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  1. Article: Thyroid Disfunction in Critically Ill COVID-19 Patients. Relationship with In-Hospital Mortality.

    Ballesteros Vizoso, María Antonieta / Castilla, Albert Figueras / Barceló, Antonia / Raurich, Joan Maria / Argente Del Castillo, Paula / Morell-García, Daniel / Velasco, Julio / Pérez-Bárcena, Jon / Llompart-Pou, Juan Antonio

    Journal of clinical medicine

    2021  Volume 10, Issue 21

    Abstract: The incidence of thyroid disfunction has not been analyzed in critically ill COVID-19 patients. Our objective was to analyze the relationship of the thyroid profile and in-hospital mortality in critically ill COVID-19 patients. This was a prospective ... ...

    Abstract The incidence of thyroid disfunction has not been analyzed in critically ill COVID-19 patients. Our objective was to analyze the relationship of the thyroid profile and in-hospital mortality in critically ill COVID-19 patients. This was a prospective single-center study involving critically ill COVID-19 patients admitted to the ICU of a tertiary University Hospital. Thyroid hormones were measured through drawing blood samples from a central venous catheter at ICU admission and on the fifth day. A multiple logistic regression analysis was performed to analyze the variables associated with mortality. The ability of the different thyroid hormones to predict in-hospital mortality was evaluated by calculating the receiver operating characteristics (ROCs) and the area under the curve (AUC). A total of 78 patients were included in the study at ICU admission; 72 had their thyroid profile measured at day 5. In-hospital mortality reached 29.5%. Multiple logistic regression analysis showed that variables associated with mortality were age and prior beta-blocker therapy at ICU admission and age fT4 at day 5. The AUC for in-hospital mortality predictions of fT4 at day 5 was 0.69. Thyroid responses are commonly observed in critically ill COVID-19 patients. fT4 at day 5 after ICU admission was associated with mortality.
    Language English
    Publishing date 2021-10-29
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2662592-1
    ISSN 2077-0383
    ISSN 2077-0383
    DOI 10.3390/jcm10215057
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Impact of SARS-CoV-2 infection on liver disease.

    Salgüero Fernández, Sergio / Gabriel Medina, Pablo / Almería Lafuente, Alejandro / Ballesteros Vizoso, María Antonieta / Zamora Trillo, Angielys / Casals Mercadal, Gregori / Solé Enrech, Gemma / Lalana Garcés, Marta / Guerra Ruiz, Armando R / Ortiz Pastor, Oihana / Morales Ruiz, Manuel

    Advances in laboratory medicine

    2022  Volume 3, Issue 2, Page(s) 126–141

    Abstract: Introduction: Abnormal liver biochemistry is not a rare finding in the context of SARS-CoV-2 infection, regardless of patients having pre-existing chronic disease or not.: Content: This review examines the current body of knowledge on the ... ...

    Abstract Introduction: Abnormal liver biochemistry is not a rare finding in the context of SARS-CoV-2 infection, regardless of patients having pre-existing chronic disease or not.
    Content: This review examines the current body of knowledge on the relationship between COVID-19 and liver injury, which is frequently found in this setting.
    Summary: Although the pathogenesis of liver injury is not fully understood, it has been suggested to be the result of a combination of multiple factors. These include direct injury caused by the virus, immune system hyperactivation, ischemic and drug-induced injury. The prognostic valor of these alterations is also the subject of intense research. Due to their potential impact, these alterations require proper management and treatment, especially in patients with chronic liver disease or liver transplant recipients.
    Outlook: Some aspects associated with liver injury during COVID-19, especially in severe presentations, are not well understood. Studies assessing the clinical impact of COVID-19 on the healthy or diseased liver may help adjust treatment and immunization guidelines to the profile of the patient.
    Language Spanish
    Publishing date 2022-06-02
    Publishing country Germany
    Document type Journal Article ; Review
    ISSN 2628-491X
    ISSN (online) 2628-491X
    DOI 10.1515/almed-2022-0037
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Urine biomarkers for the prediction of mortality in COVID-19 hospitalized patients.

    Morell-Garcia, Daniel / Ramos-Chavarino, David / Bauça, Josep M / Argente Del Castillo, Paula / Ballesteros-Vizoso, Maria Antonieta / García de Guadiana-Romualdo, Luis / Gómez-Cobo, Cristina / Pou, J Albert / Amezaga-Menéndez, Rocío / Alonso-Fernández, Alberto / Llompart, Isabel / García-Raja, Ana

    Scientific reports

    2021  Volume 11, Issue 1, Page(s) 11134

    Abstract: Risk factors associated with severity and mortality attributable to COVID-19 have been reported in different cohorts, highlighting the occurrence of acute kidney injury (AKI) in 25% of them. Among other, SARS-CoV-2 targets renal tubular cells and can ... ...

    Abstract Risk factors associated with severity and mortality attributable to COVID-19 have been reported in different cohorts, highlighting the occurrence of acute kidney injury (AKI) in 25% of them. Among other, SARS-CoV-2 targets renal tubular cells and can cause acute renal damage. The aim of the present study was to evaluate the usefulness of urinary parameters in predicting intensive care unit (ICU) admission, mortality and development of AKI in hospitalized patients with COVID-19. Retrospective observational study, in a tertiary care hospital, between March 1st and April 19th, 2020. We recruited adult patients admitted consecutively and positive for SARS-CoV-2. Urinary and serum biomarkers were correlated with clinical outcomes (AKI, ICU admission, hospital discharge and in-hospital mortality) and evaluated using a logistic regression model and ROC curves. A total of 199 COVID-19 hospitalized patients were included. In AKI, the logistic regression model with a highest area under the curve (AUC) was reached by the combination of urine blood and previous chronic kidney disease, with an AUC of 0.676 (95%CI 0.512-0.840; p = 0.023); urine specific weight, sodium and albumin in serum, with an AUC of 0.837 (95% CI 0.766-0.909; p < 0.001) for ICU admission; and age, urine blood and lactate dehydrogenase levels in serum, with an AUC of 0.923 (95%CI 0.866-0.979; p < 0.001) for mortality prediction. For hospitalized patients with COVID-19, renal involvement and early alterations of urinary and serum parameters are useful as prognostic factors of AKI, the need for ICU admission and death.
    MeSH term(s) Acute Kidney Injury/complications ; Acute Kidney Injury/mortality ; Acute Kidney Injury/physiopathology ; Acute Kidney Injury/urine ; Adult ; Aged ; Area Under Curve ; Biomarkers/urine ; COVID-19/complications ; COVID-19/mortality ; COVID-19/physiopathology ; COVID-19/urine ; Critical Care ; Female ; Hospitalization ; Humans ; Logistic Models ; Male ; Middle Aged ; Observational Studies as Topic ; Prognosis ; ROC Curve ; Retrospective Studies ; Risk Factors ; Severity of Illness Index ; Urine/chemistry
    Chemical Substances Biomarkers
    Language English
    Publishing date 2021-05-27
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2615211-3
    ISSN 2045-2322 ; 2045-2322
    ISSN (online) 2045-2322
    ISSN 2045-2322
    DOI 10.1038/s41598-021-90610-y
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Control of occult hepatitis B virus infection.

    Lalana Garcés, Marta / Ortiz Pastor, Oihana / Solé Enrech, Gemma / Guerra-Ruiz, Armando R / Casals Mercadal, Gregori / Almería Lafuente, Alejandro / Ballesteros Vizoso, María Antonieta / Medina, Pablo Gabriel / Salgüero Fernández, Sergio / Zamora Trillo, Angielys / Aured de la Serna, Isabel / Hurtado, Juan Carlos / Pérez-Del-Pulgar, Sofía / Forns, Xavier / Morales Ruiz, Manuel

    Advances in laboratory medicine

    2022  Volume 3, Issue 4, Page(s) 321–341

    Abstract: Background: The diagnosis of hepatitis B virus (HBV) infection requires HBV DNA testing and serologic testing for detection of the surface antigen (HBsAg) and the hepatitis B core antibody (anti-HBc). There is a population of patients with occult HBV ... ...

    Abstract Background: The diagnosis of hepatitis B virus (HBV) infection requires HBV DNA testing and serologic testing for detection of the surface antigen (HBsAg) and the hepatitis B core antibody (anti-HBc). There is a population of patients with occult HBV infection (OBI), which is not detected by HBsAg or HBV DNA quantification in blood, despite the presence of active replication in the liver.
    Scope: This document provides a definition of OBI and describes the diagnostic techniques currently used. It also addresses the detection of patients with risk factors and the need for screening for OBI in these patients.
    Summary: Correct diagnosis of OBI prevents HBV reactivation and transmission. Diagnosis of OBI is based on the detection of HBV DNA in patients with undetectable HBsAg in blood.
    Perspectives: A high number of patients with OBI may remain undiagnosed; therefore, screening for OBI in patients with factor risks is essential. For a correct diagnosis of OBI, it is necessary that new markers such as ultrasensitive HBsAg are incorporated, and a more comprehensive marker study is performed by including markers such as cccDNA.
    Language Spanish
    Publishing date 2022-08-15
    Publishing country Germany
    Document type Journal Article
    ISSN 2628-491X
    ISSN (online) 2628-491X
    DOI 10.1515/almed-2022-0065
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

    Inter-library loan at ZB MED

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