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Article ; Online: Evaluation of 20 clinical chemistry and 12 immunoassay analytes in terms of total analytical error and measurement uncertainty.

Balık, Ahmet Rıfat / Gücel, Funda

Scandinavian journal of clinical and laboratory investigation

2021 Volume 81, Issue 7, Page(s) 517–522

Abstract: In analytical quality management, target setting models that are selected by the purpose together with the error models that are applied correctly have critical importance. In our study, we aimed to compare the analytical performance characteristics of ... ...

Abstract	In analytical quality management, target setting models that are selected by the purpose together with the error models that are applied correctly have critical importance. In our study, we aimed to compare the analytical performance characteristics of routine clinical chemistry and immunoassay tests with different target-setting models proposed by various organizations. Our study was performed with internal and external quality control data obtained using Beckman Coulter AU680 for clinical chemistry analytes and Roche Cobas 8000 autoanalyzer for immunoassay analytes. The total analytical error (TAE) was calculated by the formula TAH%=1.65×(CV%)+Bias%. Measurement uncertainty (MU) has been calculated adhering to the Nordtest guideline. Results were compared with BVEFLM, CLIA, RCPA, PRDEQA%, pUEQAS%, and permissible MU (pU%) data to investigate analytical performance qualities. When we compare the results of TAE and MU, MU was found to be higher than TAE for all analytes. ALT, AST, glucose, K, and triglycerides m
MeSH term(s)	Chemistry, Clinical/methods ; Humans ; Immunoassay/methods ; Quality Control ; Uncertainty
Language	English
Publishing date	2021-07-27
Publishing country	England
Document type	Evaluation Study ; Journal Article
ZDB-ID	3150-1
ISSN	1502-7686 ; 0036-5513
ISSN (online)	1502-7686
ISSN	0036-5513
DOI	10.1080/00365513.2021.1955294
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Article: Evaluation of Thiol Disulfide Homeostasis and Ischemia-Modified Albumin Levels as an Indicator of Oxidative Stress in Acne Vulgaris.

Balık, Zeynep Büşra / Balık, Ahmet Rıfat / Oğuz, Esra Fırat / Erel, Özcan / Tunca, Mustafa

Dermatology practical & conceptual

2023 Volume 13, Issue 4

Abstract: Introduction: Acne vulgaris (AV) is the most common skin disease. AV is a skin disease often associated with oxidative stress. Thiols and ischemia modified albumin (IMA) analysis are used as oxidative stress markers.: Objectives: In this study, it ... ...

Abstract	Introduction: Acne vulgaris (AV) is the most common skin disease. AV is a skin disease often associated with oxidative stress. Thiols and ischemia modified albumin (IMA) analysis are used as oxidative stress markers. Objectives: In this study, it was aimed to evaluate the blood levels of thiols and IMA, which are accepted as oxidative stress markers, and to determine the severity of the disease in AV patients whose severity is determined by the global acne score rate (GAS). Methods: Thiol parameters and IMA values were measured spectrophotometrically in blood samples taken from patients and controls. Determine GAS values in AV patients. The thiol and IMA values obtained were compared between the patient and control groups and their correlation with the patient's GAS values was evaluated. Results: In our study, in acne patients, native thiol (NT), total thiol (TT) and index 3 (I3=NT/TT100) were significantly lower than the control group, disulfide (SS), index 1 (I1=SS/NT100), index 2 (I2=SS/TT100) and IMA values were found to be significantly higher. GAS values, which are accepted as an indicator of the degree and severity of acne disease, and SS, I1 and I2 showed a positive correlation, while I3 showed a negative correlation. Conclusions:* Our study suggests that oxidative stress associated with AV disease pathogenesis may occur through mechanisms dependent on thiol and IMA levels. Therefore, in AV, oral supplementation or topical application of antioxidants may be a good way to increase drug efficacy or prevent potential harm.
Language	English
Publishing date	2023-10-01
Publishing country	Austria
Document type	Journal Article
ZDB-ID	2685397-8
ISSN	2160-9381
ISSN	2160-9381
DOI	10.5826/dpc.1304a280
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Article ; Online: Investigation of thiol-disulfide homeostasis and ischemia-modified albumin levels in patients with hidradenitis supurativa.

Balik, Zeynep Busra / Balik, Ahmet Rifat / Yucel, Cigdem / Hayran, Yildiz / Çaliskan, Ercan / Erel, Ozcan

Journal of cosmetic dermatology

2022 Volume 21, Issue 10, Page(s) 4748–4753

Abstract: Background: Hidradenitis suppurativa (HS) is a chronic inflammatory skin disease. The pathogenesis of HS is not clear, and the triggering mechanism for the initiation of the disease is still a controversy.: Aims: The present study aims to investigate ...

Abstract	Background: Hidradenitis suppurativa (HS) is a chronic inflammatory skin disease. The pathogenesis of HS is not clear, and the triggering mechanism for the initiation of the disease is still a controversy. Aims: The present study aims to investigate the relationship between thiol-disulfide homeostasis (TDH), ischemia-modified albumin (IMA), and HS. To our knowledge, this will be the first report evaluating TDH and IMA status in HS. Patients/methods: The study included 30 patients with HS as the patient group and 30 healthy individuals as the control group. For determination of HS severity, Hurley and Hidradenitis suppurativa physician global assessment (PGA) scores were used. One tube venous blood specimen from every participant was obtained. IMA and TDH tests were analyzed in sera of participants. The results were evaluated statistically. Results: Disulfide (p < 0.001), Index I (p = 0.001), and Index II (p = 0.001) levels in HS group were significantly higher than control group. IMA levels in patients with higher Hurley scores are significantly higher (p = 0.032, r = 0.39). A positive correlation was observed between IMA level and disease duration (p = 0.021, r = 0.42). Conclusions: The shift in thiol/disulfide balance toward disulfide and significant increase in IMA levels put out the importance of oxidation status in HS etiopathogenesis.
MeSH term(s)	Humans ; Disulfides ; Sulfhydryl Compounds ; Biomarkers ; Hidradenitis Suppurativa/diagnosis ; Serum Albumin ; Homeostasis
Chemical Substances	Disulfides ; Sulfhydryl Compounds ; ischemia-modified albumin ; Biomarkers ; Serum Albumin
Language	English
Publishing date	2022-01-12
Publishing country	England
Document type	Journal Article
ZDB-ID	2280551-5
ISSN	1473-2165 ; 1473-2130
ISSN (online)	1473-2165
ISSN	1473-2130
DOI	10.1111/jocd.14753
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Article: Evaluation of erythrocyte membrane fatty-acid compositions in association with interleukin-6 levels in patients with COVID-19

Sertoglu, Erdim / Yucel, Cigdem / Balık, Ahmet Rıfat / Taşçı, Cantürk / Bilge, Sedat / Ertuğrul, Meryem Sebla / Nazaroğlu, Namık Kemal / Ozgurtas, Taner

Nutrition. 2022 Apr., v. 96

2022

Abstract: The cytokine storm presented in the hyperimmune response is related to poor prognosis in people with COVID-19. Interleukin-6 (IL-6) is one of the most prominent cytokines, especially on mucosal surfaces during infection, causing the cytokine storm. ... ...

Abstract	The cytokine storm presented in the hyperimmune response is related to poor prognosis in people with COVID-19. Interleukin-6 (IL-6) is one of the most prominent cytokines, especially on mucosal surfaces during infection, causing the cytokine storm. Polyunsaturated fatty acids (PUFAs) are the precursors of eicosanoids, which play critical roles in immune regulation and inflammation. The balance between ω-3 and ω-6 levels in the cell membrane has a critical role in regulating the equilibrium between proinflammatory and antiinflammatory processes and inducing IL-6 production. The present study focused on inflammatory and antiinflammatory mechanisms in COVID-19 over PUFAs and on relating their levels with disease prognosis and severity.A total of 106 participants were included in the study. They were divided into three groups according to IL-6 level— 1: <35 pg/mL, 2: between 35 and 300 pg/mL, and 3: >300 pg/mL. Erythrocyte membrane PUFA compositions were analyzed by group.Levels of γ-linolenic acid and ω-6/ω-3 ratios were significantly increased in all comparison groups (P < 0.05). Total ω-6 and the ratio of arachidonic acid to eicosopentaenoic acid showed a statistically significant difference only between groups 1 and 3 (P < 0.05). There was a moderately negative correlation between total ω-3 and IL-6 and procalcitonin. There were positive correlations with ω-6/ω-3 ratio inflammatory markers, and the total ω-6 index also showed a moderately positive correlation with IL-6, procalcitonin, and D-dimer levels.The ratio of arachidonic acid to eicosopentaenoic acid, and ω-3 PUFAs, can be systemic signs of poor prognosis, increased lung damage, and high mortality in COVID-19, together with IL-6.
Keywords	COVID-19 infection ; arachidonic acid ; eicosanoids ; erythrocyte membrane ; inflammation ; interleukin-6 ; lungs ; mortality ; nutrition ; prognosis
Language	English
Dates of publication	2022-04
Publishing place	Elsevier Inc.
Document type	Article
ZDB-ID	639259-3
ISSN	1873-1244 ; 0899-9007
ISSN (online)	1873-1244
ISSN	0899-9007
DOI	10.1016/j.nut.2021.111581
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Article ; Online: Thiol/disulfide homeostasis in retinitis pigmentosa patients.

Ertan, Elif / Duman, Rahmi / Duman, Reşat / Erel, Özcan / Balik, Ahmet Rifat

European journal of ophthalmology

2020 Volume 31, Issue 2, Page(s) 572–577

Abstract: Purpose: This research is aimed at determination of total oxidant status, total antioxidant status, serum thiol-disulfide, catalase, albumin, ischemia-modified albumin, and ceruloplasmin in patients suffering from retinitis pigmentosa and drawing a ... ...

Abstract	Purpose: This research is aimed at determination of total oxidant status, total antioxidant status, serum thiol-disulfide, catalase, albumin, ischemia-modified albumin, and ceruloplasmin in patients suffering from retinitis pigmentosa and drawing a comparison with these parameters determined from healthy controls. Methods: The study involved 35 patients of retinitis pigmentosa and 33 controls who were healthy individuals of comparable gender and age. Native thiol, total thiol, disulfide concentration, disulfide/native thiol, disulfide/total thiol, native thiol/total thiol ratios, total oxidant status, total antioxidant status, catalase, ceruloplasmin, albumin, and ischemia-modified albumin were determined from peripheral blood samples and comparison was drawn between the measurements of retinitis pigmentosa and controls. Results: The two groups were similar in gender and age distributions. It was found that retinitis pigmentosa group demonstrated greater total oxidant status, ischemia-modified albumin, and disulfide concentrations as compared to controls (p < 0.001). However, total antioxidant status, catalase, native thiol, total thiol, albumin, and ceruloplasmin of the two groups did not show statistically significant difference (p > 0.05). Moreover, disulfide/total thiol and disulfide/native thiol ratios of the retinitis pigmentosa group were significantly greater in comparison to controls (p < 0.05). Conclusion: The researchers reached the conclusion that thiol oxidation in retinitis pigmentosa patients caused the dynamic thiol/disulfide homeostasis to shift toward the generation of disulfide. This is a novel research that involves analysis of thiol/disulfide homeostasis in retinitis pigmentosa patients using a novel automated assay. The researchers identified the cause for persistent oxidative stress and damage reported in retinitis pigmentosa patients. Still, future research is required for analysis of progression of antioxidant-oxidant state through various retinitis pigmentosa stages.
MeSH term(s)	Adult ; Biomarkers/blood ; Catalase/blood ; Ceruloplasmin/metabolism ; Disulfides/blood ; Female ; Homeostasis/physiology ; Humans ; Male ; Middle Aged ; Oxidative Stress ; Retinitis Pigmentosa/blood ; Serum Albumin/metabolism ; Serum Albumin, Human ; Sulfhydryl Compounds/blood
Chemical Substances	Biomarkers ; Disulfides ; Serum Albumin ; Sulfhydryl Compounds ; ischemia-modified albumin ; Catalase (EC 1.11.1.6) ; Ceruloplasmin (EC 1.16.3.1) ; Serum Albumin, Human (ZIF514RVZR)
Language	English
Publishing date	2020-02-05
Publishing country	United States
Document type	Journal Article
ZDB-ID	1089461-5
ISSN	1724-6016 ; 1120-6721
ISSN (online)	1724-6016
ISSN	1120-6721
DOI	10.1177/1120672120902285
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Article ; Online: Examination of androgenetic alopecia with serum biomarkers.

Balık, Ahmet Rıfat / Balık, Zeynep Büşra / Aktaş, Akın / Neşelioğlu, Salim / Karabulut, Ercan / Karabulut, Aysun Bay

Journal of cosmetic dermatology

2020 Volume 20, Issue 6, Page(s) 1855–1859

Abstract: Background: Androgenetic alopecia (AGA) is the most common type of hair loss and affects approximately 50% of the male population.: Aims: In the present study, to investigate microinflammation, perifollicular fibrosis, and oxidative stress in AGA ... ...

Abstract	Background: Androgenetic alopecia (AGA) is the most common type of hair loss and affects approximately 50% of the male population. Aims: In the present study, to investigate microinflammation, perifollicular fibrosis, and oxidative stress in AGA cases, some serum biomarker levels were measured and evaluated. Patients/methods: Serum samples were drawn from patients (n = 58) and control (n = 30) groups referring to Atatürk Training and Investigation Hospital Dermatology Outpatient clinic. In serum samples, NF-κB, TNF-α, TGF-β1, thioredoxin, nitric oxide, TOS, TAS, and thiol disulfide homeostasis (native thiol, total thiol, disulfide) were measured and evaluated. Results: In patients with AGA, NF-κB (P = .005), TNF-α (P = .008), TGF-β1 (P = .028), thioredoxin (P = .004), nitric oxide (P < .001), and TOS (P < .001) serum levels were found to be significantly higher than those in control group, while TAS (P = .003), native thiol (P < .001), total thiol (P < .001), and disulfide (P < .001) serum levels were found to be significantly lower. Conclusions: According to the results of the present study, it was concluded that in that AGA androgens lead to oxidative stress by increasing free oxygen radicals, which accelerates hair loss by causing microinflammation and fibrosis. The recognition of the effect of androgens and associated factors on the hair follicle cycle is essential for the development of new and effective treatment methods.
MeSH term(s)	Alopecia/metabolism ; Androgens ; Biomarkers/metabolism ; Hair Follicle/metabolism ; Humans ; Male ; Oxidative Stress
Chemical Substances	Androgens ; Biomarkers
Language	English
Publishing date	2020-10-07
Publishing country	England
Document type	Journal Article
ZDB-ID	2280551-5
ISSN	1473-2165 ; 1473-2130
ISSN (online)	1473-2165
ISSN	1473-2130
DOI	10.1111/jocd.13732
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Article ; Online: Evaluation of erythrocyte membrane fatty-acid compositions in association with interleukin-6 levels in patients with COVID-19.

Sertoglu, Erdim / Yucel, Cigdem / Balık, Ahmet Rıfat / Taşçı, Cantürk / Bilge, Sedat / Ertuğrul, Meryem Sebla / Nazaroğlu, Namık Kemal / Ozgurtas, Taner

Nutrition (Burbank, Los Angeles County, Calif.)

2021 Volume 96, Page(s) 111581

Abstract: Objective: The cytokine storm presented in the hyperimmune response is related to poor prognosis in people with COVID-19. Interleukin-6 (IL-6) is one of the most prominent cytokines, especially on mucosal surfaces during infection, causing the cytokine ... ...

Abstract	Objective: The cytokine storm presented in the hyperimmune response is related to poor prognosis in people with COVID-19. Interleukin-6 (IL-6) is one of the most prominent cytokines, especially on mucosal surfaces during infection, causing the cytokine storm. Polyunsaturated fatty acids (PUFAs) are the precursors of eicosanoids, which play critical roles in immune regulation and inflammation. The balance between ω-3 and ω-6 levels in the cell membrane has a critical role in regulating the equilibrium between proinflammatory and antiinflammatory processes and inducing IL-6 production. The present study focused on inflammatory and antiinflammatory mechanisms in COVID-19 over PUFAs and on relating their levels with disease prognosis and severity. Methods: A total of 106 participants were included in the study. They were divided into three groups according to IL-6 level- 1: <35 pg/mL, 2: between 35 and 300 pg/mL, and 3: >300 pg/mL. Erythrocyte membrane PUFA compositions were analyzed by group. Results: Levels of γ-linolenic acid and ω-6/ω-3 ratios were significantly increased in all comparison groups (P < 0.05). Total ω-6 and the ratio of arachidonic acid to eicosopentaenoic acid showed a statistically significant difference only between groups 1 and 3 (P < 0.05). There was a moderately negative correlation between total ω-3 and IL-6 and procalcitonin. There were positive correlations with ω-6/ω-3 ratio inflammatory markers, and the total ω-6 index also showed a moderately positive correlation with IL-6, procalcitonin, and D-dimer levels. Conclusions: The ratio of arachidonic acid to eicosopentaenoic acid, and ω-3 PUFAs, can be systemic signs of poor prognosis, increased lung damage, and high mortality in COVID-19, together with IL-6.
MeSH term(s)	COVID-19 ; Erythrocyte Membrane ; Fatty Acids ; Fatty Acids, Omega-3 ; Humans ; Interleukin-6
Chemical Substances	Fatty Acids ; Fatty Acids, Omega-3 ; Interleukin-6
Language	English
Publishing date	2021-12-26
Publishing country	United States
Document type	Journal Article
ZDB-ID	639259-3
ISSN	1873-1244 ; 0899-9007
ISSN (online)	1873-1244
ISSN	0899-9007
DOI	10.1016/j.nut.2021.111581
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Article ; Online: Dynamic thiol disulfide homeostasis in painters as indices of oxidative stress.

Özakıncı, Osman Gökhan / Gündüzöz, Meside / Buyuksekerci, Murat / Karataş, Mevlüt / Balik, Ahmet Rifat / Neselioglu, Salim / Erel, Özcan

International journal of environmental health research

2020 Volume 32, Issue 5, Page(s) 1067–1075

Abstract: This study was designed to determine thiol-disulfide homeostasis as indices of oxidative stress in painters by using a novel and automated colorimetric measurement method. Male painters ( ...

Abstract	This study was designed to determine thiol-disulfide homeostasis as indices of oxidative stress in painters by using a novel and automated colorimetric measurement method. Male painters (
MeSH term(s)	Adolescent ; Biomarkers/metabolism ; Child ; Child, Preschool ; Disulfides ; Homeostasis ; Humans ; Male ; Oxidative Stress ; Serum Albumin ; Sulfhydryl Compounds
Chemical Substances	Biomarkers ; Disulfides ; Serum Albumin ; Sulfhydryl Compounds
Language	English
Publishing date	2020-09-29
Publishing country	England
Document type	Journal Article
ZDB-ID	1104887-6
ISSN	1369-1619 ; 0960-3123
ISSN (online)	1369-1619
ISSN	0960-3123
DOI	10.1080/09603123.2020.1827227
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Article ; Online: Ischemia-Modified Albumin Levels and Thiol-Disulphide Homeostasis in Diabetic Macular Edema in Patients with Diabetes Mellitus Type 2.

Kalayci, Mustafa / Cetinkaya, Ersan / Yigit, Kenan / Sabaner, Mehmet Cem / Duman, Reşat / Balik, Ahmet Rifat / Erel, Özcan

Current eye research

2020 Volume 46, Issue 5, Page(s) 683–688

Abstract: Purpose: It was aimed to assess the role of thiol-disulphide homeostasis and ischemia-modified albumin (IMA) level in the development of diabetic macular edema (DME) in patients with diabetes mellitus type 2 (T2DM).: Materials and methods: Sixty-six ... ...

Abstract	Purpose: It was aimed to assess the role of thiol-disulphide homeostasis and ischemia-modified albumin (IMA) level in the development of diabetic macular edema (DME) in patients with diabetes mellitus type 2 (T2DM). Materials and methods: Sixty-six study patients were divided into two groups. Group I included 43 patients with T2DM and DME, and Group 2 included 23 patients with T2DM without eye involvement. A novel colorimetric method was used to assess thiol-disulphide homeostasis. Between the two groups IMA, total anti-oxidant, and total oxidant levels were measured and compared. Results: In Group 1, total and native thiol levels and disulphide levels were lower compared to Group 2 ( Conclusions: The disruption in thiol/disulphide homeostasis, increased IMA and oxidative stress have an impact on the development of diabetic macular edema.
MeSH term(s)	Aged ; Aged, 80 and over ; Biomarkers/blood ; Case-Control Studies ; Diabetes Mellitus, Type 2/blood ; Diabetic Retinopathy/blood ; Disulfides/blood ; Female ; Homeostasis ; Humans ; Macular Edema/blood ; Male ; Middle Aged ; Oxidative Stress ; Prospective Studies ; Serum Albumin, Human ; Sulfhydryl Compounds/blood ; Visual Acuity/physiology
Chemical Substances	Biomarkers ; Disulfides ; Sulfhydryl Compounds ; ischemia-modified albumin ; Serum Albumin, Human (ZIF514RVZR)
Language	English
Publishing date	2020-09-14
Publishing country	England
Document type	Journal Article
ZDB-ID	82079-9
ISSN	1460-2202 ; 0271-3683
ISSN (online)	1460-2202
ISSN	0271-3683
DOI	10.1080/02713683.2020.1818261
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Article ; Online: Hemodilution is not the only reason of difference: Comparison of fasting and non-fasting lipoproteins in paired samples.

Özbek İpteç, Betül / Balik, Ahmet Rıfat / Yüksel, Selcen / Yilmaz, Fatma Meriç / Yilmaz, Gülsen

Clinical biochemistry

2018 Volume 61, Page(s) 28–33

Abstract: Introduction: Low-density lipoprotein cholesterol (LDL) is an important risk factor for cardiovascular disease (CVD) and generally measured after 8-12 h fasting. However, some recent studies have pointed that non-fasting lipoproteins, especially LDL ... ...

Abstract	Introduction: Low-density lipoprotein cholesterol (LDL) is an important risk factor for cardiovascular disease (CVD) and generally measured after 8-12 h fasting. However, some recent studies have pointed that non-fasting lipoproteins, especially LDL concentrations, are better indicators for demonstrating CVD risk and atherosclerosis. They asserted that nutrition is a negligible factor on changes in lipoprotein concentrations and claimed this difference as a result of hemodilution effect, caused from fluid intake and can be eliminated by applying some adjustments. We aimed to compare the fasting and non-fasting LDL values of the same individuals and discuss whether non-fasting and fasting LDL results can be used in place of each other, directly or after applying hemodilution correction models. Material and methods: Fasting and non-fasting blood samples of 248 apparently healthy participants were collected. Lipid panel tests, albumin and hemoglobin levels were studied in each sample. Results were evaluated in seven different models which were recommended to correct the hemodilution effect on fasting and non-fasting lipid concentrations of the same individual. Concordance of fasting and non-fasting risk group of the individual were calculated according to the National Cholesterol Education Program classification. Results: Fasting and non-fasting LDL and non-high density lipoprotein cholesterol (non-HDL) concentrations were significantly different in every model (p < 0.001). Concordance results of fasting and non-fasting LDL and non-HDL risk groups were 63.8% and 77.9% respectively. Conclusions: Our results demonstrated that fasting and non-fasting LDL and non-HDL concentrations could not be used in place of each other even when the results were adjusted for elimination of the hemodilution effect.
MeSH term(s)	Admitting Department, Hospital ; Adult ; Aged ; Asymptomatic Diseases/epidemiology ; Biomarkers/blood ; Cardiovascular Diseases/blood ; Cardiovascular Diseases/diagnosis ; Cardiovascular Diseases/epidemiology ; Fasting/blood ; Female ; Hemodilution ; Hospitals, Teaching ; Humans ; Lipoproteins/blood ; Lipoproteins, LDL/blood ; Male ; Mass Screening/methods ; Middle Aged ; Models, Cardiovascular ; Prospective Studies ; Risk Factors ; Turkey/epidemiology
Chemical Substances	Biomarkers ; Lipoproteins ; Lipoproteins, LDL
Language	English
Publishing date	2018-08-25
Publishing country	United States
Document type	Comparative Study ; Journal Article
ZDB-ID	390372-2
ISSN	1873-2933 ; 0009-9120
ISSN (online)	1873-2933
ISSN	0009-9120
DOI	10.1016/j.clinbiochem.2018.08.009
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