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Article ; Online: 4D

Bjegovic, Kristina / Sun, Leshan / Kumar Pandey, Prabodh / Grilj, Veljko / Ballesteros-Zebadua, Paola / Paisley, Ryan / Gonzalez, Gilberto / Wang, Siqi / Vozenin, Marie Catherine / Limoli, Charles L / Xiang, Liangzhong

Physics in medicine and biology

2024

Abstract: Objective: The primary goal of this research is to demonstrate the feasibility of radiation-induced acoustic imaging (RAI) as a volumetric dosimetry tool for ultra-high dose rate FLASH electron radiotherapy (FLASH-RT) in real time. This technology aims ...

Abstract	Objective: The primary goal of this research is to demonstrate the feasibility of radiation-induced acoustic imaging (RAI) as a volumetric dosimetry tool for ultra-high dose rate FLASH electron radiotherapy (FLASH-RT) in real time. This technology aims to improve patient outcomes by accurate measurements of in vivo dose delivery to target tumor volumes. Approach: The study utilized the FLASH-capable eRT6 LINAC to deliver electron beams under various doses (1.2 Gy/pulse to 4.95 Gy/ pulse) and instantaneous dose rates (1.55×105 Gy/s to 2.75×106 Gy/s), for imaging the beam in water and in a rabbit cadaver with RAI. A custom 256-element matrix ultrasound array was employed for real-time, volumetric (4D) imaging of individual pulses. This allowed for the exploration of dose linearity by varying the dose per pulse and analyzing the results through signal processing and image reconstruction in RAI. Main Results: By varying the dose per pulse through changes in source-to-surface distance (SSD), a direct correlation was established between the peak-to-peak amplitudes of pressure waves captured by the RAI system and the radiochromic film dose measurements. This correlation demonstrated dose rate linearity, including in the FLASH regime, without any saturation even at an instantaneous dose rate up to 2.75×106 Gy/s. Further, the use of the 2D matrix array enabled 4D tracking of FLASH electron beam dose distributions on animal tissue for the first time. Significance: This research successfully shows that 4D in vivo dosimetry is feasible during FLASH-RT using a RAI system. It allows for precise spatial (~mm) and temporal (25 frames/s) monitoring of individual FLASH beamlets during delivery. This advancement is crucial for the clinical translation of FLASH-RT as enhancing the accuracy of dose delivery to the target volume the safety and efficacy of radiotherapeutic procedures will be improved. .
Language	English
Publishing date	2024-05-09
Publishing country	England
Document type	Journal Article
ZDB-ID	208857-5
ISSN	1361-6560 ; 0031-9155
ISSN (online)	1361-6560
ISSN	0031-9155
DOI	10.1088/1361-6560/ad4950
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Article ; Online: Whole-brain irradiation differentially modifies neurotransmitters levels and receptors in the hypothalamus and the prefrontal cortex.

Franco-Pérez, Javier / Montes, Sergio / Sánchez-Hernández, Josué / Ballesteros-Zebadúa, Paola

Radiation oncology (London, England)

2020 Volume 15, Issue 1, Page(s) 269

Abstract: Background: Whole-brain radiotherapy is a primary treatment for brain tumors and brain metastasis, but it also induces long-term undesired effects. Since cognitive impairment can occur, research on the etiology of secondary effects has focused on the ... ...

Abstract	Background: Whole-brain radiotherapy is a primary treatment for brain tumors and brain metastasis, but it also induces long-term undesired effects. Since cognitive impairment can occur, research on the etiology of secondary effects has focused on the hippocampus. Often overlooked, the hypothalamus controls critical homeostatic functions, some of which are also susceptible after whole-brain radiotherapy. Therefore, using whole-brain irradiation (WBI) in a rat model, we measured neurotransmitters and receptors in the hypothalamus. The prefrontal cortex and brainstem were also analyzed since they are highly connected to the hypothalamus and its regulatory processes. Methods: Male Wistar rats were exposed to WBI with 11 Gy (Biologically Effective Dose = 72 Gy). After 1 month, we evaluated changes in gamma-aminobutyric acid (GABA), glycine, taurine, aspartate, glutamate, and glutamine in the hypothalamus, prefrontal cortex, and brainstem according to an HPLC method. Ratios of Glutamate/GABA and Glutamine/Glutamate were calculated. Through Western Blott analysis, we measured the expression of GABAa and GABAb receptors, and NR1 and NR2A subunits of NMDA receptors. Changes were analyzed comparing results with sham controls using the non-parametric Mann-Whitney U test (p < 0.05). Results: WBI with 11 Gy induced significantly lower levels of GABA, glycine, taurine, aspartate, and GABAa receptor in the hypothalamus. Also, in the hypothalamus, a higher Glutamate/GABA ratio was found after irradiation. In the prefrontal cortex, WBI induced significant increases of glutamine and glutamate, Glutamine/Glutamate ratio, and increased expression of both GABAa receptor and NMDA receptor NR1 subunit. The brainstem showed no statistically significant changes after irradiation. Conclusion: Our findings confirm that WBI can affect rat brain regions differently and opens new avenues for study. After 1 month, WBI decreases inhibitory neurotransmitters and receptors in the hypothalamus and, conversely, increases excitatory neurotransmitters and receptors in the prefrontal cortex. Increments in Glutamate/GABA in the hypothalamus and Glutamine/Glutamate in the frontal cortex indicate a neurochemical imbalance. Found changes could be related to several reported radiotherapy secondary effects, suggesting new prospects for therapeutic targets.
MeSH term(s)	Animals ; Brain Chemistry/radiation effects ; Cranial Irradiation ; Hypothalamus/chemistry ; Hypothalamus/radiation effects ; Male ; Neurotransmitter Agents/analysis ; Prefrontal Cortex/chemistry ; Prefrontal Cortex/radiation effects ; Rats ; Rats, Wistar ; Receptors, GABA/analysis ; Receptors, N-Methyl-D-Aspartate/analysis
Chemical Substances	Neurotransmitter Agents ; Receptors, GABA ; Receptors, N-Methyl-D-Aspartate
Language	English
Publishing date	2020-11-23
Publishing country	England
Document type	Journal Article
ZDB-ID	2224965-5
ISSN	1748-717X ; 1748-717X
ISSN (online)	1748-717X
ISSN	1748-717X
DOI	10.1186/s13014-020-01716-y
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Article ; Online: The sparing effect of FLASH-RT on synaptic plasticity is maintained in mice with standard fractionation.

Limoli, Charles L / Kramár, Eniko A / Almeida, Aymeric / Petit, Benoit / Grilj, Veljko / Baulch, Janet E / Ballesteros-Zebadua, Paola / Loo, Billy W / Wood, Marcelo A / Vozenin, Marie-Catherine

Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology

2023 Volume 186, Page(s) 109767

Abstract: Long-term potentiation (LTP) was used to gauge the impact of conventional and FLASH dose rates on synaptic transmission. Data collected from the hippocampus and medial prefrontal cortex confirmed significant inhibition of LTP after 10 fractions of 3 Gy ( ... ...

Abstract	Long-term potentiation (LTP) was used to gauge the impact of conventional and FLASH dose rates on synaptic transmission. Data collected from the hippocampus and medial prefrontal cortex confirmed significant inhibition of LTP after 10 fractions of 3 Gy (30 Gy total) conventional radiotherapy. Remarkably, 10x3Gy FLASH radiotherapy and unirradiated controls were identical and exhibited normal LTP.
MeSH term(s)	Mice ; Animals ; Neuronal Plasticity/physiology ; Long-Term Potentiation/physiology ; Hippocampus/physiology ; Synaptic Transmission/physiology
Language	English
Publishing date	2023-06-28
Publishing country	Ireland
Document type	Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
ZDB-ID	605646-5
ISSN	1879-0887 ; 0167-8140
ISSN (online)	1879-0887
ISSN	0167-8140
DOI	10.1016/j.radonc.2023.109767
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Article ; Online: Uncovering the Protective Neurologic Mechanisms of Hypofractionated FLASH Radiotherapy.

Alaghband, Yasaman / Allen, Barrett D / Kramár, Eniko A / Zhang, Richard / Drayson, Olivia G G / Ru, Ning / Petit, Benoit / Almeida, Aymeric / Doan, Ngoc-Lien / Wood, Marcelo A / Baulch, Janet E / Ballesteros-Zebadua, Paola / Vozenin, Marie-Catherine / Limoli, Charles L

Cancer research communications

2023 Volume 3, Issue 4, Page(s) 725–737

Abstract: Implementation of ultra-high dose-rate FLASH radiotherapy (FLASH-RT) is rapidly gaining traction as a unique cancer treatment modality able to dramatically minimize normal tissue toxicity while maintaining antitumor efficacy compared with standard-of- ... ...

Abstract	Implementation of ultra-high dose-rate FLASH radiotherapy (FLASH-RT) is rapidly gaining traction as a unique cancer treatment modality able to dramatically minimize normal tissue toxicity while maintaining antitumor efficacy compared with standard-of-care radiotherapy at conventional dose rate (CONV-RT). The resultant improvements in the therapeutic index have sparked intense investigations in pursuit of the underlying mechanisms. As a preamble to clinical translation, we exposed non-tumor-bearing male and female mice to hypofractionated (3 × 10 Gy) whole brain FLASH- and CONV-RT to evaluate differential neurologic responses using a comprehensive panel of functional and molecular outcomes over a 6-month follow-up. In each instance, extensive and rigorous behavioral testing showed FLASH-RT to preserve cognitive indices of learning and memory that corresponded to a similar protection of synaptic plasticity as measured by long-term potentiation (LTP). These beneficial functional outcomes were not found after CONV-RT and were linked to a preservation of synaptic integrity at the molecular (synaptophysin) level and to reductions in neuroinflammation (CD68 Significance: Functional preservation of cognition and LTP after hypofractionated FLASH-RT are linked to a protection of synaptic integrity and a reduction in neuroinflammation over protracted after irradiation times.
MeSH term(s)	Male ; Mice ; Female ; Animals ; Neuroinflammatory Diseases ; Long-Term Potentiation ; Neuronal Plasticity ; Radiation Dose Hypofractionation
Language	English
Publishing date	2023-04-27
Publishing country	United States
Document type	Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
ISSN	2767-9764
ISSN (online)	2767-9764
DOI	10.1158/2767-9764.CRC-23-0117
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Article ; Online: Irreversible hippocampal changes induced by high fructose diet in rats.

Fierros-Campuzano, Juan / Ballesteros-Zebadúa, Paola / Manjarrez-Marmolejo, Joaquín / Aguilera, Penélope / Méndez-Diaz, Mónica / Prospero-García, Oscar / Franco-Pérez, Javier

Nutritional neuroscience

2020 Volume 25, Issue 6, Page(s) 1325–1337

Abstract: Some reports have described that a high fructose diet is associated with a deficit of hippocampus-dependent cognitive functions. In this study, we have evaluated the effects of fructose on spatial memory and molecular markers in the hippocampus and ... ...

Abstract	Some reports have described that a high fructose diet is associated with a deficit of hippocampus-dependent cognitive functions. In this study, we have evaluated the effects of fructose on spatial memory and molecular markers in the hippocampus and prefrontal cortex and analyzed whether those alterations are reversible. Male Wistar rats (
MeSH term(s)	Animals ; Diet ; Fructose ; Hippocampus/metabolism ; Male ; Maze Learning ; Rats ; Rats, Wistar ; Spatial Memory
Chemical Substances	Fructose (30237-26-4)
Language	English
Publishing date	2020-12-03
Publishing country	England
Document type	Journal Article
ZDB-ID	1447449-9
ISSN	1476-8305 ; 1028-415X
ISSN (online)	1476-8305
ISSN	1028-415X
DOI	10.1080/1028415X.2020.1853418
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Article ; Online: Quinine and carbenoxolone enhance the anticonvulsant activity of some classical antiepileptic drugs.

Franco-Pérez, Javier / Manjarrez-Marmolejo, Joaquín / Rodríguez-Balderas, Cesar / Castro, Nelly / Ballesteros-Zebadua, Paola

Neurological research

2018 Volume 40, Issue 1, Page(s) 26–33

Abstract: Objective Quinine (QUIN) and carbenoxolone (CNX) elicit anticonvulsant effects typically characterized by the reduction of the epileptiform activity as well as changes in behavioral parameters related to seizures. Therefore, the aim of this study was to ... ...

Abstract	Objective Quinine (QUIN) and carbenoxolone (CNX) elicit anticonvulsant effects typically characterized by the reduction of the epileptiform activity as well as changes in behavioral parameters related to seizures. Therefore, the aim of this study was to analyze the effects of these molecules on the anticonvulsant activity of some classical antiepileptic drugs. Methods Male Wistar rats were used. Valproate (VPA), phenytoin (PHT), or carbamazepine (CBZ) was administered at sub-therapeutic doses for intraperitoneal via. Subsequently, animals were administered with a single dose of QUIN or CNX. The anticonvulsant activity was evaluated with the maximal electroshock (MES) test and pentylenetetrazole (PTZ) administration. Additionally, the plasma levels of CBZ were determined using an HPLC method. Results All the control rats presented generalized tonic-clonic seizures after the MES test or the administration of PTZ. For the MES test, all of the antiepileptic drugs increased their anticonvulsant activity when were co-administered with QUIN. For the PTZ test, only the combination CBZ plus QUIN significantly increased the percentage of protection against the generalized tonic-clonic seizures. The co-administration of CBZ plus QUIN resulted in an augmented concentration of CBZ in plasma. Discussion The present study shows that QUIN and CNX enhance the anticonvulsant activity of some classical antiepileptic drugs. However, only the combination CBZ/QUIN had significant effects on both MES and PTZ models. Such anticonvulsant activity could be attributed to increased levels of CBZ in plasma. We propose that these molecules could improve the pharmacological actions of antiepileptic drugs administered at sub-therapeutic doses.
MeSH term(s)	Animals ; Anticonvulsants/therapeutic use ; Carbenoxolone/blood ; Carbenoxolone/therapeutic use ; Convulsants/toxicity ; Disease Models, Animal ; Dose-Response Relationship, Drug ; Drug Therapy, Combination ; Electroshock/adverse effects ; Epilepsy/drug therapy ; Epilepsy/etiology ; Male ; Pentylenetetrazole/toxicity ; Quinine/therapeutic use ; Rats ; Rats, Wistar
Chemical Substances	Anticonvulsants ; Convulsants ; Quinine (A7V27PHC7A) ; Carbenoxolone (MM6384NG73) ; Pentylenetetrazole (WM5Z385K7T)
Language	English
Publishing date	2018-01
Publishing country	England
Document type	Journal Article
ZDB-ID	424428-x
ISSN	1743-1328 ; 0161-6412
ISSN (online)	1743-1328
ISSN	0161-6412
DOI	10.1080/01616412.2017.1384092
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Article ; Online: Anticonvulsant effects of mefloquine on generalized tonic-clonic seizures induced by two acute models in rats.

Franco-Pérez, Javier / Ballesteros-Zebadúa, Paola / Manjarrez-Marmolejo, Joaquín

BMC neuroscience

2015 Volume 16, Page(s) 7

Abstract: Background: Mefloquine can cross the blood-brain barrier and block the gap junction intercellular communication in the brain. Enhanced electrical coupling mediated by gap junctions is an underlying mechanism involved in the generation and maintenance of ...

Abstract	Background: Mefloquine can cross the blood-brain barrier and block the gap junction intercellular communication in the brain. Enhanced electrical coupling mediated by gap junctions is an underlying mechanism involved in the generation and maintenance of seizures. For this reason, the aim of this study was to analyze the effects of the systemic administration of mefloquine on tonic-clonic seizures induced by two acute models such as pentylenetetrazole and maximal electroshock. Results: All the control rats presented generalized tonic-clonic seizures after the administration of pentylenetetrazole. However, the incidence of seizures induced by pentylenetetrazole significantly decreased in the groups administered systematically with 40 and 80 mg/kg of mefloquine. In the control group, none of the rats survived after the generalized tonic-clonic seizures induced by pentylenetetrazole, but survival was improved by mefloquine. Besides, mefloquine significantly modified the total spectral power as well as the duration, amplitude and frequency of the epileptiform activity induced by pentylenetetrazole. For the maximal electroshock model, mefloquine did not change the occurrence of tonic hindlimb extension. However, this gap junction blocker significantly decreased the duration of the tonic hindlimb extension induced by the acute electroshock. Conclusions: These data suggest that mefloquine at low doses might be eliciting some anticonvulsant effects when is systemically administered to rats.
MeSH term(s)	Acute Disease ; Animals ; Anticonvulsants/pharmacology ; Brain/drug effects ; Brain/physiopathology ; Disease Models, Animal ; Dose-Response Relationship, Drug ; Electrodes, Implanted ; Electroencephalography ; Electroshock ; Hindlimb/drug effects ; Hindlimb/physiopathology ; Male ; Mefloquine/pharmacology ; Pentylenetetrazole ; Random Allocation ; Rats ; Rats, Wistar ; Seizures/drug therapy ; Seizures/physiopathology ; Survival Analysis
Chemical Substances	Anticonvulsants ; Mefloquine (TML814419R) ; Pentylenetetrazole (WM5Z385K7T)
Language	English
Publishing date	2015-03-01
Publishing country	England
Document type	Journal Article
ISSN	1471-2202
ISSN (online)	1471-2202
DOI	10.1186/s12868-015-0145-7
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Article ; Online: Unilateral microinjection of carbenoxolone into the pontis caudalis nucleus inhibits the pentylenetetrazole-induced epileptiform activity in rats.

Franco-Pérez, Javier / Ballesteros-Zebadúa, Paola / Manjarrez-Marmolejo, Joaquín

Neuroscience letters

2015 Volume 602, Page(s) 38–43

Abstract: Pontine reticular formation (PRF) is involved in the generation and maintenance of generalized epileptic seizures. Carbenoxolone (CBX) is a gap junction blocker with anticonvulsant properties. Therefore, the present study was designed to explore the ... ...

Abstract	Pontine reticular formation (PRF) is involved in the generation and maintenance of generalized epileptic seizures. Carbenoxolone (CBX) is a gap junction blocker with anticonvulsant properties. Therefore, the present study was designed to explore the effects of CBX microinjected into the pontis caudalis nucleus (PnC) on generalized tonic-clonic seizures (GTCS) and epileptiform activity induced by pentylenetetrazole (PTZ). All control rats presented GTCS after a single dose of PTZ. The microinjection of CBX into the PnC reduced the GTCS incidence induced by PTZ. Moreover, the CBX significantly increased the latency to the first myoclonic jerk. Additionally, CBX significantly decreased the spectral power and the amplitude of the epileptiform activity induced by PTZ. By contrast, the microinjection of a gap junction opener (trimethylamine) did not cause anticonvulsant effects and even increased the duration of the GTCS. These findings suggest that the PnC is a particular nucleus where the CBX could exert its action mechanisms and elicit anticonvulsant effects.
MeSH term(s)	Animals ; Anticonvulsants/pharmacology ; Anticonvulsants/therapeutic use ; Carbenoxolone/pharmacology ; Carbenoxolone/therapeutic use ; Epilepsy/chemically induced ; Epilepsy/physiopathology ; Male ; Microinjections ; Pentylenetetrazole ; Pontine Tegmentum/drug effects ; Pontine Tegmentum/physiopathology ; Rats, Wistar ; Seizures/physiopathology
Chemical Substances	Anticonvulsants ; Carbenoxolone (MM6384NG73) ; Pentylenetetrazole (WM5Z385K7T)
Language	English
Publishing date	2015-08-18
Publishing country	Ireland
Document type	Journal Article
ZDB-ID	194929-9
ISSN	1872-7972 ; 0304-3940
ISSN (online)	1872-7972
ISSN	0304-3940
DOI	10.1016/j.neulet.2015.06.037
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Article: Chronic Consumption of Fructose Induces Behavioral Alterations by Increasing Orexin and Dopamine Levels in the Rat Brain

Franco-Pérez, Javier / Manjarrez-Marmolejo, Joaquín / Ballesteros-Zebadúa, Paola / Neri-Santos, Adriana / Montes, Sergio / Suarez-Rivera, Norma / Hernández-Cerón, Miguel / Pérez-Koldenkova, Vadim

Nutrients. 2018 Nov. 10, v. 10, no. 11

2018

Abstract: It has been widely described that chronic intake of fructose causes metabolic alterations which can be associated with brain function impairment. In this study, we evaluated the effects of fructose intake on the sleep–wake cycle, locomotion, and ... ...

Abstract	It has been widely described that chronic intake of fructose causes metabolic alterations which can be associated with brain function impairment. In this study, we evaluated the effects of fructose intake on the sleep–wake cycle, locomotion, and neurochemical parameters in Wistar rats. The experimental group was fed with 10% fructose in drinking water for five weeks. After treatment, metabolic indicators were quantified in blood. Electroencephalographic recordings were used to evaluate the sleep architecture and the spectral power of frequency bands. Likewise, the locomotor activity and the concentrations of orexin A and monoamines were estimated. Our results show that fructose diet significantly increased the blood levels of glucose, cholesterol, and triglycerides. Fructose modified the sleep–wake cycle of rats, increasing the waking duration and conversely decreasing the non-rapid eye movement sleep. Furthermore, these effects were accompanied by increases of the spectral power at different frequency bands. Chronic consumption of fructose caused a slight increase in the locomotor activity as well as an increase of orexin A and dopamine levels in the hypothalamus and brainstem. Specifically, immunoreactivity for orexin A was increased in the ventral tegmental area after the intake of fructose. Our study suggests that fructose induces metabolic changes and stimulates the activity of orexinergic and dopaminergic neurons, which may be responsible for alterations of the sleep–wake cycle.
Keywords	blood ; brain stem ; cholesterol ; diet ; dopamine ; drinking water ; electroencephalography ; eyes ; fructose ; glucose ; hypothalamus ; laboratory animals ; locomotion ; monoamines ; neurons ; rats ; sleep ; triacylglycerols
Language	English
Dates of publication	2018-1110
Publishing place	Multidisciplinary Digital Publishing Institute
Document type	Article
ZDB-ID	2518386-2
ISSN	2072-6643
ISSN	2072-6643
DOI	10.3390/nu10111722
Database	NAL-Catalogue (AGRICOLA)

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Article ; Online: Chronic paroxetine treatment: effects on other non-serotonergic neurotransmitter systems.

Ballesteros-Zebadua, Paola / Manjarrez-Marmolejo, Joaquin / Franco-Perez, Javier

CNS & neurological disorders drug targets

2013 Volume 12, Issue 8, Page(s) 1226–1232

Abstract: Due to its efficacy and acceptability, paroxetine is situated in the top ten of drugs prescribed for the treatment of major depression and essentially all anxiety disorders. Adults under paroxetine treatment report relief after 4-6 weeks of ... ...

Abstract	Due to its efficacy and acceptability, paroxetine is situated in the top ten of drugs prescribed for the treatment of major depression and essentially all anxiety disorders. Adults under paroxetine treatment report relief after 4-6 weeks of administration; furthermore, this drug can be prescribed for periods lasting longer than one year. Therefore, paroxetine treatment has a pattern of ingestion that is mainly chronic rather than acute. There is a considerable number of reviews in the literature concerning the effects of paroxetine on the serotonergic system; however, the alterations caused by chronic ingestion of this drug in other neurotransmitter systems have received little attention. For this reason, we consider very important to review the experimental studies concerning the effects of chronic paroxetine intake on neurotransmitter levels, neuronal firing rate and the expression of receptors and transporters in different neurotransmitter systems in the brain. According to the experimental data analyzed in this work, we can establish that long-term paroxetine intake has the ability to increase GABA, glutamate, dopamine and noradrenaline levels in the brain. Furthermore, high levels of AMPA, orexine-1,2 and histamine-1 receptors have been reported in different brain regions after treatment with paroxetine over several weeks. In addition, paroxetine has differential effects on neuropeptide systems, such as galanine, opioid receptors and substance P. Available data lead us to establish that chronic ingestion of paroxetine induces changes in several neurotransmitters and neuropeptides, thus illuminating how each one may contribute to the antidepressant and anxiolytic response elicited by this drug. We consider that all reported changes in the neurotransmitter systems should be further considered to individualize clinical treatment and, in the case of patients taking a drug "cocktail", to gain better control over drug interactions and adverse effects.
MeSH term(s)	Animals ; Brain/drug effects ; Brain/metabolism ; Drug Administration Schedule ; Humans ; Mental Disorders/drug therapy ; Mental Disorders/metabolism ; Neurotransmitter Agents/metabolism ; Paroxetine/administration & dosage ; Serotonin Uptake Inhibitors/administration & dosage ; Treatment Outcome
Chemical Substances	Neurotransmitter Agents ; Serotonin Uptake Inhibitors ; Paroxetine (41VRH5220H)
Language	English
Publishing date	2013-10-09
Publishing country	United Arab Emirates
Document type	Journal Article ; Review
ZDB-ID	2228394-8
ISSN	1996-3181 ; 1871-5273
ISSN (online)	1996-3181
ISSN	1871-5273
DOI	10.2174/18715273113126660182
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