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  1. Article ; Online: Prof. Amod Gupta - The leader and the legacy.

    Bansal, Reema / Sen, Alok

    Indian journal of ophthalmology

    2023  Volume 71, Issue 5, Page(s) 1671–1674

    Language English
    Publishing date 2023-05-18
    Publishing country India
    Document type Journal Article
    ZDB-ID 187392-1
    ISSN 1998-3689 ; 0301-4738
    ISSN (online) 1998-3689
    ISSN 0301-4738
    DOI 10.4103/IJO.IJO_937_23
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  2. Article ; Online: Central Retinal Artery Occlusion With Cilioretinal Artery Sparing.

    Menia, Nitin / Kapil, Arun / Bansal, Reema

    JAMA ophthalmology

    2024  Volume 142, Issue 2, Page(s) e234731

    MeSH term(s) Humans ; Retinal Artery Occlusion/diagnosis ; Arteries
    Language English
    Publishing date 2024-02-15
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2701705-9
    ISSN 2168-6173 ; 2168-6165
    ISSN (online) 2168-6173
    ISSN 2168-6165
    DOI 10.1001/jamaophthalmol.2023.4731
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article: Tubercular serpiginous choroiditis.

    Bansal, Reema / Gupta, Vishali

    Journal of ophthalmic inflammation and infection

    2022  Volume 12, Issue 1, Page(s) 37

    Abstract: Tubercular association with serpiginous choroiditis, also called 'serpiginous-like choroiditis' or 'multifocal serpiginoid choroiditis' (MSC) is reported from world over, especially from endemic countries. Though the exact mechanism is not yet clear, a ... ...

    Abstract Tubercular association with serpiginous choroiditis, also called 'serpiginous-like choroiditis' or 'multifocal serpiginoid choroiditis' (MSC) is reported from world over, especially from endemic countries. Though the exact mechanism is not yet clear, a direct or indirect infectious trigger by Mycobacterium tuberculosis (MTB) is believed to cause choroiditis.The link of immune mechanisms with ocular inflammation caused by MTB is emerging, and has been supported by both experimental and human data. The molecular and histopathological findings of tubercular serpiginous-like choroiditis have been demonstrated in clinicopathological reports, as well as in animal models. Young to middle-aged healthy males are more frequently affected. The choroiditis lesions of tubercular serpiginous-like choroiditis evolve as multifocal lesions, affecting the retinal periphery as well as posterior pole. They begin as discrete lesions, and spread in a serpiginoid pattern to become confluent. Fundus imaging including autofluorescence is extremely helpful in monitoring patients for response to therapy. Its diagnosis is essentially clinical. Corroborative evidence is obtained by a positive tuberculin skin test, or a positive QuantiFERON-TB Gold (Cellestis, Carnegie, Victoria, Australia) test, and/or radiological (chest X-ray or chest CT scan) evidence of TB elsewhere in the body. Systemic corticosteroids are the mainstay of therapy to control active inflammation, while ATT helps to reduce recurrence of inflammatory attacks. Immunosuppressive agents are indicated in cases with relentless progression, paradoxical worsening, or recurrent choroiditis.
    Language English
    Publishing date 2022-11-09
    Publishing country Germany
    Document type Journal Article ; Review
    ZDB-ID 2592309-2
    ISSN 1869-5760
    ISSN 1869-5760
    DOI 10.1186/s12348-022-00312-3
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  4. Article: Choroidal metastases as presenting manifestation of lung squamous cell carcinoma.

    Bansal, Reema / Menia, Nitin Kumar

    The Indian journal of medical research

    2022  Volume 152, Issue Suppl 1, Page(s) S172

    MeSH term(s) Carcinoma, Non-Small-Cell Lung ; Carcinoma, Squamous Cell/diagnostic imaging ; Humans ; Lung/pathology ; Lung Neoplasms/diagnostic imaging ; Lung Neoplasms/pathology
    Language English
    Publishing date 2022-03-08
    Publishing country India
    Document type Journal Article
    ZDB-ID 390883-5
    ISSN 0971-5916 ; 0019-5340
    ISSN 0971-5916 ; 0019-5340
    DOI 10.4103/ijmr.IJMR_2268_19
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  5. Article ; Online: Retrolental Bullous Retinal Detachment as the Presenting Feature of Vogt-Koyanagi-Harada Disease in an Elderly Indian Female: Diagnostic and Therapeutic Challenge.

    Kumar Menia, Nitin / Bansal, Reema / Gupta, Vishali

    Ocular immunology and inflammation

    2023  Volume 32, Issue 4, Page(s) 429–432

    Abstract: Purpose: To report an atypical case of Vogt-Koyanagi-Harada (VKH) disease with retrolental bullous retinal detachment (RD).: Methods: A case report.: Case: A 67-year-old Indian woman with bilateral, gradual visual loss presented with both eyes ... ...

    Abstract Purpose: To report an atypical case of Vogt-Koyanagi-Harada (VKH) disease with retrolental bullous retinal detachment (RD).
    Methods: A case report.
    Case: A 67-year-old Indian woman with bilateral, gradual visual loss presented with both eyes light perception, keratic precipitates, 2+ cells and bullous RD, which was retrolental in right eye (RE). Systemic investigations were unremarkable. She received systemic corticosteroids, and underwent pars plana vitrectomy (PPV) in left eye (LE). Intraoperatively, sunset glow with leopard-spot fundus were suggestive of VKH disease. Immunosuppressive therapy was added. At 2 years, vision was 3/60 in RE and 6/36 in LE. The LE retina reattached immediately following surgery, while RE exudative RD resolved very gradually following corticosteroids.
    Summary: This report illustrates diagnostic as well as therapeutic challenge in VKH disease presenting with retrolental bullous RD. PPV provided a faster anatomical and functional restoration than systemic corticosteroid therapy alone, which has potential adverse effects in the elderly.
    MeSH term(s) Humans ; Female ; Uveomeningoencephalitic Syndrome/diagnosis ; Uveomeningoencephalitic Syndrome/complications ; Uveomeningoencephalitic Syndrome/drug therapy ; Aged ; Retinal Detachment/diagnosis ; Retinal Detachment/etiology ; Retinal Detachment/surgery ; Glucocorticoids/therapeutic use ; Visual Acuity/physiology ; Vitrectomy ; Tomography, Optical Coherence ; India ; Immunosuppressive Agents/therapeutic use ; Fluorescein Angiography
    Chemical Substances Glucocorticoids ; Immunosuppressive Agents
    Language English
    Publishing date 2023-03-10
    Publishing country England
    Document type Case Reports ; Journal Article
    ZDB-ID 1193873-0
    ISSN 1744-5078 ; 0927-3948
    ISSN (online) 1744-5078
    ISSN 0927-3948
    DOI 10.1080/09273948.2023.2183222
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  6. Article ; Online: Pathogenesis of Bacterial Uveitis.

    Wildner, Gerhild / Bansal, Reema / Ayyadurai, Nikitha / Thurau, Stephan / Basu, Soumyava

    Ocular immunology and inflammation

    2023  Volume 31, Issue 7, Page(s) 1396–1404

    Abstract: Purpose: To describe the pathogenesis and the general immune mechanisms of the most frequent causes of bacterial uveitis.: Methodology: Narrative review.: Results: Both extra- and intracellular bacteria can induce uveitis, whereas intracellular ... ...

    Abstract Purpose: To describe the pathogenesis and the general immune mechanisms of the most frequent causes of bacterial uveitis.
    Methodology: Narrative review.
    Results: Both extra- and intracellular bacteria can induce uveitis, whereas intracellular bacteria are generally transported into the inner eye via cells of the innate immune system, mainly macrophages. Systemic adaptive immunity is usually induced before the bacteria are localized to the inner eye, and once T and B cells have detected the pathogens behind the blood-eye barriers they elicit an acute and/or chronic inflammatory response deteriorating visual acuity that can severely affect the non-regenerating, intraocular tissues.
    Conclusions: An understanding of pathogenic mechanisms, and its correlation with clinical and imaging features, can facilitate early recognition of microbial factors and institution of appropriate therapy.
    MeSH term(s) Humans ; Uveitis/drug therapy ; Inflammation ; Bacteria
    Language English
    Publishing date 2023-01-09
    Publishing country England
    Document type Review ; Journal Article
    ZDB-ID 1193873-0
    ISSN 1744-5078 ; 0927-3948
    ISSN (online) 1744-5078
    ISSN 0927-3948
    DOI 10.1080/09273948.2022.2155842
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  7. Article ; Online: Protein Biomarkers in Uveitis.

    Bansal, Reema / Gupta, Amod

    Frontiers in immunology

    2020  Volume 11, Page(s) 610428

    Abstract: The diseases affecting the retina or uvea (iris, ciliary body, or choroid) generate changes in the biochemical or protein composition of ocular fluids/tissues due to disruption of blood-retinal barrier. Ocular infections and inflammations are sight- ... ...

    Abstract The diseases affecting the retina or uvea (iris, ciliary body, or choroid) generate changes in the biochemical or protein composition of ocular fluids/tissues due to disruption of blood-retinal barrier. Ocular infections and inflammations are sight-threatening diseases associated with various infectious and non-infectious etiologies. Several etiological entities cause uveitis, a complex intraocular inflammatory disease. These causes of uveitis differ in different populations due to geographical, racial, and socioeconomic variations. While clinical appearance is sufficiently diagnostic in many diseases, some of the uveitic entities manifest nonspecific or atypical clinical presentation. Identification of biomarkers in such diseases is an important aid in their diagnostic armamentarium. Different diseases and their different severity states release varying concentrations of proteins, which can serve as biomarkers. Proteomics is a high throughput technology and a powerful screening tool for serum biomarkers in various diseases that identifies proteins by mass spectrometry and helps to improve the understanding of pathogenesis of a disease. Proteins determine the biological state of a cell. Once identified as biomarkers, they serve as future diagnostic and pharmaceutical targets. With a potential to redirect the diagnosis of idiopathic uveitis, ocular proteomics provide a new insight into the pathophysiology and therapeutics of various ocular inflammatory diseases. Tears, aqueous and vitreous humor represent potential repositories for proteomic biomarkers discovery in uveitis. With an extensive proteomics work done on animal models of uveitis, various types of human uveitis are being subjected to proteome analysis for biomarker discovery in different ocular fluids (vitreous, aqueous, or tears).
    MeSH term(s) Animals ; Aqueous Humor/metabolism ; Biomarkers/metabolism ; Eye/metabolism ; Humans ; Predictive Value of Tests ; Prognosis ; Proteins/metabolism ; Proteome ; Proteomics ; Tears/metabolism ; Uveitis/diagnosis ; Uveitis/metabolism ; Uveitis/therapy ; Vitreous Body/metabolism
    Chemical Substances Biomarkers ; Proteins ; Proteome
    Language English
    Publishing date 2020-12-03
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2606827-8
    ISSN 1664-3224 ; 1664-3224
    ISSN (online) 1664-3224
    ISSN 1664-3224
    DOI 10.3389/fimmu.2020.610428
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  8. Article ; Online: Pigmentation of optic discs.

    Kumar, Nitin / Bansal, Reema

    Indian journal of ophthalmology

    2020  Volume 68, Issue 6, Page(s) 1183

    MeSH term(s) Humans ; Intraocular Pressure ; Optic Disk ; Pigmentation ; Pigmentation Disorders ; Visual Fields
    Language English
    Publishing date 2020-05-26
    Publishing country India
    Document type Journal Article
    ZDB-ID 187392-1
    ISSN 1998-3689 ; 0301-4738
    ISSN (online) 1998-3689
    ISSN 0301-4738
    DOI 10.4103/ijo.IJO_1874_19
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  9. Article ; Online: Pseudohypopyon after cataract surgery.

    Kumar, Nitin / Bansal, Reema

    Indian journal of ophthalmology

    2020  Volume 68, Issue 9, Page(s) 1973

    MeSH term(s) Anterior Chamber ; Cataract ; Cataract Extraction ; Eye Diseases ; Humans
    Language English
    Publishing date 2020-08-04
    Publishing country India
    Document type Journal Article
    ZDB-ID 187392-1
    ISSN 1998-3689 ; 0301-4738
    ISSN (online) 1998-3689
    ISSN 0301-4738
    DOI 10.4103/ijo.IJO_499_20
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  10. Article ; Online: Optical Coherence Tomography and Optical Coherence Tomography Angiography in Neglected Diseases.

    Mahendradas, Padmamalini / Acharya, Isha / Rana, Vipin / Bansal, Reema / Ben Amor, Hager / Khairallah, Moncef

    Ocular immunology and inflammation

    2023  , Page(s) 1–8

    Abstract: A group of self-limiting and frequently neglected diseases exist in the literature like Rickettsial disease, Malaria, Dengue fever, Chikungunya, West Nile virus infection, Rift Valley fever, Bartonellosis, or Lyme disease which are poorly understood due ... ...

    Abstract A group of self-limiting and frequently neglected diseases exist in the literature like Rickettsial disease, Malaria, Dengue fever, Chikungunya, West Nile virus infection, Rift Valley fever, Bartonellosis, or Lyme disease which are poorly understood due to lack of proper diagnostic testing. Currently, multimodal imaging has become a critical modality in the diagnosis and management of ocular diseases. Optical coherence tomography (OCT) is one such remarkable imaging modality in the field of ophthalmology providing high-resolution, cross-sectional images of the retina and choroid with the recent advances such as enhanced depth imaging and swept source OCT. Additionally, OCT angiography (OCTA) has further revolutionised dynamic imaging of retinal and choroidal vasculature non-invasively. This review article highlights the OCT and OCTA biomarkers in the diagnosis and prognosis of the aforementioned neglected diseases.
    Language English
    Publishing date 2023-05-19
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 1193873-0
    ISSN 1744-5078 ; 0927-3948
    ISSN (online) 1744-5078
    ISSN 0927-3948
    DOI 10.1080/09273948.2023.2211161
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