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  1. Article: Effects of double intravenous furosemide administration at different doses on clinical variables, electrocardiographic indices and serum electrolytes in miniature donkeys.

    Banihashemi, Seyed Hesamaddin / Samimi, Amir Saeed / Samimi, Kamyab / Tajik, Javad

    Veterinary research forum : an international quarterly journal

    2023  Volume 14, Issue 1, Page(s) 53–57

    Abstract: The intravenous (IV) usage of diuretics such as furosemide may cause changes in clinical variables, electrocardiographic (ECG) indices and some serum electrolytes concentrations in miniature donkeys. The purpose of this study was to evaluate the effects ... ...

    Abstract The intravenous (IV) usage of diuretics such as furosemide may cause changes in clinical variables, electrocardiographic (ECG) indices and some serum electrolytes concentrations in miniature donkeys. The purpose of this study was to evaluate the effects of double intravenous (IV) administration of furosemide at different doses on the clinical variables, ECG indices and serum electrolytes levels in miniature donkeys. A total of 21 clinically and para-clinically healthy miniature donkeys with a mean age of 6.00 ± 1.00 years and weight of 95.00 ± 5.00 kg were used. The animals were randomly divided into three groups of control (normal saline) and low- (1.00 mg kg
    Language English
    Publishing date 2023-01-15
    Publishing country Iran
    Document type Journal Article
    ISSN 2008-8140
    ISSN 2008-8140
    DOI 10.30466/vrf.2020.127810.2954
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Investigating the Relationship between the Levels of IL18, RANKL Gene Expression, MicroRNA-146a and Inflammatory Factors with the Severity of COVID-19.

    Hamad Khdhir, Karmand / Alipour, Shahriar / Gholizadeh-Ghaleh Aziz, Shiva / Banihashemi, Seyed Hesamaddin

    Iranian journal of allergy, asthma, and immunology

    2023  Volume 22, Issue 1, Page(s) 82–90

    Abstract: COVID-19 can induce lung inflammation, and inflammatory factors play an essential role in its pathogenesis. This inflammation can be controlled to a great extent by microRNAs(miRs). This study evaluated miR-146a-5p expression levels in the serum of ... ...

    Abstract COVID-19 can induce lung inflammation, and inflammatory factors play an essential role in its pathogenesis. This inflammation can be controlled to a great extent by microRNAs(miRs). This study evaluated miR-146a-5p expression levels in the serum of patients with COVID-19 and their association with the expression of interleukin (IL)-18 and receptor activator of nuclear factor kappa-Β ligand (RANKL) genes, and lung damage. patients with COVID-19 were divided into two groups: mild and severe phases. The severe phase is defined as having a positive polymerase chain reaction (PCR) for SARS-CoV2, and acute pulmonary symptoms. The subjects' demographic, clinical, and paraclinical characteristics were collected according to a pre-prepared checklist. Total RNA was isolated from all samples using the Trizol kit to assess gene expression. The extracted product was then evaluated for the expression of miR-146a and the target genes (i.e., IL-18 and RANKL) using real-time PCR. The miR-146a gene's mean expression in mild and severe patients was 0.73 and 1.89, respectively, and this difference was statistically significant between the two groups. Also, the mean Expression of the IL-18 gene, 1.37±0.38 in the mild and 2.83±0.58 in the severe groups of the disease, demonstrated a significant difference between the two groups. In contrast, the expression levels of the RANKL gene did not show a significant difference between the two groups. Therefore, it may be hypothesized that altered levels of miR-146a may contribute to the severe COVID-19 that is more commonly observed in smokers, but further research is required.
    MeSH term(s) Humans ; COVID-19/blood ; COVID-19/epidemiology ; COVID-19/pathology ; Male ; Female ; Middle Aged ; Aged ; Patient Acuity ; MicroRNAs/blood ; RANK Ligand/blood ; Interleukin-18/blood ; Lung/pathology ; Lung/virology ; Biomarkers/blood ; Iran/epidemiology
    Chemical Substances MIRN146 microRNA, human ; MicroRNAs ; RANK Ligand ; Interleukin-18 ; IL18 protein, human ; TNFSF11 protein, human ; Biomarkers
    Language English
    Publishing date 2023-02-20
    Publishing country Iran
    Document type Journal Article
    ZDB-ID 2488724-9
    ISSN 1735-5249 ; 1735-1502
    ISSN (online) 1735-5249
    ISSN 1735-1502
    DOI 10.18502/ijaai.v22i1.12009
    Database MEDical Literature Analysis and Retrieval System OnLINE

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