LIVIVO - The Search Portal for Life Sciences

zur deutschen Oberfläche wechseln
Advanced search

Search results

Result 1 - 4 of total 4

Search options

  1. Article ; Online: Anti-inflammation of LZTFL1 knockdown in OVA-induced asthmatic mice: Through ERK/GATA3 signaling pathway.

    Song, Guihua / Sun, Mengmeng / Zhang, Yan / Zhang, Bingxue / Peng, Minghao / Bao, Beibei

    Molecular immunology

    2024  Volume 167, Page(s) 16–24

    Abstract: Asthma is a common chronic respiratory disease characterized by Th2-type inflammation in the airways. Leucine zip transcription factor-like 1 (LZTFL1) has been implicated in the regulation of Th2-related factors. The knockdown of LZTFL1 resulted in ... ...

    Abstract Asthma is a common chronic respiratory disease characterized by Th2-type inflammation in the airways. Leucine zip transcription factor-like 1 (LZTFL1) has been implicated in the regulation of Th2-related factors. The knockdown of LZTFL1 resulted in decreased levels of IL-4, IL-5, and IL-13. We hypothesize that LZTFL1 may have an effect on asthma. We established an acute asthmatic mouse model using the Ovalbumin (OVA) sensitization, and we found that LZTFL1 expression was upregulated in OVA-induced CD4 + T cells. Mice challenged with OVA were administered 5 × 10
    MeSH term(s) Animals ; Mice ; Anti-Inflammatory Agents/metabolism ; Asthma/chemically induced ; Asthma/genetics ; Asthma/drug therapy ; Bronchoalveolar Lavage Fluid ; Cytokines/metabolism ; Disease Models, Animal ; Inflammation/pathology ; Interleukin-13/metabolism ; Interleukin-4/metabolism ; Interleukin-5 ; Lung/metabolism ; Mice, Inbred BALB C ; Ovalbumin/metabolism ; Signal Transduction ; Th2 Cells ; Transcription Factors/metabolism ; MAP Kinase Signaling System
    Chemical Substances Anti-Inflammatory Agents ; Cytokines ; Gata3 protein, mouse ; Interleukin-13 ; Interleukin-4 (207137-56-2) ; Interleukin-5 ; Lztfl1 protein, mouse ; Ovalbumin (9006-59-1) ; Transcription Factors
    Language English
    Publishing date 2024-02-03
    Publishing country England
    Document type Journal Article
    ZDB-ID 424427-8
    ISSN 1872-9142 ; 0161-5890
    ISSN (online) 1872-9142
    ISSN 0161-5890
    DOI 10.1016/j.molimm.2024.01.010
    Database MEDical Literature Analysis and Retrieval System OnLINE

    Full text online

    More links

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Zs.A 166: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  2. Article: Mary Ip: at the intersection of art and science.

    Bao, Beibei

    The Lancet. Respiratory medicine

    2013  Volume 1, Issue 4, Page(s) 290

    MeSH term(s) Biomedical Research/history ; History, 20th Century ; History, 21st Century ; Hong Kong ; Pulmonary Medicine/history ; Societies, Medical/history
    Language English
    Publishing date 2013-06
    Publishing country England
    Document type Biography ; Historical Article ; Portraits
    ZDB-ID 2686754-0
    ISSN 2213-2619 ; 2213-2600
    ISSN (online) 2213-2619
    ISSN 2213-2600
    DOI 10.1016/S2213-2600(13)70112-7
    Database MEDical Literature Analysis and Retrieval System OnLINE

    Full text online

    More links

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Zs.A 7041: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  3. Article ; Online: Protective effect of berberine against LPS-induced endothelial cell injury via the JNK signaling pathway and autophagic mechanisms.

    Guo, Junping / Chen, Wei / Bao, Beibei / Zhang, Dayong / Pan, Jianping / Zhang, Mao

    Bioengineered

    2021  Volume 12, Issue 1, Page(s) 1324–1337

    Abstract: The role of autophagic mechanisms in the protective effect of berberine (BBR) on lipopolysaccharide (LPS)-induced injury in the endothelial cells human umbilical vein endothelial cells (HUVECs) and human pulmonary microvascular endothelial cells (HPMECs) ...

    Abstract The role of autophagic mechanisms in the protective effect of berberine (BBR) on lipopolysaccharide (LPS)-induced injury in the endothelial cells human umbilical vein endothelial cells (HUVECs) and human pulmonary microvascular endothelial cells (HPMECs) was investigated. Cell viability, proliferation, and apoptosis were detected by the CCK-8 assay, the EdU kit, and flow cytometry, respectively, and autophagy-related protein expression, the number of autophagic vacuoles, and LC3 double-fluorescence were examined using western blot analysis, transmission electron microscopy, and confocal microscopy, respectively. LPS resulted in a decrease in the cell viability and proliferation of HUVECs and HPMECs and an increase in the number of apoptotic cells, while BBR treatment resulted in an increase in cell viability and proliferation, as well as a decrease in cell apoptosis. Furthermore, BBR could inhibit LPS-induced autophagy, as demonstrated by its inhibitory effects on the LC3-II/LC3-I ratio and Beclin-1 levels and its promotive effect on p62 expression. Addition of the autophagy inducer rapamycin (RAPA) aggravated LPS-induced injury, while treatment with the autophagy blocker 3-methyladenine (3-MA) attenuated the injury. Further, the protective effect of BBR was inhibited by rapamycin. JNK inhibition by SP600125 inhibited LPS-induced autophagy, and BBR could not alter the LPS-induced autophagy in HUVECs and HPMECs that were pretreated with SP600125. The present data indicate that BBR attenuated LPS-induced cell apoptosis by blocking JNK-mediated autophagy in HUVECs and HPMECs. Therefore, the JNK-mediated autophagy pathway could be a potential target for the prevention and treatment of cardiovascular disease.
    MeSH term(s) Adenine/analogs & derivatives ; Adenine/pharmacology ; Anthracenes/pharmacology ; Autophagy/drug effects ; Berberine/pharmacology ; Cell Proliferation/drug effects ; Cell Survival/drug effects ; Endothelial Cells/drug effects ; Endothelial Cells/enzymology ; Endothelial Cells/pathology ; Endothelial Cells/ultrastructure ; Human Umbilical Vein Endothelial Cells ; Humans ; Lipopolysaccharides/toxicity ; MAP Kinase Signaling System/drug effects ; Protective Agents/pharmacology ; Sirolimus/pharmacology
    Chemical Substances Anthracenes ; Lipopolysaccharides ; Protective Agents ; Berberine (0I8Y3P32UF) ; pyrazolanthrone (1TW30Y2766) ; 3-methyladenine (5142-23-4) ; Adenine (JAC85A2161) ; Sirolimus (W36ZG6FT64)
    Language English
    Publishing date 2021-04-26
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2737830-5
    ISSN 2165-5987 ; 2165-5979
    ISSN (online) 2165-5987
    ISSN 2165-5979
    DOI 10.1080/21655979.2021.1915671
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  4. Article ; Online: China progresses with health reform but challenges remain.

    Alcorn, Ted / Bao, Beibei

    Lancet (London, England)

    2010  Volume 377, Issue 9777, Page(s) 1557–1558

    MeSH term(s) China ; Health Care Reform ; Humans
    Language English
    Publishing date 2010-11-22
    Publishing country England
    Document type News
    ZDB-ID 3306-6
    ISSN 1474-547X ; 0023-7507 ; 0140-6736
    ISSN (online) 1474-547X
    ISSN 0023-7507 ; 0140-6736
    DOI 10.1016/s0140-6736(11)60625-9
    Database MEDical Literature Analysis and Retrieval System OnLINE

    Full text online

    More links

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Ua VI Zs.5: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)
    Zs.MG 94: Show issues

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

To top