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  1. AU="Balzarini, Piera"
  2. AU="Tim Edwards Powers"
  3. AU="Nils Hartmann"
  4. AU="Simionescu, Maya"
  5. AU="Feng, Yicheng"
  6. AU="Roger Le Grand"
  7. AU="Tesfalidet, Solomon"
  8. AU="Geladari, Eleni"
  9. AU="Pallabi Mustafi"
  10. AU=Mountfort Katrina
  11. AU="Horne, Patrick"
  12. AU="Mhurchu, Cliona Ni"
  13. AU="Yatoo, Ali Mohd"
  14. AU="Zhang, Zhiru"
  15. AU="Hadie Adams"
  16. AU="Gaskin, Thomas R"
  17. AU="Guo, Chong"
  18. AU="Guocan Wang"
  19. AU="Catherine Crenn-Hebert"
  20. AU="Alistar, Cristina F"
  21. AU="Makhani, Sarah S"
  22. AU="Tayyeb Pourfallah"
  23. AU="Mauad, Thais"

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  1. Artikel ; Online: Correction to: Large B-cell lymphoma with IRF4 rearrangement: a multi-centric study with focus on potential misleading phenotypes.

    Pizzi, Marco / Bongiovanni, Lucia / Lorenzi, Luisa / Righi, Simona / Scarmozzino, Federico / Balzarini, Piera / Santoro, Luisa / Mussolin, Lara / Carraro, Elisa / Pillon, Marta / Bonaldi, Laura / Vianello, Fabrizio / Agostinelli, Claudio / Ponzoni, Maurilio / Dei Tos, Angelo Paolo / Sabattini, Elena

    Virchows Archiv : an international journal of pathology

    2024  Band 484, Heft 3, Seite(n) 549

    Sprache Englisch
    Erscheinungsdatum 2024-01-30
    Erscheinungsland Germany
    Dokumenttyp Published Erratum
    ZDB-ID 1184867-4
    ISSN 1432-2307 ; 0945-6317
    ISSN (online) 1432-2307
    ISSN 0945-6317
    DOI 10.1007/s00428-024-03751-6
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  2. Artikel ; Online: Sclerotic Fibroma-Like Dermatofibrosarcoma Protuberans With Pleomorphic Sarcomatous Transformation: A Diagnostic Challenge.

    Saggini, Andrea / Cerroni, Lorenzo / Balzarini, Piera / di Prete, Monia / Lora, Viviana / Cota, Carlo

    The American Journal of dermatopathology

    2020  Band 43, Heft 4, Seite(n) 315–317

    Mesh-Begriff(e) Antigens, CD34/metabolism ; Cell Transformation, Neoplastic/pathology ; Dermatofibrosarcoma/diagnosis ; Dermatofibrosarcoma/genetics ; Dermatofibrosarcoma/metabolism ; Dermatofibrosarcoma/pathology ; Gene Rearrangement ; Humans ; Male ; Middle Aged ; Proto-Oncogene Proteins c-sis/genetics ; Sclerosis ; Skin/pathology ; Skin Neoplasms/diagnosis ; Skin Neoplasms/genetics ; Skin Neoplasms/metabolism ; Skin Neoplasms/pathology
    Chemische Substanzen Antigens, CD34 ; Proto-Oncogene Proteins c-sis
    Sprache Englisch
    Erscheinungsdatum 2020-07-28
    Erscheinungsland United States
    Dokumenttyp Case Reports ; Letter
    ZDB-ID 448469-1
    ISSN 1533-0311 ; 0193-1091
    ISSN (online) 1533-0311
    ISSN 0193-1091
    DOI 10.1097/DAD.0000000000001762
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  3. Artikel: Targeting mTOR Pathway in PTEN Deleted Newly Isolated Chordoma Cell Line.

    Pagani, Francesca / Gryzik, Magdalena / Somenza, Elena / Cominelli, Manuela / Balzarini, Piera / Schreiber, Alberto / Mattavelli, Davide / Nicolai, Piero / Doglietto, Francesco / Poliani, Pietro Luigi

    Journal of personalized medicine

    2023  Band 13, Heft 3

    Abstract: Chordomas are rare primary malignant tumours of notochordal origin usually arising along the axial skeleton with particular predilection of the skull base and sacrococcygeal region. Albeit usually slow-growing, chordomas can be aggressive mostly ... ...

    Abstract Chordomas are rare primary malignant tumours of notochordal origin usually arising along the axial skeleton with particular predilection of the skull base and sacrococcygeal region. Albeit usually slow-growing, chordomas can be aggressive mostly depending on their invasive behaviour and according to different histotypes and molecular alterations, including
    Sprache Englisch
    Erscheinungsdatum 2023-02-27
    Erscheinungsland Switzerland
    Dokumenttyp Journal Article
    ZDB-ID 2662248-8
    ISSN 2075-4426
    ISSN 2075-4426
    DOI 10.3390/jpm13030425
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  4. Artikel ; Online: MYC rearrangements in HIV-associated large B-cell lymphomas: EUROMYC, a European retrospective study.

    Pagani, Chiara / Rusconi, Chiara / Dalla Pria, Alessia / Ravano, Emanuele / Schommers, Philipp / Bastos-Oreiro, Mariana / Verga, Luisa / Gini, Guido / Spina, Michele / Arcaini, Luca / Steffanoni, Sara / Dalu, Davide / Crucitti, Lara / Lorenzi, Luisa / Balzarini, Piera / Cattaneo, Chiara / Bongiovanni, Lucia / Rosenwald, Andreas / Facchetti, Fabio /
    Bower, Mark / Ferreri, Andrés J M / Rossi, Giuseppe / Tucci, Alessandra / Re, Alessandro

    Blood advances

    2024  Band 8, Heft 4, Seite(n) 968–977

    Abstract: Abstract: Large B-cell lymphoma (LBCL) carrying MYC rearrangement, alone or together with BCL2 and/or BCL6 translocations, have shown a poor prognosis when treated with rituximab plus cyclophosphamide, doxorubicin, vincristine, and prednisone (R-CHOP) ... ...

    Abstract Abstract: Large B-cell lymphoma (LBCL) carrying MYC rearrangement, alone or together with BCL2 and/or BCL6 translocations, have shown a poor prognosis when treated with rituximab plus cyclophosphamide, doxorubicin, vincristine, and prednisone (R-CHOP) in the HIV population. Scanty data are available on the prevalence and prognostic impact of MYC rearrangements in HIV-associated LBCL. We conducted a retrospective study to evaluate the clinical effect of MYC rearrangement in HIV-associated LBCL. We evaluated clinical characteristics, treatment received, and outcome of LBCL in patients with HIV with MYC rearrangement (MYC+) and without MYC rearrangement (MYC-). A total of 155 patients with HIV who had received fluorescence in situ hybridization analysis for MYC were enrolled in 11 European centers: 43 with MYC+ and 112 MYC-. Among patients with MYC, 10 had double-/triple-hit lymphomas, and 33 had isolated MYC rearrangement (single-hit lymphoma). Patients with MYC+ had more frequently advanced stage, >2 extranodal site at presentation, and higher proliferative index. There were no significant differences in overall survival and progression-free survival (PFS) between the 2 groups. However, patients with MYC+ received more frequently intensive chemotherapy (iCT) (44%) than (R)CHOP alone (35%) or infusional treatment (DA-EPOCH-R and R-CDE) (19%). Among patients with MYC+, those who received iCT achieved a better outcome than patients who received nonintensive treatment (complete remission, 84% vs 52%; P = .028; 5-year PFS, 66% vs 36%; P = .021). Our retrospective results suggest that HIV-associated LBCL with MYC+ could be considered for an intensive therapeutic approach whenever possible, whereas (R)CHOP seems to give inferior results in this subset of patients in terms of complete remission and PFS.
    Mesh-Begriff(e) Humans ; Cyclophosphamide/therapeutic use ; HIV Infections/drug therapy ; HIV Infections/epidemiology ; In Situ Hybridization, Fluorescence ; Lymphoma, Large B-Cell, Diffuse/drug therapy ; Proto-Oncogene Proteins c-myc/genetics ; Retrospective Studies ; Rituximab/therapeutic use ; Vincristine/therapeutic use
    Chemische Substanzen Cyclophosphamide (8N3DW7272P) ; Proto-Oncogene Proteins c-myc ; Rituximab (4F4X42SYQ6) ; Vincristine (5J49Q6B70F) ; MYC protein, human
    Sprache Englisch
    Erscheinungsdatum 2024-01-10
    Erscheinungsland United States
    Dokumenttyp Journal Article
    ZDB-ID 2915908-8
    ISSN 2473-9537 ; 2473-9529
    ISSN (online) 2473-9537
    ISSN 2473-9529
    DOI 10.1182/bloodadvances.2023010704
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  5. Artikel ; Online: Correction to: Immunoglobulin light chain transcript detection by ultrasensitive RNA in situ hybridization for B-cell lymphoma diagnosis.

    Lorenzi, Luisa / Lonardi, Silvia / Bonezzi, Michela / Zini, Stefania / Bugatti, Mattia / Valzelli, Arianna / Melotti, Flavia / Facchetti, Mattia / Ghini, Iacopo / Villanacci, Vincenzo / Balzarini, Piera / Pizzi, Marco / Giustini, Viviana / Galvagni, Anna / Chiarini, Marco / Dei Tos, Angelo Paolo / Vermi, William / Casola, Stefano / Facchetti, Fabio

    Virchows Archiv : an international journal of pathology

    2023  

    Sprache Englisch
    Erscheinungsdatum 2023-11-16
    Erscheinungsland Germany
    Dokumenttyp Published Erratum
    ZDB-ID 1184867-4
    ISSN 1432-2307 ; 0945-6317
    ISSN (online) 1432-2307
    ISSN 0945-6317
    DOI 10.1007/s00428-023-03705-4
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  6. Artikel ; Online: Large B-cell lymphoma with IRF4 rearrangement: a multi-centric study with focus on potential misleading phenotypes.

    Pizzi, Marco / Bongiovanni, Lucia / Lorenzi, Luisa / Righi, Simona / Scarmozzino, Federico / Balzarini, Piera / Santoro, Luisa / Mussolin, Lara / Carraro, Elisa / Pillon, Marta / Bonaldi, Laura / Vianello, Fabrizio / Agostinelli, Claudio / Ponzoni, Maurilio / Dei Tos, Angelo Paolo / Sabattini, Elena

    Virchows Archiv : an international journal of pathology

    2023  Band 484, Heft 3, Seite(n) 521–526

    Abstract: Large B-cell lymphoma with IRF4 rearrangement (LBCL-IRF4) is a rare lymphoid neoplasm, usually occurring in the pediatric/young-adult age. Despite this, subsets of cases occur in elderly patients and express CD5, possibly entering the differential ... ...

    Abstract Large B-cell lymphoma with IRF4 rearrangement (LBCL-IRF4) is a rare lymphoid neoplasm, usually occurring in the pediatric/young-adult age. Despite this, subsets of cases occur in elderly patients and express CD5, possibly entering the differential diagnosis with adult aggressive lymphomas, such as blastoid/pleomorphic mantle cell lymphoma (MCL-B/P). To better characterize the clinical-pathological features and differential diagnosis of LBCL-IRF4, we conducted a multi-centric study on 12 cases, focusing on CD5, Cyclin D1, and SOX11 expression. While most cases had typical presentation, adult-to-elderly age at diagnosis and unusual anatomic locations were reported in 3/12 (25.0%) and 2/12 (16.7%) patients, respectively. Histologically, CD5 was positive in 4/12 (33.3%) cases, Cyclin D1 was invariably negative, and SOX11 was weakly/partially expressed in 1/12 (8.3%) case. In conclusion, LBCL-IRF4 can have unconventional clinical presentations that may challenge its recognition. Although CD5 is frequently expressed, negativity for Cyclin D1 and SOX11 contributes to the differential diagnosis with MCL-B/P.
    Mesh-Begriff(e) Adult ; Humans ; Child ; Aged ; Cyclin D1/genetics ; Lymphoma, Mantle-Cell/diagnosis ; Lymphoma, Mantle-Cell/genetics ; Lymphoma, Mantle-Cell/pathology ; Lymphoma, Large B-Cell, Diffuse/pathology ; Diagnosis, Differential ; Phenotype
    Chemische Substanzen Cyclin D1 (136601-57-5)
    Sprache Englisch
    Erscheinungsdatum 2023-11-14
    Erscheinungsland Germany
    Dokumenttyp Journal Article
    ZDB-ID 1184867-4
    ISSN 1432-2307 ; 0945-6317
    ISSN (online) 1432-2307
    ISSN 0945-6317
    DOI 10.1007/s00428-023-03689-1
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  7. Artikel ; Online: Immunoglobulin light chain transcript detection by ultrasensitive RNA in situ hybridization for B-cell lymphoma diagnosis.

    Lorenzi, Luisa / Lonardi, Silvia / Bonezzi, Michela / Zini, Stefania / Bugatti, Mattia / Valzelli, Arianna / Melotti, Flavia / Facchetti, Mattia / Ghini, Iacopo / Villanacci, Vincenzo / Balzarini, Piera / Pizzi, Marco / Giustini, Viviana / Galvagni, Anna / Chiarini, Marco / Dei Tos, Angelo Paolo / Vermi, William / Casola, Stefano / Facchetti, Fabio

    Virchows Archiv : an international journal of pathology

    2023  

    Abstract: Evaluation of B-cell clonality can be challenging in the interpretation of lymphoid infiltrates on tissue sections. Clonality testing based on IG gene rearrangements analysis by PCR (IG-PCR) is the gold standard. Alternatively, B-cell clonality can be ... ...

    Abstract Evaluation of B-cell clonality can be challenging in the interpretation of lymphoid infiltrates on tissue sections. Clonality testing based on IG gene rearrangements analysis by PCR (IG-PCR) is the gold standard. Alternatively, B-cell clonality can be assessed by the recognition of immunoglobulin light chain (IgLC) restriction, by immunohistochemistry (IHC), chromogenic in situ hybridization (ISH) or flow cytometry (FC). IG-PCR requires molecular facilities, and FC requires cell suspensions, both not widely available in routine pathology units. This study evaluates the performance of B-cell clonality detection by IgLC-RNAscope® (RNAsc) in a group of 216 formalin-fixed, paraffin-embedded samples including 185 non-Hodgkin B-cell lymphomas, 11 Hodgkin lymphomas (HL) and 20 reactive samples. IgLC-RNAsc, performed in parallel with FC in 53 cases, demonstrated better performances (93% vs 83%), particularly in diffuse large B-cell lymphoma (98% vs 71%) and follicular lymphoma (93% vs 83%) diagnosis. IgLC-RNAsc was also superior to IHC and ISH especially in samples with limited tumor cell content, where IG-PCR was not informative. Performed for the first time on mediastinal lymphomas, IgLC-RNAsc identified monotypic IgLC transcripts in 69% of primary mediastinal large B-cell lymphoma (PMBCL) and 67% of mediastinal gray zone lymphomas (MGZL). IGK/L double-negative cells were detected in 1 PMBCL, 2 MGZL, and all classical HL, while monotypic IgLC expression appeared to be a hallmark in nodular lymphocyte-predominant HL. IgLC-RNAsc demonstrates to be a powerful tool in B-cell lymphoma diagnosis, above all in challenging cases with limited tumor cell content, ensuring in situ investigations on mechanisms of Ig regulation across lymphoma entities.
    Sprache Englisch
    Erscheinungsdatum 2023-10-26
    Erscheinungsland Germany
    Dokumenttyp Journal Article
    ZDB-ID 1184867-4
    ISSN 1432-2307 ; 0945-6317
    ISSN (online) 1432-2307
    ISSN 0945-6317
    DOI 10.1007/s00428-023-03682-8
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  8. Artikel ; Online: Massive parallel sequencing unveils homologous recombination deficiency in follicular dendritic cell sarcoma.

    Lorenzi, Luisa / Haferlach, Torsten / Mori, Luigi / Simbeni, Matteo / Walter, Wencke / Balzarini, Piera / Meggendorfer, Manja / Döring, Claudia / Lonardi, Silvia / Bugatti, Mattia / Agostinelli, Claudio / Mehta, Jay / Borges, Anita / Agaimy, Abbas / Simonitsch-Klupp, Ingrid / Cabeçadas, José / Campo, Elias / Pileri, Stefano Aldo / Facchetti, Fabio /
    Leo Hansmann, Martin / Hartmann, Sylvia

    Haematologica

    2023  

    Abstract: Standardized treatment options are lacking for patients with unresectable or multifocal follicular dendritic cell sarcoma (FDCS) and disease-related mortality is as high as 20%. Applying whole genome sequencing (WGS) in one case and whole exome ... ...

    Abstract Standardized treatment options are lacking for patients with unresectable or multifocal follicular dendritic cell sarcoma (FDCS) and disease-related mortality is as high as 20%. Applying whole genome sequencing (WGS) in one case and whole exome sequencing (WES) in additional twelve, this study adds information on the molecular landscape of FDCS, expanding knowledge on pathobiological mechanisms and identifying novel markers of potential theragnostic significance. Massive parallel sequencing showed high frequency of mutations on oncosuppressor genes, particularly in RB1, CARS and BRCA2 and unveiled alterations on homologous recombination DNA damage repair related genes in 70% (9/13) of cases. This indicates that patients with high stage FDCS may be eligible for poly ADP ribose polymerase inhibition protocols. Low tumor mutational burden was confirmed in this study despite common PDL1 expression in FDCS arguing on the efficacy of immune checkpoint inhibitors. CDKN2A deletion, detected by WGS and confirmed by FISH in 41% of cases (9/22) indicates that impairment of cell cycle regulation may sustain oncogenesis in FDCS. Absence of mutations in the RAS/RAF/MAPK pathway and lack of clonal hematopoiesis related mutations in FDCS sanction its differences from dendritic cell-derived neoplasms of haematopoietic derivation. WGS and WES in FDCS provides additional information on the molecular landscape of this rare tumor, proposing novel candidate genes for innovative therapeutical approaches to improve survival of patients with multifocal disease.
    Sprache Englisch
    Erscheinungsdatum 2023-11-23
    Erscheinungsland Italy
    Dokumenttyp Journal Article
    ZDB-ID 2333-4
    ISSN 1592-8721 ; 0017-6567 ; 0390-6078
    ISSN (online) 1592-8721
    ISSN 0017-6567 ; 0390-6078
    DOI 10.3324/haematol.2023.283669
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  9. Artikel ; Online: Spatial transcriptome of a germinal center plasmablastic burst hints at MYD88/CD79B mutants-enriched diffuse large B-cell lymphomas.

    L'Imperio, Vincenzo / Morello, Gaia / Vegliante, Maria Carmela / Cancila, Valeria / Bertolazzi, Giorgio / Mazzara, Saveria / Belmonte, Beatrice / Mangogna, Alessandro / Balzarini, Piera / Corral, Lilia / Lopez, Gianluca / Di Napoli, Arianna / Facchetti, Fabio / Pagni, Fabio / Tripodo, Claudio

    European journal of immunology

    2022  Band 52, Heft 8, Seite(n) 1350–1361

    Abstract: The GC reaction results in the selection of B cells acquiring effector Ig secreting ability by progressing toward plasmablastic differentiation. This transition is associated with exclusion from the GC microenvironment. The aberrant expansion of ... ...

    Abstract The GC reaction results in the selection of B cells acquiring effector Ig secreting ability by progressing toward plasmablastic differentiation. This transition is associated with exclusion from the GC microenvironment. The aberrant expansion of plasmablastic elements within the GC fringes configures an atypical condition, the biological characteristics of which have not been defined yet. We investigated the in situ immunophenotypical and transcriptional characteristics of a nonclonal germinotropic expansion of plasmablastic elements (GEx) occurring in the tonsil of a young patient. Compared to neighboring GC and perifollicular regions, the GEx showed a distinctive signature featuring key regulators of plasmacytic differentiation, cytokine signaling, and cell metabolism. The GEx signature was tested in the setting of diffuse large B-cell lymphoma (DLBCL) as a prototypical model of lymphomagenesis encompassing transformation at different stages of GC and post-GC functional differentiation. The signature outlined DLBCL clusters with different immune microenvironment composition and enrichment in genetic subtypes. This report represents the first insight into the transcriptional features of a germinotropic plasmablastic burst, shedding light into the molecular hallmarks of B cells undergoing plasmablastic differentiation and aberrant expansion within the noncanonical setting of the GC microenvironment.
    Mesh-Begriff(e) CD79 Antigens/genetics ; CD79 Antigens/metabolism ; Germinal Center/metabolism ; Humans ; Lymphoma, Large B-Cell, Diffuse/genetics ; Lymphoma, Large B-Cell, Diffuse/metabolism ; Lymphoma, Large B-Cell, Diffuse/pathology ; Myeloid Differentiation Factor 88/genetics ; Myeloid Differentiation Factor 88/metabolism ; Plasma Cells/metabolism ; Transcriptome ; Tumor Microenvironment/genetics
    Chemische Substanzen CD79 Antigens ; CD79B protein, human ; Myeloid Differentiation Factor 88
    Sprache Englisch
    Erscheinungsdatum 2022-06-15
    Erscheinungsland Germany
    Dokumenttyp Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 120108-6
    ISSN 1521-4141 ; 0014-2980
    ISSN (online) 1521-4141
    ISSN 0014-2980
    DOI 10.1002/eji.202149746
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  10. Artikel ; Online: Novel cellular systems unveil mucosal melanoma initiating cells and a role for PI3K/Akt/mTOR pathway in mucosal melanoma fitness.

    Monti, Matilde / Benerini Gatta, Luisa / Bugatti, Mattia / Pezzali, Irene / Picinoli, Sara / Manfredi, Marcello / Lavazza, Antonio / Vanella, Virginia Vita / De Giorgis, Veronica / Zanatta, Lucia / Missale, Francesco / Lonardi, Silvia / Zanetti, Benedetta / Bozzoni, Giovanni / Cadei, Moris / Abate, Andrea / Vergani, Barbara / Balzarini, Piera / Battocchio, Simonetta /
    Facco, Carla / Turri-Zanoni, Mario / Castelnuovo, Paolo / Nicolai, Piero / Fonsatti, Ester / Leone, Biagio Eugenio / Marengo, Emilio / Sigala, Sandra / Ronca, Roberto / Perego, Michela / Lombardi, Davide / Vermi, William

    Journal of translational medicine

    2024  Band 22, Heft 1, Seite(n) 35

    Abstract: Background: Mucosal Melanomas (MM) are highly aggressive neoplasms arising from mucosal melanocytes. Current treatments offer a limited survival benefit for patients with advanced MM; moreover, the lack of pre-clinical cellular systems has significantly ...

    Abstract Background: Mucosal Melanomas (MM) are highly aggressive neoplasms arising from mucosal melanocytes. Current treatments offer a limited survival benefit for patients with advanced MM; moreover, the lack of pre-clinical cellular systems has significantly limited the understanding of their immunobiology.
    Methods: Five novel cell lines were obtained from patient-derived biopsies of MM arising in the sino-nasal mucosa and designated as SN-MM1-5. The morphology, ultrastructure and melanocytic identity of SN-MM cell lines were validated by transmission electron microscopy and immunohistochemistry. Moreover, in vivo tumorigenicity of SN-MM1-5 was tested by subcutaneous injection in NOD/SCID mice. Molecular characterization of SN-MM cell lines was performed by a mass-spectrometry proteomic approach, and their sensitivity to PI3K chemical inhibitor LY294002 was validated by Akt activation, measured by pAkt(Ser473) and pAkt(Thr308) in immunoblots, and MTS assay.
    Results: This study reports the validation and functional characterization of five newly generated SN-MM cell lines. Compared to the normal counterpart, the proteomic profile of SN-MM is consistent with transformed melanocytes showing a heterogeneous degree of melanocytic differentiation and activation of cancer-related pathways. All SN-MM cell lines resulted tumorigenic in vivo and display recurrent structural variants according to aCGH analysis. Of relevance, the microscopic analysis of the corresponding xenotransplants allowed the identification of clusters of MITF-/CDH1-/CDH2 + /ZEB1 + /CD271 + cells, supporting the existence of melanoma-initiating cells also in MM, as confirmed in clinical samples. In vitro, SN-MM cell lines were sensitive to cisplatin, but not to temozolomide. Moreover, the proteomic analysis of SN-MM cell lines revealed that RICTOR, a subunit of mTORC2 complex, is the most significantly activated upstream regulator, suggesting a relevant role for the PI3K-Akt-mTOR pathway in these neoplasms. Consistently, phosphorylation of NDRG1 and Akt activation was observed in SN-MM, the latter being constitutive and sustained by PTEN loss in SN-MM2 and SN-MM3. The cell viability impairment induced by LY294002 confirmed a functional role for the PI3K-Akt-mTOR pathway in SN-MM cell lines.
    Conclusions: Overall, these novel and unique cellular systems represent relevant experimental tools for a better understanding of the biology of these neoplasms and, as an extension, to MM from other sites.
    Mesh-Begriff(e) Mice ; Animals ; Humans ; Mice, Inbred NOD ; Mice, SCID ; Melanoma ; Phosphatidylinositol 3-Kinases ; Proto-Oncogene Proteins c-akt ; Proteomics ; TOR Serine-Threonine Kinases
    Chemische Substanzen Phosphatidylinositol 3-Kinases (EC 2.7.1.-) ; Proto-Oncogene Proteins c-akt (EC 2.7.11.1) ; TOR Serine-Threonine Kinases (EC 2.7.11.1)
    Sprache Englisch
    Erscheinungsdatum 2024-01-08
    Erscheinungsland England
    Dokumenttyp Journal Article
    ZDB-ID 2118570-0
    ISSN 1479-5876 ; 1479-5876
    ISSN (online) 1479-5876
    ISSN 1479-5876
    DOI 10.1186/s12967-023-04784-2
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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