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  1. Article ; Online: Dehydration, Rehydration and Thermal Treatment: Effect on Bioactive Compounds of Red Seaweeds

    Pires, Carla / Sapatinha, Maria / Mendes, Rogério / Bandarra, Narcisa M / Gonçalves, Amparo

    Marine drugs

    2024  Volume 22, Issue 4

    Abstract: The nutritional and bioactive value of seaweeds is widely recognized, making them a valuable food source. To use seaweeds as food, drying and thermal treatments are required, but these treatments may have a negative impact on valuable bioactive compounds. ...

    Abstract The nutritional and bioactive value of seaweeds is widely recognized, making them a valuable food source. To use seaweeds as food, drying and thermal treatments are required, but these treatments may have a negative impact on valuable bioactive compounds. In this study, the effects of dehydration, rehydration, and thermal treatment on the bioactive compounds (carotenoids, phycobiliproteins, total phenolic content (TPC), total flavonoids content (TFC)), antioxidant (ABTS and DPPH radical scavenging activities) and anti-Alzheimer's (Acetylcholinesterase (AchE) inhibitory activities, and color properties of
    MeSH term(s) Antioxidants/chemistry ; Carotenoids/chemistry ; Cholinesterase Inhibitors/chemistry ; Desiccation ; Edible Seaweeds ; Flavonoids/chemistry ; Hot Temperature ; Phenols/chemistry ; Phycobiliproteins ; Porphyra/chemistry ; Seaweed/chemistry
    Chemical Substances Antioxidants ; Carotenoids (36-88-4) ; Cholinesterase Inhibitors ; Flavonoids ; Phenols ; Phycobiliproteins
    Language English
    Publishing date 2024-04-09
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2175190-0
    ISSN 1660-3397 ; 1660-3397
    ISSN (online) 1660-3397
    ISSN 1660-3397
    DOI 10.3390/md22040166
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: New Forms of Neuroactive Phospholipids for DHA Enrichment in Brain.

    Gomes, Romina / Mendes, Inês / Duarte, Maria Paula / Bandarra, Narcisa M / Gomes-Bispo, Ana

    Marine drugs

    2024  Volume 22, Issue 3

    Abstract: Low levels of docosahexaenoic acid (DHA) in the brain have been related to neurological disorders, like Alzheimer's disease (AD). After ingestion, dietary DHA must cross the blood-brain barrier, where it is absorbed as lysophosphatidylcholine (LPC), due ... ...

    Abstract Low levels of docosahexaenoic acid (DHA) in the brain have been related to neurological disorders, like Alzheimer's disease (AD). After ingestion, dietary DHA must cross the blood-brain barrier, where it is absorbed as lysophosphatidylcholine (LPC), due to its role as a preferential DHA carrier in the brain. This work aimed at the production of LPC-DHA extracts to be used in supplementation/food fortification intended neural enrichment in DHA. As it is rich in DHA, especially its phospholipids (PL), Atlantic mackerel (
    MeSH term(s) Animals ; Phospholipids ; Docosahexaenoic Acids ; Brain ; Blood-Brain Barrier ; Phosphatidylcholines ; Fatty Acids ; Lysophosphatidylcholines
    Chemical Substances Phospholipids ; Docosahexaenoic Acids (25167-62-8) ; Phosphatidylcholines ; Fatty Acids ; Lysophosphatidylcholines
    Language English
    Publishing date 2024-02-29
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2175190-0
    ISSN 1660-3397 ; 1660-3397
    ISSN (online) 1660-3397
    ISSN 1660-3397
    DOI 10.3390/md22030116
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Marine Sources of DHA-Rich Phospholipids with Anti-Alzheimer Effect.

    Ferreira, Inês / Rauter, Amélia P / Bandarra, Narcisa M

    Marine drugs

    2022  Volume 20, Issue 11

    Abstract: Alzheimer's disease (AD) is a complex and progressive disease, which affects millions of people around the world. Despite the many efforts over the years to find efficient therapeutics, there is no cure yet. Nonetheless, many compounds have been proven ... ...

    Abstract Alzheimer's disease (AD) is a complex and progressive disease, which affects millions of people around the world. Despite the many efforts over the years to find efficient therapeutics, there is no cure yet. Nonetheless, many compounds have been proven to decrease Alzheimer's symptoms. After a short overview of the hypotheses considered in AD drug development and the drugs approved for AD treatment, which lead to symptom release, we focus on the valorization of natural marine sources that decrease AD symptoms, particularly on docosahexaenoic acid (DHA), an important component in membrane phospholipids and the most abundant n-3 polyunsaturated fatty acids (PUFA) found in gray matter of the brain and in retina and on the DHA-containing phospholipids (DHA-PLs) present in marine sources, namely fish, krill, mollusks and in fisheries and aquaculture by-products. DHA-PLs' bioactivities are presented, namely their properties in anti-neurodegeneration, neuroinflammation, as anticancer agents, as well as their benefits to obesity and visual problems. Fisheries and aquaculture by-products are also highlighted as they have a high content of DHA and DHA-rich phospholipids, can be extracted by green methodologies and should be considered in a circular economy for a healthy sustainable future.
    MeSH term(s) Animals ; Docosahexaenoic Acids/pharmacology ; Docosahexaenoic Acids/therapeutic use ; Phospholipids ; Eicosapentaenoic Acid ; Fish Oils ; Euphausiacea ; Alzheimer Disease/drug therapy
    Chemical Substances Docosahexaenoic Acids (25167-62-8) ; Phospholipids ; Eicosapentaenoic Acid (AAN7QOV9EA) ; Fish Oils
    Language English
    Publishing date 2022-10-25
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2175190-0
    ISSN 1660-3397 ; 1660-3397
    ISSN (online) 1660-3397
    ISSN 1660-3397
    DOI 10.3390/md20110662
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Effect of the season on the production and chemical properties of fish protein hydrolysates and high-quality oils obtained from gurnard (Trigla spp.) by-products

    Vázquez, José Antonio / Valcarcel, Jesus / Sapatinha, Maria / Bandarra, Narcisa M. / Mendes, Rogério / Pires, Carla

    LWT. 2023 Mar., v. 177 p.114576-

    2023  

    Abstract: Currently valorization of fish discards by-products is becoming fundamental for the sustainable management of fisheries and seafood transforming industries. Thus, we have studied the changes in the production and chemical properties of fish protein ... ...

    Abstract Currently valorization of fish discards by-products is becoming fundamental for the sustainable management of fisheries and seafood transforming industries. Thus, we have studied the changes in the production and chemical properties of fish protein hydrolysates (FPH) and oils from by-products (heads (He) and skins + bones (SB)) of gurnard (Trigla spp.) captured at different seasons. Hydrolyses were performed by Alcalase (2.5 mL/kg of by-product) at pH 8.60, 60.6 °C, 200 rpm, for 3 h. Seasonality effect was not significant in the majority of FPH properties, obtaining high digestion yields and excellent amino acid contents (more than 43% of essential amino acids per total amino acids in He). However, the maximum degree of hydrolysis for He were higher (24-26.5%) than observed for SB (19-23.6%). In the case of oil, concomitantly recovered to the production of hydrolysates, the yield of recovery was largest in SB landing on autumn (89 mL/kg SB) and winter (67 mL/kg SB), and the best content in ω-3 fatty acids was also found in autumn (257 g/kg oil). In general, FPH and oil from gurnard residues were excellent in productive, compositional and nutritional terms, indicating their valuable interest as potential food and nutraceutical ingredient.
    Keywords Trigla ; amino acids ; autumn ; byproducts ; dietary supplements ; digestion ; fish ; hydrolysis ; ingredients ; oils ; pH ; seafoods ; subtilisin ; winter ; Marine biorefinery ; Circular economy ; Fish by-catch ; Omega-3 fatty acid ; Protein hydrolysate
    Language English
    Dates of publication 2023-03
    Publishing place Elsevier Ltd
    Document type Article ; Online
    Note Use and reproduction
    ZDB-ID 241369-3
    ISSN 0460-1173 ; 0023-6438
    ISSN 0460-1173 ; 0023-6438
    DOI 10.1016/j.lwt.2023.114576
    Database NAL-Catalogue (AGRICOLA)

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  5. Article: Influence of cooking methods and storage time on colour, texture, and fatty acid profile of a novel fish burger for the prevention of cognitive decline.

    Valentim, Jorge / Afonso, Cláudia / Gomes, Romina / Gomes-Bispo, Ana / Prates, José A M / Bandarra, Narcisa M / Cardoso, Carlos

    Heliyon

    2024  Volume 10, Issue 5, Page(s) e27171

    Abstract: Western diets are poor in healthy n-3 polyunsaturated fatty acids (n-3 PUFA), namely eicosapentaenoic (EPA) and docosahexaenoic acid (DHA), iodine (I), and other nutrients that may protect against cognitive ageing. Given DHA richness in chub mackerel ( ...

    Abstract Western diets are poor in healthy n-3 polyunsaturated fatty acids (n-3 PUFA), namely eicosapentaenoic (EPA) and docosahexaenoic acid (DHA), iodine (I), and other nutrients that may protect against cognitive ageing. Given DHA richness in chub mackerel (
    Language English
    Publishing date 2024-02-28
    Publishing country England
    Document type Journal Article
    ZDB-ID 2835763-2
    ISSN 2405-8440
    ISSN 2405-8440
    DOI 10.1016/j.heliyon.2024.e27171
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article: First comparative genomic characterization of the MSSA ST398 lineage detected in aquaculture and other reservoirs.

    Salgueiro, Vanessa / Manageiro, Vera / Bandarra, Narcisa M / Ferreira, Eugénia / Clemente, Lurdes / Caniça, Manuela

    Frontiers in microbiology

    2023  Volume 14, Page(s) 1035547

    Abstract: Staphylococcus ... ...

    Abstract Staphylococcus aureus
    Language English
    Publishing date 2023-03-08
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2587354-4
    ISSN 1664-302X
    ISSN 1664-302X
    DOI 10.3389/fmicb.2023.1035547
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: Alzheimer's Disease and Toxins Produced by Marine Dinoflagellates: An Issue to Explore.

    Botelho, Maria João / Milinovic, Jelena / Bandarra, Narcisa M / Vale, Carlos

    Marine drugs

    2022  Volume 20, Issue 4

    Abstract: This paper examined the toxins naturally produced by marine dinoflagellates and their effects on increases in β-amyloid plaques along with tau protein hyperphosphorylation, both major drivers of Alzheimer's disease (AD). This approach is in line with the ...

    Abstract This paper examined the toxins naturally produced by marine dinoflagellates and their effects on increases in β-amyloid plaques along with tau protein hyperphosphorylation, both major drivers of Alzheimer's disease (AD). This approach is in line with the demand for certain natural compounds, namely those produced by marine invertebrates that have the potential to be used in the treatment of AD. Current advances in AD treatment are discussed as well as the main factors that potentially affect the puzzling global AD pattern. This study focused on yessotoxins (YTXs), gymnodimine (GYM), spirolides (SPXs), and gambierol, all toxins that have been shown to reduce β-amyloid plaques and tau hyperphosphorylation, thus preventing the neuronal or synaptic dysfunction that ultimately causes the cell death associated with AD (or other neurodegenerative diseases). Another group of toxins described, okadaic acid (OA) and its derivatives, inhibit protein phosphatase activity, which facilitates the presence of phosphorylated tau proteins. A few studies have used OA to trigger AD in zebrafish, providing an opportunity to test in vivo the effectiveness of new drugs in treating or attenuating AD. Constraints on the production of marine toxins for use in these tests have been considered. Different lines of research are anticipated regarding the action of the two groups of toxins.
    MeSH term(s) Alzheimer Disease/drug therapy ; Alzheimer Disease/metabolism ; Amyloid beta-Peptides ; Animals ; Dinoflagellida/metabolism ; Marine Toxins/pharmacology ; Okadaic Acid/pharmacology ; Plaque, Amyloid ; Zebrafish/metabolism ; tau Proteins/metabolism
    Chemical Substances Amyloid beta-Peptides ; Marine Toxins ; tau Proteins ; Okadaic Acid (1W21G5Q4N2)
    Language English
    Publishing date 2022-04-02
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2175190-0
    ISSN 1660-3397 ; 1660-3397
    ISSN (online) 1660-3397
    ISSN 1660-3397
    DOI 10.3390/md20040253
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  8. Article: The brown seaweed genus Zonaria: major features, biotechnological potential, and applications

    Cardoso, Carlos / Afonso, Cláudia / Quintã, Raquel / Bandarra, Narcisa M.

    Journal of applied phycology. 2022 Oct., v. 34, no. 5

    2022  

    Abstract: This review is a broad overview of species of the genus Zonaria, a relevant taxonomic grouping within the brown algae, considering data regarding the most common species. The article covers: classification, taxonomy, morphology, ecology, biochemical ... ...

    Abstract This review is a broad overview of species of the genus Zonaria, a relevant taxonomic grouping within the brown algae, considering data regarding the most common species. The article covers: classification, taxonomy, morphology, ecology, biochemical composition, biological activities, extraction procedures, and possible applications are analysed and discussed. The majority of the Zonaria species are distributed worldwide and encompass different environments. There is a total of 18 species, with Z. diesingiana, Z. farlowii, Z. tournefortii, and Z. turneriana being the most studied. However, even these species exhibit significant knowledge gaps. The study of Zonaria seaweeds is also rendered more difficult due to taxonomical uncertainties and the over-reliance on phenotypic traits for the identification of the genus and particular species. The biological traits of Zonaria spp. point to a highly adaptable seaweed; these organisms can modulate nutrient uptake depending on prevailing abiotic and biotic conditions. The study of the biochemical composition of Zonaria species enabled identification of potential bioactive compounds, such as phenols, sterols, fatty acids, and other lipids and lipophilic substances. Furthermore, relevant bioactivities (antioxidant, anti-microbial, and anti-cancer) have been reported in some of the species. The molecules underlying these bioactivities may be extracted through the application of highly innovative green technologies. There are already some studies in this direction, but many more are needed. Possible applications of Zonaria biomass or extracts thereof could encompass human and animal nutrition, but also the plant-stimulant market. The incorporation of Zonaria spp.-derived bioactivities to novel products, e.g., cosmetic, cosmeceutical, nutraceutical, and pharmaceutical applications is also within genuine reach of sustainable utilisation.
    Keywords Phaeophyceae ; algology ; animal nutrition ; antioxidants ; biomass ; chemical composition ; cosmetics ; dietary supplements ; ecology ; humans ; lipophilicity ; macroalgae ; markets ; nutrient uptake ; phenotype ; sterols ; taxonomy
    Language English
    Dates of publication 2022-10
    Size p. 2243-2257.
    Publishing place Springer Netherlands
    Document type Article
    Note Review
    ZDB-ID 1002324-0
    ISSN 1573-5176 ; 0921-8971
    ISSN (online) 1573-5176
    ISSN 0921-8971
    DOI 10.1007/s10811-022-02773-4
    Database NAL-Catalogue (AGRICOLA)

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  9. Article ; Online: Snapshot of resistome, virulome and mobilome in aquaculture.

    Salgueiro, Vanessa / Manageiro, Vera / Rosado, Tânia / Bandarra, Narcisa M / Botelho, Maria João / Dias, Elsa / Caniça, Manuela

    The Science of the total environment

    2023  Volume 905, Page(s) 166351

    Abstract: Aquaculture environments can be hotspots for resistance genes through the surrounding environment. Our objective was to study the resistome, virulome and mobilome of Gram-negative bacteria isolated in seabream and bivalve molluscs, using a WGS approach. ... ...

    Abstract Aquaculture environments can be hotspots for resistance genes through the surrounding environment. Our objective was to study the resistome, virulome and mobilome of Gram-negative bacteria isolated in seabream and bivalve molluscs, using a WGS approach. Sixty-six Gram-negative strains (Aeromonadaceae, Enterobacteriaceae, Hafniaceae, Morganellaceae, Pseudomonadaceae, Shewanellaceae, Vibrionaceae, and Yersiniaceae families) were selected for genomic characterization. The species and MLST were determined, and antibiotic/disinfectants/heavy metals resistance genes, virulence determinants, MGE, and pathogenicity to humans were investigated. Our study revealed new sequence-types (e.g. Aeromonas spp. ST879, ST880, ST881, ST882, ST883, ST887, ST888; Shewanella spp. ST40, ST57, ST58, ST60, ST61, ST62; Vibrio spp. ST206, ST205). >140 different genes were identified in the resistome of seabream and bivalve molluscs, encompassing genes associated with β-lactams, tetracyclines, aminoglycosides, quinolones, sulfonamides, trimethoprim, phenicols, macrolides and fosfomycin resistance. Disinfectant resistance genes qacE-type, sitABCD-type and formA-type were found. Heavy metals resistance genes mdt, acr and sil stood out as the most frequent. Most resistance genes were associated with antibiotics/disinfectants/heavy metals commonly used in aquaculture settings. We also identified 25 different genes related with increased virulence, namely associated with adherence, colonization, toxins production, red blood cell lysis, iron metabolism, escape from the immune system of the host. Furthermore, 74.2 % of the strains analysed were considered pathogenic to humans. We investigated the genetic environment of several antibiotic resistance genes, including bla
    MeSH term(s) Humans ; Multilocus Sequence Typing ; Anti-Bacterial Agents/pharmacology ; Aquaculture ; Metals, Heavy ; Disinfectants
    Chemical Substances Anti-Bacterial Agents ; Metals, Heavy ; Disinfectants
    Language English
    Publishing date 2023-08-19
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 121506-1
    ISSN 1879-1026 ; 0048-9697
    ISSN (online) 1879-1026
    ISSN 0048-9697
    DOI 10.1016/j.scitotenv.2023.166351
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article: Characterization of Protein Hydrolysates from Fish Discards and By-Products from the North-West Spain Fishing Fleet as Potential Sources of Bioactive Peptides

    Henriques, Andreia / Vázquez, José A. / Valcarcel, Jesus / Mendes, Rogério / Bandarra, Narcisa M. / Pires, Carla

    Marine drugs. 2021 June 13, v. 19, no. 6

    2021  

    Abstract: Fish discards and by-products can be transformed into high value-added products such as fish protein hydrolysates (FPH) containing bioactive peptides. Protein hydrolysates were prepared from different parts (whole fish, skin and head) of several ... ...

    Abstract Fish discards and by-products can be transformed into high value-added products such as fish protein hydrolysates (FPH) containing bioactive peptides. Protein hydrolysates were prepared from different parts (whole fish, skin and head) of several discarded species of the North-West Spain fishing fleet using Alcalase. All hydrolysates had moisture and ash contents lower than 10% and 15%, respectively. The fat content of FPH varied between 1.5% and 9.4% and had high protein content (69.8–76.6%). The amino acids profiles of FPH are quite similar and the most abundant amino acids were glutamic and aspartic acids. All FPH exhibited antioxidant activity and those obtained from Atlantic horse mackerel heads presented the highest 2,2-diphenyl-1-picrylhydrazyl (DPPH) radical scavenging activity, reducing power and Cu²⁺ chelating activity. On the other hand, hydrolysates from gurnard heads showed the highest ABTS radical scavenging activity and Fe²⁺ chelating activity. In what concerns the α-amylase inhibitory activity, the IC₅₀ values recorded for FPH ranged between 5.70 and 84.37 mg/mL for blue whiting heads and whole Atlantic horse mackerel, respectively. α-Glucosidase inhibitory activity of FPH was relatively low but all FPH had high Angiotensin Converting Enzyme (ACE) inhibitory activity. Considering the biological activities, these FPH are potential natural additives for functional foods or nutraceuticals.
    Keywords 2,2-diphenyl-1-picrylhydrazyl ; Trachurus trachurus ; antioxidant activity ; dietary supplements ; fish ; head ; lipid content ; peptides ; protein content ; subtilisin ; value added ; Spain
    Language English
    Dates of publication 2021-0613
    Publishing place Multidisciplinary Digital Publishing Institute
    Document type Article
    ZDB-ID 2175190-0
    ISSN 1660-3397
    ISSN 1660-3397
    DOI 10.3390/md19060338
    Database NAL-Catalogue (AGRICOLA)

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