Article ; Online: Copper Metabolism and Cuproptosis: Molecular Mechanisms and Therapeutic Perspectives in Neurodegenerative Diseases.
2024 Volume 44, Issue 1, Page(s) 28–50
Abstract: Copper is an essential trace element, and plays a vital role in numerous physiological processes within the human body. During normal metabolism, the human body maintains copper homeostasis. Copper deficiency or excess can adversely affect cellular ... ...
| Abstract | Copper is an essential trace element, and plays a vital role in numerous physiological processes within the human body. During normal metabolism, the human body maintains copper homeostasis. Copper deficiency or excess can adversely affect cellular function. Therefore, copper homeostasis is stringently regulated. Recent studies suggest that copper can trigger a specific form of cell death, namely, cuproptosis, which is triggered by excessive levels of intracellular copper. Cuproptosis induces the aggregation of mitochondrial lipoylated proteins, and the loss of iron-sulfur cluster proteins. In neurodegenerative diseases, the pathogenesis and progression of neurological disorders are linked to copper homeostasis. This review summarizes the advances in copper homeostasis and cuproptosis in the nervous system and neurodegenerative diseases. This offers research perspectives that provide new insights into the targeted treatment of neurodegenerative diseases based on cuproptosis. |
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| MeSH term(s) | Humans ; Neurodegenerative Diseases/drug therapy ; Copper ; Cell Death ; Mitochondrial Proteins |
| Chemical Substances | Copper (789U1901C5) ; Mitochondrial Proteins |
| Language | English |
| Publishing date | 2024-02-10 |
| Publishing country | China |
| Document type | Review ; Journal Article |
| ZDB-ID | 2931065-9 |
| ISSN | 2523-899X ; 2096-5230 |
| ISSN (online) | 2523-899X |
| ISSN | 2096-5230 |
| DOI | 10.1007/s11596-024-2832-z |
| Database | MEDical Literature Analysis and Retrieval System OnLINE |
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