Article ; Online: Assessment of gait mechanics and muscle strength in hypermobile Ehlers Danlos Syndrome.
Clinical biomechanics (Bristol, Avon)
2024 Volume 113, Page(s) 106210
Abstract: Background: Hypermobile Ehlers Danlos Syndrome, a heritable connective tissue disorder, is associated with muscle dysfunction, joint subluxations and pain. The impact of hypermobile Ehlers Danlos Syndrome on musculoskeletal mechanics is understudied. ... ...
| Abstract | Background: Hypermobile Ehlers Danlos Syndrome, a heritable connective tissue disorder, is associated with muscle dysfunction, joint subluxations and pain. The impact of hypermobile Ehlers Danlos Syndrome on musculoskeletal mechanics is understudied. Therefore, the aim of this study was to assess the effects of hypermobile Ehlers Danlos Syndrome on lower extremity gait mechanics and muscle strength. Methods: Eleven people with hypermobile Ehlers Danlos Syndrome and 11 asymptomatic controls underwent a 3D gait analysis and isometric hip and knee muscle strength assessment. Joint subluxations were self-reported by the hypermobile Ehlers Danlos syndrome group. Independent t-tests and Mann Whitney U tests were used to analyze joint mechanics, muscle strength, and patient report outcomes (p < 0.05). Findings: Both groups exhibited similar walking speeds as well as similar hip, knee, and ankle joint kinematics. The hypermobile Ehlers Danlos Syndrome group walked with a lower peak hip extensor moment (hypermobile Ehlers Danlos Syndrome: -0.52 ± 0.28 Nmˑkg Interpretation: Patients with hypermobile Ehlers Danlos Syndrome ambulated with altered hip extensor moments and exhibit hip extensor weakness. Future work should investigate the underlying mechanisms of hip extensor weakness and corresponding effects on joint health in people with hypermobile Ehlers Danlos Syndrome. |
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| MeSH term(s) | Humans ; Ehlers-Danlos Syndrome ; Gait/physiology ; Joint Dislocations ; Muscle Strength/physiology ; Joint Instability | |||||
| Language | English | |||||
| Publishing date | 2024-02-18 | |||||
| Publishing country | England | |||||
| Document type | Journal Article ; Research Support, N.I.H., Extramural | |||||
| ZDB-ID | 632747-3 | |||||
| ISSN | 1879-1271 ; 0268-0033 | |||||
| ISSN (online) | 1879-1271 | |||||
| ISSN | 0268-0033 | |||||
| DOI | 10.1016/j.clinbiomech.2024.106210 | |||||
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| Database | MEDical Literature Analysis and Retrieval System OnLINE |
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