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  1. Article ; Online: A new piece of the microbiota pie: Mining 'omics for DNA inversion states.

    Campbell, Danielle E / Baldridge, Megan T

    Cell host & microbe

    2024  Volume 32, Issue 3, Page(s) 293–295

    Abstract: In this issue of Cell Host & Microbe, Carasso et al. survey invertible DNA sites in Bacteroidales from patients with inflammatory bowel disease (IBD) and healthy control individuals. They identify complex functional interactions between Bacteroides ... ...

    Abstract In this issue of Cell Host & Microbe, Carasso et al. survey invertible DNA sites in Bacteroidales from patients with inflammatory bowel disease (IBD) and healthy control individuals. They identify complex functional interactions between Bacteroides fragilis, an invertible promoter, a capsular polysaccharide, a bacteriophage, and the human host. The establishment of 'omics approaches to characterizing genomic targets and functional roles is still required.
    MeSH term(s) Humans ; Bacteroides fragilis/genetics ; Inflammatory Bowel Diseases/genetics ; DNA ; Promoter Regions, Genetic ; Microbiota
    Chemical Substances DNA (9007-49-2)
    Language English
    Publishing date 2024-01-30
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2278004-X
    ISSN 1934-6069 ; 1931-3128
    ISSN (online) 1934-6069
    ISSN 1931-3128
    DOI 10.1016/j.chom.2024.02.009
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 6578: Show issues Location:
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  2. Article ; Online: Modelling human immune responses using microbial exposures in rodents.

    Li, Yuhao / Baldridge, Megan T

    Nature microbiology

    2023  Volume 8, Issue 3, Page(s) 363–366

    MeSH term(s) Animals ; Humans ; Rodentia ; Immunity
    Language English
    Publishing date 2023-02-10
    Publishing country England
    Document type Journal Article
    ISSN 2058-5276
    ISSN (online) 2058-5276
    DOI 10.1038/s41564-023-01334-w
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Norovirus from the mouths of babes.

    Kennedy, Elizabeth A / Baldridge, Megan T

    Nature

    2022  Volume 607, Issue 7918, Page(s) 247–248

    MeSH term(s) Mouth ; Norovirus ; Parent-Child Relations ; Virology
    Language English
    Publishing date 2022-06-29
    Publishing country England
    Document type News ; Comment
    ZDB-ID 120714-3
    ISSN 1476-4687 ; 0028-0836
    ISSN (online) 1476-4687
    ISSN 0028-0836
    DOI 10.1038/d41586-022-01731-x
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 26: Show issues Location:
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  4. Article ; Online: Enteric viruses seize their immunomodulatory niche.

    Campbell, Danielle E / Baldridge, Megan T

    Cell host & microbe

    2022  Volume 29, Issue 6, Page(s) 858–861

    Abstract: Enteric eukaryotic viruses are increasingly recognized as non-pathogenic, immunomodulatory participants in the healthy intestinal microbiota. In this issue of Cell Host & Microbe, Dallari et al. (2021) use a single virus infection approach to reveal both ...

    Abstract Enteric eukaryotic viruses are increasingly recognized as non-pathogenic, immunomodulatory participants in the healthy intestinal microbiota. In this issue of Cell Host & Microbe, Dallari et al. (2021) use a single virus infection approach to reveal both generalized viral immune responses and numerous unique, virus-specific response profiles.
    MeSH term(s) Enterovirus ; Enterovirus Infections ; Humans ; Immunity ; Microbiota ; Viruses/genetics
    Language English
    Publishing date 2022-01-04
    Publishing country United States
    Document type Journal Article ; Comment
    ZDB-ID 2278004-X
    ISSN 1934-6069 ; 1931-3128
    ISSN (online) 1934-6069
    ISSN 1931-3128
    DOI 10.1016/j.chom.2021.05.007
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  5. Article ; Online: Advances in understanding interferon-mediated immune responses to enteric viruses in intestinal organoids.

    Nolan, Lila S / Baldridge, Megan T

    Frontiers in immunology

    2022  Volume 13, Page(s) 943334

    Abstract: Interferons (IFN) are antiviral cytokines with critical roles in regulating pathogens at epithelial barriers, but their capacity to restrict human enteric viruses has been incompletely characterized in part due to challenges in cultivating some ... ...

    Abstract Interferons (IFN) are antiviral cytokines with critical roles in regulating pathogens at epithelial barriers, but their capacity to restrict human enteric viruses has been incompletely characterized in part due to challenges in cultivating some viruses
    MeSH term(s) Antiviral Agents ; Enterovirus ; Enterovirus Infections ; Humans ; Immunity, Innate ; Interferons ; Organoids
    Chemical Substances Antiviral Agents ; Interferons (9008-11-1)
    Language English
    Publishing date 2022-07-22
    Publishing country Switzerland
    Document type Journal Article ; Review ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
    ZDB-ID 2606827-8
    ISSN 1664-3224 ; 1664-3224
    ISSN (online) 1664-3224
    ISSN 1664-3224
    DOI 10.3389/fimmu.2022.943334
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Crossing the T's on Norovirus.

    Lee, Sanghyun / Baldridge, Megan T

    Cellular and molecular gastroenterology and hepatology

    2021  Volume 11, Issue 5, Page(s) 1543–1544

    MeSH term(s) Norovirus
    Language English
    Publishing date 2021-02-19
    Publishing country United States
    Document type Editorial ; Research Support, N.I.H., Extramural ; Comment
    ZDB-ID 2819778-1
    ISSN 2352-345X ; 2352-345X
    ISSN (online) 2352-345X
    ISSN 2352-345X
    DOI 10.1016/j.jcmgh.2021.01.021
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: Impact of the Microbiota on Viral Infections.

    Campbell, Danielle E / Li, Yuhao / Ingle, Harshad / Baldridge, Megan T

    Annual review of virology

    2023  Volume 10, Issue 1, Page(s) 371–395

    Abstract: The mammalian gastrointestinal tract (GIT) hosts a diverse and highly active microbiota composed of bacteria, eukaryotes, archaea, and viruses. Studies of the GIT microbiota date back more than a century, although modern techniques, including mouse ... ...

    Abstract The mammalian gastrointestinal tract (GIT) hosts a diverse and highly active microbiota composed of bacteria, eukaryotes, archaea, and viruses. Studies of the GIT microbiota date back more than a century, although modern techniques, including mouse models, sequencing technology, and novel therapeutics in humans, have been foundational to our understanding of the roles of commensal microbes in health and disease. Here, we review the impacts of the GIT microbiota on viral infection, both within the GIT and systemically. GIT-associated microbes and their metabolites alter the course of viral infection through a variety of mechanisms, including direct interactions with virions, alteration of the GIT landscape, and extensive regulation of innate and adaptive immunity. Mechanistic understanding of the full breadth of interactions between the GIT microbiota and the host is still lacking in many ways but will be vital for the development of novel therapeutics for viral and nonviral diseases alike.
    MeSH term(s) Animals ; Mice ; Humans ; Microbiota ; Virus Diseases ; Gastrointestinal Tract/microbiology ; Gastrointestinal Microbiome ; Viruses/genetics ; Mammals
    Language English
    Publishing date 2023-04-18
    Publishing country United States
    Document type Journal Article ; Review ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
    ZDB-ID 2764224-0
    ISSN 2327-0578 ; 2327-056X
    ISSN (online) 2327-0578
    ISSN 2327-056X
    DOI 10.1146/annurev-virology-111821-115754
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: Microbiota regulation of viral infections through interferon signaling.

    Wirusanti, Nurul I / Baldridge, Megan T / Harris, Vanessa C

    Trends in microbiology

    2022  Volume 30, Issue 8, Page(s) 778–792

    Abstract: The interferon (IFN) response is the major early innate immune response against invading viral pathogens and is even capable of mediating sterilizing antiviral immunity without the support of the adaptive immune system. Cumulative evidence suggests that ... ...

    Abstract The interferon (IFN) response is the major early innate immune response against invading viral pathogens and is even capable of mediating sterilizing antiviral immunity without the support of the adaptive immune system. Cumulative evidence suggests that the gut microbiota can modulate IFN responses, indirectly determining virological outcomes. This review outlines our current knowledge of the interactions between the gut microbiota and IFN responses and dissects the different mechanisms by which the gut microbiota may alter IFN expression to diverse viral infections. This knowledge offers a basis for translating experimental evidence from animal studies into the human context and identifies avenues for leveraging the gut microbiota-IFN-virus axis to improve control of viral infections and performance of viral vaccines.
    MeSH term(s) Animals ; Antiviral Agents/therapeutic use ; Humans ; Immunity, Innate ; Interferons/metabolism ; Microbiota ; Virus Diseases
    Chemical Substances Antiviral Agents ; Interferons (9008-11-1)
    Language English
    Publishing date 2022-02-06
    Publishing country England
    Document type Journal Article ; Review ; Research Support, Non-U.S. Gov't ; Research Support, N.I.H., Extramural
    ZDB-ID 1158963-2
    ISSN 1878-4380 ; 0966-842X
    ISSN (online) 1878-4380
    ISSN 0966-842X
    DOI 10.1016/j.tim.2022.01.007
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    Zs.A 3738: Show issues Location:
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    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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  9. Article ; Online: A role for the microbiota in complex regional pain syndrome?

    Crock, Lara W / Baldridge, Megan T

    Neurobiology of pain (Cambridge, Mass.)

    2020  Volume 8, Page(s) 100054

    Abstract: Complex regional pain syndrome (CRPS) is a debilitating neuroinflammatory condition of unknown etiology. Symptoms include excruciating pain and trophic changes in the limbs as defined by the Budapest criteria. The severity and functional recovery of CRPS, ...

    Abstract Complex regional pain syndrome (CRPS) is a debilitating neuroinflammatory condition of unknown etiology. Symptoms include excruciating pain and trophic changes in the limbs as defined by the Budapest criteria. The severity and functional recovery of CRPS, unlike most pain conditions, is quantifiable using a variation of the Budapest criteria known as the CRPS severity score. Like many chronic pain conditions, CRPS is difficult to treat once pain has been present for more than 12 months. However, previous work has demonstrated that a subset of patients with new-onset CRPS (~50%) improve if treated within one year, while the rest have minimal to no symptom improvement. Unfortunately, this leads to permanent disability and often requires invasive and costly treatments such as spinal cord stimulation or long-term opioid therapy. Because the etiology is unknown, treatment is multimodal, and often supportive. Biomarkers that predict severity or resolution of symptoms would significantly change treatment but have not yet been identified. Interestingly, there are case reports of remission or resolution of CRPS symptoms with the use of antibiotics known to affect the gut flora. Mouse studies have demonstrated that modulation of the gut microbiome is anti-nociceptive in visceral, inflammatory and neuropathic pain models. We hypothesize that the variable clinical potential for recovery and response to therapy in CRPS may be secondary to or reflected in changes in the gut microbiota. We suggest that the microbiota may mediate or reflect clinical status via the metabolome, activation of the immune system and/or microglial activation. We hypothesize that the gut microbiome is a potential mediator in development and persistence of CRPS symptoms and propose that the clinical condition of CRPS could provide a unique opportunity to identify biomarkers of the microbiota and potential therapies to prevent pain chronification.
    Language English
    Publishing date 2020-11-25
    Publishing country United States
    Document type Journal Article ; Review
    ISSN 2452-073X
    ISSN (online) 2452-073X
    DOI 10.1016/j.ynpai.2020.100054
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article: Experimental Methods to Study the Pathogenesis of Human Enteric RNA Viruses

    Aggarwal, Somya / Hassan, Ebrahim / Baldridge, Megan T.

    Viruses. 2021 May 25, v. 13, no. 6

    2021  

    Abstract: Every year, millions of children are infected with viruses that target the gastrointestinal tract, causing acute gastroenteritis and diarrheal illness. Indeed, approximately 700 million episodes of diarrhea occur in children under five annually, with RNA ...

    Abstract Every year, millions of children are infected with viruses that target the gastrointestinal tract, causing acute gastroenteritis and diarrheal illness. Indeed, approximately 700 million episodes of diarrhea occur in children under five annually, with RNA viruses norovirus, rotavirus, and astrovirus serving as major causative pathogens. Numerous methodological advancements in recent years, including the establishment of novel cultivation systems using enteroids as well as the development of murine and other animal models of infection, have helped provide insight into many features of viral pathogenesis. However, many aspects of enteric viral infections remain elusive, demanding further study. Here, we describe the different in vitro and in vivo tools available to explore different pathophysiological attributes of human enteric RNA viruses, highlighting their advantages and limitations depending upon the question being explored. In addition, we discuss key areas and opportunities that would benefit from further methodological progress.
    Keywords Norovirus ; RNA ; Rotavirus ; diarrhea ; digestive tract ; gastroenteritis ; humans ; mice ; pathogenesis
    Language English
    Dates of publication 2021-0525
    Publishing place Multidisciplinary Digital Publishing Institute
    Document type Article
    ZDB-ID 2516098-9
    ISSN 1999-4915
    ISSN 1999-4915
    DOI 10.3390/v13060975
    Database NAL-Catalogue (AGRICOLA)

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