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  1. Article ; Online: The dopamine 3 receptor as a candidate biomarker and therapeutic for opioid use disorder.

    Banks, Matthew L / Sprague, Jon E

    Addiction biology

    2024  Volume 29, Issue 2, Page(s) e13369

    Abstract: Here, we present recent studies suggesting that specific DRD3 single nucleotide polymorphisms (SNPs, e.g. rs324029 and rs2654754) might serve as prognostic biomarkers for opioid use disorder (OUD). Additionally, preclinical studies with novel dopamine 3 ... ...

    Abstract Here, we present recent studies suggesting that specific DRD3 single nucleotide polymorphisms (SNPs, e.g. rs324029 and rs2654754) might serve as prognostic biomarkers for opioid use disorder (OUD). Additionally, preclinical studies with novel dopamine 3 receptor (D3R) partial agonists and antagonists have been evaluated as candidate OUD therapeutics and have shown a reduced risk of cardiovascular toxicity compared with the original D3R antagonist. From these findings, we argue that DRD3 SNPs could serve as a diagnostic tool for assessing OUD risk and that more research is warranted examining the D3R as a safe and effective therapeutic target for treating OUD.
    MeSH term(s) Humans ; Receptors, Dopamine ; Dopamine ; Receptors, Dopamine D3/genetics ; Opioid-Related Disorders/genetics ; Dopamine Antagonists ; Dopamine Agonists ; Analgesics, Opioid
    Chemical Substances Receptors, Dopamine ; Dopamine (VTD58H1Z2X) ; Receptors, Dopamine D3 ; Dopamine Antagonists ; Dopamine Agonists ; Analgesics, Opioid
    Language English
    Publishing date 2024-02-06
    Publishing country United States
    Document type Journal Article
    ZDB-ID 1324314-7
    ISSN 1369-1600 ; 1355-6215
    ISSN (online) 1369-1600
    ISSN 1355-6215
    DOI 10.1111/adb.13369
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    Zs.A 4586: Show issues Location:
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  2. Article ; Online: Environmental influence on the preclinical evaluation of substance use disorder therapeutics.

    Banks, Matthew L

    Advances in pharmacology (San Diego, Calif.)

    2021  Volume 93, Page(s) 219–242

    Abstract: Substance use disorders (SUD) develop as a result of complex interactions between the environment, the subject, and the drug of abuse. Preclinical basic research investigating each of these tripartite components of SUD individually has resulted in ... ...

    Abstract Substance use disorders (SUD) develop as a result of complex interactions between the environment, the subject, and the drug of abuse. Preclinical basic research investigating each of these tripartite components of SUD individually has resulted in advancements in our fundamental knowledge regarding the progression from drug abuse to SUD and severe drug addiction and the underlying behavioral and neurobiological mechanisms. How these complex interactions between the environment, the subject, and the drug of abuse impact the effectiveness of candidate or clinically used medications for SUD has not been as extensively investigated. The focus of this chapter will address the current state of our knowledge how these environmental, subject, and pharmacological variables have been shown to impact candidate or clinical SUD medication evaluation in preclinical research using drug self-administration procedures as the primary dependent measure. The results discussed in this chapter highlight the importance of considering environmental variables such as the schedule of reinforcement, concurrent availability of alternative nondrug reinforcers, and experimental housing conditions in the context of SUD therapeutic evaluation. The thesis of this chapter is that improved understanding of environmental variables in the context of SUD research will facilitate the utility of preclinical drug self-administration studies in the evaluation and development of candidate SUD therapeutics.
    MeSH term(s) Humans ; Substance-Related Disorders/drug therapy
    Language English
    Publishing date 2021-11-09
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural
    ISSN 1557-8925
    ISSN (online) 1557-8925
    DOI 10.1016/bs.apha.2021.10.004
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  3. Article: A concurrently available negative reinforcer robustly decreases cocaine self-administration in male and female rats.

    Marcus, Madison M / Banks, Matthew L

    bioRxiv : the preprint server for biology

    2023  

    Abstract: Continued drug-taking despite adverse consequences is hypothesized to be an insidious behavioral hallmark of drug addiction. Although most preclinical research has focused on drug self-administration in the presence of positive punishment, another source ...

    Abstract Continued drug-taking despite adverse consequences is hypothesized to be an insidious behavioral hallmark of drug addiction. Although most preclinical research has focused on drug self-administration in the presence of positive punishment, another source of potential adverse consequences is behavioral allocation away from negative reinforcers (i.e., escape/avoid electric shock) and towards drug reinforcers. The goals of the present study were to establish a discrete-trial cocaine-vs-negative reinforcer choice procedure in male and female rats and determine sensitivity of choice behavior to environmental and pharmacological manipulations. Rats could make up to nine discrete choices between an intravenous cocaine infusion (0.32 - 1.8 mg/kg/inf) under a fixed-ratio (FR) 3 schedule and a negative reinforcer (escape or avoidance of electric shock, 0.1 - 0.7 mA) under an FR1 schedule. The negative reinforcer was consistently chosen over all cocaine doses. Lowering shock magnitude decreased negative reinforcer trials, increased omitted trials, and failed to promote behavioral reallocation towards cocaine. Increasing the negative reinforcement response requirement between sessions only increased omitted trials. Introduction of 12-hr extended access cocaine self-administration sessions across two weeks resulted in high daily cocaine intakes but failed to significantly increase cocaine choice. Acute diazepam pretreatment also did not impact choice behavior up to doses that produced behavioral depression. Overall, the lack of behavioral allocation between cocaine infusions and a negative reinforcer suggests these two reinforcers may be economic independents. Additionally, the failure of extended cocaine access to increase cocaine choice highlights the importance of alternative reinforcers and environmental context in preclinical models of drug addiction.
    Language English
    Publishing date 2023-03-31
    Publishing country United States
    Document type Preprint
    DOI 10.1101/2023.03.29.534800
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  4. Article ; Online: Effects of environmental and pharmacological manipulations on cocaine-vs-negative reinforcer choice in male and female rats.

    Marcus, Madison M / Banks, Matthew L

    Psychopharmacology

    2023  Volume 240, Issue 8, Page(s) 1677–1689

    Abstract: Rationale: The adverse consequences of human addictive drug use could be the result of either addictive drug consumption resulting in punishment (e.g., incarceration) or failure to engage in negative-reinforced behaviors that might compete with drug- ... ...

    Abstract Rationale: The adverse consequences of human addictive drug use could be the result of either addictive drug consumption resulting in punishment (e.g., incarceration) or failure to engage in negative-reinforced behaviors that might compete with drug-maintained behaviors (e.g., contingency management strategies that reset payment amounts for drug free urines).
    Objective: The goal of the present study was to establish a discrete-trial cocaine-vs-negative reinforcer (S
    Methods: Responding was maintained in male and female rats by IV cocaine infusions (0.32-1.8 mg/kg/inf) and a S
    Results: Negative reinforcement was chosen over all cocaine doses. Lowering shock magnitude or increasing S
    Conclusions: These results suggest that S
    MeSH term(s) Humans ; Rats ; Male ; Female ; Animals ; Cocaine ; Reinforcement, Psychology ; Cocaine-Related Disorders ; Punishment ; Diazepam ; Self Administration ; Dose-Response Relationship, Drug ; Reinforcement Schedule
    Chemical Substances Cocaine (I5Y540LHVR) ; Diazepam (Q3JTX2Q7TU)
    Language English
    Publishing date 2023-06-20
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 130601-7
    ISSN 1432-2072 ; 0033-3158
    ISSN (online) 1432-2072
    ISSN 0033-3158
    DOI 10.1007/s00213-023-06404-9
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  5. Article: The Rise and Fall of Kappa-Opioid Receptors in Drug Abuse Research.

    Banks, Matthew L

    Handbook of experimental pharmacology

    2019  Volume 258, Page(s) 147–165

    Abstract: Substance use disorders represent a global public health issue. This mental health disorder is hypothesized to result from neurobiological changes as a result of chronic drug exposure and clinically manifests as inappropriate behavioral allocation toward ...

    Abstract Substance use disorders represent a global public health issue. This mental health disorder is hypothesized to result from neurobiological changes as a result of chronic drug exposure and clinically manifests as inappropriate behavioral allocation toward the procurement and use of the abused substance and away from other behaviors maintained by more adaptive nondrug reinforcers (e.g., social relationships, work). The dynorphin/kappa-opioid receptor (KOR) is one receptor system that has been altered following chronic exposure to drugs of abuse (e.g., cocaine, opioids, alcohol) in both laboratory animals and humans, implicating the dynorphin/KOR system in the expression, mechanisms, and treatment of substance use disorders. KOR antagonists have reduced drug self-administration in laboratory animals under certain experimental conditions, but not others. Recently, several human laboratory and clinical trials have evaluated the effectiveness of KOR antagonists as candidate pharmacotherapies for cocaine or tobacco use disorder to test hypotheses generated from preclinical studies. KOR antagonists failed to significantly alter drug use metrics in humans suggesting translational discordance between some preclinical drug self-administration studies and consistent with other preclinical drug self-administration studies that provide concurrent access to an alternative nondrug reinforcer (e.g., food). The implications of this translational discordance and future directions for examining the therapeutic potential of KOR agonists or antagonists as candidate substance use disorder pharmacotherapies are discussed.
    MeSH term(s) Animals ; Dynorphins ; Humans ; Receptors, Opioid, kappa/antagonists & inhibitors ; Substance-Related Disorders/drug therapy
    Chemical Substances Receptors, Opioid, kappa ; Dynorphins (74913-18-1)
    Language English
    Publishing date 2019-08-28
    Publishing country Germany
    Document type Journal Article ; Review
    ISSN 0171-2004
    ISSN 0171-2004
    DOI 10.1007/164_2019_268
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    Sign. bis Bd. 125 (1997): 1982 A 2146: Show issues
     danach: Sign. bei den Einzelbänden: Show issues

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  6. Article ; Online: Impaired cognitive behavioral flexibility following methamphetamine or high caloric diet consumption: a common 5-HT

    Banks, Matthew L

    Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology

    2018  Volume 44, Issue 3, Page(s) 461–462

    MeSH term(s) Animals ; Cognition ; Diet ; Female ; Macaca mulatta ; Methamphetamine ; Receptor, Serotonin, 5-HT2C ; Reversal Learning ; Serotonin
    Chemical Substances Receptor, Serotonin, 5-HT2C ; Serotonin (333DO1RDJY) ; Methamphetamine (44RAL3456C)
    Language English
    Publishing date 2018-10-24
    Publishing country England
    Document type Journal Article ; Comment
    ZDB-ID 639471-1
    ISSN 1740-634X ; 0893-133X
    ISSN (online) 1740-634X
    ISSN 0893-133X
    DOI 10.1038/s41386-018-0243-1
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    Zs.A 2379: Show issues Location:
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  7. Article ; Online: Adding dopamine to the complexity of sex differences in opioid reinforcement.

    Robinson, Hannah L / Banks, Matthew L

    Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology

    2021  Volume 46, Issue 10, Page(s) 1705–1706

    MeSH term(s) Analgesics, Opioid ; Dopamine ; Female ; Humans ; Male ; Reinforcement, Psychology ; Sex Characteristics
    Chemical Substances Analgesics, Opioid ; Dopamine (VTD58H1Z2X)
    Language English
    Publishing date 2021-06-18
    Publishing country England
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Comment
    ZDB-ID 639471-1
    ISSN 1740-634X ; 0893-133X
    ISSN (online) 1740-634X
    ISSN 0893-133X
    DOI 10.1038/s41386-021-01060-z
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    Zs.A 2379: Show issues Location:
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  8. Article ; Online: Xylazine does not enhance fentanyl reinforcement in rats: A behavioral economic analysis.

    St Onge, Celsey M / Canfield, Jeremy R / Ortiz, Allison / Sprague, Jon E / Banks, Matthew L

    Drug and alcohol dependence

    2024  Volume 258, Page(s) 111282

    Abstract: The adulteration of illicit fentanyl with the alpha-2 agonist xylazine has been designated an emerging public health threat. The clinical rationale for combining fentanyl with xylazine is currently unclear, and the inability to study fentanyl/xylazine ... ...

    Abstract The adulteration of illicit fentanyl with the alpha-2 agonist xylazine has been designated an emerging public health threat. The clinical rationale for combining fentanyl with xylazine is currently unclear, and the inability to study fentanyl/xylazine interactions in humans warrants the need for preclinical research. We studied fentanyl and xylazine pharmacodynamic and pharmacokinetic interactions in male and female rats using drug self-administration behavioral economic methods. Fentanyl, but not xylazine, functioned as a reinforcer under both fixed-ratio and progressive-ratio drug self-administration procedures. Xylazine combined with fentanyl at three fixed dose-proportion mixtures did not significantly alter fentanyl reinforcement as measured using behavioral economic analyses. Xylazine produced a proportion-dependent decrease in the behavioral economic Q
    MeSH term(s) Fentanyl/pharmacology ; Animals ; Xylazine/pharmacology ; Rats ; Male ; Female ; Self Administration ; Reinforcement, Psychology ; Economics, Behavioral ; Rats, Sprague-Dawley ; Reinforcement Schedule ; Adrenergic alpha-2 Receptor Agonists/pharmacology ; Analgesics, Opioid ; Conditioning, Operant/drug effects
    Chemical Substances Fentanyl (UF599785JZ) ; Xylazine (2KFG9TP5V8) ; Adrenergic alpha-2 Receptor Agonists ; Analgesics, Opioid
    Language English
    Publishing date 2024-04-02
    Publishing country Ireland
    Document type Journal Article ; Research Support, N.I.H., Extramural
    ZDB-ID 519918-9
    ISSN 1879-0046 ; 0376-8716
    ISSN (online) 1879-0046
    ISSN 0376-8716
    DOI 10.1016/j.drugalcdep.2024.111282
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    Zs.A 1310: Show issues Location:
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  9. Article ; Online: Effects of naltrexone on amphetamine choice in rhesus monkeys and rats.

    Robinson, Hannah L / Moerke, Megan Jo / Banks, Matthew L / Negus, S Stevens

    Experimental and clinical psychopharmacology

    2023  Volume 31, Issue 6, Page(s) 1080–1091

    Abstract: Clinical amphetamine use is constrained by high abuse potential, and amphetamine use disorder is a persistent clinical problem with no approved medications for its treatment. The opioid antagonist naltrexone has been reported to reduce some abuse-related ...

    Abstract Clinical amphetamine use is constrained by high abuse potential, and amphetamine use disorder is a persistent clinical problem with no approved medications for its treatment. The opioid antagonist naltrexone has been reported to reduce some abuse-related effects of amphetamine. This study used an amphetamine-versus-food choice procedure in rhesus monkeys and rats to test the hypothesis that naltrexone might serve as either (a) a maintenance medication for amphetamine use disorder treatment or (b) an "abuse-deterrent" adjunct to clinical amphetamine formulations. Male rhesus monkeys and male and female rats were trained to choose between increasing unit doses of intravenous amphetamine and an alternative food reinforcer during daily behavioral sessions. Experiment 1 evaluated effectiveness of continuous naltrexone maintenance to reduce amphetamine-versus-food choice in both monkeys and rats. Experiment 2 combined naltrexone with amphetamine in fixed-proportion amphetamine + naltrexone mixtures to evaluate the effectiveness of naltrexone in both species to reduce mixture choice relative to amphetamine-alone choice. Amphetamine maintained a dose-dependent increase in amphetamine choice in both monkeys and rats. Naltrexone maintenance did not significantly decrease amphetamine choice in either species. Addition of naltrexone to amphetamine reduced amphetamine choices per session in monkeys, but behavior was not reallocated to food choice, and in rats, the addition of naltrexone only decreased food choice without significantly affecting amphetamine choice. These results argue against the use of naltrexone as either (a) a maintenance medication for treatment of amphetamine use disorder or (b) an "abuse-deterrent" adjunct to amphetamine for clinical applications. (PsycInfo Database Record (c) 2023 APA, all rights reserved).
    MeSH term(s) Male ; Female ; Rats ; Animals ; Amphetamine/pharmacology ; Naltrexone/pharmacology ; Naltrexone/therapeutic use ; Macaca mulatta ; Cocaine ; Narcotic Antagonists/pharmacology ; Narcotic Antagonists/therapeutic use ; Substance-Related Disorders/drug therapy ; Choice Behavior ; Dose-Response Relationship, Drug ; Self Administration
    Chemical Substances Amphetamine (CK833KGX7E) ; Naltrexone (5S6W795CQM) ; Cocaine (I5Y540LHVR) ; Narcotic Antagonists
    Language English
    Publishing date 2023-05-15
    Publishing country United States
    Document type Journal Article
    ZDB-ID 1209960-0
    ISSN 1936-2293 ; 1064-1297
    ISSN (online) 1936-2293
    ISSN 1064-1297
    DOI 10.1037/pha0000655
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    Zs.A 4462: Show issues Location:
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  10. Article ; Online: Utility of preclinical drug versus food choice procedures to evaluate candidate medications for methamphetamine use disorder.

    Banks, Matthew L

    Annals of the New York Academy of Sciences

    2017  Volume 1394, Issue 1, Page(s) 92–105

    Abstract: Substance use disorders are diagnosed as a manifestation of inappropriate behavioral allocation toward abused drugs and away from other behaviors maintained by more adaptive nondrug reinforcers (e.g., money and social relationships). Substance use ... ...

    Abstract Substance use disorders are diagnosed as a manifestation of inappropriate behavioral allocation toward abused drugs and away from other behaviors maintained by more adaptive nondrug reinforcers (e.g., money and social relationships). Substance use disorder treatment goals include not only decreasing drug-maintained behavior but also promoting behavioral reallocation toward these socially adaptive alternative reinforcers. Preclinical drug self-administration procedures that offer concurrent access to both drug and nondrug reinforcers provide a translationally relevant dependent measure of behavioral allocation that may be useful for candidate medication evaluation. In contrast to other abused drugs, such as heroin or cocaine, preclinical methamphetamine versus food choice procedures have been a more recent development. We hypothesize that preclinical to clinical translatability would be improved by the evaluation of repeated pharmacological treatment effects on methamphetamine self-administration under a methamphetamine versus food choice procedure. In support of this hypothesis, a literature review suggests strong concordance between preclinical pharmacological treatment effects on methamphetamine versus food choice in nonhuman primates and clinical medication treatment effects on methamphetamine self-administration in human laboratory studies or methamphetamine abuse metrics in clinical trials. In conclusion, this literature suggests preclinical methamphetamine versus food choice procedures may be useful in developing innovative pharmacotherapies for methamphetamine use disorder.
    MeSH term(s) Animals ; Dopamine Agents/therapeutic use ; Food Preferences ; Humans ; Methamphetamine/administration & dosage ; Self Medication ; Substance Abuse Detection ; Substance-Related Disorders/diagnosis ; Substance-Related Disorders/drug therapy
    Chemical Substances Dopamine Agents ; Methamphetamine (44RAL3456C)
    Language English
    Publishing date 2017-04
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 211003-9
    ISSN 1749-6632 ; 0077-8923
    ISSN (online) 1749-6632
    ISSN 0077-8923
    DOI 10.1111/nyas.13276
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