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Article ; Online: Management of cholelithiasis in times of COVID-19: A challenge for the system.

Prieto, Mikel / Ortega, Irene / Balibrea, Jose Maria / Ielpo, Benedetto

Cirugia espanola

2021 Volume 99, Issue 9, Page(s) 699–700

MeSH term(s)	COVID-19 ; Cholecystectomy, Laparoscopic ; Cholelithiasis/surgery ; Humans ; SARS-CoV-2
Language	English
Publishing date	2021-10-01
Publishing country	Spain
Document type	Letter ; Comment
ISSN	2173-5077
ISSN (online)	2173-5077
DOI	10.1016/j.cireng.2021.05.013
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Article: FABP4 Expression in Subcutaneous Adipose Tissue Is Independently Associated with Circulating Triglycerides in Obesity.

Osorio-Conles, Óscar / Ibarzabal, Ainitze / Balibrea, José María / Vidal, Josep / Ortega, Emilio / de Hollanda, Ana

Journal of clinical medicine

2023 Volume 12, Issue 3

Abstract: Hypertriglyceridemia (HTG) has been associated with an increased risk of pancreatitis and cardiovascular disease. Adipose tissue plays a major role in lipid metabolism, mobilization and distribution. We have compared the histological and transcriptomic ... ...

Abstract	Hypertriglyceridemia (HTG) has been associated with an increased risk of pancreatitis and cardiovascular disease. Adipose tissue plays a major role in lipid metabolism, mobilization and distribution. We have compared the histological and transcriptomic profiles of the subcutaneous (SAT) and visceral (VAT) adipose tissues from subjects with severe obesity undergoing bariatric surgery with (Ob-HTG,
Language	English
Publishing date	2023-01-28
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2662592-1
ISSN	2077-0383
ISSN	2077-0383
DOI	10.3390/jcm12031013
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Article ; Online: Expression of Adipose Tissue Extracellular Matrix-Related Genes Predicts Weight Loss after Bariatric Surgery.

Osorio-Conles, Óscar / Olbeyra, Romina / Vidal, Josep / Ibarzabal, Ainitze / Balibrea, José María / de Hollanda, Ana

Cells

2023 Volume 12, Issue 9

Abstract: Background: We evaluated the association between white adipose tissue parameters before bariatric surgery (BS) and post-surgical weight loss, with an especial focus on extracellular matrix (ECM) gene expression.: Methods: Paired samples from ... ...

Abstract	Background: We evaluated the association between white adipose tissue parameters before bariatric surgery (BS) and post-surgical weight loss, with an especial focus on extracellular matrix (ECM) gene expression. Methods: Paired samples from subcutaneous (SAT) and visceral adipose tissue (VAT) were obtained from 144 subjects undergoing BS. The association between total body weight loss (%TBWL) at 12 months after BS and the histological characteristics and gene expression of selected genes in SAT and VAT was analyzed. Results: Fat cell area, size-frequency distribution, and fibrosis in SAT or VAT prior to surgery were not associated with %TBWL. On the contrary, the SAT expression of Conclusions: Our data suggest that the expression of SAT ECM-related genes may help explain the variability in TBWL following BS.
MeSH term(s)	Humans ; Subcutaneous Fat/metabolism ; Diabetes Mellitus, Type 2/metabolism ; Adipose Tissue ; Bariatric Surgery ; Weight Loss/genetics ; Extracellular Matrix/genetics ; Collagen/metabolism
Chemical Substances	Collagen (9007-34-5)
Language	English
Publishing date	2023-04-26
Publishing country	Switzerland
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2661518-6
ISSN	2073-4409 ; 2073-4409
ISSN (online)	2073-4409
ISSN	2073-4409
DOI	10.3390/cells12091262
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Article ; Online: Limited Bariatric Surgery-induced Weight Loss in Subjects With Type 2 Diabetes: Predictor Variables in Adipose Tissue.

Osorio-Conles, Óscar / Jiménez, Amanda / Ibarzabal, Ainitze / Balibrea, José María / de Hollanda, Ana / Vidal, Josep

The Journal of clinical endocrinology and metabolism

2023 Volume 108, Issue 11, Page(s) e1205–e1213

Abstract: Context: The impact of type 2 diabetes mellitus (T2D) at baseline on limited weight loss (WL) after bariatric surgery (BS) remains controversial, and the potential underlying mechanisms incompletely understood.: Objective: We aimed at gaining further ...

Abstract	Context: The impact of type 2 diabetes mellitus (T2D) at baseline on limited weight loss (WL) after bariatric surgery (BS) remains controversial, and the potential underlying mechanisms incompletely understood. Objective: We aimed at gaining further insight on this relationship and identifying novel associations between adipose tissue (AT) parameters and short-term WL outcomes in subjects with or without T2D undergoing BS. Methods: Mid-term WL trajectories after BS have been evaluated in a cohort of 1659 subjects (cohort 1) with (n = 543) and without T2D (n = 1116). Paired subcutaneous and visceral AT samples were obtained from a cohort of 48 pairs of subjects with and without T2D matched for age, sex, BMI, and type of BS (cohort 2). Differences in AT parameters between groups were evaluated and potential associations with WL response explored. Results: T2D was independently associated with a 5% lesser mid-term WL in cohort 1, while HbA1c, insulin treatment, and number of T2D medications prior to BS were only related to short-term WL outcomes. In cohort 2, a number of differentially expressed genes in AT were identified between groups, while fat cell size and fibrosis were comparable. Subcutaneous ATG7 expression was found as an independent predictor of limited WL 1 year after surgery (β: -12.21 ± 4.41, P = .008) and its addition to a clinical model significantly improved the amount of WL variability explained (R2 = 0.131 vs R2 = 0.248, F change P = .009). Conclusion: Our results highlight the importance of T2D as determinant of limited WL following BS and suggest that dysregulated macroautophagy in subcutaneous AT may contribute to this association.
MeSH term(s)	Humans ; Diabetes Mellitus, Type 2/complications ; Treatment Outcome ; Bariatric Surgery ; Weight Loss/physiology ; Subcutaneous Fat/metabolism ; Obesity, Morbid/surgery
Language	English
Publishing date	2023-05-29
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	3029-6
ISSN	1945-7197 ; 0021-972X
ISSN (online)	1945-7197
ISSN	0021-972X
DOI	10.1210/clinem/dgad271
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Article: Recommendations on the management of severe obesity in patients with inflammatory bowel disease of the Spanish Group on Crohn's Disease and Ulcerative Colitis (GETECCU), Spanish Society of Obesity (SEEDO), Spanish Association of Surgery (AEC) and Spanish Society of Digestive Endoscopy (SEED).

Domènech, Eugeni / Ciudin, Andreea / Balibrea, José María / Espinet-Coll, Eduard / Cañete, Fiorella / Flores, Lilliam / Ferrer-Márquez, Manuel / Turró, Román / Hernández-Camba, Alejandro / Zabana, Yamile / Gutiérrez, Ana

Gastroenterologia y hepatologia

2024

Abstract: Obesity is a multifactorial, chronic, progressive and recurrent disease considered a public health issue worldwide and an important determinant of disability and death. In Spain, its current prevalence in the adult population is about 24% and an ... ...

Title translation	Recomendaciones sobre el manejo de la obesidad grave en pacientes con enfermedad inflamatoria intestinal del Grupo Español de Trabajo en Enfermedad Inflamatoria Intestinal (GETECCU), Sociedad Española de Obesidad (SEEDO), Asociación Española de Cirugía (AEC) y Sociedad Española de Endoscopia Digestiva (SEED).
Abstract	Obesity is a multifactorial, chronic, progressive and recurrent disease considered a public health issue worldwide and an important determinant of disability and death. In Spain, its current prevalence in the adult population is about 24% and an estimated prevalence in 2035 of 37%. Obesity increases the probability of several diseases linked to higher mortality such as diabetes, cardiovascular disease, hyperlipidemia, arterial hypertension, non-alcoholic fatty liver disease, several types of cancer, or obstructive sleep apnea. On the other hand, although the incidence of inflammatory bowel disease (IBD) is stabilizing in Western countries, its prevalence already exceeds 0.3%. Paralleling to general population, the current prevalence of obesity in adult patients with IBD is estimated at 15-40%. Obesity in patients with IBD could entail, in addition to its already known impact on disability and mortality, a worse evolution of the IBD itself and a worse response to treatments. The aim of this document, performed in collaboration by four scientific societies involved in the clinical care of severe obesity and IBD, is to establish clear and concise recommendations on the therapeutic possibilities of severe or typeIII obesity in patients with IBD. The document establishes general recommendations on dietary, pharmacological, endoscopic, and surgical treatment of severe obesity in patients with IBD, as well as pre- and post-treatment evaluation.
Language	Spanish
Publishing date	2024-01-28
Publishing country	Spain
Document type	Practice Guideline
ZDB-ID	632502-6
ISSN	0210-5705
ISSN	0210-5705
DOI	10.1016/j.gastrohep.2023.12.008
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Article ; Online: Antimicrobial stewardship programs and surgery: What is our role?

Manuel Vázquez, Alba / Balibrea, José María / Ramia, José Manuel

Cirugia espanola

2018 Volume 97, Issue 4, Page(s) 187–189

Title translation	Programas de optimización de antibióticos y cirugía: ¿cuál es nuestro papel?
MeSH term(s)	Anti-Bacterial Agents/adverse effects ; Anti-Bacterial Agents/economics ; Anti-Bacterial Agents/therapeutic use ; Antimicrobial Stewardship/economics ; Antimicrobial Stewardship/history ; Antimicrobial Stewardship/statistics & numerical data ; Awareness ; Communicable Diseases/drug therapy ; Drug Resistance, Microbial/physiology ; Drug Utilization/standards ; Europe/epidemiology ; General Surgery/standards ; History, 21st Century ; Humans ; Patient Safety ; Program Development ; Surgical Wound Infection/drug therapy ; Surgical Wound Infection/prevention & control ; United States/epidemiology ; World Health Organization/organization & administration
Chemical Substances	Anti-Bacterial Agents
Language	Spanish
Publishing date	2018-09-11
Publishing country	Spain
Document type	Editorial ; Historical Article
ISSN	2173-5077
ISSN (online)	2173-5077
DOI	10.1016/j.ciresp.2018.07.008
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Article ; Online: Biological Determinants of Metabolic Syndrome in Visceral and Subcutaneous Adipose Tissue from Severely Obese Women.

Osorio-Conles, Óscar / Vega-Beyhart, Arturo / Ibarzabal, Ainitze / Balibrea, José María / Vidal, Josep / de Hollanda, Ana

International journal of molecular sciences

2022 Volume 23, Issue 4

Abstract: The metabolic syndrome (MetS) is a cluster of the most dangerous heart attack risk factors: diabetes or raised fasting plasma glucose, abdominal obesity, high cholesterol and high blood pressure. The goal of this study is to compare the state of the main ...

Abstract	The metabolic syndrome (MetS) is a cluster of the most dangerous heart attack risk factors: diabetes or raised fasting plasma glucose, abdominal obesity, high cholesterol and high blood pressure. The goal of this study is to compare the state of the main features of obesity-associated white adipose tissue (WAT) dysfunction in 66 women with severe obesity without (MetS-) or with MetS (MetS+). Fat cell area, adipocyte size distribution and histological fibrosis were analysed in visceral (VAT) and abdominal subcutaneous WAT (SAT) in 33 age- and BMI-matched pairs of MetS- and MetS+ subjects. The mRNA expression of 93 genes implicated in obesity-associated WAT dysfunction was analysed by RT-qPCR in both fat depots. MetS+ females showed higher adipocyte hypertrophy in both fat depots and increased fibrosis and expression of macrophage and hypoxia markers in SAT. Transcriptional data suggest increased fatty acid oxidation in SAT and impaired thermogenesis and extracellular matrix remodelling in VAT from MetS+ subjects. A sPLS-DA model, including SAT expression of
MeSH term(s)	Adipocytes/metabolism ; Adipocytes/pathology ; Adipose Tissue, White/metabolism ; Adipose Tissue, White/pathology ; Body Composition/physiology ; Body Mass Index ; Diabetes Mellitus/metabolism ; Diabetes Mellitus/pathology ; Female ; Humans ; Hypertension/metabolism ; Hypertension/pathology ; Intra-Abdominal Fat/metabolism ; Metabolic Syndrome/metabolism ; Metabolic Syndrome/pathology ; Middle Aged ; Obesity, Abdominal/metabolism ; Obesity, Abdominal/pathology ; Obesity, Morbid/metabolism ; Obesity, Morbid/pathology ; Subcutaneous Fat, Abdominal/metabolism ; Subcutaneous Fat, Abdominal/pathology ; Thermogenesis/physiology
Language	English
Publishing date	2022-02-21
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2019364-6
ISSN	1422-0067 ; 1422-0067 ; 1661-6596
ISSN (online)	1422-0067
ISSN	1422-0067 ; 1661-6596
DOI	10.3390/ijms23042394
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Article ; Online: Prevalence of low skeletal muscle mass following bariatric surgery

Molero, Judith / Olbeyra, Romina / Flores, Lilliam / Jiménez, Amanda / Hollanda, Ana de / Andreu, Alba / Ibarzabal, Ainitze / Moizé, Violeta / Cañizares, Sílvia / Balibrea, José María / Obach, Amadeu / Vidal, Josep

Clinical Nutrition ESPEN. 2022 June, v. 49 p.436-441

2022

Abstract: Evidence on the occurrence of low skeletal muscle mass (low-SMM) following bariatric surgery (BS) as well as on the impact of low-SMM antedating BS on post-surgical body composition (BC) are scant. In this context, we aimed to prospectively evaluate the ... ...

Abstract	Evidence on the occurrence of low skeletal muscle mass (low-SMM) following bariatric surgery (BS) as well as on the impact of low-SMM antedating BS on post-surgical body composition (BC) are scant. In this context, we aimed to prospectively evaluate the prevalence of low-SMM prior to and up to 5 years after BS, and to evaluate pre-surgical low-SMM as an independent risk factor for the presence of low-SMM after BS. Retrospective analysis of prospectively collected database. BC was assessed by bioelectrical impedance analysis (BIA). A BIA-based formula was used to calculate skeletal muscle mass (SMM). Class I and class II low-SMM were defined respectively as a SMM index (SMMI = SMM/height²) value between −1 and −2, or > −2 standard deviations from the gender-specific regression line of the BMI versus the SMMI relationship in our reference group. A total 952 subjects were included, with BC being available for 877 (92%) subjects at 12 months and for 576 subjects (60%) at 60 months after BS. Prior to surgery, and at 12-, or at 60-months after surgery, class I and class II low-SMM was ascertained respectively in 15.6% and 4.6%, 5.3% and 1.4%, and 16.6% and 6.3% of the study participants. Logistic regression analysis showed that the occurrence of low-SMM at 12- and 60-months follow-up, was independently predicted not only by age at the time of surgery [respectively, HR: 1.052 (95% CI 1.020–1.084), p = 0.001; and 1.042 (95% CI 1.019–1.066); p < 0.001] but also by the presence of low-SMM prior to surgery [respectively, HR: 10.717 (95% CI 5.771–19.904), p < 0.001; and 5.718 (95% CI 3.572–9.153); p < 0.001]. Our data suggest that a low-SMM phenotype occurs not only in obesity surgery candidates but also after BS, and that low-SMM prior to surgery is an important risk factor for low-SMM throughout post-surgical follow-up.
Keywords	bariatric surgery ; bioelectrical impedance ; body composition ; clinical nutrition ; databases ; obesity ; phenotype ; regression analysis ; retrospective studies ; risk factors ; skeletal muscle ; Sarcopenia ; Gastric bypass ; Sleeve gastrectomy ; Weight loss ; Inflammation
Language	English
Dates of publication	2022-06
Size	p. 436-441.
Publishing place	Elsevier Ltd
Document type	Article ; Online
ISSN	2405-4577
DOI	10.1016/j.clnesp.2022.03.009
Database	NAL-Catalogue (AGRICOLA)

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Article ; Online: A Distinctive NAFLD Signature in Adipose Tissue from Women with Severe Obesity.

Osorio-Conles, Óscar / Vega-Beyhart, Arturo / Ibarzabal, Ainitze / Balibrea, José María / Graupera, Isabel / Rimola, Jordi / Vidal, Josep / de Hollanda, Ana

International journal of molecular sciences

2021 Volume 22, Issue 19

Abstract: Development and severity of nonalcoholic fatty liver disease (NAFLD) have been linked to obesity and white adipose tissue (WAT) dysfunction plays a key role in this relation. We compared the main features of subcutaneous (SAT) and visceral WAT (VAT) ... ...

Abstract	Development and severity of nonalcoholic fatty liver disease (NAFLD) have been linked to obesity and white adipose tissue (WAT) dysfunction plays a key role in this relation. We compared the main features of subcutaneous (SAT) and visceral WAT (VAT) tissue dysfunction in 48 obese women without (Ob) and with NAFLD (Ob-NAFLD) undergoing bariatric surgery and matched for age, BMI and T2D status. Fat cell area, adipocyte size distribution, the degree of histological fibrosis and the mRNA expression of adipokines and genes implicated in inflammation, adipogenesis, angiogenesis, metabolism and extracellular matrix remodeling were measured by RT-qPCR in both fat depots. Ob-NAFLD group showed higher TG and lower HDL circulating levels, increased VAT fat cell area and similar WAT fibrosis in comparison with Ob group. A sPLS-DA was performed in order to identify the set of genes that better characterize the presence of NAFLD. Finally, we build a multinomial logistic model including seven genes that explained 100% of the variance in NAFLD and correctly predicted 100% of cases. Our data support the existence of distinctive NAFLD signatures in WAT from women with severe obesity. A better understanding of these pathways may help in future strategies for the prevention and treatment of NAFLD.
MeSH term(s)	Adipokines/biosynthesis ; Adult ; Female ; Gene Expression Regulation ; Humans ; Intra-Abdominal Fat/metabolism ; Intra-Abdominal Fat/pathology ; Middle Aged ; Models, Biological ; Non-alcoholic Fatty Liver Disease/metabolism ; Non-alcoholic Fatty Liver Disease/pathology ; Obesity, Morbid/metabolism ; Obesity, Morbid/pathology ; Real-Time Polymerase Chain Reaction ; Reverse Transcriptase Polymerase Chain Reaction ; Subcutaneous Fat/metabolism ; Subcutaneous Fat/pathology
Chemical Substances	Adipokines
Language	English
Publishing date	2021-09-29
Publishing country	Switzerland
Document type	Clinical Trial ; Comparative Study ; Journal Article
ZDB-ID	2019364-6
ISSN	1422-0067 ; 1422-0067 ; 1661-6596
ISSN (online)	1422-0067
ISSN	1422-0067 ; 1661-6596
DOI	10.3390/ijms221910541
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Article ; Online: Prevalence of low skeletal muscle mass following bariatric surgery.

Molero, Judith / Olbeyra, Romina / Flores, Lilliam / Jiménez, Amanda / de Hollanda, Ana / Andreu, Alba / Ibarzabal, Ainitze / Moizé, Violeta / Cañizares, Sílvia / Balibrea, José María / Obach, Amadeu / Vidal, Josep

Clinical nutrition ESPEN

2022 Volume 49, Page(s) 436–441

Abstract: Background and aims: Evidence on the occurrence of low skeletal muscle mass (low-SMM) following bariatric surgery (BS) as well as on the impact of low-SMM antedating BS on post-surgical body composition (BC) are scant. In this context, we aimed to ... ...

Abstract	Background and aims: Evidence on the occurrence of low skeletal muscle mass (low-SMM) following bariatric surgery (BS) as well as on the impact of low-SMM antedating BS on post-surgical body composition (BC) are scant. In this context, we aimed to prospectively evaluate the prevalence of low-SMM prior to and up to 5 years after BS, and to evaluate pre-surgical low-SMM as an independent risk factor for the presence of low-SMM after BS. Methods: Retrospective analysis of prospectively collected database. BC was assessed by bioelectrical impedance analysis (BIA). A BIA-based formula was used to calculate skeletal muscle mass (SMM). Class I and class II low-SMM were defined respectively as a SMM index (SMMI = SMM/height Results: A total 952 subjects were included, with BC being available for 877 (92%) subjects at 12 months and for 576 subjects (60%) at 60 months after BS. Prior to surgery, and at 12-, or at 60-months after surgery, class I and class II low-SMM was ascertained respectively in 15.6% and 4.6%, 5.3% and 1.4%, and 16.6% and 6.3% of the study participants. Logistic regression analysis showed that the occurrence of low-SMM at 12- and 60-months follow-up, was independently predicted not only by age at the time of surgery [respectively, HR: 1.052 (95% CI 1.020-1.084), p = 0.001; and 1.042 (95% CI 1.019-1.066); p < 0.001] but also by the presence of low-SMM prior to surgery [respectively, HR: 10.717 (95% CI 5.771-19.904), p < 0.001; and 5.718 (95% CI 3.572-9.153); p < 0.001]. Conclusions: Our data suggest that a low-SMM phenotype occurs not only in obesity surgery candidates but also after BS, and that low-SMM prior to surgery is an important risk factor for low-SMM throughout post-surgical follow-up.
MeSH term(s)	Bariatric Surgery/adverse effects ; Electric Impedance ; Humans ; Muscle, Skeletal/physiology ; Prevalence ; Retrospective Studies
Language	English
Publishing date	2022-03-17
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ISSN	2405-4577
ISSN (online)	2405-4577
DOI	10.1016/j.clnesp.2022.03.009
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