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  1. Article ; Online: Strepolyketide D, a new SEK15-derived polyketide compound from salt-lake-derived Streptomyces sp. DBC5

    Bao, Xiao-Wei / Li, Yi-Xin / Chen, Xiao-ming / Zhang, Zhi-Dong / Xu, Li-Juan / Liu, Xiao-Lu / Song, Su-Qin / Ma, Zhong Jun

    Journal of Asian Natural Products Research. 2023 Feb. 1, v. 25, no. 2 p.197-204

    2023  

    Abstract: A new SEK15-derived polyketide compound, strepolyketide D (1), was isolated from salt-lake-derived Streptomyces sp. DBC5, together with two known analogues (2-3). Their structures were elucidated based on spectroscopic analysis of IR, MS, 1 D and 2 D NMR. ...

    Abstract A new SEK15-derived polyketide compound, strepolyketide D (1), was isolated from salt-lake-derived Streptomyces sp. DBC5, together with two known analogues (2-3). Their structures were elucidated based on spectroscopic analysis of IR, MS, 1 D and 2 D NMR. Compound 2 elicited moderate antioxidation with IC₅₀ value of 39.26 μg/ml. The results of the study revealed that salt-lake actinomycetes of Lake Dabancheng appear to have immense potential as a source of polyketide compounds.
    Keywords Streptomyces ; lakes ; polyketides ; research ; spectral analysis ; Streptomyces sp. ; polyketide ; antioxidant activity ; strepolyketide D
    Language English
    Dates of publication 2023-0201
    Size p. 197-204.
    Publishing place Taylor & Francis
    Document type Article ; Online
    ZDB-ID 2077926-4
    ISSN 1477-2213 ; 1028-6020
    ISSN (online) 1477-2213
    ISSN 1028-6020
    DOI 10.1080/10286020.2022.2076673
    Database NAL-Catalogue (AGRICOLA)

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  2. Article ; Online: Strepolyketide D, a new SEK15-derived polyketide compound from salt-lake-derived

    Bao, Xiao-Wei / Li, Yi-Xin / Chen, Xiao-Ming / Zhang, Zhi-Dong / Xu, Li-Juan / Liu, Xiao-Lu / Song, Su-Qin / Ma, Zhong-Jun

    Journal of Asian natural products research

    2022  Volume 25, Issue 2, Page(s) 197–204

    Abstract: A new SEK15-derived polyketide compound, strepolyketide D ( ...

    Abstract A new SEK15-derived polyketide compound, strepolyketide D (
    MeSH term(s) Streptomyces/chemistry ; Polyketides ; Lakes ; Magnetic Resonance Spectroscopy
    Chemical Substances Polyketides
    Language English
    Publishing date 2022-05-25
    Publishing country England
    Document type Journal Article
    ZDB-ID 2077926-4
    ISSN 1477-2213 ; 1028-6020
    ISSN (online) 1477-2213
    ISSN 1028-6020
    DOI 10.1080/10286020.2022.2076673
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article: [Protective effect of raspberry extract on ConA-induced acute liver injuryin mice].

    Ji, Yu-Bin / Bao, Xiao-Wei / Shan, Yu / Yang, Shu-Xian / Zhang, Li-Mei / Hou, Si-Yuan / Li, Li-Yong / Cao, Li

    Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica

    2019  Volume 44, Issue 4, Page(s) 774–780

    Abstract: In this experiment,the antioxidant capacity of raspberry extract and the protective effect on liver injury induced by ConA in mice were investigated. Balb/C male mice were randomly divided into six groups: normal group,model group,bicyclol control group( ...

    Abstract In this experiment,the antioxidant capacity of raspberry extract and the protective effect on liver injury induced by ConA in mice were investigated. Balb/C male mice were randomly divided into six groups: normal group,model group,bicyclol control group( 200 mg·kg~(-1)),low-dose raspberry extract group( 200 mg·kg~(-1)),middle-dose raspberry extract group( 400 mg·kg~(-1)),and highdose raspberry extract group( 800 mg·kg~(-1)). Each group was intragastrically administered with drugs according to the body weight once a day. Seven days later,all of the groups except for the normal group were treated with ConA( 20 mg·kg~(-1)) through tail vein injection to establish the acute liver injury model. The mice were put to death 8 hours later. The organ indexes were calculated. These rum levels of ALT,AST and LDH and the activities of SOD,CAT,GSH and MDA in liver tissue were detected. HE staining was used to observe the pathological changes of liver tissue in mice. Western blot was used to detect the expressions of Bax,Bcl-2,Nrf2 and Keap-1. The antioxidant capacity of raspberry extract was measured by CAA assay. The results showed that,raspberry extract had a strong antioxidant capacity. Simultaneously,compared with the model group,raspberry extract can significantly improve the pathological conditions of liver,and significantly reduce ALT,AST and LDH activities in serum of liver injury mice( P<0. 01). The activities of SOD,CAT in liver homogenate supernatant were significantly increased in the high-dose group,the content of GSH increased,while the content of MDA was sharply declined in the high-dose group( P<0. 01). Meanwhile,raspberry extract down-regulated the expressions of Bax and Keap-1 and up-regulated the expressions of Bcl-2 and Nrf2. CAA showed that the compound raspberry extract had a strong antioxidant capacity. Therefore,raspberry extract has an obvious protective effect on acute liver injury induced by ConA in mice.
    MeSH term(s) Animals ; Antioxidants ; Chemical and Drug Induced Liver Injury ; Liver ; Male ; Mice ; Mice, Inbred BALB C ; Protective Agents ; Rubus
    Chemical Substances Antioxidants ; Protective Agents
    Language Chinese
    Publishing date 2019-06-03
    Publishing country China
    Document type Journal Article
    ZDB-ID 1004649-5
    ISSN 1001-5302 ; 0254-0029
    ISSN 1001-5302 ; 0254-0029
    DOI 10.19540/j.cnki.cjcmm.20181101.005
    Database MEDical Literature Analysis and Retrieval System OnLINE

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