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Article ; Online: Interplay of mitochondria-associated membrane proteins and autophagy: Implications in neurodegeneration.

Kulkarni, Prakash G / Mohire, Vaibhavi M / Waghmare, Pranjal P / Banerjee, Tanushree

2024 Volume 76, Page(s) 101874

Abstract: Since the discovery of membrane contact sites between ER and mitochondria called mitochondria-associated membranes (MAMs), several pieces of evidence identified their role in the regulation of different cellular processes such as ... ...

Abstract	Since the discovery of membrane contact sites between ER and mitochondria called mitochondria-associated membranes (MAMs), several pieces of evidence identified their role in the regulation of different cellular processes such as Ca
Language	English
Publishing date	2024-03-20
Publishing country	Netherlands
Document type	Journal Article ; Review
ZDB-ID	2056923-3
ISSN	1872-8278 ; 1567-7249
ISSN (online)	1872-8278
ISSN	1567-7249
DOI	10.1016/j.mito.2024.101874
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Article ; Online: Association of Diet-dependent Systemic Acid Load, Renal Function, and Serum Albumin Concentration.

Banerjee, Tanushree / Sebastian, Anthony / Frassetto, Lynda

Journal of renal nutrition : the official journal of the Council on Renal Nutrition of the National Kidney Foundation

2023 Volume 33, Issue 3, Page(s) 428–434

Abstract: Objective: Inflammation may be present with chronic kidney disease CKD and diet composition high in protein intake and fats may affect inflammation thereby impacting kidney health. We investigated whether acid load estimated from urine measures is ... ...

Abstract	Objective: Inflammation may be present with chronic kidney disease CKD and diet composition high in protein intake and fats may affect inflammation thereby impacting kidney health. We investigated whether acid load estimated from urine measures is associated with kidney function decline and whether the effect of acid load on an inflammatory marker, serum albumin, is a pathway to this association. Methods: We studied 188 postmenopausal women in a randomized clinical trial of potassium bicarbonate treatment for up to 36 months. Twenty-four-hour urine and arterialized blood collections were done at baseline and at subsequent follow-up visits at 3 months interval. Acid load was estimated from potential renal acid load calculated using urinary measures of chloride, phosphate, sodium, potassium, calcium, and magnesium (UPRAL). Mixed effects model with random-intercept and slope was used to estimate subjects' annual decline rate in creatinine clearance (CrCl), and the association between (i) UPRAL and serum albumin and (ii) serum albumin and CrCl, adjusting for age, body mass index, systolic BP, and glucose. A Cox proportional regression model was used to study the relative hazard (RH) for rapid progression of kidney function decline (defined as loss of ≥5 mL/min CrCl/yr based on the last CrCl in the rolling window) with UPRAL, adjusting for the potential covariates and baseline CrCl. Results: A 25 mEq/day increase in UPRAL was inversely associated with serum albumin (Adjusted β[95% CI]: -0.02[-0.09;-0.001). During a mean follow-up of 28 months, 19 women (10%) had a rapid decline in kidney function. For each 25 mEq/day increase in UPRAL, the risk of a rapid decline in CrCl increased by 17% (95% CI: 1.06-1.28). On adjustment for potential confounders, the risk attenuated to 5% (1.02-1.14). Mediation analysis indicated that of the total effect of the association between UPRAL and CrCl, the proportion mediated by serum albumin increased to 0.346 (i.e. 34.6%). Conclusion: Higher UPRAL was associated with lower serum albumin as well as greater kidney function decline in postmenopausal women. Our findings suggest inflammatory response may exert a modulatory effect on the association of UPRAL and kidney function and might be a potential pathway explaining the effects of systemic acid load on progression of kidney failure.
MeSH term(s)	Humans ; Female ; Serum Albumin/metabolism ; Disease Progression ; Kidney ; Renal Insufficiency, Chronic ; Glomerular Filtration Rate ; Inflammation ; Diet
Chemical Substances	Serum Albumin
Language	English
Publishing date	2023-02-02
Publishing country	United States
Document type	Randomized Controlled Trial ; Journal Article
ZDB-ID	1080003-7
ISSN	1532-8503 ; 1051-2276
ISSN (online)	1532-8503
ISSN	1051-2276
DOI	10.1053/j.jrn.2023.01.007
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Article ; Online: A decoy strategy to activate the immune system.

Deshpande, Manisha S / Banerjee, Tanushree

IUBMB life

2021 Volume 73, Issue 10, Page(s) 1205–1209

Abstract: An approach comprising a novel fusion protein and inactivated virus, as a more efficacious vaccine against invading viruses is presented, using SARS-CoV-2 as a most prominent example. The fusion protein consists of the Hepatitis B surface antigen (HBsAg) ...

Abstract	An approach comprising a novel fusion protein and inactivated virus, as a more efficacious vaccine against invading viruses is presented, using SARS-CoV-2 as a most prominent example. The fusion protein consists of the Hepatitis B surface antigen (HBsAg) conjugated to the N-terminal helix (NTH) of Angiotensin-Converting Enzyme 2 (ACE2), which is the receptor for SARS-CoV-2. For vaccination, this fusion protein is to be administered together with the whole killed virus. The NTH would bind to the Receptor Binding Domain (RBD) of the Spike protein of the killed virus. Due to HBsAg acting as a decoy, immune responses would be mounted. Neutralizing antibodies (NAbs) pre-existing in people already vaccinated with the recombinant Hepatitis B vaccine, fresh production of NAbs, and NAbs produced by memory B cells would bind to the HBsAg. This would lead to "presentation" of the killed virus to elements of the immune system at close range. Also, there would be enhanced opsonization and effective antigen presentation. This two-component vaccine could be a platform strategy, wherein HBsAg could be linked to the part of the cellular receptor that any new intractable virus binds to, and is administered together with whole inactivated virus. Now, the same fusion protein, administered by itself to persons with infection, would have therapeutic action, yet by harnessing elements of the immune system. NAbs would bind to the fusion protein as above, the NTH of which would bind to the RBDs of the infecting virus, which, in effect would be neutralized.
MeSH term(s)	Antibodies, Neutralizing/immunology ; Antibodies, Viral/immunology ; COVID-19/immunology ; COVID-19/virology ; Humans ; SARS-CoV-2/immunology ; SARS-CoV-2/isolation & purification
Chemical Substances	Antibodies, Neutralizing ; Antibodies, Viral
Language	English
Publishing date	2021-08-29
Publishing country	England
Document type	Journal Article
ZDB-ID	1492141-8
ISSN	1521-6551 ; 1521-6543
ISSN (online)	1521-6551
ISSN	1521-6543
DOI	10.1002/iub.2548
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Article ; Online: Dietary Contributions to Metabolic Acidosis.

Frassetto, Lynda / Remer, Thomas / Banerjee, Tanushree

Advances in chronic kidney disease

2022 Volume 29, Issue 4, Page(s) 373–380

Abstract: Eating a net acid-producing diet can produce an "acid stress" of severity proportional to the diet net acid load, as indexed by the steady-state renal net acid excretion rate. Depending on how much acid or base is ingested or produced from endogenous ... ...

Abstract	Eating a net acid-producing diet can produce an "acid stress" of severity proportional to the diet net acid load, as indexed by the steady-state renal net acid excretion rate. Depending on how much acid or base is ingested or produced from endogenous metabolic processes and how well our homeostatic mechanisms can buffer or eliminate the additional acids or bases, we can alter our systemic acid-base balance. With increasing age, the kidney's ability to excrete daily net acid loads declines (a condition similar to that of mild CKD), invoking increased utilization of potential base stores (eg, bone, skeletal muscle) on a daily basis to mitigate the acid accumulation, thereby contributing to development of osteoporosis, loss of muscle mass, and age-related renal insufficiency. Patients suffering from more advanced CKD often present with more severe acid stress or metabolic acidosis, as the kidney can no longer excrete the entire acid load. Alkaline diets based on fruits and vegetables may have a positive effect on long-term preservation of renal function while maintaining nutritional status. This chapter discusses the biochemistry of dietary precursors that affect acid or base production.
MeSH term(s)	Acid-Base Equilibrium ; Acidosis/etiology ; Diet ; Humans ; Renal Insufficiency, Chronic ; Vegetables
Language	English
Publishing date	2022-09-26
Publishing country	United States
Document type	Journal Article ; Review
ISSN	1548-5609 ; 1548-5595
ISSN (online)	1548-5609
ISSN	1548-5595
DOI	10.1053/j.ackd.2022.03.008
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Zs.A 4627: Show issues

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Article: Diet-dependent acid load is associated with mean arterial pressure in a cohort of non-obese, non-black, postmenopausal women

Banerjee, Tanushree / Sebastian, Anthony / Frassetto, Lynda

Applied physiology, nutrition and metabolism. 2022, v. 47, no. 3

2022

Abstract: Higher sodium (Na⁺) intake is associated with higher blood pressure (BP). Whether this relationship is stronger with diet-dependent acid load (DAL) and in patients diagnosed with hypertension or normal BP is not well determined. We studied 170 ... ...

Abstract	Higher sodium (Na⁺) intake is associated with higher blood pressure (BP). Whether this relationship is stronger with diet-dependent acid load (DAL) and in patients diagnosed with hypertension or normal BP is not well determined. We studied 170 postmenopausal women randomized to receive potassium bicarbonate or placebo for 36 months, after which 24-hour urine and arterialized blood samples were collected. We investigated the association between DAL estimated as urinary potential renal acid load (UPRAL) and mean arterial pressure (MAP) using a mixed-effects model, adjusting for age, anthropometrics, creatinine clearance, and treatment. Adjusted regression estimates for changes in Na⁺ and UPRAL on MAP after 12 months of follow-up were calculated, and further adjustments were made for changes in potassium (K⁺) and body mass index (BMI). MAP was inversely associated with UPRAL (β [95% confidence interval]: –0.11 [–0.25, –0.001]). There was an effect modification by hypertension (p-interaction = 0.04); MAP decreased significantly in normotensives, but the association was not significant in hypertensives. A decrease of 0.70 mm Hg in MAP [0.13, 1.69] per 50 mmol/24 hour reduction in Na⁺ was noted when the model was adjusted for change in K⁺. Our results with UPRAL exhibited a stronger dose–response for MAP, which remained significant after adjusting for BMI. UPRAL was independently associated with MAP even after adjusting for potential confounders, and the data showed that this association was more pronounced in normotensive patients. Novelty: First longitudinal study on the association of UPRAL and MAP. Association was a more robust relationship than that between U [Na⁺/K⁺] ratio and MAP. UPRAL may play a significant role in the pathogenesis of primary hypertension.
Keywords	blood ; blood pressure ; body mass index ; confidence interval ; creatinine ; dose response ; hypertension ; longitudinal studies ; metabolism ; models ; nutrition ; pathogenesis ; placebos ; postmenopause ; potassium ; potassium bicarbonate ; sodium ; urine
Language	English
Size	p. 227-233.
Publishing place	Canadian Science Publishing
Document type	Article
ZDB-ID	2236708-1
ISSN	1715-5320 ; 1715-5312
ISSN (online)	1715-5320
ISSN	1715-5312
DOI	10.1139/apnm-2020-0928
Database	NAL-Catalogue (AGRICOLA)

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Article ; Online: Nanotized curcumin-benzothiophene conjugate: A potential combination for treatment of cerebral malaria.

Ghosh, Aparajita / Banerjee, Tanushree

IUBMB life

2020 Volume 72, Issue 12, Page(s) 2637–2650

Abstract: The declining effectiveness of the available antimalarial drugs due to drug resistance requires a continued effort to develop new therapeutic approaches. In this context, combination therapies hold a great promise for developing effective first-line ... ...

Abstract	The declining effectiveness of the available antimalarial drugs due to drug resistance requires a continued effort to develop new therapeutic approaches. In this context, combination therapies hold a great promise for developing effective first-line antimalarial treatments for reducing malaria mortality. The present study explores the antimalarial efficacy of nanotized formulation of curcumin in combination with benzothiophene compound 6 (3-bromo-N-(4-fluorobenzyl)-benzo[b]thiophene-2-carboxamide) with a view to achieve better efficacy at a very low dose in comparison to that accomplished with monotherapy alone. Herein, we formulated nanotized conjugate of curcumin and compound 6 (cur-compound 6) in the size range of 30-90 nm as observed via TEM, AFM and DLS analysis in the study. The nanotized preparation was found to be readily dispersible in water, physically and chemically stable and exhibited sustained release profile of both curcumin and compound 6 till 48 hr. Treatment of P. falciparum parasites with the nanotized conjugate for 24 hr resulted in rapid clearance of the parasites. Furthermore, P. berghei infected mice treated with nanotized conjugate formulation survived till 90 days with complete eradication of the parasites from RBC. This improved efficacy of the nanotized formulation was possible because of the increased absorption of the compounds via oral administration owing to enhanced dispersibility of the formulation in aqueous medium. Moreover, an improved oral bioavailability of the nanotized formulation lowered the dosage at which the pharmacological effect was achieved while avoiding any observable adverse harmful side effects.
MeSH term(s)	Administration, Oral ; Animals ; Anti-Inflammatory Agents, Non-Steroidal/chemistry ; Anti-Inflammatory Agents, Non-Steroidal/pharmacology ; Antimalarials/administration & dosage ; Antimalarials/chemistry ; Antimalarials/pharmacology ; Biological Availability ; Curcumin/administration & dosage ; Curcumin/chemistry ; Curcumin/pharmacology ; Malaria, Cerebral/drug therapy ; Malaria, Cerebral/parasitology ; Malaria, Cerebral/pathology ; Malaria, Falciparum/drug therapy ; Malaria, Falciparum/parasitology ; Malaria, Falciparum/pathology ; Mice ; Mice, Inbred C57BL ; Nanoparticles/administration & dosage ; Nanoparticles/chemistry ; Plasmodium berghei/drug effects ; Thiophenes/chemistry
Chemical Substances	Anti-Inflammatory Agents, Non-Steroidal ; Antimalarials ; Thiophenes ; benzothiophene (073790YQ2G) ; Curcumin (IT942ZTH98)
Language	English
Publishing date	2020-10-09
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	1492141-8
ISSN	1521-6551 ; 1521-6543
ISSN (online)	1521-6551
ISSN	1521-6543
DOI	10.1002/iub.2394
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Article ; Online: Riverine connectivity influences the phytoplankton ecology in the open floodplain wetland of the lower river Ganga.

Mohanty, Trupti Rani / Tiwari, Nitish Kumar / Das, Basanta Kumar / Swain, Himanshu Sekhar / Jhonson, Canciyal / Banerjee, Tanushree

Environmental monitoring and assessment

2023 Volume 195, Issue 12, Page(s) 1403

Abstract: The river Ganga has several floodplain wetlands that support its ecology and ecosystem. Phytoplankton is an important component of the aquatic ecosystem, which plays an important role as a bioindicator for the assessment of aquatic health. The present ... ...

Abstract	The river Ganga has several floodplain wetlands that support its ecology and ecosystem. Phytoplankton is an important component of the aquatic ecosystem, which plays an important role as a bioindicator for the assessment of aquatic health. The present study was conducted between 2018 and 2019 to understand the seasonal variation in the phytoplankton diversity of the Charaganga wetland and, parallelly, in the river Ganga in Nabadweep, India. The study explains how riverine connectivity affects the structure of the algal community in the wetland ecosystem. In the study, it has been observed that in the wetland, maximum mean phytoplankton density was noticed during pre-monsoon, i.e., 4079 unit l
MeSH term(s)	Phytoplankton ; Ecosystem ; Wetlands ; Rivers/chemistry ; Environmental Monitoring ; Diatoms ; Seasons ; Water
Chemical Substances	Water (059QF0KO0R)
Language	English
Publishing date	2023-11-02
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	782621-7
ISSN	1573-2959 ; 0167-6369
ISSN (online)	1573-2959
ISSN	0167-6369
DOI	10.1007/s10661-023-11983-3
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Article ; Online: Understanding the role of nACE2 in neurogenic hypertension among COVID-19 patients.

Kulkarni, Prakash G / Sakharkar, Amul / Banerjee, Tanushree

Hypertension research : official journal of the Japanese Society of Hypertension

2021 Volume 45, Issue 2, Page(s) 254–269

Abstract: Currently, the third and fourth waves of the coronavirus disease -19 (COVID-19) pandemic are creating havoc in many parts of the world. Although vaccination programs have been launched in most countries, emerging new strains of the virus along with ... ...

Abstract	Currently, the third and fourth waves of the coronavirus disease -19 (COVID-19) pandemic are creating havoc in many parts of the world. Although vaccination programs have been launched in most countries, emerging new strains of the virus along with geographical variations are leading to varying success rates of the available vaccines. The presence of comorbidities such as diabetes, cardiovascular diseases and hypertension is responsible for increasing the severity of COVID-19 and, thus, the COVID-19 mortality rate. Angiotensin-converting enzyme 2 (ACE2), which is utilized by SARS-CoV-2 for entry into host cells, is widely expressed in the lungs, kidneys, testes, gut, adipose tissue, and brain. Infection within host cells mediates RAS overactivation, which leads to a decrease in the ACE2/ACE ratio, AT2R/AT1R ratio, and MasR/AT1R ratio. Such imbalances lead to the development of heightened inflammatory responses, such as cytokine storms, leading to post-COVID-19 complications and mortality. As the association of SARS-CoV-2 infection and hypertension remains unclear, this report provides an overview of the effects of SARS-CoV-2 infection on patients with hypertension. We discuss here the interaction of ACE2 with SARS-CoV-2, focusing on neuronal ACE2 (nACE2), and further shed light on the possible involvement of nACE2 in hypertension. SARS-CoV-2 enters the brain through neuronal ACE2 and spreads in various regions of the brain. The effect of viral binding to neuronal ACE2 in areas of the brain that regulate salt/water balance and blood pressure is also discussed in light of the neural regulation of hypertension in COVID-19.
MeSH term(s)	Angiotensin-Converting Enzyme 2 ; COVID-19 ; Humans ; Hypertension ; Peptidyl-Dipeptidase A/metabolism ; Renin-Angiotensin System ; SARS-CoV-2
Chemical Substances	Peptidyl-Dipeptidase A (EC 3.4.15.1) ; ACE2 protein, human (EC 3.4.17.23) ; Angiotensin-Converting Enzyme 2 (EC 3.4.17.23)
Language	English
Publishing date	2021-11-30
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't ; Review
ZDB-ID	1175297-x
ISSN	1348-4214 ; 0916-9636
ISSN (online)	1348-4214
ISSN	0916-9636
DOI	10.1038/s41440-021-00800-4
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Zs.A 3898: Show issues

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Article ; Online: DNA Methylation-Mediated Mfn2 Gene Regulation in the Brain: A Role in Brain Trauma-Induced Mitochondrial Dysfunction and Memory Deficits.

Kulkarni, Prakash G / Balasubramanian, Nagalakshmi / Manjrekar, Ritika / Banerjee, Tanushree / Sakharkar, Amul

Cellular and molecular neurobiology

2023 Volume 43, Issue 7, Page(s) 3479–3495

Abstract: Repeated mild traumatic brain injuries (rMTBI) affect mitochondrial homeostasis in the brain. However, mechanisms of long-lasting neurobehavioral effects of rMTBI are largely unknown. Mitofusin 2 (Mfn2) is a critical component of tethering complexes in ... ...

Abstract	Repeated mild traumatic brain injuries (rMTBI) affect mitochondrial homeostasis in the brain. However, mechanisms of long-lasting neurobehavioral effects of rMTBI are largely unknown. Mitofusin 2 (Mfn2) is a critical component of tethering complexes in mitochondria-associated membranes (MAMs) and thereby plays a pivotal role in mitochondrial functions. Herein, we investigated the implications of DNA methylation in the Mfn2 gene regulation, and its consequences on mitochondrial dysfunction in the hippocampus after rMTBI. rMTBI dramatically reduced the mitochondrial mass, which was concomitant with decrease in Mfn2 mRNA and protein levels. DNA hypermethylation at the Mfn2 gene promoter was observed post 30 days of rMTBI. The treatment of 5-Azacytidine, a pan DNA methyltransferase inhibitor, normalized DNA methylation levels at Mfn2 promoter, which further resulted into restoration of Mfn2 function. The normalization of Mfn2 function was well correlated with recovery in memory deficits in rMTBI-exposed rats. Since, glutamate excitotoxicity serves as a primary insult after TBI, we employed in vitro model of glutamate excitotoxicity in human neuronal cell line SH-SY5Y to investigate the causal epigenetic mechanisms of Mfn2 gene regulation. The glutamate excitotoxicity reduced Mfn2 levels via DNA hypermethylation at Mfn2 promoter. Loss of Mfn2 caused significant surge in cellular and mitochondrial ROS levels with lowered mitochondrial membrane potential in cultured SH-SY5Y cells. Like rMTBI, these consequences of glutamate excitotoxicity were also prevented by 5-AzaC pre-treatment. Therefore, DNA methylation serves as a vital epigenetic mechanism involved in Mfn2 expression in the brain; and this Mfn2 gene regulation may play a pivotal role in rMTBI-induced persistent cognitive deficits. Closed head weight drop injury method was employed to induce repeated mild traumatic brain (rMTBI) in jury in adult, male Wistar rats. rMTBI causes hyper DNA methylation at the Mfn2 promoter and lowers the Mfn2 expression triggering mitochondrial dysfunction. However, the treatment of 5-azacytidine normalizes DNA methylation at the Mfn2 promoter and restores mitochondrial function.
MeSH term(s)	Animals ; Male ; Rats ; Azacitidine/pharmacology ; Brain/metabolism ; Brain Injuries, Traumatic/complications ; Brain Injuries, Traumatic/genetics ; Brain Injuries, Traumatic/metabolism ; DNA/metabolism ; DNA Methylation ; Glutamates/metabolism ; Memory Disorders/etiology ; Mitochondria/metabolism ; Neuroblastoma ; Rats, Wistar
Chemical Substances	Azacitidine (M801H13NRU) ; DNA (9007-49-2) ; Glutamates ; Mfn2 protein, rat (EC 3.6.1.-)
Language	English
Publishing date	2023-05-16
Publishing country	United States
Document type	Journal Article
ZDB-ID	283404-2
ISSN	1573-6830 ; 0272-4340
ISSN (online)	1573-6830
ISSN	0272-4340
DOI	10.1007/s10571-023-01358-0
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Article ; Online: Diet-dependent acid load is associated with mean arterial pressure in a cohort of non-obese, non-black, postmenopausal women.

Banerjee, Tanushree / Sebastian, Anthony / Frassetto, Lynda

Applied physiology, nutrition, and metabolism = Physiologie appliquee, nutrition et metabolisme

2021 Volume 47, Issue 3, Page(s) 227–233

Abstract: Higher sodium ( ... ...

Abstract	Higher sodium (Na
MeSH term(s)	Arterial Pressure ; Blood Pressure ; Diet ; Female ; Humans ; Hypertension/etiology ; Longitudinal Studies ; Postmenopause ; Potassium ; Sodium
Chemical Substances	Sodium (9NEZ333N27) ; Potassium (RWP5GA015D)
Language	English
Publishing date	2021-10-06
Publishing country	Canada
Document type	Journal Article ; Randomized Controlled Trial
ZDB-ID	2236708-1
ISSN	1715-5320 ; 1715-5312
ISSN (online)	1715-5320
ISSN	1715-5312
DOI	10.1139/apnm-2020-0928
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