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Artikel ; Online: Comparative single-cell multiplex immunophenotyping of therapy-naive patients with rheumatoid arthritis, systemic sclerosis, and systemic lupus erythematosus shed light on disease-specific composition of the peripheral immune system.

Balog, József Á / Zvara, Ágnes / Bukovinszki, Vivien / Puskás, László G / Balog, Attila / Szebeni, Gábor J

2024 Band 15, Seite(n) 1376933

Abstract: Introduction: Systemic autoimmune diseases (SADs) are a significant burden on the healthcare system. Understanding the complexity of the peripheral immunophenotype in SADs may facilitate the differential diagnosis and identification of potential ... ...

Abstract	Introduction: Systemic autoimmune diseases (SADs) are a significant burden on the healthcare system. Understanding the complexity of the peripheral immunophenotype in SADs may facilitate the differential diagnosis and identification of potential therapeutic targets. Methods: Single-cell mass cytometric immunophenotyping was performed on peripheral blood mononuclear cells (PBMCs) from healthy controls (HCs) and therapy-naive patients with rheumatoid arthritis (RA), progressive systemic sclerosis (SSc), and systemic lupus erythematosus (SLE). Immunophenotyping was performed on 15,387,165 CD45 Results: Using the t-SNE (t-distributed stochastic neighbor embedding) algorithm, the following 17 main immune cell types were determined: CD4
Mesh-Begriff(e)	Humans ; Immunophenotyping ; Lupus Erythematosus, Systemic/immunology ; Lupus Erythematosus, Systemic/diagnosis ; Female ; Single-Cell Analysis/methods ; Arthritis, Rheumatoid/immunology ; Arthritis, Rheumatoid/diagnosis ; Middle Aged ; Adult ; Male ; Scleroderma, Systemic/immunology ; Aged ; Leukocytes, Mononuclear/immunology ; Leukocytes, Mononuclear/metabolism ; Biomarkers
Chemische Substanzen	Biomarkers
Sprache	Englisch
Erscheinungsdatum	2024-04-25
Erscheinungsland	Switzerland
Dokumenttyp	Journal Article ; Research Support, Non-U.S. Gov't ; Comparative Study
ZDB-ID	2606827-8
ISSN	1664-3224 ; 1664-3224
ISSN (online)	1664-3224
ISSN	1664-3224
DOI	10.3389/fimmu.2024.1376933
Datenquelle	MEDical Literature Analysis and Retrieval System OnLINE

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Artikel ; Online: Calcium Influx Kinetics and the Characteristics of Potassium Channels in Peripheral T Lymphocytes in Systemic Sclerosis.

Toldi, Gergely / Legány, Nóra / Ocsovszki, Imre / Balog, Attila

Pathobiology : journal of immunopathology, molecular and cellular biology

2020 Band 87, Heft 5, Seite(n) 311–316

Abstract: Background: Systemic sclerosis (SSc) is a chronic, immune-mediated, connective tissue disease causing microvascular abnormalities and fibrosis. The cytoplasmic calcium influx kinetics in T lymphocytes governs lymphocyte activation in this inflammatory ... ...

Abstract	Background: Systemic sclerosis (SSc) is a chronic, immune-mediated, connective tissue disease causing microvascular abnormalities and fibrosis. The cytoplasmic calcium influx kinetics in T lymphocytes governs lymphocyte activation in this inflammatory process. The inhibition of Kv1.3 and IKCa1 potassium channels reduces calcium influx. Methods: This study aimed to analyze cytoplasmic calcium influx kinetics following activation in Th1, Th2, and CD8 cells in peripheral blood of 12 healthy individuals and 16 patients with systemic sclerosis using flow cytometry. We also evaluated the effect of the specific inhibition of the Kv1.3 and IKCa1 potassium channels. Results: We observed higher levels of activation in CD8 compared with Th1 cells in SSc. However, the activation of CD8 cells was lower in SSc compared to healthy controls. Moreover, activation of Th1 lymphocytes was slower in SSc than in healthy controls. The inhibition of IKCa1 channels decreased the activation of Th1 cells, while the inhibition of Kv1.3 channels modified the dynamics of activation of Th1 and Th2 lymphocytes in SSc. Conclusion: Th1 and CD8 cells demonstrate specific activation dynamics and sensitivity to potassium channel inhibition in SSc, distinguishing this condition both from healthy controls and other autoimmune diseases.
Sprache	Englisch
Erscheinungsdatum	2020-09-10
Erscheinungsland	Switzerland
Dokumenttyp	Journal Article
ZDB-ID	1022703-9
ISSN	1423-0291 ; 1015-2008
ISSN (online)	1423-0291
ISSN	1015-2008
DOI	10.1159/000509674
Datenquelle	MEDical Literature Analysis and Retrieval System OnLINE

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Artikel ; Online: Evidence of Disruption in Neural Regeneration in Dry Eye Secondary to Rheumatoid Arthritis.

Sonkodi, Balázs / Csorba, Anita / Marsovszky, László / Balog, Attila / Kopper, Bence / Nagy, Zoltán Zsolt / Resch, Miklós D

International journal of molecular sciences

2023 Band 24, Heft 8

Abstract: The purpose of our study was to analyze abnormal neural regeneration activity in the cornea through means of confocal microscopy in rheumatoid arthritis patients with concomitant dry eye disease. We examined 40 rheumatoid arthritis patients with variable ...

Abstract	The purpose of our study was to analyze abnormal neural regeneration activity in the cornea through means of confocal microscopy in rheumatoid arthritis patients with concomitant dry eye disease. We examined 40 rheumatoid arthritis patients with variable severity and 44 volunteer age- and gender-matched healthy control subjects. We found that all examined parameters were significantly lower (
Mesh-Begriff(e)	Humans ; Channelopathies/complications ; Dry Eye Syndromes/complications ; Arthritis, Rheumatoid/complications ; Cornea/innervation ; Corneal Keratocytes ; Microscopy, Confocal/methods ; Ion Channels
Chemische Substanzen	PIEZO1 protein, human ; Ion Channels
Sprache	Englisch
Erscheinungsdatum	2023-04-19
Erscheinungsland	Switzerland
Dokumenttyp	Journal Article
ZDB-ID	2019364-6
ISSN	1422-0067 ; 1422-0067 ; 1661-6596
ISSN (online)	1422-0067
ISSN	1422-0067 ; 1661-6596
DOI	10.3390/ijms24087514
Datenquelle	MEDical Literature Analysis and Retrieval System OnLINE

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Artikel ; Online: Disrupted Neural Regeneration in Dry Eye Secondary to Ankylosing Spondylitis-With a Theoretical Link between Piezo2 Channelopathy and Gateway Reflex, WDR Neurons, and Flare-Ups.

Sonkodi, Balázs / Marsovszky, László / Csorba, Anita / Balog, Attila / Kopper, Bence / Keller-Pintér, Anikó / Nagy, Zoltán Zsolt / Resch, Miklós D

International journal of molecular sciences

2023 Band 24, Heft 20

Abstract: This study aimed at analyzing the corneal neural regeneration in ankylosing spondylitis patients using in vivo corneal confocal microscopy in correlation with Langerhans cell density, morphology, and dry eye parameters. Approximately 24 ankylosing ... ...

Abstract	This study aimed at analyzing the corneal neural regeneration in ankylosing spondylitis patients using in vivo corneal confocal microscopy in correlation with Langerhans cell density, morphology, and dry eye parameters. Approximately 24 ankylosing spondylitis subjects and 35 age- and gender-matched control subjects were enrolled. Data analysis showed that all corneal nerve-fiber descriptives were lower in the ankylosing spondylitis group, implicating disrupted neural regeneration. Peripheral Langerhans cell density showed a negative correlation with nerve fiber descriptions. A negative correlation between tear film break-up time and corneal nerve fiber total branch density was detected. The potential role of somatosensory terminal Piezo2 channelopathy in the pathogenesis of dry eye disease and ankylosing spondylitis is highlighted in our study, exposing the neuroimmunological link between these diseases. We hypothesized earlier that spinal neuroimmune-induced sensitization due to this somatosensory terminal primary damage could lead to Langerhans cell activation in the cornea, in association with downregulated Piezo1 channels on these cells. This activation could lead to a Th17/Treg imbalance in dry eye secondary to ankylosing spondylitis. Hence, the corneal Piezo2 channelopathy-induced impaired Piezo2-Piezo1 crosstalk could explain the disrupted neural regeneration. Moreover, the translation of our findings highlights the link between Piezo2 channelopathy-induced gateway to pathophysiology and the gateway reflex, not to mention the potential role of spinal wide dynamic range neurons in the evolution of neuropathic pain and the flare-ups in ankylosing spondylitis and dry eye disease.
Mesh-Begriff(e)	Humans ; Channelopathies/complications ; Cornea/pathology ; Dry Eye Syndromes/pathology ; Nerve Fibers/pathology ; Reflex ; Spondylitis, Ankylosing/pathology
Chemische Substanzen	PIEZO2 protein, human
Sprache	Englisch
Erscheinungsdatum	2023-10-22
Erscheinungsland	Switzerland
Dokumenttyp	Journal Article
ZDB-ID	2019364-6
ISSN	1422-0067 ; 1422-0067 ; 1661-6596
ISSN (online)	1422-0067
ISSN	1422-0067 ; 1661-6596
DOI	10.3390/ijms242015455
Datenquelle	MEDical Literature Analysis and Retrieval System OnLINE

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Artikel ; Online: Neural Regeneration in Dry Eye Secondary to Systemic Lupus Erythematosus Is Also Disrupted like in Rheumatoid Arthritis, but in a Progressive Fashion.

Sonkodi, Balázs / Marsovszky, László / Csorba, Anita / Balog, Attila / Kopper, Bence / Nagy, Zoltán Zsolt / Resch, Miklós D

International journal of molecular sciences

2023 Band 24, Heft 13

Abstract: Our objective in this study was to analyze the aberrant neural regeneration activity in the cornea by means of in vivo confocal microscopy in systemic lupus erythematosus patients with concurrent dry eye disease. We examined 29 systemic lupus ... ...

Abstract	Our objective in this study was to analyze the aberrant neural regeneration activity in the cornea by means of in vivo confocal microscopy in systemic lupus erythematosus patients with concurrent dry eye disease. We examined 29 systemic lupus erythematosus patients and 29 age-matched healthy control subjects. Corneal nerve fiber density (CNFD, the number of fibers/mm
Mesh-Begriff(e)	Humans ; Dry Eye Syndromes ; Cornea/innervation ; Nerve Fibers ; Nerve Tissue ; Arthritis, Rheumatoid/complications ; Microscopy, Confocal
Sprache	Englisch
Erscheinungsdatum	2023-06-26
Erscheinungsland	Switzerland
Dokumenttyp	Journal Article
ZDB-ID	2019364-6
ISSN	1422-0067 ; 1422-0067 ; 1661-6596
ISSN (online)	1422-0067
ISSN	1422-0067 ; 1661-6596
DOI	10.3390/ijms241310680
Datenquelle	MEDical Literature Analysis and Retrieval System OnLINE

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Artikel ; Online: Kynurenic Acid Analog Attenuates the Production of Tumor Necrosis Factor-α, Calgranulins (S100A 8/9 and S100A 12), and the Secretion of HNP1-3 and Stimulates the Production of Tumor Necrosis Factor-Stimulated Gene-6 in Whole Blood Cultures of Patients With Rheumatoid Arthritis.

Balog, Attila / Varga, Borisz / Fülöp, Ferenc / Lantos, Ildikó / Toldi, Gergely / Vécsei, László / Mándi, Yvette

Frontiers in immunology

2021 Band 12, Seite(n) 632513

Abstract: Objectives: ...

Abstract	Objectives:
Mesh-Begriff(e)	Aged ; Anti-Inflammatory Agents/pharmacology ; Arthritis, Rheumatoid/blood ; Arthritis, Rheumatoid/immunology ; Cell Adhesion Molecules/blood ; Cell Adhesion Molecules/immunology ; Female ; Humans ; Inflammation Mediators/blood ; Inflammation Mediators/immunology ; Kynurenic Acid/analogs & derivatives ; Kynurenic Acid/pharmacology ; Male ; Middle Aged ; Rheumatoid Factor/blood ; S100 Proteins/blood ; S100 Proteins/immunology ; Staphylococcus aureus/immunology ; Tumor Necrosis Factor-alpha/blood ; Tumor Necrosis Factor-alpha/immunology ; alpha-Defensins/blood ; alpha-Defensins/immunology
Chemische Substanzen	Anti-Inflammatory Agents ; Cell Adhesion Molecules ; Inflammation Mediators ; S100 Proteins ; SZR 72 ; TNFAIP6 protein, human ; Tumor Necrosis Factor-alpha ; alpha-Defensins ; Rheumatoid Factor (9009-79-4) ; Kynurenic Acid (H030S2S85J)
Sprache	Englisch
Erscheinungsdatum	2021-04-09
Erscheinungsland	Switzerland
Dokumenttyp	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2606827-8
ISSN	1664-3224 ; 1664-3224
ISSN (online)	1664-3224
ISSN	1664-3224
DOI	10.3389/fimmu.2021.632513
Datenquelle	MEDical Literature Analysis and Retrieval System OnLINE

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Artikel ; Online: Investigation of Newly Diagnosed Drug-Naive Patients with Systemic Autoimmune Diseases Revealed the Cleaved Peptide Tyrosine Tyrosine (PYY 3-36) as a Specific Plasma Biomarker of Rheumatoid Arthritis.

Balog, Jozsef A / Kemeny, Agnes / Puskas, Laszlo G / Burcsar, Szilard / Balog, Attila / Szebeni, Gabor J

Mediators of inflammation

2021 Band 2021, Seite(n) 5523582

Abstract: There is a current imperative to reveal more precisely the molecular pathways of early onset of systemic autoimmune diseases (SADs). The investigation of newly diagnosed drug-naive SAD patients might contribute to identify novel disease-specific and ... ...

Abstract	There is a current imperative to reveal more precisely the molecular pathways of early onset of systemic autoimmune diseases (SADs). The investigation of newly diagnosed drug-naive SAD patients might contribute to identify novel disease-specific and prognostic markers. The multiplex analysis of 30 plasma proteins in 60 newly diagnosed drug-naive SADs, such as RA (rheumatoid arthritis,
Mesh-Begriff(e)	Aged ; Arthritis, Rheumatoid/blood ; Arthritis, Rheumatoid/immunology ; Autoimmune Diseases/drug therapy ; Autoimmune Diseases/physiopathology ; Biomarkers/blood ; Cytokines/metabolism ; Female ; Humans ; Lupus Erythematosus, Systemic/blood ; Lupus Erythematosus, Systemic/immunology ; Machine Learning ; Male ; Middle Aged ; Pattern Recognition, Automated ; Prognosis ; Scleroderma, Systemic/blood ; Scleroderma, Systemic/immunology ; Tyrosine/chemistry
Chemische Substanzen	Biomarkers ; Cytokines ; Tyrosine (42HK56048U)
Sprache	Englisch
Erscheinungsdatum	2021-06-17
Erscheinungsland	United States
Dokumenttyp	Journal Article
ZDB-ID	1137605-3
ISSN	1466-1861 ; 0962-9351
ISSN (online)	1466-1861
ISSN	0962-9351
DOI	10.1155/2021/5523582
Datenquelle	MEDical Literature Analysis and Retrieval System OnLINE

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Artikel ; Online: Urine soluble urokinase plasminogen activator receptor as a potential biomarker of lupus nephritis activity.

Burcsár, Szilárd / Toldi, Gergely / Kovács, László / Szalay, Balázs / Vásárhelyi, Barna / Balog, Attila

Biomarkers : biochemical indicators of exposure, response, and susceptibility to chemicals

2021 Band 26, Heft 5, Seite(n) 443–449

Abstract: There is a lack of non-invasive biomarkers to identify lupus nephritis (LN). Soluble urokinase plasminogen activator receptor (suPAR) is a sensitive biomarker of ongoing inflammation and a potential marker of podocyte dysfunction. The aim of this study ... ...

Abstract	There is a lack of non-invasive biomarkers to identify lupus nephritis (LN). Soluble urokinase plasminogen activator receptor (suPAR) is a sensitive biomarker of ongoing inflammation and a potential marker of podocyte dysfunction. The aim of this study was to assess urine and plasma suPAR in LN. 14 systemic lupus erythematosus (SLE) patients with newly diagnosed LN, 8 active SLE patients (SLEDAI >8) without LN and 31 healthy individuals were enrolled. Urine and plasma samples were taken before the initiation of LN induction therapy, and monthly thereafter. Global and renal disease activity were defined using the SLEDAI-2K and the SLEDAI-2K renal domain score, respectively. suPAR concentrations were measured with the suPARnostic Flex ELISA assay. Urine and plasma suPAR levels were elevated in SLE patients with active LN compared with resolved LN and healthy controls. Urine suPAR levels were comparable to healthy controls in active SLE without LN. Urine and plasma suPAR levels were higher before than after the initiation of LN induction therapy. Prospective follow-up measurements also suggested that urine suPAR levels raised again in patients with a relapse of LN according to SLEDAI-2K renal domain score, whereas plasma suPAR levels did not correlate with renal disease activity. Urine suPAR is a promising LN activity biomarker, given its isolated elevation in urine in active LN and pronounced decrease with LN improvement.
Mesh-Begriff(e)	Adolescent ; Adult ; Aged ; Biomarkers/blood ; Biomarkers/urine ; Case-Control Studies ; Enzyme-Linked Immunosorbent Assay ; Female ; Humans ; Immunosuppressive Agents/therapeutic use ; Longitudinal Studies ; Lupus Nephritis/blood ; Lupus Nephritis/diagnosis ; Lupus Nephritis/drug therapy ; Lupus Nephritis/urine ; Male ; Middle Aged ; Predictive Value of Tests ; Prospective Studies ; Receptors, Urokinase Plasminogen Activator/blood ; Receptors, Urokinase Plasminogen Activator/metabolism ; Time Factors ; Treatment Outcome ; Urinalysis ; Young Adult
Chemische Substanzen	Biomarkers ; Immunosuppressive Agents ; PLAUR protein, human ; Receptors, Urokinase Plasminogen Activator
Sprache	Englisch
Erscheinungsdatum	2021-04-19
Erscheinungsland	England
Dokumenttyp	Journal Article
ZDB-ID	1324372-x
ISSN	1366-5804 ; 1354-750X
ISSN (online)	1366-5804
ISSN	1354-750X
DOI	10.1080/1354750X.2021.1910343
Datenquelle	MEDical Literature Analysis and Retrieval System OnLINE

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Artikel: Ultra-low emission combustion of diesel-coconut biodiesel fuels by a mixture temperature-controlled combustion mode

Józsa, Viktor / Hidegh, Gyöngyvér / Kun-Balog, Attila / Ng, Jo-Han / Chong, Cheng Tung

Energy conversion and management. 2020 June 15, v. 214

2020

Abstract: Liquid fuels are likely to remain the main energy source in long-range transportation and aviation for several decades. To reduce our dependence on fossil fuels, liquid biofuels can be blended to fossil fuels – or used purely. In this paper, coconut ... ...

Abstract	Liquid fuels are likely to remain the main energy source in long-range transportation and aviation for several decades. To reduce our dependence on fossil fuels, liquid biofuels can be blended to fossil fuels – or used purely. In this paper, coconut methyl ester, standard diesel fuel (EN590:2017), and their blends were investigated in 25 V/V% steps. A novel turbulent combustion chamber was developed to facilitate combustion in a large volume that leads to ultra-low emissions. The combustion power of the swirl burner was 13.3 kW, and the air-to-fuel equivalence ratio was 1.25. Two parameters, combustion air preheating temperature and atomizing air pressure were adjusted in the range of 150–350 °C and 0.3–0.9 bar, respectively. Both straight and lifted flames were observed. The closed, atmospheric combustion chamber resulted in CO emission below 10 ppm in the majority of the cases. NO emission varied between 60 and 183 ppm at straight flame cases and decreased below 20 ppm when the flame was lifted since the combustion occurred in a large volume. This operation mode fulfills the 2015/2193/EU directive for gas combustion by 25%, which is twice as strict as liquid fuel combustion regulations. The 90% NO emission reduction was also concluded when compared to a lean premixed prevaporized burner under similar conditions. This favorable operation mode was named as Mixture Temperature-Controlled (MTC) Combustion. The chemiluminescent emission of lifted flames was also low, however, the OH* emission of straight flames was clearly observable and followed the trends of NO emission. The MTC mode may lead to significantly decreased pollutant emission of steady-operating devices like boilers, furnaces, and both aviation and industrial gas turbines, meaning an outstanding contribution to more environmentally friendly technologies.
Schlagwörter	administrative management ; air ; atmospheric pressure ; atomization ; aviation ; biodiesel ; boilers ; chemiluminescence ; coconuts ; diesel fuel ; emissions ; energy conversion ; fossil fuels ; fuel combustion ; furnaces ; lead ; liquids ; paper ; pollutants ; sustainable technology ; temperature ; transportation ; turbines ; volume
Sprache	Englisch
Erscheinungsverlauf	2020-0615
Erscheinungsort	Elsevier Ltd
Dokumenttyp	Artikel
Anmerkung	NAL-light
ZDB-ID	2000891-0
ISSN	0196-8904
ISSN	0196-8904
DOI	10.1016/j.enconman.2020.112908
Datenquelle	NAL Katalog (AGRICOLA)

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Artikel: Comparison of humoral and cellular immune responses in hematologic diseases following completed vaccination protocol with BBIBP-CorV, or AZD1222, or BNT162b2 vaccines against SARS-CoV-2.

Szabó, Enikő / Modok, Szabolcs / Rónaszéki, Benedek / Faragó, Anna / Gémes, Nikolett / Nagy, Lajos I / Hackler, László / Farkas, Katalin / Neuperger, Patrícia / Balog, József Á / Balog, Attila / Puskás, László G / Szebeni, Gabor J

Frontiers in medicine

2023 Band 10, Seite(n) 1176168

Abstract: Background: Vaccination has proven the potential to control the COVID-19 pandemic worldwide. Although recent evidence suggests a poor humoral response against SARS-CoV-2 in vaccinated hematological disease (HD) patients, data on vaccination in these ... ...

Abstract	Background: Vaccination has proven the potential to control the COVID-19 pandemic worldwide. Although recent evidence suggests a poor humoral response against SARS-CoV-2 in vaccinated hematological disease (HD) patients, data on vaccination in these patients is limited with the comparison of mRNA-based, vector-based or inactivated virus-based vaccines. Methods: Forty-nine HD patients and 46 healthy controls (HCs) were enrolled who received two-doses complete vaccination with BNT162b2, or AZD1222, or BBIBP-CorV, respectively. The antibodies reactive to the receptor binding domain of spike protein of SARS-CoV-2 were assayed by Siemens ADVIA Centaur assay. The reactive cellular immunity was assayed by flow cytometry. The PBMCs were reactivated with SARS-CoV-2 antigens and the production of activation-induced markers (TNF-α, IFN-γ, CD40L) was measured in CD4 Results: The anti-RBD IgG level was the highest upon BNT162b2 vaccination in HDs (1264 BAU/mL) vs. HCs (1325 BAU/mL) among the studied groups. The BBIBP-CorV vaccination in HDs (339.8 BAU/mL Conclusion: We have demonstrated a significant weaker overall response to vaccines in the immunologically impaired HD population vs. HCs regardless of vaccine type. Although, the humoral immune activity against SARS-CoV-2 can be highly evoked by mRNA-based BNT162b2 vaccination compared to vector-based AZD1222 vaccine, or inactivated virus vaccine BBIBP-CorV, whereas the CD4
Sprache	Englisch
Erscheinungsdatum	2023-07-17
Erscheinungsland	Switzerland
Dokumenttyp	Journal Article
ZDB-ID	2775999-4
ISSN	2296-858X
ISSN	2296-858X
DOI	10.3389/fmed.2023.1176168
Datenquelle	MEDical Literature Analysis and Retrieval System OnLINE

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