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  1. Book ; Online: Application of Neural Technology to Neuro-Management and Neuro-Marketing

    Opris, Ioan / Cristian Ionescu, Sorin / Lebedev, Mikhail A. / Boy, Frederic / Lewinski, Peter / Ballerini, Laura

    2020  

    Keywords Science: general issues ; Neurosciences ; neuromarketing ; Neuromanagement ; Brand preference ; consumer ; ERPs
    Size 1 electronic resource (243 pages)
    Publisher Frontiers Media SA
    Document type Book ; Online
    Note English ; Open Access
    HBZ-ID HT021230614
    ISBN 9782889635429 ; 2889635422
    Database ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

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  2. Article ; Online: The brain cytokine orchestra in multiple sclerosis: from neuroinflammation to synaptopathology.

    Amoriello, Roberta / Memo, Christian / Ballerini, Laura / Ballerini, Clara

    Molecular brain

    2024  Volume 17, Issue 1, Page(s) 4

    Abstract: The central nervous system (CNS) is finely protected by the blood-brain barrier (BBB). Immune soluble factors such as cytokines (CKs) are normally produced in the CNS, contributing to physiological immunosurveillance and homeostatic synaptic scaling. CKs ...

    Abstract The central nervous system (CNS) is finely protected by the blood-brain barrier (BBB). Immune soluble factors such as cytokines (CKs) are normally produced in the CNS, contributing to physiological immunosurveillance and homeostatic synaptic scaling. CKs are peptide, pleiotropic molecules involved in a broad range of cellular functions, with a pivotal role in resolving the inflammation and promoting tissue healing. However, pro-inflammatory CKs can exert a detrimental effect in pathological conditions, spreading the damage. In the inflamed CNS, CKs recruit immune cells, stimulate the local production of other inflammatory mediators, and promote synaptic dysfunction. Our understanding of neuroinflammation in humans owes much to the study of multiple sclerosis (MS), the most common autoimmune and demyelinating disease, in which autoreactive T cells migrate from the periphery to the CNS after the encounter with a still unknown antigen. CNS-infiltrating T cells produce pro-inflammatory CKs that aggravate local demyelination and neurodegeneration. This review aims to recapitulate the state of the art about CKs role in the healthy and inflamed CNS, with focus on recent advances bridging the study of adaptive immune system and neurophysiology.
    MeSH term(s) Humans ; Multiple Sclerosis ; Cytokines ; Neuroinflammatory Diseases ; Brain ; Central Nervous System
    Chemical Substances Cytokines
    Language English
    Publishing date 2024-01-23
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 2436057-0
    ISSN 1756-6606 ; 1756-6606
    ISSN (online) 1756-6606
    ISSN 1756-6606
    DOI 10.1186/s13041-024-01077-7
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Using citizen science data to monitor the Sustainable Development Goals: a bottom-up analysis.

    Ballerini, Laura / Bergh, Sylvia I

    Sustainability science

    2021  Volume 16, Issue 6, Page(s) 1945–1962

    Abstract: Official data are not sufficient for monitoring the United Nations Sustainable Development Goals (SDGs): they do not reach remote locations or marginalized populations and can be manipulated by governments. Citizen science data (CSD), defined as data ... ...

    Abstract Official data are not sufficient for monitoring the United Nations Sustainable Development Goals (SDGs): they do not reach remote locations or marginalized populations and can be manipulated by governments. Citizen science data (CSD), defined as data that citizens voluntarily gather by employing a wide range of technologies and methodologies, could help to tackle these problems and ultimately improve SDG monitoring. However, the link between CSD and the SDGs is still understudied. This article aims to develop an empirical understanding of the CSD-SDG link by focusing on the perspective of projects which employ CSD. Specifically, the article presents primary and secondary qualitative data collected on 30 of these projects and an explorative comparative case study analysis. It finds that projects which use CSD recognize that the SDGs can provide a valuable framework and legitimacy, as well as attract funding, visibility, and partnerships. But, at the same time, the article reveals that these projects also encounter several barriers with respect to the SDGs: a widespread lack of knowledge of the goals, combined with frustration and political resistance towards the UN, may deter these projects from contributing their data to the SDG monitoring apparatus.
    Supplementary information: The online version contains supplementary material available at 10.1007/s11625-021-01001-1.
    Language English
    Publishing date 2021-07-23
    Publishing country Japan
    Document type Journal Article
    ZDB-ID 2260333-5
    ISSN 1862-4057 ; 1862-4065
    ISSN (online) 1862-4057
    ISSN 1862-4065
    DOI 10.1007/s11625-021-01001-1
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article: Using citizen science data to monitor the Sustainable Development Goals: a bottom-up analysis

    Ballerini, Laura / Bergh, Sylvia I.

    Sustainability science. 2021 Nov., v. 16, no. 6

    2021  

    Abstract: Official data are not sufficient for monitoring the United Nations Sustainable Development Goals (SDGs): they do not reach remote locations or marginalized populations and can be manipulated by governments. Citizen science data (CSD), defined as data ... ...

    Abstract Official data are not sufficient for monitoring the United Nations Sustainable Development Goals (SDGs): they do not reach remote locations or marginalized populations and can be manipulated by governments. Citizen science data (CSD), defined as data that citizens voluntarily gather by employing a wide range of technologies and methodologies, could help to tackle these problems and ultimately improve SDG monitoring. However, the link between CSD and the SDGs is still understudied. This article aims to develop an empirical understanding of the CSD-SDG link by focusing on the perspective of projects which employ CSD. Specifically, the article presents primary and secondary qualitative data collected on 30 of these projects and an explorative comparative case study analysis. It finds that projects which use CSD recognize that the SDGs can provide a valuable framework and legitimacy, as well as attract funding, visibility, and partnerships. But, at the same time, the article reveals that these projects also encounter several barriers with respect to the SDGs: a widespread lack of knowledge of the goals, combined with frustration and political resistance towards the UN, may deter these projects from contributing their data to the SDG monitoring apparatus.
    Keywords case studies ; citizen science ; politics ; sustainability science and engineering ; sustainable development
    Language English
    Dates of publication 2021-11
    Size p. 1945-1962.
    Publishing place Springer Japan
    Document type Article
    ZDB-ID 2260333-5
    ISSN 1862-4057 ; 1862-4065
    ISSN (online) 1862-4057
    ISSN 1862-4065
    DOI 10.1007/s11625-021-01001-1
    Database NAL-Catalogue (AGRICOLA)

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  5. Article ; Online: Exploring Ca

    Pachetti, Maria / Palandri, Anabela / de Castro Reis, Fernanda / Recupero, Luca / Ballerini, Laura

    eNeuro

    2024  

    Abstract: Oligodendrocytes, the myelin-producing glial cells of the central nervous system (CNS), crucially contribute to myelination and circuit function. An increasing amount of evidence suggests that intracellular calcium ( ... ...

    Abstract Oligodendrocytes, the myelin-producing glial cells of the central nervous system (CNS), crucially contribute to myelination and circuit function. An increasing amount of evidence suggests that intracellular calcium (Ca
    Language English
    Publishing date 2024-05-14
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2800598-3
    ISSN 2373-2822 ; 2373-2822
    ISSN (online) 2373-2822
    ISSN 2373-2822
    DOI 10.1523/ENEURO.0540-23.2024
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Impact of Magnetite Nanowires on In Vitro Hippocampal Neural Networks.

    Cortés-Llanos, Belén / Rauti, Rossana / Ayuso-Sacido, Ángel / Pérez, Lucas / Ballerini, Laura

    Biomolecules

    2023  Volume 13, Issue 5

    Abstract: Nanomaterials design, synthesis, and characterization are ever-expanding approaches toward developing biodevices or neural interfaces to treat neurological diseases. The ability of nanomaterials features to tune neuronal networks' morphology or ... ...

    Abstract Nanomaterials design, synthesis, and characterization are ever-expanding approaches toward developing biodevices or neural interfaces to treat neurological diseases. The ability of nanomaterials features to tune neuronal networks' morphology or functionality is still under study. In this work, we unveil how interfacing mammalian brain cultured neurons and iron oxide nanowires' (NWs) orientation affect neuronal and glial densities and network activity. Iron oxide NWs were synthesized by electrodeposition, fixing the diameter to 100 nm and the length to 1 µm. Scanning electron microscopy, Raman, and contact angle measurements were performed to characterize the NWs' morphology, chemical composition, and hydrophilicity. Hippocampal cultures were seeded on NWs devices, and after 14 days, the cell morphology was studied by immunocytochemistry and confocal microscopy. Live calcium imaging was performed to study neuronal activity. Using random nanowires (R-NWs), higher neuronal and glial cell densities were obtained compared with the control and vertical nanowires (V-NWs), while using V-NWs, more stellate glial cells were found. R-NWs produced a reduction in neuronal activity, while V-NWs increased the neuronal network activity, possibly due to a higher neuronal maturity and a lower number of GABAergic neurons, respectively. These results highlight the potential of NWs manipulations to design ad hoc regenerative interfaces.
    MeSH term(s) Animals ; Nanowires/chemistry ; Ferrosoferric Oxide ; Ferric Compounds ; Nanostructures ; Mammals
    Chemical Substances ferric oxide (1K09F3G675) ; Ferrosoferric Oxide (XM0M87F357) ; Ferric Compounds
    Language English
    Publishing date 2023-04-30
    Publishing country Switzerland
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2701262-1
    ISSN 2218-273X ; 2218-273X
    ISSN (online) 2218-273X
    ISSN 2218-273X
    DOI 10.3390/biom13050783
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: MoS

    Di Mauro, Giuseppe / González, Viviana Jehová / Bambini, Francesco / Camarda, Silvia / Prado, Eduardo / Holgado, Juan Pedro / Vázquez, Ester / Ballerini, Laura / Cellot, Giada

    Nanoscale horizons

    2024  Volume 9, Issue 5, Page(s) 785–798

    Abstract: ... ...

    Abstract MoS
    MeSH term(s) Animals ; Zebrafish ; Locomotion/drug effects ; Disulfides/chemistry ; Disulfides/toxicity ; Molybdenum/toxicity ; Molybdenum/chemistry ; Spinal Cord/drug effects ; Neuroinflammatory Diseases/chemically induced ; Nanostructures/toxicity ; Nanostructures/chemistry ; Larva/drug effects ; Neurons/drug effects
    Chemical Substances molybdenum disulfide (ZC8B4P503V) ; Disulfides ; Molybdenum (81AH48963U)
    Language English
    Publishing date 2024-04-29
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ISSN 2055-6764
    ISSN (online) 2055-6764
    DOI 10.1039/d4nh00041b
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: Graphene Oxide Nanosheets Hamper Glutamate Mediated Excitotoxicity and Protect Neuronal Survival In An In vitro Stroke Model.

    Tortella, Lorenza / Santini, Irene / Lozano, Neus / Kostarelos, Kostas / Cellot, Giada / Ballerini, Laura

    Chemistry (Weinheim an der Bergstrasse, Germany)

    2023  Volume 29, Issue 67, Page(s) e202301762

    Abstract: Small graphene oxide (s-GO) nanosheets reversibly downregulate central nervous system (CNS) excitatory synapses, with potential developments as future therapeutic tools to treat neuro-disorders characterized by altered glutamatergic transmission. ... ...

    Abstract Small graphene oxide (s-GO) nanosheets reversibly downregulate central nervous system (CNS) excitatory synapses, with potential developments as future therapeutic tools to treat neuro-disorders characterized by altered glutamatergic transmission. Excitotoxicity, namely cell death triggered by exceeding ambient glutamate fueling over-activation of excitatory synapses, is a pathogenic mechanism shared by several neural diseases, from ischemic stroke to neurodegenerative disorders. In this work, CNS cultures were exposed to oxygen-glucose deprivation (OGD) to mimic ischemic stroke in vitro, and it is show that the delivery of s-GO following OGD, during the endogenous build-up of secondary damage and excitotoxicity, improved neuronal survival. In a different paradigm, excitotoxicity cell damage was reproduced through exogenous glutamate application, and s-GO co-treatment protected neuronal integrity, potentially by directly downregulating the synaptic over-activation brought about by exogenous glutamate. This proof-of-concept study suggests that s-GO may find novel applications in therapeutic developments for treating excitotoxicity-driven neural cell death.
    MeSH term(s) Humans ; Glutamic Acid ; Neurons/metabolism ; Stroke/metabolism ; Stroke/pathology ; Oxygen/metabolism ; Ischemic Stroke/metabolism ; Ischemic Stroke/pathology
    Chemical Substances Glutamic Acid (3KX376GY7L) ; graphene oxide ; Oxygen (S88TT14065)
    Language English
    Publishing date 2023-10-20
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 1478547-X
    ISSN 1521-3765 ; 0947-6539
    ISSN (online) 1521-3765
    ISSN 0947-6539
    DOI 10.1002/chem.202301762
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: Nanomedicine and graphene-based materials: advanced technologies for potential treatments of diseases in the developing nervous system.

    Cellot, Giada / Franceschi Biagioni, Audrey / Ballerini, Laura

    Pediatric research

    2021  Volume 92, Issue 1, Page(s) 71–79

    Abstract: The interest in graphene-based nanomaterials (GBNs) application in nanomedicine, in particular in neurology, steadily increased in the last decades. GBNs peculiar physical-chemical properties allow the design of innovative therapeutic tools able to ... ...

    Abstract The interest in graphene-based nanomaterials (GBNs) application in nanomedicine, in particular in neurology, steadily increased in the last decades. GBNs peculiar physical-chemical properties allow the design of innovative therapeutic tools able to manipulate biological structures with subcellular resolution. In this review, we report GBNs applications to the central nervous system (CNS) when these nanomaterials are engineered as potential therapeutics to treat brain pathologies, with a focus on those of the pediatric age. We revise the state-of-the art studies addressing the impact of GBNs in the CNS, showing that the design of GBNs with different dimensions and chemical compositions or the use of specific administration routes and doses can limit unwanted side effects, exploiting GBNs efficacy in therapeutic approaches. These features favor the development of GBNs-based multifunctional devices that may find applications in the field of precision medicine for the treatment of disorders in the developing CNS. In this framework, we address the suitability of GBNs to become successful therapeutic tools, such as drug nano-delivery vectors when being chemically decorated with pharmaceutical agents and/or other molecules to obtain a high specific targeting of the diseased area and to achieve a controlled release of active molecules. IMPACT: The translational potential of graphene-based nanomaterials (GBNs) can be used for the design of novel therapeutic approaches to treat pathologies affecting the brain with a focus on the pediatric age. GBNs can be chemically decorated with pharmaceutical agents and molecules to obtain a highly specific targeting of the diseased site and a controlled drug release. The type of GBNs, the selected functionalization, the dose, and the way of administration are factors that should be considered to potentiate the therapeutic efficacy of GBNs, limiting possible side effects. GBNs-based multifunctional devices might find applications in the precision medicine and theranostics fields.
    MeSH term(s) Brain ; Child ; Graphite/chemistry ; Humans ; Nanomedicine ; Nanostructures/chemistry ; Pharmaceutical Preparations
    Chemical Substances Pharmaceutical Preparations ; Graphite (7782-42-5)
    Language English
    Publishing date 2021-09-03
    Publishing country United States
    Document type Journal Article ; Review ; Research Support, Non-U.S. Gov't
    ZDB-ID 4411-8
    ISSN 1530-0447 ; 0031-3998
    ISSN (online) 1530-0447
    ISSN 0031-3998
    DOI 10.1038/s41390-021-01681-6
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: Foetal neural progenitors contribute to postnatal circuits formation ex vivo: an electrophysiological investigation.

    Manzati, Matteo / Sorbo, Teresa / Giugliano, Michele / Ballerini, Laura

    Molecular brain

    2020  Volume 13, Issue 1, Page(s) 78

    Abstract: Neuronal progenitor cells (NPC) play an essential role in homeostasis of the central nervous system (CNS). Considering their ability to differentiate into specific lineages, their manipulation and control could have a major therapeutic impact for those ... ...

    Abstract Neuronal progenitor cells (NPC) play an essential role in homeostasis of the central nervous system (CNS). Considering their ability to differentiate into specific lineages, their manipulation and control could have a major therapeutic impact for those CNS injuries or degenerative diseases characterized by neuronal cell loss. In this work, we established an in vitro co-culture and tested the ability of foetal NPC (fNPC) to integrate among post-mitotic hippocampal neurons and contribute to the electrical activity of the resulting networks. We performed extracellular electrophysiological recordings of the activity of neuronal networks and compared the properties of spontaneous spiking in hippocampal control cultures (HCC), fNPC, and mixed circuitries ex vivo. We further employed patch-clamp intracellular recordings to examine single-cell excitability. We report of the capability of fNPC to mature when combined to hippocampal neurons, shaping the profile of network activity, a result suggestive of newly formed connectivity ex vivo.
    MeSH term(s) Action Potentials/physiology ; Animals ; Cells, Cultured ; Coculture Techniques ; Electrophysiological Phenomena/physiology ; Hippocampus/cytology ; Hippocampus/physiology ; Nerve Net/physiology ; Neurogenesis ; Neurons/cytology ; Neurons/physiology ; Patch-Clamp Techniques ; Rats ; Rats, Wistar ; Single-Cell Analysis
    Language English
    Publishing date 2020-05-19
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2436057-0
    ISSN 1756-6606 ; 1756-6606
    ISSN (online) 1756-6606
    ISSN 1756-6606
    DOI 10.1186/s13041-020-00619-z
    Database MEDical Literature Analysis and Retrieval System OnLINE

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