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  1. Article ; Online: HLA-A*24:07

    Capule, Francis / Tragulpiankit, Pramote / Mahasirimongkol, Surakameth / Jittikoon, Jiraphun / Wichukchinda, Nuanjun / Alentajan-Aleta, Lara Theresa / Barit, Jay-V James / Casanova-Gutierrez, Josephine / Cabral-Lim, Leonor / Baltazar Reyes, Jose Paciano / Roa, Francisca / Salonga, Raymark / San Gabriel, Katrina Faith / Silao, Catherine Lynn

    Pharmacogenomics

    2021  Volume 22, Issue 8, Page(s) 465–472

    Abstract: Aim: ...

    Abstract Aim:
    MeSH term(s) Adolescent ; Adult ; Alleles ; Asians/genetics ; Biomarkers/metabolism ; Carbamazepine/adverse effects ; Case-Control Studies ; DNA/genetics ; Female ; Genetic Predisposition to Disease/genetics ; Genotype ; HLA-A Antigens/genetics ; HLA-B Antigens/genetics ; Humans ; Male ; Middle Aged ; Polymorphism, Genetic/genetics ; Retrospective Studies ; Stevens-Johnson Syndrome/etiology ; Stevens-Johnson Syndrome/genetics ; Young Adult
    Chemical Substances Biomarkers ; HLA-A Antigens ; HLA-B Antigens ; Carbamazepine (33CM23913M) ; DNA (9007-49-2)
    Language English
    Publishing date 2021-04-29
    Publishing country England
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
    ZDB-ID 2019513-8
    ISSN 1744-8042 ; 1462-2416
    ISSN (online) 1744-8042
    ISSN 1462-2416
    DOI 10.2217/pgs-2020-0191
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 5247: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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  2. Article ; Online: Association of carbamazepine-induced Stevens-Johnson syndrome/toxic epidermal necrolysis with the HLA-B75 serotype or HLA-B*15:21 allele in Filipino patients.

    Capule, Francis / Tragulpiankit, Pramote / Mahasirimongkol, Surakameth / Jittikoon, Jiraphun / Wichukchinda, Nuanjun / Theresa Alentajan-Aleta, Lara / James Barit, Jay-V / Casanova-Gutierrez, Josephine / Cabral-Lim, Leonor / Baltazar Reyes, Jose Paciano / Roa, Francisca / Salonga, Raymark / San Gabriel, Katrina Faith / Lynn Silao, Catherine

    The pharmacogenomics journal

    2020  Volume 20, Issue 3, Page(s) 533–541

    Abstract: A case-control study was conducted to investigate the association of HLA-A alleles, HLA-B alleles including HLA-B*15:02 and HLA-B75 serotype with carbamazepine-induced SJS/TEN in Filipino patients. A retrospective review of medical records was performed. ...

    Abstract A case-control study was conducted to investigate the association of HLA-A alleles, HLA-B alleles including HLA-B*15:02 and HLA-B75 serotype with carbamazepine-induced SJS/TEN in Filipino patients. A retrospective review of medical records was performed. Pertinent clinical data were collected. Eight (8) carbamazepine-induced SJS/TEN cases and 32 tolerant controls were recruited. Genomic DNA was extracted from the saliva samples and genotyping was performed by employing allele-specific polymerase chain reaction. Data were analyzed using the Fisher's exact test, Mann-Whitney U test, univariate logistic regression, and multivariate logistic regression. Single allele association analysis was done. The strength of association was expressed as odds ratio with 95% confidence interval. Positive predictive value, negative predictive value, sensitivity, and specificity were computed. Of all the alleles tested, the HLA-B75 serotype (p = 0.007, OR = 23.25, 95% CI = 2.33-232.21) and HLA-B*15:21 (p = 0.026, OR = 7.53, 95% CI = 1.27-44.79) were significantly associated with carbamazepine-induced SJS/TEN. The HLA-B75 serotype or HLA-B*15:21 allele may be used as a genetic risk assessment prior to prescription for prevention of carbamazepine-induced SJS/TEN in Filipino patients.
    MeSH term(s) Adult ; Alleles ; Anticonvulsants/adverse effects ; Asian Continental Ancestry Group/genetics ; Carbamazepine/adverse effects ; Case-Control Studies ; Female ; HLA-B Antigens/genetics ; Humans ; Male ; Middle Aged ; Philippines/epidemiology ; Serogroup ; Stevens-Johnson Syndrome/epidemiology ; Stevens-Johnson Syndrome/genetics ; Young Adult
    Chemical Substances Anticonvulsants ; HLA-B Antigens ; HLA-B75 antigen ; Carbamazepine (33CM23913M)
    Language English
    Publishing date 2020-01-03
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2106831-8
    ISSN 1473-1150 ; 1470-269X
    ISSN (online) 1473-1150
    ISSN 1470-269X
    DOI 10.1038/s41397-019-0143-8
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 5806: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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  3. Article ; Online: Carbamazepine-induced Stevens-Johnson syndrome/toxic epidermal necrolysis overlap in a Filipino with positive HLA-B75 serotype.

    Capule, Francis / Tragulpiankit, Pramote / Mahasirimongkol, Surakameth / Wichukchinda, Nuanjun / Jittikoon, Jiraphun / Alentajan-Aleta, Lara Theresa / James Barit, Jay-V / Casanova-Gutierrez, Josephine / Cabral-Lim, Leonor / Baltazar Reyes, Jose Paciano / Roa, Francisca / San Gabriel, Katrina Faith / Silao, Catherine Lynn

    BMJ case reports

    2018  Volume 2018

    Abstract: Stevens-Johnson syndrome (SJS) and toxic epidermal necrolysis (TEN) are two related mucocutaneous disorders with different severities. Although the incidence is low, SJS and TEN are life-threatening and predominantly drug-induced conditions. There is a ... ...

    Abstract Stevens-Johnson syndrome (SJS) and toxic epidermal necrolysis (TEN) are two related mucocutaneous disorders with different severities. Although the incidence is low, SJS and TEN are life-threatening and predominantly drug-induced conditions. There is a strong relationship between the
    MeSH term(s) Adult ; Antimanic Agents/adverse effects ; Carbamazepine/adverse effects ; HLA-B Antigens/blood ; Humans ; Male ; Mental Disorders/drug therapy ; Stevens-Johnson Syndrome/etiology ; Stevens-Johnson Syndrome/genetics
    Chemical Substances Antimanic Agents ; HLA-B Antigens ; HLA-B75 antigen ; Carbamazepine (33CM23913M)
    Language English
    Publishing date 2018-07-17
    Publishing country England
    Document type Case Reports ; Journal Article
    ISSN 1757-790X
    ISSN (online) 1757-790X
    DOI 10.1136/bcr-2018-225028
    Database MEDical Literature Analysis and Retrieval System OnLINE

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