transplantation. ... ...

Abstract	Posterior reversible encephalopathy syndrome (PRES) is known to occur after solid organ transplantation, and is caused by immunosuppressive agents such as tacrolimus. PRES onset usually occurs within the first 2months after liver transplantation. Clinical findings include seizures, headache, focal neurological deficits, visual disturbances, and altered mental status. These are associated with characteristic imaging features of subcortical white matter lesions on brain MRI. Atypical localizations of this posterior leukoencephalopathy have been reported. Expeditious recognition of the syndrome may lead to a complete recovery. Abnormalities of EEG during follow-up might be associated with unfavorable seizure outcome, even when neuroimaging changes resolve. We report a case of late-onset PRES with atypical localization following liver transplantation. The patient developed epilepsy despite resolution of MRI lesions at 8 months of follow-up. EEG was a prognostic factor of seizure persistence, suggesting an incomplete recovery of brain lesions in contrast to neuroimaging findings.
MeSH term(s)	Electroencephalography/methods ; Epilepsy, Tonic-Clonic/chemically induced ; Female ; Follow-Up Studies ; Frontal Lobe/pathology ; Humans ; Immunosuppressive Agents/adverse effects ; Magnetic Resonance Imaging/methods ; Tacrolimus/adverse effects ; Young Adult
Chemical Substances	Immunosuppressive Agents ; Tacrolimus (WM0HAQ4WNM)
Language	English
Publishing date	2010-04
Publishing country	United States
Document type	Case Reports ; Journal Article
ZDB-ID	2010587-3
ISSN	1525-5069 ; 1525-5050
ISSN (online)	1525-5069
ISSN	1525-5050
DOI	10.1016/j.yebeh.2010.01.014
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Article ; Online: Establishing pathological cut-offs of brain atrophy rates in multiple sclerosis.

De Stefano, Nicola / Stromillo, Maria Laura / Giorgio, Antonio / Bartolozzi, Maria Letizia / Battaglini, Marco / Baldini, Mariella / Portaccio, Emilio / Amato, Maria Pia / Sormani, Maria Pia

Journal of neurology, neurosurgery, and psychiatry

2016 Volume 87, Issue 1, Page(s) 93–99

Abstract: Objective: To assess whether it is feasible to establish specific cut-off values able to discriminate 'physiological' or 'pathological' brain volume rates in patients with multiple sclerosis (MS).: Methods: The study was based on the analysis of ... ...

Abstract	Objective: To assess whether it is feasible to establish specific cut-off values able to discriminate 'physiological' or 'pathological' brain volume rates in patients with multiple sclerosis (MS). Methods: The study was based on the analysis of longitudinal MRI data sets of patients with MS (n=206, 87% relapsing-remitting, 7% secondary progressive and 6% primary progressive) and healthy controls (HC; n=35). Brain atrophy rates were computed over a mean follow-up of 7.5 years (range 1-12) for patients with MS and 6.3 years (range 1-12.5) for HC with the SIENA software and expressed as annualised per cent brain volume change (PBVC/y). A weighted (on the follow-up length) receiver operating characteristic analysis and the area under the curve (AUC) were used for statistics. Results: The weighted PBVC/y was -0.51±0.27% in patients with MS and -0.27±0.15% in HC (p<0.0001). There was a significant age-related difference in PBVC/y between HC older and younger than 35 years of age (p=0.02), but not in patients with MS (p=0.8). The cut-off of PBVC/y, as measured by SIENA that could maximise the accuracy in discriminating patients with MS from HC, was -0.37%, with 67% sensitivity and 80% specificity. According to the observed distribution, values of PBVC/y as measured by SIENA that could define a pathological range were above -0.52% with 95% specificity, above -0.46% with 90% specificity and above -0.40% with 80% specificity. Conclusions: Our evidence-based criteria provide values able to discriminate the presence or absence of 'pathological' brain volume loss in MS with high specificity. Such results could be of great value in a clinical setting, particularly in assessing treatment efficacy in MS.
MeSH term(s)	Adult ; Age Factors ; Area Under Curve ; Atrophy ; Brain/pathology ; Disease Progression ; Evidence-Based Medicine ; Female ; Follow-Up Studies ; Humans ; Longitudinal Studies ; Magnetic Resonance Imaging ; Male ; Middle Aged ; Multiple Sclerosis/epidemiology ; Multiple Sclerosis/pathology ; Multiple Sclerosis/therapy ; ROC Curve ; Reference Standards ; Reproducibility of Results ; Young Adult
Language	English
Publishing date	2016-01
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	3087-9
ISSN	1468-330X ; 0022-3050
ISSN (online)	1468-330X
ISSN	0022-3050
DOI	10.1136/jnnp-2014-309903
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Article ; Online: Age-related burden and characteristics of embolic stroke of undetermined source in the real world clinical practice.

Grifoni, Elisa / Giglio, Davide / Guazzini, Giulia / Cosentino, Eleonora / Latini, Ester / Dei, Alessandro / Del Rosso, Attilio / Guarnaccia, Vincenzo / Baldini, Mariella / Bartolozzi, Maria Letizia / Martinucci, Pietro / Sani, Francesca / Giordano, Antonio / Dainelli, Francesca / Maggi, Francesca / Giulietti, Chiara / Romagnoli, Mario / Cinotti, Stefano / Schipani, Elena /

Murgida, Giuseppe Salvatore / Di Martino, Stefania / Cozzi, Andrea / Carli Ballola, Adele / Dacomo, Debora / Valori, Debora / Masotti, Luca

Journal of thrombosis and thrombolysis

2019 Volume 49, Issue 1, Page(s) 75–85

Abstract: Few data are available on age-related burden and characteristics of embolic stroke of undetermined source (ESUS) in the real world clinical practice. The aim of our study was to provide information about it. We retrospectively analyzed data of patients ... ...

Abstract	Few data are available on age-related burden and characteristics of embolic stroke of undetermined source (ESUS) in the real world clinical practice. The aim of our study was to provide information about it. We retrospectively analyzed data of patients consecutively admitted to our Stroke Unit along 1 year (2017, November 1st-2018, October 31st). The etiology of ischemic stroke was defined at hospital discharge; ESUS was considered as a subset of cryptogenic stroke, and defined according to the 2014 international criteria. In the analyzed period, 306 patients, 52.3% females, mean age ± SD 77.9 ± 11.9 years, were discharged with diagnosis of ischemic stroke. Ischemic strokes of cardioembolic and lacunar origin were the most frequent subtypes: 30.1% and 29.4%, respectively. Cardioembolic strokes were particularly frequent in patients ≥ 75 years, and almost always associated with atrial fibrillation. Overall, in 80 patients (26.1%) the etiology of stroke was undetermined; in 25 (8.2%) it remained undefined because of death or severe comorbidity, making further diagnostic work-up not worthy. Cryptogenic stroke occurred in 55 patients (18%), and ESUS criteria were satisfied in 39 of them (12.7%). According to age, cryptogenic stroke was diagnosed in 21.1% (21.1% ESUS) of patients < 65 years, 24.2% (19.4% ESUS) of patients aged 65-74 years, 15.5% (9.2% ESUS) of patients ≥ 75 years. After diagnostic work-up, patent foramen ovale was most commonly associated with ESUS (17.9%), especially in patients < 65 years (62.5%); covert paroxysmal atrial fibrillation was detected in 10.5% of ESUS patients ≥ 75 years. In the real world clinical practice, the frequency of ischemic strokes of undetermined etiology, and of those satisfying ESUS criteria, is not negligible, especially in younger patients. A thorough diagnostic work-up, with an age-specific approach, is therefore necessary and of the utmost importance for the identification of stroke etiology, in order to optimize secondary stroke prevention strategies.
MeSH term(s)	Age Factors ; Aged ; Aged, 80 and over ; Brain Ischemia/diagnosis ; Brain Ischemia/epidemiology ; Brain Ischemia/etiology ; Female ; Follow-Up Studies ; Foramen Ovale ; Humans ; Intracranial Embolism/diagnosis ; Intracranial Embolism/epidemiology ; Intracranial Embolism/etiology ; Male ; Middle Aged ; Retrospective Studies ; Stroke/diagnosis ; Stroke/epidemiology ; Stroke/etiology
Language	English
Publishing date	2019-09-04
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	1230645-9
ISSN	1573-742X ; 0929-5305
ISSN (online)	1573-742X
ISSN	0929-5305
DOI	10.1007/s11239-019-01951-5
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