Article ; Online: Sirtuin-2, NAD-Dependent Deacetylase, Is a New Potential Therapeutic Target for HIV-1 Infection and HIV-Related Neurological Dysfunction.
2023 Volume 97, Issue 2, Page(s) e0165522
Abstract: The implementation and access to combined antiretroviral treatment (cART) have dramatically improved the quality of life of people living with HIV (PLWH). However, some comorbidities, such as neurological disorders associated with HIV infection still ... ...
| Abstract | The implementation and access to combined antiretroviral treatment (cART) have dramatically improved the quality of life of people living with HIV (PLWH). However, some comorbidities, such as neurological disorders associated with HIV infection still represent a serious clinical challenge. Soluble factors in plasma that are associated with control of HIV replication and neurological dysfunction could serve as early biomarkers and as new therapeutic targets for this comorbidity. We used a customized antibody array for determination of blood plasma factors in 40 untreated PLWH with different levels of viremia and found sirtuin-2 (SIRT2), an NAD-dependent deacetylase, to be strongly associated with elevated viral loads and HIV provirus levels, as well as with markers of neurological damage (a-synuclein [SNCA], brain-derived neurotrophic factor [BDNF], microtubule-associated protein tau [MAPT], and neurofilament light protein [NFL]). Also, longitudinal analysis in HIV-infected individuals with immediate ( |
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| MeSH term(s) | Humans ; Biomarkers ; HIV Infections/complications ; HIV Infections/drug therapy ; HIV-1 ; Neurofilament Proteins/metabolism ; Proviruses/metabolism ; Quality of Life ; Sirtuin 2/metabolism ; Nervous System Diseases/drug therapy ; Nervous System Diseases/etiology ; Nervous System Diseases/virology ; Viral Load | |||||
| Chemical Substances | Biomarkers ; Neurofilament Proteins ; Sirtuin 2 (EC 3.5.1.-) | |||||
| Language | English | |||||
| Publishing date | 2023-01-31 | |||||
| Publishing country | United States | |||||
| Document type | Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't | |||||
| ZDB-ID | 80174-4 | |||||
| ISSN | 1098-5514 ; 0022-538X | |||||
| ISSN (online) | 1098-5514 | |||||
| ISSN | 0022-538X | |||||
| DOI | 10.1128/jvi.01655-22 | |||||
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| Database | MEDical Literature Analysis and Retrieval System OnLINE |
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