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  1. Article: [Forty cases of chronic prostatitis/chronic pelvic pain syndrome treated by acupuncture and crude herb moxibustion].

    Bao, Yi-mei / Luo, Fang / Wei, Jian-hua

    Zhongguo zhen jiu = Chinese acupuncture & moxibustion

    2011  Volume 31, Issue 6, Page(s) 571–572

    MeSH term(s) Acupuncture Therapy ; Adult ; Chronic Disease/therapy ; Humans ; Male ; Moxibustion ; Pelvic Pain/therapy ; Prostatitis/therapy ; Treatment Outcome ; Young Adult
    Language Chinese
    Publishing date 2011-06
    Publishing country China
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ISSN 0255-2930
    ISSN 0255-2930
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Olgotrelvir, a dual inhibitor of SARS-CoV-2 M

    Mao, Long / Shaabani, Namir / Zhang, Xiaoying / Jin, Can / Xu, Wanhong / Argent, Christopher / Kushnareva, Yulia / Powers, Colin / Stegman, Karen / Liu, Jia / Xie, Hui / Xu, Changxu / Bao, Yimei / Xu, Lijun / Zhang, Yuren / Yang, Haigang / Qian, Shengdian / Hu, Yong / Shao, Jianping /
    Zhang, Can / Li, Tingting / Li, Yi / Liu, Na / Lin, Zhenhao / Wang, Shanbo / Wang, Chao / Shen, Wei / Lin, Yuanlong / Shu, Dan / Zhu, Zhenhong / Kotoi, Olivia / Kerwin, Lisa / Han, Qing / Chumakova, Ludmila / Teijaro, John / Royal, Mike / Brunswick, Mark / Allen, Robert / Ji, Henry / Lu, Hongzhou / Xu, Xiao

    Med (New York, N.Y.)

    2024  Volume 5, Issue 1, Page(s) 42–61.e23

    Abstract: Background: Oral antiviral drugs with improved antiviral potency and safety are needed to address current challenges in clinical practice for treatment of COVID-19, including the risks of rebound, drug-drug interactions, and emerging resistance.: ... ...

    Abstract Background: Oral antiviral drugs with improved antiviral potency and safety are needed to address current challenges in clinical practice for treatment of COVID-19, including the risks of rebound, drug-drug interactions, and emerging resistance.
    Methods: Olgotrelvir (STI-1558) is designed as a next-generation antiviral targeting the SARS-CoV-2 main protease (M
    Findings: Olgotrelvir is a highly bioavailable oral prodrug that is converted in plasma to its active form, AC1115. The dual mechanism of action of olgotrelvir and AC1115 was confirmed by enzyme activity inhibition assays and co-crystal structures of AC1115 with SARS-CoV-2 M
    Conclusions: Olgotrelvir is an oral inhibitor targeting M
    Funding: Funded by Sorrento Therapeutics.
    MeSH term(s) Animals ; Humans ; Mice ; Antiviral Agents/pharmacology ; Antiviral Agents/therapeutic use ; Cathepsin L/antagonists & inhibitors ; COVID-19/prevention & control ; Disease Models, Animal ; Mice, Transgenic ; SARS-CoV-2 ; Coronavirus Protease Inhibitors/chemistry ; Coronavirus Protease Inhibitors/pharmacology ; Coronavirus 3C Proteases/antagonists & inhibitors ; COVID-19 Drug Treatment/methods
    Chemical Substances Antiviral Agents ; Cathepsin L (EC 3.4.22.15) ; STI-1558 ; Coronavirus Protease Inhibitors ; Coronavirus 3C Proteases (EC 3.4.22.28)
    Language English
    Publishing date 2024-01-04
    Publishing country United States
    Document type Journal Article
    ISSN 2666-6340
    ISSN (online) 2666-6340
    DOI 10.1016/j.medj.2023.12.004
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Olgotrelvir, a dual inhibitor of SARS-CoV-2 M

    Mao, Long / Shaabani, Namir / Zhang, Xiaoying / Jin, Can / Xu, Wanhong / Argent, Christopher / Kushnareva, Yulia / Powers, Colin / Stegman, Karen / Liu, Jia / Xie, Hui / Xu, Changxu / Bao, Yimei / Xu, Lijun / Zhang, Yuren / Yang, Haigang / Qian, Shengdian / Hu, Yong / Shao, Jianping /
    Zhang, Can / Li, Tingting / Li, Yi / Liu, Na / Lin, Zhenhao / Wang, Shanbo / Wang, Chao / Shen, Wei / Lin, Yuanlong / Shu, Dan / Zhu, Zhenhong / Kotoi, Olivia / Kerwin, Lisa / Han, Qing / Chumakova, Ludmila / Teijaro, John / Royal, Mike / Brunswick, Mark / Allen, Robert / Ji, Henry / Lu, Hongzhou / Xu, Xiao

    Med (New York, N.Y.)

    2024  Volume 5, Issue 2, Page(s) 169–171

    Language English
    Publishing date 2024-02-02
    Publishing country United States
    Document type Published Erratum
    ISSN 2666-6340
    ISSN (online) 2666-6340
    DOI 10.1016/j.medj.2024.01.013
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article: [Experimental study on effect of pre-acupuncture and moxibustion on molecular markers in pre-thrombosis state of rats].

    Niu, Xiang-Lai / Zhou, Yu / Lin, Qing / Bao, Yi-Mei / Song, Xiao-Ping

    Zhongguo zhen jiu = Chinese acupuncture & moxibustion

    2010  Volume 30, Issue 10, Page(s) 845–847

    Abstract: Objective: To explore the best method for prevention and treatment of thrombosis and its mechanism.: Methods: Forty SD rats were randomly divided into a blank group, a model group, an electroacupuncture group and a crude herb moxibustion group. In ... ...

    Abstract Objective: To explore the best method for prevention and treatment of thrombosis and its mechanism.
    Methods: Forty SD rats were randomly divided into a blank group, a model group, an electroacupuncture group and a crude herb moxibustion group. In the electroacupuncture group and the crude herb moxibustion group. "Zusanli" (ST 36), "Sanyinjiao" (SP 6), "Pishu" (BL 20) and "Geshu" (BL 17) were punctured or moxibusted for 2 weeks, then pre-thrombosis model was induced by Adrenalin Hydrochloride and ice water method in the model group, the electroacupuncture group and the crude herb moxibustion group, respectively. Molecular markers in venous blood after the model made in 18 hours were detected.
    Results: Act: vaty of tissue-type plasminogen activator (t-PA) and content of alpha-granule membrane protein (GMP-140) decreased and content of nitrogen monoxidum (NO) increased after electroacupuncture or crude herb moxibustion. The levels of t-PA and GMP-140 in the model group were higher than those in the electroacupuncture group, the crude herb moxibustion group and the blank group (all P < 0.05), and the content of NO in the model group was lower than those in the electroacupuncture group, the crude herb moxibustion group and the blank group (all P < 0.05), while there was no significant difference in t- PA, GMP-140 and NO among the crude herb moxibustion group, electroacupuncture group and blank group (all P > 0.05).
    Conclusion: Electroacupuncture and crude herb moxibustion can significantly change the contents of t-PA, GMP-140 and NO and there was no significant difference between the two therapies.
    MeSH term(s) Acupuncture Therapy ; Animals ; Disease Models, Animal ; Female ; Humans ; Male ; Moxibustion ; Nitric Oxide/blood ; P-Selectin/blood ; Random Allocation ; Rats ; Rats, Sprague-Dawley ; Thrombosis/blood ; Thrombosis/pathology ; Thrombosis/therapy ; Tissue Plasminogen Activator/blood
    Chemical Substances P-Selectin ; Nitric Oxide (31C4KY9ESH) ; Tissue Plasminogen Activator (EC 3.4.21.68)
    Language Chinese
    Publishing date 2010-10
    Publishing country China
    Document type English Abstract ; Journal Article ; Research Support, Non-U.S. Gov't
    ISSN 0255-2930
    ISSN 0255-2930
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article: Quantitative determination of anti-tumor agent bis(4-fluorobenzyl)trisulfide, fluorapacin and its pharmaceutical preparation by high-performance liquid chromatography.

    Bao, Yimei / He, Yuyu / Xu, Xiaoying / Mo, Xiaopeng / Xu, Xiao / Wang, Xiaobo / An, Haoyun

    Journal of pharmaceutical and biomedical analysis

    2008  Volume 46, Issue 1, Page(s) 206–210

    Abstract: A simple isocratic and stability-indicating HPLC method was developed and validated for the quantitative determination of anti-tumor agent fluorapacin and its pharmaceutical preparation. A Spherisorb ODS II C(18) (250 mm x 4.6 mm, 5 microm) column was ... ...

    Abstract A simple isocratic and stability-indicating HPLC method was developed and validated for the quantitative determination of anti-tumor agent fluorapacin and its pharmaceutical preparation. A Spherisorb ODS II C(18) (250 mm x 4.6 mm, 5 microm) column was eluted with a mobile phase consisting of acetonitrile/water (85:15, v/v). The analyses were performed at 40+/-1 degrees C with a flow rate of 1.0 mL/min and UV detection at 218 nm. The calibration curve was linear over a concentration range of 160-240 microg/mL with the correlation coefficient of 0.9997. The LOD and LOQ were determined to be 1.4 and 7.0 ng/mL, respectively. Average recoveries were 98.27% and 100.40% for fluorapacin API and its drug product with corresponding relative standard deviations (R.S.D.) of 0.41% and 0.30%, respectively. Good repeatability (precision and intermediate precision), accuracy and tolerability were obtained with R.S.D. of <1.0%. This specific and reliable method has been successfully applied for quality control of fluorapacin API and drug product.
    MeSH term(s) Antineoplastic Agents/analysis ; Antineoplastic Agents/chemistry ; Calibration ; Chromatography, High Pressure Liquid/methods ; Drug Stability ; Ethanol/analysis ; Ethanol/chemistry ; Fluorobenzenes/analysis ; Fluorobenzenes/chemistry ; Glycerol/analogs & derivatives ; Glycerol/analysis ; Glycerol/chemistry ; Molecular Structure ; Pharmaceutical Preparations/analysis ; Pharmaceutical Preparations/chemistry ; Quality Control ; Reproducibility of Results ; Sulfides/analysis ; Sulfides/chemistry ; Technology, Pharmaceutical/methods ; alpha-Tocopherol/analysis ; alpha-Tocopherol/chemistry
    Chemical Substances Antineoplastic Agents ; Fluorobenzenes ; Pharmaceutical Preparations ; Sulfides ; fluorapacin ; Ethanol (3K9958V90M) ; cremophor EL (6D4M1DAL6O) ; alpha-Tocopherol (H4N855PNZ1) ; Glycerol (PDC6A3C0OX)
    Language English
    Publishing date 2008-01-07
    Publishing country England
    Document type Journal Article
    ZDB-ID 604917-5
    ISSN 1873-264X ; 0731-7085
    ISSN (online) 1873-264X
    ISSN 0731-7085
    DOI 10.1016/j.jpba.2007.09.018
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1850: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  6. Article: Stability studies of anticancer agent bis(4-fluorobenzyl)trisulfide and synthesis of related substances.

    Bao, Yimei / Mo, Xiaopeng / Xu, Xiaoying / He, Yuyu / Xu, Xiao / An, Haoyun

    Journal of pharmaceutical and biomedical analysis

    2008  Volume 48, Issue 3, Page(s) 664–671

    Abstract: Bis(4-fluorobenzyl)trisulfide, fluorapacin, has been extensively developed as a promising new anticancer drug candidate. Its degradation products were identified and verified by the newly synthesized compounds bis(4-fluorobenzyl)disulfide (A) and bis(4- ... ...

    Abstract Bis(4-fluorobenzyl)trisulfide, fluorapacin, has been extensively developed as a promising new anticancer drug candidate. Its degradation products were identified and verified by the newly synthesized compounds bis(4-fluorobenzyl)disulfide (A) and bis(4-fluorobenzyl)tetrasulfide (B) which were resulted from the disproportionation of fluorapacin under forced conditions. A stability-indicating HPLC method was used for the stability evaluation of active pharmaceutical ingredient (API) fluorapacin and finished pharmaceutical product (FPP) under various conditions. High recovery (99.57%) of API was found after three freeze-thaw cycle processes of fluorapacin FPP. Susceptibility of fluorapacin to oxidative degradation was studied by treating fluorapacin and FPP in 30% hydrogen peroxide aqueous solution, and the result verified the oxidative stability of fluorapacin. However, treatment of this drug candidate under strong light (4500 Lx+/-500 Lx) for 10 days showed substantial effect on the recovery of fluorapacin, especially from fluorapacin FPP. Strong acid (1.0M, HCl) did not affect the recovery of fluorapacin while strong basic condition (1.0M, NaOH) accelerated the disproportionation of fluorapacin to its related substances A and B. The stability of fluorapacin in its aqueous media at a pH range of 2.0-10.0 for up to 6h was further investigated, and 4.0-8.0 was found to be the most stable pH range. Fluorapacin and FPP were exposed to the elevated temperatures of 40 and 60 degrees C for 10 days without obvious impact on their stability. The thermal stability of fluorapacin API and FPP under constant humidity with light protection was also thoroughly investigated under accelerated (40+/-2 degrees C, RH 75+/-5%, 6 months) and long-term (25+/-2 degrees C, RH 60+/-10%, 24 months) conditions. There was no significant change except minor color change of fluorapacin FPP. Therefore, fluorapacin has excellent stability as a potential drug candidate for further clinical development investigation.
    MeSH term(s) Antineoplastic Agents/analysis ; Antineoplastic Agents/chemistry ; Chemistry, Pharmaceutical ; Chromatography, High Pressure Liquid/methods ; Drug Stability ; Fluorobenzenes/analysis ; Fluorobenzenes/chemistry ; Freezing ; Humidity ; Hydrogen Peroxide/pharmacology ; Hydrogen-Ion Concentration ; Light ; Molecular Structure ; Oxidation-Reduction ; Pharmaceutical Preparations/chemistry ; Sulfides/analysis ; Sulfides/chemistry ; Technology, Pharmaceutical/methods ; Temperature ; Time Factors ; Water/chemistry
    Chemical Substances Antineoplastic Agents ; Fluorobenzenes ; Pharmaceutical Preparations ; Sulfides ; fluorapacin ; Water (059QF0KO0R) ; Hydrogen Peroxide (BBX060AN9V)
    Language English
    Publishing date 2008-11-04
    Publishing country England
    Document type Journal Article
    ZDB-ID 604917-5
    ISSN 1873-264X ; 0731-7085
    ISSN (online) 1873-264X
    ISSN 0731-7085
    DOI 10.1016/j.jpba.2008.06.013
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1850: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  7. Article: [Impacts of electroacupuncture on left hippocampus NAA/Cr for patients of Uygur and Han nationality with mild cognitive impairment].

    Liu, Zhi-Yan / Guo, Hui / Zhang, Xiao-Lin / Liu, Juan / Qu, Hong-Yan / Peng, Wei / Bao, Yi-Mei / Yin, Li-Li / Song, Yi-Xing

    Zhongguo zhen jiu = Chinese acupuncture & moxibustion

    2011  Volume 31, Issue 9, Page(s) 773–777

    Abstract: Objective: To observe the clinical efficacy of electroacupuncture (EA) on mild cognitive impairment (MCI) for patients of Uygur and Han nationality and explore the national diversity among the patients with MCI.: Methods: Twenty-five cases were ... ...

    Abstract Objective: To observe the clinical efficacy of electroacupuncture (EA) on mild cognitive impairment (MCI) for patients of Uygur and Han nationality and explore the national diversity among the patients with MCI.
    Methods: Twenty-five cases were divided into Han nationality group (15 cases) and Uygur nationality group (10 cases) according to patient's nationality. In either group, EA was applied to Baihui (GV 20), Fengchi (GB 20), Xuanzhong (GB 39), Fuliu (KI 7), Sanyinjiao (SP 6) and Taixi (KI 3), once per day, 15 treatments made one session and there were 5 days at the interval among the sessions. Totally, 3 sessions of treatment were required. The proton magnetic resonance spectroscopy (1H-MRS) was used to observe the changes in the ratio of N-acetylaspartate and creatine (NAA/Cr) on the left hippocampus for the patients in two groups before and after treatment as well as the changes in the results of the Mini-Mental State Examination (MMSE) and the Montreal Cognitive Assessment (MoCA) separately.
    Results: NAA/Cr in Uygur nationality group was higher than that in Han nationality group before treatment (1.659 +/- 0.418 vs 1.137 +/- 0.190, P < 0.05). After treatment, MMSE and MoCA scores all increased apparently as compared with those before treatment in two groups (P < 0.05, P < 0.01), and NAA/Cr on the left hippocampus in either group was up-regulated as compared with that before treatment (both P < 0.01).
    Conclusion: EA can improve the overall cognitive function for the patients with MCI. There is the national diversity in the partial brain metabolite level between Uygur patients and Han patients with MCI.
    MeSH term(s) Aged ; Aged, 80 and over ; Aspartic Acid/analogs & derivatives ; Aspartic Acid/analysis ; China/ethnology ; Cognition Disorders/metabolism ; Cognition Disorders/therapy ; Creatine/analysis ; Electroacupuncture ; Female ; Hippocampus/chemistry ; Humans ; Magnetic Resonance Spectroscopy ; Male ; Middle Aged
    Chemical Substances Aspartic Acid (30KYC7MIAI) ; N-acetylaspartate (997-55-7) ; Creatine (MU72812GK0)
    Language Chinese
    Publishing date 2011-09
    Publishing country China
    Document type English Abstract ; Journal Article ; Research Support, Non-U.S. Gov't
    ISSN 0255-2930
    ISSN 0255-2930
    Database MEDical Literature Analysis and Retrieval System OnLINE

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