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  1. Article ; Online: Postoperative fluid therapy in enhanced recovery after surgery for pancreaticoduodenectomy.

    Koek, Sharnice / Lo, Johnny / Ledger, Rupert / Ballal, Mohammed

    Annals of hepato-biliary-pancreatic surgery

    2024  Volume 28, Issue 1, Page(s) 80–91

    Abstract: Backgrounds/aims: Optimal intravenous fluid management during the perioperative period for patients undergoing pancreaticoduodenectomy (PD) within the framework of enhanced recovery after surgery (ERAS) is unclear. Studies have indicated that excessive ... ...

    Abstract Backgrounds/aims: Optimal intravenous fluid management during the perioperative period for patients undergoing pancreaticoduodenectomy (PD) within the framework of enhanced recovery after surgery (ERAS) is unclear. Studies have indicated that excessive total body salt and water can contribute to the development of oedema, leading to increased morbidity and extended hospital stays. This study aimed to assess the effects of an intravenous therapy regimen during postoperative day (POD) 0 to 2 in PD patients within ERAS.
    Methods: A retrospective interventional cohort study was conducted, and it involved all PD patients before and after implementation of ERAS (2009-2017). In the ERAS group, a targeted maintenance fluid regimen of 20 mL/kg/day with a sodium requirement of 0.5 mmoL/kg/day was administered. Outcome measures included the mmol of sodium and chloride administered, length of stay, and morbidity (postoperative pancreatic fistula, POPF; acute kidney injury, AKI; ileus).
    Results: The study included 169 patients, with a mean age of 64 ± 11.3 years. Following implementation of the intravenous fluid therapy protocol, there was a significant reduction in chloride and sodium loading. However, in the multivariable analysis, chloride administered (mmoL/kg) did not independently influence the length of stay; or rates of POPF, ileus, or AKI (
    Conclusions: The findings suggested that a postoperative intravenous fluid therapy regimen did not significantly impact morbidity. Notably, there was a trend towards reduced length of stay within an increasingly comorbid patient cohort. This targeted fluid regimen appears to be safe for PD patients within the ERAS program. Further prospective research is needed to explore this area.
    Language English
    Publishing date 2024-01-12
    Publishing country Korea (South)
    Document type Journal Article
    ZDB-ID 3012179-6
    ISSN 2508-5859 ; 2508-5778
    ISSN (online) 2508-5859
    ISSN 2508-5778
    DOI 10.14701/ahbps.23-084
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Laparoscopic Pancreaticojejunostomy Anastamosis Using an Articulating Needle Holder.

    Bibo, Liam / Ballal, Mohammed

    Surgical laparoscopy, endoscopy & percutaneous techniques

    2021  Volume 32, Issue 2, Page(s) 279–280

    Abstract: Introduction: Pancreaticojejunal anastomosis is a technically challenging stage of the pancreaticoduodenectomy procedure for even the most experienced surgeon. We illustrate a buttressed duct-to-mucosa anastomosis (modified Blumgart technique) during ... ...

    Abstract Introduction: Pancreaticojejunal anastomosis is a technically challenging stage of the pancreaticoduodenectomy procedure for even the most experienced surgeon. We illustrate a buttressed duct-to-mucosa anastomosis (modified Blumgart technique) during laparoscopic pancreaticoduodenectomy using an articulating needle holder (FlexDex) (Video, Supplemental Digital Content 1, http://links.lww.com/SLE/A299).
    Materials and methods: While performing a minimally invasive pancreaticoduodenectomy, an articulating needle holder (FlexDex) is introduced through an 8 mm laparoscopic port and used to perform the duct-to-mucosa pancreaticojejunal anastomosis. Parenchymal buttressing using 3/0 double ended barbed suture (Stratafix) and pancreas duct to jejunum using 5/0 Prolene.Approval was obtained from the Office of Ethics and Research Governance at our institution. Consent was gained from the individual patient involved, to submit this intraoperative video for publication.
    Results: Successful intraoperative pancreaticojejunal anastomosis was performed using the articulating needle holder (FlexDex). The patient recovered from the procedure without complication, with no postoperative pancreatic fistula.
    Conclusions: We demonstrate the feasibility of performing a laparoscopic pancreaticojejunal anastomosis using an articulating needle holder (FlexDex).
    MeSH term(s) Anastomosis, Surgical/methods ; Humans ; Laparoscopy/methods ; Pancreatic Fistula/etiology ; Pancreaticoduodenectomy/methods ; Pancreaticojejunostomy/methods ; Postoperative Complications
    Language English
    Publishing date 2021-09-21
    Publishing country United States
    Document type Journal Article
    ZDB-ID 1475108-2
    ISSN 1534-4908 ; 1530-4515 ; 1051-7200
    ISSN (online) 1534-4908
    ISSN 1530-4515 ; 1051-7200
    DOI 10.1097/SLE.0000000000001003
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Hydroxyapatite deposition disease (HADD) of the spring ligament: an unusual cause of medial foot pain.

    Papineni, Vijay R K / Ballal, Moez / Iyengar, Karthikeyan P / Botchu, Rajesh

    Journal of ultrasound

    2023  Volume 26, Issue 4, Page(s) 923–928

    Abstract: Foot pain is one of the most common presenting complaints in orthopaedic clinical practice and can be attributed to a multitude of pathologies in the various osseous structures, ligaments, and tendons of the foot. The spring ligament complex (SLC) ... ...

    Abstract Foot pain is one of the most common presenting complaints in orthopaedic clinical practice and can be attributed to a multitude of pathologies in the various osseous structures, ligaments, and tendons of the foot. The spring ligament complex (SLC) between the calcaneum and navicular supports the talus and plays a major role in the static stability of the medial longitudinal arch of the foot. Although calcific ligamentous enthesopathy around the ankle has been described in the literature, we report the first case of its kind affecting the SLC in a 51-year-old male with medial foot pain and no history of trauma. We highlight the role of radiological interventions in the diagnosis and effective management using ultrasound (US)-guided barbotage.
    MeSH term(s) Male ; Humans ; Middle Aged ; Foot/diagnostic imaging ; Ligaments, Articular ; Ankle ; Ankle Joint ; Hydroxyapatites
    Chemical Substances Hydroxyapatites
    Language English
    Publishing date 2023-03-30
    Publishing country Italy
    Document type Case Reports ; Journal Article
    ZDB-ID 2365426-0
    ISSN 1876-7931 ; 1971-3495
    ISSN (online) 1876-7931
    ISSN 1971-3495
    DOI 10.1007/s40477-023-00781-9
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  4. Article ; Online: What is the role of intraoperative cholangiography at cholecystectomy in the modern era?

    Turco, Jennifer / Ballal, Mohammed / Fletcher, David

    ANZ journal of surgery

    2021  Volume 91, Issue 7-8, Page(s) 1329–1330

    MeSH term(s) Cholangiography ; Cholecystectomy ; Humans
    Language English
    Publishing date 2021-08-24
    Publishing country Australia
    Document type Editorial ; Comment
    ZDB-ID 2050749-5
    ISSN 1445-2197 ; 1445-1433 ; 0004-8682
    ISSN (online) 1445-2197
    ISSN 1445-1433 ; 0004-8682
    DOI 10.1111/ans.17052
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  5. Article ; Online: Following the Indian Immigrant: adoption of westernization results in a western gut microbiome and an increased risk of inflammatory bowel diseases.

    D'Aloisio, Leah D / Shetty, Vignesh / Ballal, Mamatha / Gibson, Deanna L

    FEMS microbiology ecology

    2022  Volume 98, Issue 12

    Abstract: Indians who migrate to westernized countries such as Canada, the USA, and the UK are at an increased risk of developing inflammatory bowel disease (IBD). While the underlying aetiology of IBD remains unclear, a gut microbiome, i.e. no longer symbiotic ... ...

    Abstract Indians who migrate to westernized countries such as Canada, the USA, and the UK are at an increased risk of developing inflammatory bowel disease (IBD). While the underlying aetiology of IBD remains unclear, a gut microbiome, i.e. no longer symbiotic with its host, is a major player. Increasing IBD incidence in Indian immigrants may be due to the adoption of western practices that result in loss of tolerance of a symbiotic community in the gut and its underlying immune responses. However, little is known about the microbial changes in the Indian gut, including shifts in the microbiome when they migrate to westernized countries. In this Current Opinion, we discuss what is known about the Indian gut microbiome and how living in a westernized environment may be impeding what was once a symbiotic relationship with their gut microbiome and intestinal mucosae, which may be the driving factor in their increased risk of IBD.
    MeSH term(s) Humans ; Gastrointestinal Microbiome/physiology ; Inflammatory Bowel Diseases ; Microbiota ; Symbiosis ; Emigrants and Immigrants
    Language English
    Publishing date 2022-11-09
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 283722-5
    ISSN 1574-6941 ; 0168-6496
    ISSN (online) 1574-6941
    ISSN 0168-6496
    DOI 10.1093/femsec/fiac133
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  6. Article: Large abdominal hernia repair with closed incision negative pressure therapy: a case series.

    Wang, Edward / Archer, Leigh / Foster, Amanda / Ballal, Mohammed

    Journal of wound care

    2021  Volume 30, Issue 3, Page(s) 192–196

    Abstract: Objective: A major challenge of large abdominal incisional hernia repair is the high rates of wound complications. Closed incision negative pressure therapy (CINPT) can offer many treatment advantages in the management of these wounds and has been shown ...

    Abstract Objective: A major challenge of large abdominal incisional hernia repair is the high rates of wound complications. Closed incision negative pressure therapy (CINPT) can offer many treatment advantages in the management of these wounds and has been shown to reduce complications for other postoperative incisions. This study assesses the wound outcomes for hernia repair patients receiving CINPT.
    Method: A six-year retrospective case series of patients who had undergone large abdominal incisional hernia repair wounds treated with CINPT was conducted. Outcomes for patients treated with CINPT were compared with patients who had not received CINPT acting as a control.
    Results: A total of 23 patients were treated with CINPT after hernia repair and compared with 12 patients in the control group. A statistically significant decreased rate of return to theatre (odds ratio: 0.12) was found in this study. Non-significant reductions in wound infection, seroma and wound dehiscence were also seen. No adverse events with CINPT therapy were reported.
    Conclusions: CINPT, when used after large abdominal incisional hernia repair, may help in the prevention of wound complications.
    MeSH term(s) Adult ; Aged ; Aged, 80 and over ; Herniorrhaphy ; Humans ; Middle Aged ; Negative-Pressure Wound Therapy ; Retrospective Studies ; Surgical Wound/etiology ; Surgical Wound/therapy ; Surgical Wound Infection/etiology ; Surgical Wound Infection/therapy ; Tomography, X-Ray Computed ; Treatment Outcome ; Wound Healing
    Language English
    Publishing date 2021-03-17
    Publishing country England
    Document type Journal Article
    ZDB-ID 1353951-6
    ISSN 0969-0700
    ISSN 0969-0700
    DOI 10.12968/jowc.2021.30.3.192
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  7. Article ; Online: Drain fluid amylase and lipase as a predictive factor of postoperative pancreatic fistula.

    Koek, Sharnice / Wiegele, Sophie / Ballal, Mohammed

    ANZ journal of surgery

    2021  Volume 92, Issue 3, Page(s) 414–418

    Abstract: Background: Early detection of a postoperative pancreatic fistula (POPF) may improve outcomes after pancreaticoduodenectomy (PD). The aim was to assess the role of postoperative drain fluid amylase (DFA) and lipase (DFL) measurements as a predictive ... ...

    Abstract Background: Early detection of a postoperative pancreatic fistula (POPF) may improve outcomes after pancreaticoduodenectomy (PD). The aim was to assess the role of postoperative drain fluid amylase (DFA) and lipase (DFL) measurements as a predictive indicator in the development of POPF.
    Methods: This retrospective cohort study included all PD procedures performed between 2009 and 2017 at Fremantle and Fiona Stanley Hospital in Western Australia. The DFA and DFL measurements on postoperative day (POD) three and five were correlated with the development of POPF.
    Results: A total of 169 patients were included in this study with a mean age of 64 ± 11.3 years. Of these, 17 (10.1%) developed a clinically significant POPF. In patients who had both a DFA and DFL measured on both POD 3 and 5, DFA and DFL was significantly higher in patients who developed POPF than those who did not (P < 0.001). In a receiver operating characteristic curve analysis, the most accurate test was POD 3 DFL measurement with an AUC 0.85 (CI 0.75-0.95, P < 0.001). A negative predictive value of 97.4% was observed. DFA and DFL were concordant in 89.2% of cases on POD 3 and 90.6% of cases on POD 5.
    Conclusion: In this study, DFL measured on POD 3 as a single measurement appears to carry the most benefit in prediction of clinically significant POPF. Reduction to a measurement on this day may lead to a reduction in cost, earlier drain removal and earlier identification of high-risk patients.
    MeSH term(s) Aged ; Amylases ; Drainage/methods ; Humans ; Lipase ; Middle Aged ; Pancreatic Fistula/diagnosis ; Pancreatic Fistula/epidemiology ; Pancreatic Fistula/etiology ; Pancreaticoduodenectomy/adverse effects ; Postoperative Complications/diagnosis ; Postoperative Complications/epidemiology ; Postoperative Complications/etiology ; Retrospective Studies ; Risk Factors
    Chemical Substances Lipase (EC 3.1.1.3) ; Amylases (EC 3.2.1.-)
    Language English
    Publishing date 2021-10-22
    Publishing country Australia
    Document type Journal Article
    ZDB-ID 2050749-5
    ISSN 1445-2197 ; 1445-1433 ; 0004-8682
    ISSN (online) 1445-2197
    ISSN 1445-1433 ; 0004-8682
    DOI 10.1111/ans.17296
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  8. Article ; Online: Author Correction: Metagenomics of pigmented and cholesterol gallstones: the putative role of bacteria.

    Kose, S H / Grice, K / Orsi, W D / Ballal, M / Coolen, M J L

    Scientific reports

    2020  Volume 10, Issue 1, Page(s) 4347

    Abstract: An amendment to this paper has been published and can be accessed via a link at the top of the paper. ...

    Abstract An amendment to this paper has been published and can be accessed via a link at the top of the paper.
    Language English
    Publishing date 2020-03-04
    Publishing country England
    Document type Published Erratum
    ZDB-ID 2615211-3
    ISSN 2045-2322 ; 2045-2322
    ISSN (online) 2045-2322
    ISSN 2045-2322
    DOI 10.1038/s41598-020-60081-8
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  9. Article ; Online: Profile of Helicobacter pylori cagA &vacA genotypes and its association with the spectrum of gastroduodenal disease.

    Shetty, Vignesh / Lingadakai, Ramachandra / Pai, Ganesh C / Ballal, Mamatha

    Indian journal of medical microbiology

    2021  Volume 39, Issue 4, Page(s) 495–499

    Abstract: Purpose: Globally, H. pylori virulence factors cagA and vacA genotypes and its variation is leading to the austere form of the gastroduodenal disease. Our objectives were to detect H. pylori in dyspeptic patients from biopsy samples with the validation ... ...

    Abstract Purpose: Globally, H. pylori virulence factors cagA and vacA genotypes and its variation is leading to the austere form of the gastroduodenal disease. Our objectives were to detect H. pylori in dyspeptic patients from biopsy samples with the validation of the various existing diagnostic tools and to screen the cagA, vacA genotypes profile from biopsy specimens and how it impacts in progression of gastroduodenal disease in southern India.
    Methods: 374 patients who attended endoscopy unit at Kasturba Hospital, Manipal with their consent obtained their biopsies. H. pylori were detected by HPE, Culture, RUT and PCR and its virulence gene were patterned with PCR.
    Results: The positive rate of H. pylori by HPE, RUT, Culture and PCR were 51.33%, 47.1%, 32.4% and 50.3% respectively and comparison by Bayesian LCMs analysis showed PCR is superior among them. The frequency of H. pylori virulence gene viz cagPAI (cagA) were 80.9%, and vacA alleles-s1m1 (42%), s1m2 (33%) and s2m2 (25%) genotypes by PCR respectively. Four combinations of cagA/vacA genotypes were noted, majority of strains harboured cagA
    Conclusions: This study validates and compares the existing diagnostic methods for detecting H. pylori in biopsies. Also, it reveals some pattern of virulence gene combination will play a vital role in disease progression.
    MeSH term(s) Antigens, Bacterial/genetics ; Bacterial Proteins/genetics ; Bayes Theorem ; Genotype ; Helicobacter Infections/epidemiology ; Helicobacter Infections/microbiology ; Helicobacter pylori/genetics ; Humans ; India/epidemiology ; Virulence Factors/genetics
    Chemical Substances Antigens, Bacterial ; Bacterial Proteins ; Virulence Factors
    Language English
    Publishing date 2021-06-23
    Publishing country United States
    Document type Journal Article
    ZDB-ID 1038798-5
    ISSN 1998-3646 ; 0255-0857
    ISSN (online) 1998-3646
    ISSN 0255-0857
    DOI 10.1016/j.ijmmb.2021.06.001
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  10. Article ; Online: Double trouble: a complete duplication of the biliary system.

    Teoh, Mary M K / Nyandoro, Munyaradzi G / Fahey, Brian / Labib, Amro / Ballal, Mohammed

    ANZ journal of surgery

    2022  Volume 92, Issue 12, Page(s) 3379–3380

    Language English
    Publishing date 2022-04-21
    Publishing country Australia
    Document type Case Reports
    ZDB-ID 2050749-5
    ISSN 1445-2197 ; 1445-1433 ; 0004-8682
    ISSN (online) 1445-2197
    ISSN 1445-1433 ; 0004-8682
    DOI 10.1111/ans.17714
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