Article ; Online: A case report on non-metastatic Ewing sarcoma of the lumbar spine in a young patient.
Cancer reports (Hoboken, N.J.)
2022 Volume 5, Issue 11, Page(s) e1725
Abstract: Background: Ewing sarcoma (ES), the second most common malignant bone tumor after osteosarcoma in the second decade, occurs in 0.9% of cases as the primary non-sacral form.: Case: A 20-years-old male presented with acute paraparesis of bilateral ... ...
| Abstract | Background: Ewing sarcoma (ES), the second most common malignant bone tumor after osteosarcoma in the second decade, occurs in 0.9% of cases as the primary non-sacral form. Case: A 20-years-old male presented with acute paraparesis of bilateral lower limb and numbness following initial back pain for the last 6 months. Magnetic resonance imaging (MRI) of the lumbar spine revealed a 4 cm enhancing soft tissue mass at the L4/L5 vertebra extending into the spinal canal with compression of the thecal sac. The computed tomography (CT) of the chest, abdomen, and pelvis revealed aggressive lytic lesions in the L4 spinous process with soft tissue extension into the spinal canal with no other site of distant metastasis. He was treated with IV steroids (Injection dexamethasone 10 mg IV followed by 4 mg tablet dexamethasone q6h; subsequently tapered off). A core needle biopsy showed a small, round blue cell neoplasm, (suggestive of a primitive neuroectodermal) stained positive for CD99 and vimentin stain. The diagnosis of ES lumbar spine was made which was treated with surgical resection with an appropriate margin measuring 8 × 4.5 × 2.5 cm with decompression and L4/5 laminectomies, which had a negative margin in the surgical pathology report. Concomitant local radiotherapy and chemotherapy [cycles of vincristine 2 mg/m Conclusions: The presentation of lumbar ES can vary from local pain and swelling to acute paraparesis. Timely diagnosis and treatment with multimodal therapy, namely, steroids for acute spinal cord compression and surgery with chemoradiotherapy for ES can improve spinal biomechanics and oncological control. |
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| MeSH term(s) | Humans ; Male ; Young Adult ; Adult ; Sarcoma, Ewing/therapy ; Sarcoma, Ewing/drug therapy ; Bone Neoplasms/therapy ; Bone Neoplasms/drug therapy ; Neoplasms, Second Primary ; Spine/pathology ; Paraparesis ; Dexamethasone |
| Chemical Substances | Dexamethasone (7S5I7G3JQL) |
| Language | English |
| Publishing date | 2022-10-03 |
| Publishing country | United States |
| Document type | Case Reports |
| ISSN | 2573-8348 |
| ISSN (online) | 2573-8348 |
| DOI | 10.1002/cnr2.1725 |
| Database | MEDical Literature Analysis and Retrieval System OnLINE |
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