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  1. AU="Baldus, Niklas"
  2. AU=Macpherson R I
  3. AU=Tanaka Ryo
  4. AU="Morris, Abigail S"
  5. AU="Perry, Zion R"
  6. AU="Wei, Kaiming"
  7. AU="Gunawan, Christa"
  8. AU="Bonneau, Peter N"
  9. AU="Heditsian, Diane"
  10. AU="Almane, Dace N"
  11. AU="Lerman, Dorothea C."
  12. AU="Góes, C"
  13. AU="Searle, Philip A"
  14. AU="Hudecek, Michael"
  15. AU="Joyce, Doireann P."
  16. AU="Müller, Werner Eg"
  17. AU="Takahashi, Tsutomo"
  18. AU="Jenny Zhaoying Xiang"
  19. AU=Ferraro Elisabetta
  20. AU="Jonathan Downar"
  21. AU=Rahmanzade Ramin AU=Rahmanzade Ramin
  22. AU="Edwards, Lisa-Jayne"
  23. AU="Tominaga, Shintaro"
  24. AU="Chan, Brian"
  25. AU="Julieta Carilla"

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  1. Artikel ; Online: Early SARS-CoV-2 infection: Platelet-neutrophil complexes and platelet function.

    Rieder, Marina / Baldus, Niklas / Stallmann, Daniela / Jeserich, Maren / Goller, Isabella / Wirth, Luisa / Pollmeier, Luisa / Hofmann, Maike / Bode, Christoph / Busch, Hans-Joerg / Schmid, Bonaventura / Gauchel, Nadine / Scharf, Rüdiger E / Duerschmied, Daniel / Lother, Achim / Krauel, Krystin

    Research and practice in thrombosis and haemostasis

    2022  Band 7, Heft 1, Seite(n) 100025

    Abstract: Background: Conflicting results have been reported on platelet activity : Objectives: To assess platelet reactivity in patients with moderate disease at early stages of COVID-19.: Methods: We performed a prospective, descriptive analysis of 100 ... ...

    Abstract Background: Conflicting results have been reported on platelet activity
    Objectives: To assess platelet reactivity in patients with moderate disease at early stages of COVID-19.
    Methods: We performed a prospective, descriptive analysis of 100 consecutive patients presenting with suspected SARS-CoV-2 infection at University Medical Center Freiburg during the first or second wave of the pandemic. Following polymerase chain reaction testing and compliance with study inclusion criteria, 20 SARS-CoV-2-positive and 55 SARS-CoV-2-negative patients (serving as patient controls) were enrolled. In addition, 15 healthy subjects were included. Platelet reactivity was assessed using whole-blood impedance aggregometry and flow cytometry in response to various agonists.
    Results: Platelet aggregation was significantly impaired in the patients with COVID-19 compared with that in the patient controls or healthy subjects. The reduced platelet responsiveness in the patients with COVID-19 was associated with impaired activation of GPIIb/IIIa (α
    Conclusion: Despite reduced platelet responsiveness, platelet-neutrophil complexes are increased at early stages of moderate disease. Thus, this cellular interaction may occur during COVID-19 without preceding platelet activation.
    Sprache Englisch
    Erscheinungsdatum 2022-12-23
    Erscheinungsland United States
    Dokumenttyp Journal Article
    ISSN 2475-0379
    ISSN (online) 2475-0379
    DOI 10.1016/j.rpth.2022.100025
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  2. Artikel ; Online: Serum ACE2, Angiotensin II, and Aldosterone Levels Are Unchanged in Patients With COVID-19.

    Rieder, Marina / Wirth, Luisa / Pollmeier, Luisa / Jeserich, Maren / Goller, Isabella / Baldus, Niklas / Schmid, Bonaventura / Busch, Hans-Joerg / Hofmann, Maike / Kern, Winfried / Bode, Christoph / Duerschmied, Daniel / Lother, Achim

    American journal of hypertension

    2020  Band 34, Heft 3, Seite(n) 278–281

    Abstract: Background: The role of the renin-angiotensin-aldosterone system (RAAS) in coronavirus disease 2019 (COVID-19) is controversially discussed. Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) enters host cells by binding to angiotensin- ... ...

    Abstract Background: The role of the renin-angiotensin-aldosterone system (RAAS) in coronavirus disease 2019 (COVID-19) is controversially discussed. Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) enters host cells by binding to angiotensin-converting enzyme 2 (ACE2) and activity of the RAAS may affect susceptibility to SARS-CoV-2 infection and outcome of patients with COVID-19.
    Methods: In this prospective single-center study, we determined the serum levels of ACE2, angiotensin II, and aldosterone in patients with COVID-19 compared with control patients presenting with similar symptoms in the emergency unit.
    Results: We analyzed serum samples from 24 SARS-CoV-2 positive and 61 SARS-CoV-2 negative patients. SARS-CoV-2 positive and control patients did not differ in baseline patients characteristics, symptoms, and clinical presentation. Mean serum concentrations of ACE2, angiotensin II, and aldosterone did not differ between the SARS-CoV-2 positive and the control group. In line with this, serum potassium as surrogate parameter for RAAS activity and blood pressure were similar in both groups.
    Conclusions: In summary, we did not find evidence for altered RAAS activity including angiotensin II, aldosterone, or potassium levels, and blood pressure in patients with COVID-19.
    Clinical trials registration: Trial Number DRKS00021206.
    Mesh-Begriff(e) Aldosterone/blood ; Angiotensin II/blood ; Angiotensin-Converting Enzyme 2/blood ; Angiotensin-Converting Enzyme Inhibitors/therapeutic use ; Blood Pressure Determination/statistics & numerical data ; COVID-19/blood ; COVID-19/diagnosis ; COVID-19/epidemiology ; COVID-19/physiopathology ; Female ; Germany/epidemiology ; Humans ; Hypertension/blood ; Hypertension/drug therapy ; Hypertension/epidemiology ; Hypertension/physiopathology ; Male ; Middle Aged ; Outcome Assessment, Health Care ; Potassium/blood ; Prospective Studies ; Renin-Angiotensin System/physiology ; SARS-CoV-2/isolation & purification
    Chemische Substanzen Angiotensin-Converting Enzyme Inhibitors ; Angiotensin II (11128-99-7) ; Aldosterone (4964P6T9RB) ; Angiotensin-Converting Enzyme 2 (EC 3.4.17.23) ; Potassium (RWP5GA015D)
    Schlagwörter covid19
    Sprache Englisch
    Erscheinungsdatum 2020-10-27
    Erscheinungsland United States
    Dokumenttyp Clinical Study ; Comparative Study ; Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 639383-4
    ISSN 1941-7225 ; 1879-1905 ; 0895-7061
    ISSN (online) 1941-7225 ; 1879-1905
    ISSN 0895-7061
    DOI 10.1093/ajh/hpaa169
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  3. Artikel ; Online: Serum Protein Profiling Reveals a Specific Upregulation of the Immunomodulatory Protein Progranulin in Coronavirus Disease 2019.

    Rieder, Marina / Wirth, Luisa / Pollmeier, Luisa / Jeserich, Maren / Goller, Isabella / Baldus, Niklas / Schmid, Bonaventura / Busch, Hans-Joerg / Hofmann, Maike / Thimme, Robert / Rieg, Siegbert / Kern, Winfried / Bode, Christoph / Duerschmied, Daniel / Lother, Achim

    The Journal of infectious diseases

    2020  Band 223, Heft 5, Seite(n) 775–784

    Abstract: Background: Severe courses of coronavirus disease 2019 (COVID-19) are associated with elevated levels of interleukin 6 (IL-6). However, there is a growing body of evidence pointing to a broad and more complex disorder of proinflammatory and antiviral ... ...

    Abstract Background: Severe courses of coronavirus disease 2019 (COVID-19) are associated with elevated levels of interleukin 6 (IL-6). However, there is a growing body of evidence pointing to a broad and more complex disorder of proinflammatory and antiviral responses with disturbed interferon signaling in COVID-19.
    Methods: In this prospective, single-center registry, we included severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)-positive patients and patients with similar symptoms and severity of disease but negative for SARS-CoV-2 admitted to the emergency department and compared their serum protein expression profiles.
    Results: IL-6 abundance was similar in SARS-CoV-2-positive patients (n = 24) compared with SARS-CoV-2-negative controls (n = 61). In contrast, we observed a specific upregulation of the immunomodulatory protein progranulin (GRN). High GRN abundance was associated with adverse outcomes and increased expression of IL-6 in COVID-19.
    Conclusions: The data from this registry reveal that GRN is specifically upregulated in SARS-CoV-2-positive patients while IL-6 may serve as marker for disease severity. The potential of GRN as a biomarker and a possible impact of increased GRN expression on interferon signaling, virus elimination, and virus-induced lung tissue damage in COVID-19 should be further explored.
    Mesh-Begriff(e) Aged ; COVID-19/blood ; COVID-19/immunology ; COVID-19/metabolism ; Case-Control Studies ; Female ; Humans ; Interleukin-6/blood ; Interleukin-6/metabolism ; Male ; Middle Aged ; Progranulins/blood ; Progranulins/metabolism ; Prospective Studies ; Registries ; SARS-CoV-2 ; Severity of Illness Index ; Up-Regulation
    Chemische Substanzen Interleukin-6 ; Progranulins
    Sprache Englisch
    Erscheinungsdatum 2020-10-29
    Erscheinungsland United States
    Dokumenttyp Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 3019-3
    ISSN 1537-6613 ; 0022-1899
    ISSN (online) 1537-6613
    ISSN 0022-1899
    DOI 10.1093/infdis/jiaa741
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  4. Artikel ; Online: Rate of venous thromboembolism in a prospective all-comers cohort with COVID-19.

    Rieder, Marina / Goller, Isabella / Jeserich, Maren / Baldus, Niklas / Pollmeier, Luisa / Wirth, Luisa / Supady, Alexander / Bode, Christoph / Busch, Hans-Jörg / Schmid, Bonaventura / Duerschmied, Daniel / Gauchel, Nadine / Lother, Achim

    Journal of thrombosis and thrombolysis

    2020  Band 50, Heft 3, Seite(n) 558–566

    Abstract: COVID-19 is associated with a variety of clinical complications including coagulopathy, which frequently results in venous thromboembolism (VTE). Retrospective analyses reported a markedly increased rate of VTEs in COVID-19. However, most recent studies ... ...

    Abstract COVID-19 is associated with a variety of clinical complications including coagulopathy, which frequently results in venous thromboembolism (VTE). Retrospective analyses reported a markedly increased rate of VTEs in COVID-19. However, most recent studies on coagulopathy in COVID-19 were only focused on critically ill patients, and without suitable control groups. We aimed to evaluate the rate of VTEs in an all-comers cohort with suspected COVID-19 during a 30-days follow-up period. We also studied the level of D-dimers and their association with the course of disease. In our prospective single-center study (DRKS00021206, 03/30/2020), we analyzed 190 patients with suspected COVID-19 admitted to the emergency department between March and April 2020. Forty-nine patients were SARS-CoV-2 positive (25.8%). The 141 SARS-CoV-2-negative patients served as control group. After completion of a 30-days follow-up, VTE was diagnosed in 3 patients of the SARS-CoV-2-positive group (6.1%, amongst these 2 ICU cases) versus 5 patients in the SARS-CoV-2-negative group (3.5%), however the difference was not statistically significant (p = 0.427). 30-days mortality was similar in both groups (6.1% vs. 5%, p = 0.720). Disease severity correlated with the maximum level of D-dimers during follow-up in COVID-19. The rate of VTE was numerically higher in SARS-CoV-2 positive all-comers presenting with suspected COVID-19 as compared to well-matched controls suffering from similar symptoms. VTEs in the COVID-19 group predominantly occurred in ICU courses. The maximum level of D-dimers during follow-up was associated with disease severity in COVID-19, whereas the level of D-dimers at admission was not.
    Mesh-Begriff(e) Adult ; Aged ; Aged, 80 and over ; Betacoronavirus/pathogenicity ; Biomarkers/blood ; COVID-19 ; Case-Control Studies ; Coronavirus Infections/blood ; Coronavirus Infections/diagnosis ; Coronavirus Infections/epidemiology ; Coronavirus Infections/virology ; Female ; Fibrin Fibrinogen Degradation Products/metabolism ; Germany/epidemiology ; Host-Pathogen Interactions ; Humans ; Male ; Middle Aged ; Pandemics ; Pneumonia, Viral/blood ; Pneumonia, Viral/diagnosis ; Pneumonia, Viral/epidemiology ; Pneumonia, Viral/virology ; Prospective Studies ; Pulmonary Embolism/blood ; Pulmonary Embolism/diagnosis ; Pulmonary Embolism/epidemiology ; Pulmonary Embolism/virology ; Registries ; Risk Assessment ; Risk Factors ; SARS-CoV-2 ; Severity of Illness Index ; Time Factors ; Venous Thromboembolism/blood ; Venous Thromboembolism/diagnosis ; Venous Thromboembolism/epidemiology ; Venous Thromboembolism/virology ; Venous Thrombosis/blood ; Venous Thrombosis/diagnosis ; Venous Thrombosis/epidemiology ; Venous Thrombosis/virology
    Chemische Substanzen Biomarkers ; Fibrin Fibrinogen Degradation Products ; fibrin fragment D
    Schlagwörter covid19
    Sprache Englisch
    Erscheinungsdatum 2020-04-17
    Erscheinungsland Netherlands
    Dokumenttyp Journal Article
    ZDB-ID 1230645-9
    ISSN 1573-742X ; 0929-5305
    ISSN (online) 1573-742X
    ISSN 0929-5305
    DOI 10.1007/s11239-020-02202-8
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  5. Artikel ; Online: Complement system component dysregulation is a distinctive feature of COVID-19 disease: a prospective and comparative analysis of patients admitted to the emergency department for suspected COVID-19 disease.

    Gauchel, Nadine / Rieder, Marina / Krauel, Krystin / Goller, Isabella / Jeserich, Maren / Salzer, Ulrich / Venhoff, Ana Cecilia / Baldus, Niklas / Pollmeier, Luisa / Wirth, Luisa / Kern, Winfried / Rieg, Siegbert / Busch, Hans-Jörg / Hofmann, Maike / Bode, Christoph / Duerschmied, Daniel / Lother, Achim / Heger, Lukas A

    Journal of thrombosis and thrombolysis

    2021  Band 53, Heft 4, Seite(n) 788–797

    Abstract: The complement system (CS) plays a pivotal role in Coronavirus disease 2019 (COVID-19) pathophysiology. The objective of this study was to provide a comparative, prospective data analysis of CS components in an all-comers cohort and COVID-19 patients. ... ...

    Abstract The complement system (CS) plays a pivotal role in Coronavirus disease 2019 (COVID-19) pathophysiology. The objective of this study was to provide a comparative, prospective data analysis of CS components in an all-comers cohort and COVID-19 patients. Patients with suspected COVID-19 infection admitted to the Emergency department were grouped for definite diagnosis of COVID-19 and no COVID-19 accordingly. Clinical presentation, routine laboratory and von Willebrand factor (vWF) antigen as well as CS components 3, 4 and activated 5 (C5a) were assessed. Also, total complement activity via the classical pathway (CH50) was determined. Levels of calprotectin in serum were measured using an automated quantitative lateral flow assay. We included 80 patients in this prospective trial. Of those 19 (23.7%) were tested positive for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Patients with COVID-19 had higher levels of CS components 5a and 4 (54.79 [24.14-88.79] ng/ml vs. 35 [23.15-46.1] ng/ml; p = 0.0433 and 0.3772 [± 0.1056] g/L vs. 0.286 [0.2375-0.3748] g/L; p = 0.0168). COVID-19 patients had significantly higher levels of vWF antigen when compared to the control group (288.3 [± 80.26] % vs. 212 [151-320] %; p = 0.0469). There was a significant correlation between CS C3 and 5a with vWF antigen (r
    Mesh-Begriff(e) COVID-19/diagnosis ; Emergency Service, Hospital ; Humans ; Immunologic Factors ; Leukocyte L1 Antigen Complex ; Prospective Studies ; SARS-CoV-2 ; von Willebrand Factor/analysis
    Chemische Substanzen Immunologic Factors ; Leukocyte L1 Antigen Complex ; von Willebrand Factor
    Sprache Englisch
    Erscheinungsdatum 2021-12-14
    Erscheinungsland Netherlands
    Dokumenttyp Clinical Trial ; Journal Article
    ZDB-ID 1230645-9
    ISSN 1573-742X ; 0929-5305
    ISSN (online) 1573-742X
    ISSN 0929-5305
    DOI 10.1007/s11239-021-02617-x
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  6. Artikel: Serum ACE-2, angiotensin II, and aldosterone levels are unchanged in patients with COVID-19

    Rieder, Marina / Wirth, Luisa / Pollmeier, Luisa / Jeserich, Maren / Goller, Isabella / Baldus, Niklas / Schmid, Bonaventura / Busch, Hans-Joerg / Hofmann, Maike / Kern, Winfried / Bode, Christoph / Duerschmied, Daniel / Lother, Achim

    Am. j. hypertens

    Abstract: BACKGROUND: The role of the renin-angiotensin-aldosterone system in COVID-19 is controversially discussed. SARS-CoV-2 enters host cells by binding to angiotensin-converting enzyme 2 and activity of the renin-angiotensin-aldosterone system may affect ... ...

    Abstract BACKGROUND: The role of the renin-angiotensin-aldosterone system in COVID-19 is controversially discussed. SARS-CoV-2 enters host cells by binding to angiotensin-converting enzyme 2 and activity of the renin-angiotensin-aldosterone system may affect susceptibility to SARS-CoV-2 infection and outcome of patients with COVID-19. METHODS: In this prospective single-center study, we determined the serum levels of ACE-2, angiotensin II and aldosterone in patients with COVID-19 compared to control patients presenting with similar symptoms in the emergency unit. RESULTS: We analyzed serum samples from 24 SARS-CoV-2 positive and 61 SARS-CoV-2 negative patients. SARS-CoV-2 positive and control patients did not differ in baseline patients characteristics, symptoms and clinical presentation. Mean serum concentrations of ACE2, angiotensin II, and aldosterone did not differ between the SARS-CoV-2 positive and the control group. In line with this, serum potassium as surrogate parameter for RAAS activity and blood pressure were similar in both groups. CONCLUSIONS: In summary, we did not find evidence for altered RAAS activity including angiotensin II, aldosterone, or potassium levels, and blood pressure in patients with COVID-19.
    Schlagwörter covid19
    Verlag WHO
    Dokumenttyp Artikel
    Anmerkung WHO #Covidence: #845825
    Datenquelle COVID19

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  7. Artikel: Rate of venous thromboembolism in a prospective all-comers cohort with COVID-19

    Rieder, Marina / Goller, Isabella / Jeserich, Maren / Baldus, Niklas / Pollmeier, Luisa / Wirth, Luisa / Supady, Alexander / Bode, Christoph / Busch, Hans-Jörg / Schmid, Bonaventura / Duerschmied, Daniel / Gauchel, Nadine / Lother, Achim

    J Thromb Thrombolysis

    Abstract: COVID-19 is associated with a variety of clinical complications including coagulopathy, which frequently results in venous thromboembolism (VTE). Retrospective analyses reported a markedly increased rate of VTEs in COVID-19. However, most recent studies ... ...

    Abstract COVID-19 is associated with a variety of clinical complications including coagulopathy, which frequently results in venous thromboembolism (VTE). Retrospective analyses reported a markedly increased rate of VTEs in COVID-19. However, most recent studies on coagulopathy in COVID-19 were only focused on critically ill patients, and without suitable control groups. We aimed to evaluate the rate of VTEs in an all-comers cohort with suspected COVID-19 during a 30-days follow-up period. We also studied the level of D-dimers and their association with the course of disease. In our prospective single-center study (DRKS00021206, 03/30/2020), we analyzed 190 patients with suspected COVID-19 admitted to the emergency department between March and April 2020. Forty-nine patients were SARS-CoV-2 positive (25.8%). The 141 SARS-CoV-2-negative patients served as control group. After completion of a 30-days follow-up, VTE was diagnosed in 3 patients of the SARS-CoV-2-positive group (6.1%, amongst these 2 ICU cases) versus 5 patients in the SARS-CoV-2-negative group (3.5%), however the difference was not statistically significant (p = 0.427). 30-days mortality was similar in both groups (6.1% vs. 5%, p = 0.720). Disease severity correlated with the maximum level of D-dimers during follow-up in COVID-19. The rate of VTE was numerically higher in SARS-CoV-2 positive all-comers presenting with suspected COVID-19 as compared to well-matched controls suffering from similar symptoms. VTEs in the COVID-19 group predominantly occurred in ICU courses. The maximum level of D-dimers during follow-up was associated with disease severity in COVID-19, whereas the level of D-dimers at admission was not.
    Schlagwörter covid19
    Verlag WHO
    Dokumenttyp Artikel
    Anmerkung WHO #Covidence: #621522
    Datenquelle COVID19

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  8. Artikel ; Online: Rate of venous thromboembolism in a prospective all-comers cohort with COVID-19

    Rieder, Marina / Goller, Isabella / Jeserich, Maren / Baldus, Niklas / Pollmeier, Luisa / Wirth, Luisa / Supady, Alexander / Bode, Christoph / Busch, Hans-Jörg / Schmid, Bonaventura / Dürschmied, Daniel Frank / Gauchel, Nadine / Lother, Achim

    Journal of thrombosis and thrombolysis. - 50,

    2020  Band 3, Heft , 558-566, ISSN: 1573-742X

    Abstract: COVID-19 is associated with a variety of clinical complications including coagulopathy, which frequently results in venous thromboembolism (VTE). Retrospective analyses reported a markedly increased rate of VTEs in COVID-19. However, most recent studies ... ...

    Abstract COVID-19 is associated with a variety of clinical complications including coagulopathy, which frequently results in venous thromboembolism (VTE). Retrospective analyses reported a markedly increased rate of VTEs in COVID-19. However, most recent studies on coagulopathy in COVID-19 were only focused on critically ill patients, and without suitable control groups. We aimed to evaluate the rate of VTEs in an all-comers cohort with suspected COVID-19 during a 30-days follow-up period. We also studied the level of D-dimers and their association with the course of disease. In our prospective single-center study (DRKS00021206, 03/30/2020), we analyzed 190 patients with suspected COVID-19 admitted to the emergency department between March and April 2020. Forty-nine patients were SARS-CoV-2 positive (25.8%). The 141 SARS-CoV-2-negative patients served as control group. After completion of a 30-days follow-up, VTE was diagnosed in 3 patients of the SARS-CoV-2-positive group (6.1%, amongst these 2 ICU cases) versus 5 patients in the SARS-CoV-2-negative group (3.5%), however the difference was not statistically significant (p = 0.427). 30-days mortality was similar in both groups (6.1% vs. 5%, p = 0.720). Disease severity correlated with the maximum level of D-dimers during follow-up in COVID-19. The rate of VTE was numerically higher in SARS-CoV-2 positive all-comers presenting with suspected COVID-19 as compared to well-matched controls suffering from similar symptoms. VTEs in the COVID-19 group predominantly occurred in ICU courses. The maximum level of D-dimers during follow-up was associated with disease severity in COVID-19, whereas the level of D-dimers at admission was not.
    Schlagwörter covid19
    Thema/Rubrik (Code) 610
    Sprache Englisch
    Erscheinungsland de
    Dokumenttyp Artikel ; Online
    Datenquelle BASE - Bielefeld Academic Search Engine (Lebenswissenschaftliche Auswahl)

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  9. Artikel ; Online: Serum ACE-2, angiotensin II, and aldosterone levels are unchanged in patients with COVID-19

    Rieder, Marina / Wirth, Luisa / Pollmeier, Luisa / Jeserich, Maren / Goller, Isabella / Baldus, Niklas / Schmid, Bonaventura / Busch, Hans-Joerg / Hofmann, Maike / Kern, Winfried / Bode, Christoph / Duerschmied, Daniel / Lother, Achim

    American Journal of Hypertension ; ISSN 0895-7061 1941-7225

    2020  

    Abstract: Abstract Background The role of the renin-angiotensin-aldosterone system in COVID-19 is controversially discussed. SARS-CoV-2 enters host cells by binding to angiotensin-converting enzyme 2 and activity of the renin-angiotensin-aldosterone system may ... ...

    Abstract Abstract Background The role of the renin-angiotensin-aldosterone system in COVID-19 is controversially discussed. SARS-CoV-2 enters host cells by binding to angiotensin-converting enzyme 2 and activity of the renin-angiotensin-aldosterone system may affect susceptibility to SARS-CoV-2 infection and outcome of patients with COVID-19. Methods In this prospective single-center study, we determined the serum levels of ACE-2, angiotensin II and aldosterone in patients with COVID-19 compared to control patients presenting with similar symptoms in the emergency unit. Results We analyzed serum samples from 24 SARS-CoV-2 positive and 61 SARS-CoV-2 negative patients. SARS-CoV-2 positive and control patients did not differ in baseline patients characteristics, symptoms and clinical presentation. Mean serum concentrations of ACE2, angiotensin II, and aldosterone did not differ between the SARS-CoV-2 positive and the control group. In line with this, serum potassium as surrogate parameter for RAAS activity and blood pressure were similar in both groups. Conclusions In summary, we did not find evidence for altered RAAS activity including angiotensin II, aldosterone, or potassium levels, and blood pressure in patients with COVID-19.
    Schlagwörter Internal Medicine ; covid19
    Sprache Englisch
    Verlag Oxford University Press (OUP)
    Erscheinungsland uk
    Dokumenttyp Artikel ; Online
    DOI 10.1093/ajh/hpaa169
    Datenquelle BASE - Bielefeld Academic Search Engine (Lebenswissenschaftliche Auswahl)

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  10. Artikel ; Online: Rate of venous thromboembolism in a prospective all-comers cohort with COVID-19

    Rieder, Marina / Goller, Isabella / Jeserich, Maren / Baldus, Niklas / Pollmeier, Luisa / Wirth, Luisa / Supady, Alexander / Bode, Christoph / Busch, Hans-Jörg / Schmid, Bonaventura / Duerschmied, Daniel / Gauchel, Nadine / Lother, Achim

    Journal of Thrombosis and Thrombolysis

    2020  Band 50, Heft 3, Seite(n) 558–566

    Abstract: Abstract COVID-19 is associated with a variety of clinical complications including coagulopathy, which frequently results in venous thromboembolism (VTE). Retrospective analyses reported a markedly increased rate of VTEs in COVID-19. However, most recent ...

    Abstract Abstract COVID-19 is associated with a variety of clinical complications including coagulopathy, which frequently results in venous thromboembolism (VTE). Retrospective analyses reported a markedly increased rate of VTEs in COVID-19. However, most recent studies on coagulopathy in COVID-19 were only focused on critically ill patients, and without suitable control groups. We aimed to evaluate the rate of VTEs in an all-comers cohort with suspected COVID-19 during a 30-days follow-up period. We also studied the level of D-dimers and their association with the course of disease. In our prospective single-center study (DRKS00021206, 03/30/2020), we analyzed 190 patients with suspected COVID-19 admitted to the emergency department between March and April 2020. Forty-nine patients were SARS-CoV-2 positive (25.8%). The 141 SARS-CoV-2-negative patients served as control group. After completion of a 30-days follow-up, VTE was diagnosed in 3 patients of the SARS-CoV-2-positive group (6.1%, amongst these 2 ICU cases) versus 5 patients in the SARS-CoV-2-negative group (3.5%), however the difference was not statistically significant (p = 0.427). 30-days mortality was similar in both groups (6.1% vs. 5%, p = 0.720). Disease severity correlated with the maximum level of D-dimers during follow-up in COVID-19. The rate of VTE was numerically higher in SARS-CoV-2 positive all-comers presenting with suspected COVID-19 as compared to well-matched controls suffering from similar symptoms. VTEs in the COVID-19 group predominantly occurred in ICU courses. The maximum level of D-dimers during follow-up was associated with disease severity in COVID-19, whereas the level of D-dimers at admission was not.
    Schlagwörter Hematology ; Cardiology and Cardiovascular Medicine ; covid19
    Sprache Englisch
    Verlag Springer Science and Business Media LLC
    Erscheinungsland us
    Dokumenttyp Artikel ; Online
    ZDB-ID 1230645-9
    ISSN 0929-5305
    ISSN 0929-5305
    DOI 10.1007/s11239-020-02202-8
    Datenquelle BASE - Bielefeld Academic Search Engine (Lebenswissenschaftliche Auswahl)

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