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  1. Book: Infection and immunity

    Playfair, John H. L. / Bancroft, Gregory J.

    2008  

    Author's details John H. L. Playfair ; Gregory J. Bancroft
    Keywords Immunity / immunology ; Immune System ; Infection ; Immunology
    Subject code 616.079
    Language English
    Size XVI, 341 S. : Ill., 25cm
    Edition 3. ed.
    Publisher Oxford Univ. Press
    Publishing place Oxford u.a.
    Publishing country Great Britain
    Document type Book
    Note Includes bibliographical references and index. - Previous ed.: 1995. - Formerly CIP
    Remark 2008 A 2122
    HBZ-ID HT015320352
    ISBN 978-0-19-920673-5 ; 0-19-920673-2
    Database Catalogue ZB MED Medicine, Health

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    2008 A 2122 order for loan Magazin

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  2. Book: The SCID mouse

    Bancroft, Gregory J.

    (Immunological reviews ; 124)

    1991  

    Author's details [G. J. Bancroft ...]
    Series title Immunological reviews ; 124
    Collection
    Keywords Mice, SCID
    Language English
    Size 220 S. : Ill., graph. Darst.
    Publisher Munksgaard
    Publishing place Copenhagen
    Publishing country Denmark
    Document type Book
    HBZ-ID HT003972546
    Database Catalogue ZB MED Medicine, Health

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  3. Book: Infection and immunity

    Playfair, John H. L. / Bancroft, Gregory J.

    2005  

    Author's details John H. L. Playfair ; Gregory J. Bancroft
    Keywords Immunity / immunology ; Immune System ; Infection ; Immunology
    Subject code 616.079
    Language English
    Size XVI, 312 S. : Ill., 25cm
    Edition 2. ed., reprint
    Publisher Oxford Univ. Press
    Publishing place Oxford
    Publishing country Great Britain
    Document type Book
    Note Includes bibliographical references and index. - Previous ed.: 1995. - Formerly CIP
    HBZ-ID HT014469437
    ISBN 0-19-926495-3 ; 978-0-19-926495-7
    Database Catalogue ZB MED Medicine, Health

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    In stock of ZB MED Cologne/Königswinter

    Shelf markLoan statusLocation
    2005 A 3850 order for loan Magazin

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  4. Article ; Online: Glibenclamide alters interleukin-8 and interleukin-1β of primary human monocytes from diabetes patients against Mycobacterium tuberculosis infection.

    Kewcharoenwong, Chidchamai / Saenwongsa, Wipawee / Willcocks, Samuel J / Bancroft, Gregory J / Fletcher, Helen A / Lertmemongkolchai, Ganjana

    Tuberculosis (Edinburgh, Scotland)

    2020  Volume 123, Page(s) 101939

    Abstract: Type 2 diabetes mellitus (T2DM) is an important risk factor for development of tuberculosis (TB). Our previous study showed glibenclamide, an anti-diabetic drug used to control blood glucose concentration, reduced interleukin (IL)-8 secretion from ... ...

    Abstract Type 2 diabetes mellitus (T2DM) is an important risk factor for development of tuberculosis (TB). Our previous study showed glibenclamide, an anti-diabetic drug used to control blood glucose concentration, reduced interleukin (IL)-8 secretion from primary human monocytes challenged with M. tuberculosis (Mtb). In mice infected with Mtb, IL-1β is essential for host resistance through the enhancement of cyclooxygenase that limits excessive Type I interferon (IFN) production and fosters Mtb containment. We hypothesize that glibenclamide may also interfere with monocyte mediated immune responses against Mtb and alter the balance between IL-1β and IFNα-mediated immunity. Purified monocytes from non-diabetic and diabetic individuals were infected with Mtb or M. bovis BCG. We demonstrate that monocytes from diabetes patients who were being treated with glibenclamide showed reduced IL-1β and IL-8 secretion when exposed to Mtb. Additionally, these responses also occurred when monocytes from non-diabetic individuals were pre-treated with glibenclamide in vitro. Moreover, this pre-treatment enhanced IFNa1 expression but was not involved with prostaglandin E2 (PGE2) expression in response to Mtb infection. Taken together, our data show that glibenclamide might exacerbate susceptibility of diabetes patients to Mtb infection by reducing IL-1β and IL-8 production by monocytes.
    MeSH term(s) Adult ; Aged ; Case-Control Studies ; Cells, Cultured ; Diabetes Mellitus, Type 2/blood ; Diabetes Mellitus, Type 2/drug therapy ; Diabetes Mellitus, Type 2/immunology ; Dinoprostone/metabolism ; Female ; Glyburide/toxicity ; Host-Pathogen Interactions ; Humans ; Hypoglycemic Agents/toxicity ; Interferon-alpha/metabolism ; Interleukin-1beta/metabolism ; Interleukin-8/metabolism ; Male ; Middle Aged ; Monocytes/drug effects ; Monocytes/immunology ; Monocytes/metabolism ; Monocytes/microbiology ; Mycobacterium bovis/immunology ; Mycobacterium bovis/pathogenicity ; Mycobacterium tuberculosis/immunology ; Mycobacterium tuberculosis/pathogenicity ; Risk Assessment ; Tuberculosis/immunology ; Tuberculosis/microbiology
    Chemical Substances CXCL8 protein, human ; Hypoglycemic Agents ; IL1B protein, human ; Ifna1 protein, mouse ; Interferon-alpha ; Interleukin-1beta ; Interleukin-8 ; Dinoprostone (K7Q1JQR04M) ; Glyburide (SX6K58TVWC)
    Language English
    Publishing date 2020-05-15
    Publishing country Scotland
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2046804-0
    ISSN 1873-281X ; 1472-9792
    ISSN (online) 1873-281X
    ISSN 1472-9792
    DOI 10.1016/j.tube.2020.101939
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Burkholderia pseudomallei and Burkholderia mallei vaccines: Are we close to clinical trials?

    Titball, Richard W / Burtnick, Mary N / Bancroft, Gregory J / Brett, Paul

    Vaccine

    2017  Volume 35, Issue 44, Page(s) 5981–5989

    Abstract: B. pseudomallei is the cause of melioidosis, a serious an often fatal disease of humans and animals. The closely related bacterium B. mallei, which cases glanders, is considered to be a clonal derivative of B. pseudomallei. Both B. pseudomallei and B. ... ...

    Abstract B. pseudomallei is the cause of melioidosis, a serious an often fatal disease of humans and animals. The closely related bacterium B. mallei, which cases glanders, is considered to be a clonal derivative of B. pseudomallei. Both B. pseudomallei and B. mallei were evaluated by the United States and the former USSR as potential bioweapons. Much of the effort to devise biodefence vaccines in the past decade has been directed towards the identification and formulation of sub-unit vaccines which could protect against both melioidosis and glanders. A wide range of proteins and polysaccharides have been identified which protective immunity in mice. In this review we highlight the significant progress that has been made in developing glycoconjugates as sub-unit vaccines. We also consider some of the important the criteria for licensing, including the suitability of the "animal rule" for assessing vaccine efficacy, the protection required from a vaccine and the how correlates of protection will be identified. Vaccines developed for biodefence purposes could also be used in regions of the world where naturally occurring disease is endemic.
    Language English
    Publishing date 2017-10-20
    Publishing country Netherlands
    Document type Journal Article ; Review
    ZDB-ID 605674-x
    ISSN 1873-2518 ; 0264-410X
    ISSN (online) 1873-2518
    ISSN 0264-410X
    DOI 10.1016/j.vaccine.2017.03.022
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Jg. 1995 - 2021: Lesesall (1.OG)
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    Zs.MO 458: Show issues

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  6. Article ; Online: Immune responses in beta-thalassaemia: heme oxygenase 1 reduces cytokine production and bactericidal activity of human leucocytes.

    Nithichanon, Arnone / Tussakhon, Inthira / Samer, Waraporn / Kewcharoenwong, Chidchamai / Ato, Manabu / Bancroft, Gregory J / Lertmemongkolchai, Ganjana

    Scientific reports

    2020  Volume 10, Issue 1, Page(s) 10297

    Abstract: Patients with beta-thalassaemia increase the risk of bacterial infections, particularly Burkholderia pseudomallei (Bp), the causative agent of melioidosis in Thailand. Impaired immune cell functions may be the cause of this susceptibility, but detailed ... ...

    Abstract Patients with beta-thalassaemia increase the risk of bacterial infections, particularly Burkholderia pseudomallei (Bp), the causative agent of melioidosis in Thailand. Impaired immune cell functions may be the cause of this susceptibility, but detailed mechanisms have not been defined. In this study, we observed impaired production of IFN-gamma and IL-10 by whole blood from beta-thalassaemia patients upon stimulation with a range of bacteria-derived stimuli. In contrast, IFN-gamma response via TCR and plasma IgG specific for Bp were still intact. Importantly, mRNA expression of heme oxygenase 1 (HO-1), a potential modulator of immune function, was increased in whole blood from beta-thalassaemia patients, either with or without stimulation with Bp in vitro. Induction of HO-1 by hemin or CoPP in vitro reduced production of IFN-gamma and IL-10 from healthy human PBMCs and decreased bacterial clearance activity of whole blood from healthy controls and beta-thalassaemia, while inhibition of HO-1 by SnPP enhanced both functions in healthy controls. These results were confirmed to some extent in purified human monocytes of healthy controls. Our results suggest a mechanism that excess hemin of beta-thalassaemia patients is a significant cause of immune suppression via HO-1 induction and may underlie the susceptibility of these individuals to severe bacterial infection.
    MeSH term(s) Adult ; Aged ; Burkholderia pseudomallei/immunology ; Cells, Cultured ; Female ; Healthy Volunteers ; Heme Oxygenase-1/genetics ; Heme Oxygenase-1/metabolism ; Humans ; Immune Tolerance ; Interferon-gamma/metabolism ; Interleukin-10/metabolism ; Leukocytes, Mononuclear/immunology ; Leukocytes, Mononuclear/metabolism ; Male ; Melioidosis/immunology ; Melioidosis/microbiology ; Middle Aged ; Primary Cell Culture ; RNA, Messenger/isolation & purification ; Real-Time Polymerase Chain Reaction ; Thailand ; Young Adult ; beta-Thalassemia/blood ; beta-Thalassemia/complications ; beta-Thalassemia/immunology
    Chemical Substances IFNG protein, human ; IL10 protein, human ; RNA, Messenger ; Interleukin-10 (130068-27-8) ; Interferon-gamma (82115-62-6) ; HMOX1 protein, human (EC 1.14.14.18) ; Heme Oxygenase-1 (EC 1.14.14.18)
    Language English
    Publishing date 2020-06-24
    Publishing country England
    Document type Journal Article ; Observational Study ; Research Support, Non-U.S. Gov't
    ZDB-ID 2615211-3
    ISSN 2045-2322 ; 2045-2322
    ISSN (online) 2045-2322
    ISSN 2045-2322
    DOI 10.1038/s41598-020-67346-2
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: Glibenclamide Reduces Primary Human Monocyte Functions Against Tuberculosis Infection by Enhancing M2 Polarization.

    Kewcharoenwong, Chidchamai / Prabowo, Satria A / Bancroft, Gregory J / Fletcher, Helen A / Lertmemongkolchai, Ganjana

    Frontiers in immunology

    2018  Volume 9, Page(s) 2109

    Abstract: Tuberculosis (TB) is a global public health problem, which is caused ... ...

    Abstract Tuberculosis (TB) is a global public health problem, which is caused by
    MeSH term(s) Adult ; Aged ; Cells, Cultured ; Diabetes Mellitus, Type 2/complications ; Diabetes Mellitus, Type 2/drug therapy ; Diabetes Mellitus, Type 2/immunology ; Female ; Glyburide/pharmacology ; Humans ; Hypoglycemic Agents/pharmacology ; Lectins, C-Type/immunology ; Lectins, C-Type/metabolism ; Macrophage Activation/drug effects ; Macrophage Activation/immunology ; Macrophages/immunology ; Macrophages/metabolism ; Male ; Mannose-Binding Lectins/immunology ; Mannose-Binding Lectins/metabolism ; Middle Aged ; Monocytes/immunology ; Monocytes/metabolism ; Mycobacterium tuberculosis/immunology ; Mycobacterium tuberculosis/physiology ; Receptors, Cell Surface/immunology ; Receptors, Cell Surface/metabolism ; Tuberculosis/complications ; Tuberculosis/immunology ; Tuberculosis/microbiology
    Chemical Substances Hypoglycemic Agents ; Lectins, C-Type ; Mannose-Binding Lectins ; Receptors, Cell Surface ; mannose receptor ; Glyburide (SX6K58TVWC)
    Language English
    Publishing date 2018-09-19
    Publishing country Switzerland
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2606827-8
    ISSN 1664-3224 ; 1664-3224
    ISSN (online) 1664-3224
    ISSN 1664-3224
    DOI 10.3389/fimmu.2018.02109
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Book: Infection and immunity

    Playfair, J. H. L / Bancroft, Gregory J

    2013  

    Title variant Infection & immunity
    Author's details John H.L. Playfair, Gregory J. Bancroft
    MeSH term(s) Immunity/immunology ; Immune System ; Infection
    Language English
    Size xvi, 381 pages :, illustrations
    Edition Fourth edition.
    Document type Book
    ISBN 9780199609505 ; 0199609500
    Database Catalogue of the US National Library of Medicine (NLM)

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  9. Book: Infection and immunity

    Playfair, John H. L / Bancroft, Gregory J

    2013  

    Author's details John H. L. Playfair; Gregory J. Bancroft
    Keywords Immunology ; Infection
    Language English
    Size XVI, 381 S., Ill., graph. Darst.
    Edition 4. ed.
    Publisher Oxford Univ. Press
    Publishing place Oxford
    Document type Book
    Note Literaturangaben ; Previous ed.: 2008
    ISBN 0199609500 ; 9780199609505
    Database Former special subject collection: coastal and deep sea fishing

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  10. Article ; Online: Boosting of post-exposure human T-cell and B-cell recall responses in vivo by Burkholderia pseudomallei-related proteins.

    Nithichanon, Arnone / Gourlay, Louise J / Bancroft, Gregory J / Ato, Manabu / Takahashi, Yoshimasa / Lertmemongkolchai, Ganjana

    Immunology

    2017  Volume 151, Issue 1, Page(s) 98–109

    Abstract: Burkholderia pseudomallei is the causative agent of melioidosis, an infectious disease with high incidence and mortality in South East Asia and northern Australia. To date there is no protective vaccine and antibiotic treatment is prolonged and not ... ...

    Abstract Burkholderia pseudomallei is the causative agent of melioidosis, an infectious disease with high incidence and mortality in South East Asia and northern Australia. To date there is no protective vaccine and antibiotic treatment is prolonged and not always effective. Most people living in endemic areas have been exposed to the bacteria and have developed some immunity, which may have helped to prevent disease. Here, we used a humanized mouse model (hu-PBL-SCID), reconstituted with human peripheral blood mononuclear cells from seropositive donors, to illustrate the potential of three known antigens (FliC, OmpA and N-PilO2) for boosting both T-cell and B-cell immune responses. All three antigens boosted the production of specific antibodies in vivo, and increased the number of antibody and interferon-γ-secreting cells, and induced antibody affinity maturation. Moreover, antigen-specific antibodies isolated from either seropositive individuals or boosted mice, were found to enhance phagocytosis and oxidative burst activities from human polymorphonuclear cells. Our study demonstrates that FliC, OmpA and N-PilO2 can stimulate human memory T and B cells and highlight the potential of the hu-PBL-SCID system for screening and evaluation of novel protein antigens for inclusion in future vaccine trials against melioidosis.
    MeSH term(s) Adoptive Transfer ; Animals ; Antibodies, Bacterial/blood ; B-Lymphocytes/immunology ; B-Lymphocytes/microbiology ; Bacterial Outer Membrane Proteins/immunology ; Bacterial Vaccines/immunology ; Burkholderia pseudomallei/immunology ; Cells, Cultured ; Endemic Diseases ; Fimbriae Proteins/immunology ; Flagellin/immunology ; Humans ; Interferon-gamma/metabolism ; Lymphocyte Activation ; Melioidosis/epidemiology ; Melioidosis/immunology ; Mice ; Mice, SCID ; T-Lymphocytes/immunology ; T-Lymphocytes/microbiology ; Thailand
    Chemical Substances Antibodies, Bacterial ; Bacterial Outer Membrane Proteins ; Bacterial Vaccines ; Flagellin (12777-81-0) ; Fimbriae Proteins (147680-16-8) ; OMPA outer membrane proteins (149024-69-1) ; Interferon-gamma (82115-62-6)
    Language English
    Publishing date 2017-05
    Publishing country England
    Document type Journal Article
    ZDB-ID 80124-0
    ISSN 1365-2567 ; 0019-2805 ; 0953-4954
    ISSN (online) 1365-2567
    ISSN 0019-2805 ; 0953-4954
    DOI 10.1111/imm.12709
    Database MEDical Literature Analysis and Retrieval System OnLINE

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