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  1. Article ; Online: Value of Ammonia Testing in Clinical Practice.

    Ballester, Maria Pilar / Carbonell-Asins, Juan Antonio / Reiberger, Thomas

    Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association

    2024  

    Language English
    Publishing date 2024-04-07
    Publishing country United States
    Document type Letter
    ZDB-ID 2119789-1
    ISSN 1542-7714 ; 1542-3565
    ISSN (online) 1542-7714
    ISSN 1542-3565
    DOI 10.1016/j.cgh.2024.03.019
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 5836: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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  2. Article ; Online: Vaccination in liver diseases and liver Transplantation: Recommendations, implications and opportunities in the post-covid era.

    Ballester, Maria Pilar / Jalan, Rajiv / Mehta, Gautam

    JHEP reports : innovation in hepatology

    2023  , Page(s) 100776

    Abstract: The interest in vaccination efficacy and toxicity has surged following the Covid-19 pandemic. Immune responses to several vaccines have been shown to be suboptimal in patients with chronic liver disease (CLD) or post-liver transplant (LT), as a ... ...

    Abstract The interest in vaccination efficacy and toxicity has surged following the Covid-19 pandemic. Immune responses to several vaccines have been shown to be suboptimal in patients with chronic liver disease (CLD) or post-liver transplant (LT), as a consequence of cirrhosis-associated immune dysfunction (CAID) or post-LT immunosuppression respectively. Accordingly, vaccine-preventable infections may be more common or severe than in the general population. The Covid-19 pandemic has greatly accelerated research and development into vaccination technology and platforms, which will have spillover benefits for liver patients. The aims of this review are: (i) to discuss the impact of vaccine-preventable infections on CLD and post-LT patients, (ii) to appraise current evidence supporting vaccination strategies, and (iii) to provide some insight into recent developments relevant for liver patients.
    Language English
    Publishing date 2023-04-26
    Publishing country Netherlands
    Document type Journal Article ; Review
    ISSN 2589-5559
    ISSN (online) 2589-5559
    DOI 10.1016/j.jhepr.2023.100776
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Extracorporeal liver support and liver transplantation for acute-on-chronic liver failure.

    Ballester, Maria Pilar / Elshabrawi, Ahmed / Jalan, Rajiv

    Liver international : official journal of the International Association for the Study of the Liver

    2023  

    Abstract: Acute-on-chronic liver failure (ACLF) is defined by acute decompensation, organ failure and a high risk of short-term mortality. This condition is characterized by an overwhelming systemic inflammatory response. Despite treating the precipitating event, ... ...

    Abstract Acute-on-chronic liver failure (ACLF) is defined by acute decompensation, organ failure and a high risk of short-term mortality. This condition is characterized by an overwhelming systemic inflammatory response. Despite treating the precipitating event, intensive monitoring and organ support, clinical deterioration can occur with very poor outcomes. During the last decades, several extracorporeal liver support systems have been developed to try to reduce ongoing liver injury and provide an improved environment for the liver to regenerate or as a bridging therapy until liver transplantation. Several clinical trials have been performed to evaluate the clinical efficacy of extracorporeal liver support systems, but no clear impact on survival has been proven. DIALIVE is a novel extracorporeal liver support device that has been built to specifically address the pathophysiological derangements responsible for the development of ACLF by replacing dysfunctional albumin and removing pathogen and damage-associated molecular patterns (PAMPs and DAMPs). In phase II clinical trial, DIALIVE appears to be safe, and it seems to be associated with a faster time to the resolution of ACLF compared with standard medical treatment. Even in patients with severe ACLF, liver transplantation saves lives and there is clear evidence of transplant benefit. Careful selection of patients is required to attain good results from liver transplantation, but many questions remain unanswered. In this review, we describe the current perspectives on the use of extracorporeal liver support and liver transplantation for ACLF patients.
    Language English
    Publishing date 2023-06-14
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 2102783-3
    ISSN 1478-3231 ; 1478-3223
    ISSN (online) 1478-3231
    ISSN 1478-3223
    DOI 10.1111/liv.15647
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1632: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  4. Article ; Online: Reply to: "Ammonia predicts clinical outcomes in cirrhosis - but there are caveats to consider".

    Ballester, Maria Pilar / Carbonell-Asins, Juan Antonio / Balcar, Lorenz / Reiberger, Thomas / Jalan, Rajiv

    Journal of hepatology

    2023  Volume 79, Issue 6, Page(s) e239–e241

    MeSH term(s) Humans ; Ammonia ; Liver Cirrhosis/diagnosis ; Fibrosis ; Hepatic Encephalopathy/etiology
    Chemical Substances Ammonia (7664-41-7)
    Language English
    Publishing date 2023-08-23
    Publishing country Netherlands
    Document type Letter ; Research Support, Non-U.S. Gov't ; Comment
    ZDB-ID 605953-3
    ISSN 1600-0641 ; 0168-8278
    ISSN (online) 1600-0641
    ISSN 0168-8278
    DOI 10.1016/j.jhep.2023.08.015
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 2027: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  5. Article ; Online: Quantification of camelid cytokine mRNA expression in PBMCs by microfluidic qPCR technology.

    Rodon, Jordi / Te, Nigeer / Ballester, Maria / Segalés, Joaquim / Vergara-Alert, Júlia / Bensaid, Albert

    Developmental and comparative immunology

    2023  Volume 149, Page(s) 105061

    Abstract: Camelids are economically and socially important in several parts of the world and might carry pathogens with epizootic or zoonotic potential. However, biological research in these species is limited due to lack of reagents. Here, we developed RT-qPCR ... ...

    Abstract Camelids are economically and socially important in several parts of the world and might carry pathogens with epizootic or zoonotic potential. However, biological research in these species is limited due to lack of reagents. Here, we developed RT-qPCR assays to quantify a panel of camelid innate and adaptive immune response genes, which can be monitored in a single run. The assays were validated with PHA, PMA-ionomycin, and Poly I:C-stimulated PBMCs from alpaca, dromedary camel and llama, including normalization by multiple reference genes. Further, comparative gene expression analyses for the different camelid species were performed by a unique microfluidic qPCR assay. Compared to unstimulated controls, PHA and PMA-ionomycin stimulation elicited robust Th1 and Th2 responses in PBMCs from camelid species. Additional activation of type I and type III IFN signalling pathways was described exclusively in PHA-stimulated dromedary lymphocytes, in contrast to those from alpaca and llama. We also found that PolyI:C stimulation induced robust antiviral response genes in alpaca PBMCs. The proposed methodology should be useful for the measurement of immune responses to infection or vaccination in camelid species.
    MeSH term(s) Animals ; Cytokines/genetics ; Camelids, New World ; Camelus ; Ionomycin ; Microfluidics ; RNA, Messenger
    Chemical Substances Cytokines ; Ionomycin (56092-81-0) ; RNA, Messenger
    Language English
    Publishing date 2023-09-17
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 752411-0
    ISSN 1879-0089 ; 0145-305X
    ISSN (online) 1879-0089
    ISSN 0145-305X
    DOI 10.1016/j.dci.2023.105061
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1327: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  6. Article ; Online: Measuring and Interpreting Ammonia Levels in Cirrhosis.

    Ballester, Maria Pilar / Rose, Christopher F / Carbonell-Asins, Juan-Antonio / Jalan, Rajiv

    The American journal of gastroenterology

    2023  Volume 118, Issue 7, Page(s) 1297

    MeSH term(s) Humans ; Ammonia ; Liver Cirrhosis/complications ; Liver Cirrhosis/diagnosis ; Fibrosis ; Hepatic Encephalopathy/diagnosis ; Hepatic Encephalopathy/etiology
    Chemical Substances Ammonia (7664-41-7)
    Language English
    Publishing date 2023-08-14
    Publishing country United States
    Document type Journal Article ; Comment
    ZDB-ID 390122-1
    ISSN 1572-0241 ; 0002-9270
    ISSN (online) 1572-0241
    ISSN 0002-9270
    DOI 10.14309/ajg.0000000000002245
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Ui V Zs.36: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)

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  7. Article: Alcohol and Acute-on-Chronic Liver Failure.

    Ballester, Maria Pilar / Sittner, Richard / Jalan, Rajiv

    Journal of clinical and experimental hepatology

    2021  Volume 12, Issue 5, Page(s) 1360–1370

    Abstract: Acute-on-chronic liver failure (ACLF) is a clinical syndrome that occurs in patients with cirrhosis and is characterised by acute deterioration, organ failure and high short-term mortality. Alcohol is one of the leading causes of ACLF and the most ... ...

    Abstract Acute-on-chronic liver failure (ACLF) is a clinical syndrome that occurs in patients with cirrhosis and is characterised by acute deterioration, organ failure and high short-term mortality. Alcohol is one of the leading causes of ACLF and the most frequently reported aetiology of underlying chronic liver disease. Among patients with alcoholic hepatitis (AH), ACLF is a frequent and severe complication. It is characterised by both immune dysfunction associated to an increased risk of infection and high-grade systemic inflammation that ultimately induce organ failure. Diagnosis and severity of ACLF determine AH prognosis, and therefore, ACLF prognostic scores should be used in severe AH with organ failure. Corticosteroids remain the first-line treatment for severe AH but they seem insufficient when ACLF is associated. Novel therapeutic targets to contain the excessive inflammatory response and reduce infection have been identified and are under investigation. With liver transplantation remaining one of the most effective therapies for severe AH and ACLF, adequate organ allocation represents a growing challenge. Hence, a clear understanding of the pathophysiology, clinical implications and management strategies of ACLF in AH is essential for hepatologists, which is narrated briefly in this review.
    Language English
    Publishing date 2021-12-22
    Publishing country India
    Document type Journal Article ; Review
    ISSN 0973-6883
    ISSN 0973-6883
    DOI 10.1016/j.jceh.2021.12.010
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: Stay calm and focus on the learning outcomes: Tools for taking biophysical chemistry online.

    Ballester, Maria / Van Hoozen, Brian / Sikora, Arthur K

    Biochemistry and molecular biology education : a bimonthly publication of the International Union of Biochemistry and Molecular Biology

    2020  Volume 48, Issue 5, Page(s) 504–505

    Abstract: Course specific learning outcomes are an important tool to define the scope of a course and can be very helpful when designing experiments and assessments. With slight modification, these learning outcomes can serve as a guide when transitioning to the ... ...

    Abstract Course specific learning outcomes are an important tool to define the scope of a course and can be very helpful when designing experiments and assessments. With slight modification, these learning outcomes can serve as a guide when transitioning to the distance learning format especially in courses with a traditional lab. Here we present such an example for the biophysical chemistry course.
    MeSH term(s) Biophysics/education ; Chemistry/education ; Curriculum ; Education, Distance ; Humans ; Online Systems
    Keywords covid19
    Language English
    Publishing date 2020-08-15
    Publishing country United States
    Document type Journal Article
    ISSN 1539-3429
    ISSN (online) 1539-3429
    DOI 10.1002/bmb.21421
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article: Risk factors and management strategies associated with non-response to aminosalicylates as a maintenance treatment in ulcerative colitis.

    Martí-Aguado, David / Ballester, María Pilar / Mínguez, Miguel

    Revista espanola de enfermedades digestivas : organo oficial de la Sociedad Espanola de Patologia Digestiva

    2020  Volume 113, Issue 6, Page(s) 447–453

    Abstract: Aminosalicylates (5-ASA) are used as the first-line maintenance treatment in patients with mild-moderate ulcerative colitis (UC). Early identification of patients at high risk for 5-ASA non-response and appropriate therapeutic escalation are essential to ...

    Abstract Aminosalicylates (5-ASA) are used as the first-line maintenance treatment in patients with mild-moderate ulcerative colitis (UC). Early identification of patients at high risk for 5-ASA non-response and appropriate therapeutic escalation are essential to avoid disease progression. However, the absence of a standardized definition for treatment success makes this a challenging task. The focus of the current review was to describe the risk factors and management strategies associated with 5-ASA non-response. Rates of 5-ASA failure can vary from 17 % to 75 % according to different success definitions, of which clinical relapse is the most prevalent and studied condition. Younger age and endoscopic activity at diagnosis, extensive colitis, early need for corticosteroids, elevated inflammatory markers and non-adherence are consistent risk factors of 5-ASA failure. Given the effectiveness, safety profile and tolerability of this medication, therapy optimization is critical before treatment escalation. Combined use of systemic and topical therapy at an appropriate dose in a once-daily administration and control of adherence could improve success rates.
    MeSH term(s) Administration, Oral ; Anti-Inflammatory Agents, Non-Steroidal/adverse effects ; Colitis, Ulcerative/drug therapy ; Humans ; Mesalamine/therapeutic use ; Risk Factors ; Sulfasalazine/therapeutic use
    Chemical Substances Anti-Inflammatory Agents, Non-Steroidal ; Sulfasalazine (3XC8GUZ6CB) ; Mesalamine (4Q81I59GXC)
    Language English
    Publishing date 2020-11-22
    Publishing country Spain
    Document type Journal Article ; Review
    ZDB-ID 1070381-0
    ISSN 1130-0108 ; 0212-7512
    ISSN 1130-0108 ; 0212-7512
    DOI 10.17235/reed.2021.7797/2021
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.B 199: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
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    ab Jg. 2022: Lesesaal (EG)

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  10. Article ; Online: Author Correction: Expression-based GWAS identifies variants, gene interactions and key regulators affecting intramuscular fatty acid content and composition in porcine meat.

    Puig-Oliveras, Anna / Revilla, Manuel / Castelló, Anna / Fernández, Ana I / Folch, Josep M / Ballester, Maria

    Scientific reports

    2022  Volume 12, Issue 1, Page(s) 4902

    Language English
    Publishing date 2022-03-22
    Publishing country England
    Document type Published Erratum
    ZDB-ID 2615211-3
    ISSN 2045-2322 ; 2045-2322
    ISSN (online) 2045-2322
    ISSN 2045-2322
    DOI 10.1038/s41598-022-08878-7
    Database MEDical Literature Analysis and Retrieval System OnLINE

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