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  1. Article ; Online: Breast cancer has a new metabolic Achilles' heel.

    Alfonso-Pérez, Tatiana / Baonza, Gabriel / Martin-Belmonte, Fernando

    Nature metabolism

    2021  Volume 3, Issue 5, Page(s) 590–592

    Language English
    Publishing date 2021-05-24
    Publishing country Germany
    Document type Journal Article
    ISSN 2522-5812
    ISSN (online) 2522-5812
    DOI 10.1038/s42255-021-00394-8
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Intercalate or invaginate: PI(3,4,5)P3 governs a membrane constriction switch in cell shaping.

    Baonza, Gabriel / Herranz, Gonzalo / Martin-Belmonte, Fernando

    Developmental cell

    2021  Volume 56, Issue 18, Page(s) 2542–2544

    Abstract: Although contractile processes, from tissue invagination to cell intercalation, utilize diverse ratcheting mechanisms, little is known about how ratcheting becomes engaged at specific cell surfaces. In this issue of Developmental Cell, Maio et al. ... ...

    Abstract Although contractile processes, from tissue invagination to cell intercalation, utilize diverse ratcheting mechanisms, little is known about how ratcheting becomes engaged at specific cell surfaces. In this issue of Developmental Cell, Maio et al. demonstrate that PI(3,4,5)P3 is a paramount regulator of the Sbf/RabGEF-Rab35 ratchet mechanism.
    MeSH term(s) Cell Membrane ; Constriction ; Phosphatidylinositols
    Chemical Substances Phosphatidylinositols ; phosphoinositide-3,4,5-triphosphate
    Language English
    Publishing date 2021-09-28
    Publishing country United States
    Document type Journal Article ; Comment
    ZDB-ID 2054967-2
    ISSN 1878-1551 ; 1534-5807
    ISSN (online) 1878-1551
    ISSN 1534-5807
    DOI 10.1016/j.devcel.2021.09.006
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    In stock of ZB MED Cologne/Königswinter

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  3. Article ; Online: Deciphering the interplay between autophagy and polarity in epithelial tubulogenesis.

    Alfonso-Pérez, Tatiana / Baonza, Gabriel / Herranz, Gonzalo / Martín-Belmonte, Fernando

    Seminars in cell & developmental biology

    2022  Volume 131, Page(s) 160–172

    Abstract: The Metazoan complexity arises from a primary building block, the epithelium, which comprises a layer of polarized cells that divide the organism into compartments. Most of these body compartments are organs formed by epithelial tubes that enclose an ... ...

    Abstract The Metazoan complexity arises from a primary building block, the epithelium, which comprises a layer of polarized cells that divide the organism into compartments. Most of these body compartments are organs formed by epithelial tubes that enclose an internal hollow space or lumen. Over the last decades, multiple studies have unmasked the paramount events required to form this lumen de novo. In epithelial cells, these events mainly involve recognizing external clues, establishing and maintaining apicobasal polarity, endo-lysosomal trafficking, and expanding the created lumen. Although canonical autophagy has been classically considered a catabolic process needed for cell survival, multiple studies have also emphasized its crucial role in epithelial polarity, morphogenesis and cellular homeostasis. Furthermore, non-canonical autophagy pathways have been recently discovered as atypical secretory routes. Both canonical and non-canonical pathways play essential roles in epithelial polarity and lumen formation. This review addresses how the molecular machinery for epithelial polarity and autophagy interplay in different processes and how autophagy functions influence lumenogenesis, emphasizing its role in the lumen formation key events.
    MeSH term(s) Animals ; Autophagy ; Cell Polarity ; Epithelial Cells/metabolism ; Epithelium ; Morphogenesis
    Language English
    Publishing date 2022-05-28
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 1312473-0
    ISSN 1096-3634 ; 1084-9521
    ISSN (online) 1096-3634
    ISSN 1084-9521
    DOI 10.1016/j.semcdb.2022.05.015
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    Zs.A 2918: Show issues Location:
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  4. Article ; Online: The vertebrate epithelial apical junctional complex: Dynamic interplay between Rho GTPase activity and cell polarization processes.

    Díaz-Díaz, Covadonga / Baonza, Gabriel / Martín-Belmonte, Fernando

    Biochimica et biophysica acta. Biomembranes

    2020  Volume 1862, Issue 10, Page(s) 183398

    Abstract: Epithelial tissues are made of highly specialized cells present in many organs and represent the first barrier of protection from the external environment. Essential for this critical role in protection is their capacity to polarize in the apicobasal ... ...

    Abstract Epithelial tissues are made of highly specialized cells present in many organs and represent the first barrier of protection from the external environment. Essential for this critical role in protection is their capacity to polarize in the apicobasal axis. The integrity of the epithelium and its properties as a protective barrier is mostly regulated by dynamic intercellular junctions composed of multiprotein complexes. The functionality and dynamics of these junctions are tightly controlled by several signaling processes, including Rho GTPases. Here, we review the most recent data in the contribution of Rho GTPases and their functional regulators during the morphogenesis of epithelial tissues and to maintain the homeostasis in adults.
    MeSH term(s) Animals ; Cell Polarity ; Intercellular Junctions/metabolism ; Vertebrates/metabolism ; rho GTP-Binding Proteins/metabolism
    Chemical Substances rho GTP-Binding Proteins (EC 3.6.5.2)
    Language English
    Publishing date 2020-06-17
    Publishing country Netherlands
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Review
    ZDB-ID 60-7
    ISSN 1879-2642 ; 1879-2596 ; 1879-260X ; 1872-8006 ; 1879-2618 ; 1879-2650 ; 0006-3002 ; 0005-2728 ; 0005-2736 ; 0304-4165 ; 0167-4838 ; 1388-1981 ; 0167-4889 ; 0167-4781 ; 0304-419X ; 1570-9639 ; 0925-4439 ; 1874-9399
    ISSN (online) 1879-2642 ; 1879-2596 ; 1879-260X ; 1872-8006 ; 1879-2618 ; 1879-2650
    ISSN 0006-3002 ; 0005-2728 ; 0005-2736 ; 0304-4165 ; 0167-4838 ; 1388-1981 ; 0167-4889 ; 0167-4781 ; 0304-419X ; 1570-9639 ; 0925-4439 ; 1874-9399
    DOI 10.1016/j.bbamem.2020.183398
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    Uc I Zs.247: Show issues Location:
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  5. Article ; Online: CartoCell, a high-content pipeline for 3D image analysis, unveils cell morphology patterns in epithelia.

    Andrés-San Román, Jesús A / Gordillo-Vázquez, Carmen / Franco-Barranco, Daniel / Morato, Laura / Fernández-Espartero, Cecilia H / Baonza, Gabriel / Tagua, Antonio / Vicente-Munuera, Pablo / Palacios, Ana M / Gavilán, María P / Martín-Belmonte, Fernando / Annese, Valentina / Gómez-Gálvez, Pedro / Arganda-Carreras, Ignacio / Escudero, Luis M

    Cell reports methods

    2023  Volume 3, Issue 10, Page(s) 100597

    Abstract: Decades of research have not yet fully explained the mechanisms of epithelial self-organization and 3D packing. Single-cell analysis of large 3D epithelial libraries is crucial for understanding the assembly and function of whole tissues. Combining 3D ... ...

    Abstract Decades of research have not yet fully explained the mechanisms of epithelial self-organization and 3D packing. Single-cell analysis of large 3D epithelial libraries is crucial for understanding the assembly and function of whole tissues. Combining 3D epithelial imaging with advanced deep-learning segmentation methods is essential for enabling this high-content analysis. We introduce CartoCell, a deep-learning-based pipeline that uses small datasets to generate accurate labels for hundreds of whole 3D epithelial cysts. Our method detects the realistic morphology of epithelial cells and their contacts in the 3D structure of the tissue. CartoCell enables the quantification of geometric and packing features at the cellular level. Our single-cell cartography approach then maps the distribution of these features on 2D plots and 3D surface maps, revealing cell morphology patterns in epithelial cysts. Additionally, we show that CartoCell can be adapted to other types of epithelial tissues.
    MeSH term(s) Humans ; Imaging, Three-Dimensional/methods ; Image Processing, Computer-Assisted/methods ; Epithelium ; Epithelial Cells ; Cysts
    Language English
    Publishing date 2023-09-25
    Publishing country United States
    Document type Journal Article
    ISSN 2667-2375
    ISSN (online) 2667-2375
    DOI 10.1016/j.crmeth.2023.100597
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  6. Article ; Online: Smoothelin-like 2 Inhibits Coronin-1B to Stabilize the Apical Actin Cortex during Epithelial Morphogenesis.

    Hachimi, Mariam / Grabowski, Catalina / Campanario, Silvia / Herranz, Gonzalo / Baonza, Gabriel / Serrador, Juan M / Gomez-Lopez, Sergio / Barea, Maria D / Bosch-Fortea, Minerva / Gilmour, Darren / Bagnat, Michel / Rodriguez-Fraticelli, Alejo E / Martin-Belmonte, Fernando

    Current biology : CB

    2020  Volume 31, Issue 4, Page(s) 696–706.e9

    Abstract: The actin cortex is involved in many biological processes and needs to be significantly remodeled during cell differentiation. Developing epithelial cells construct a dense apical actin cortex to carry out their barrier and exchange functions. The apical ...

    Abstract The actin cortex is involved in many biological processes and needs to be significantly remodeled during cell differentiation. Developing epithelial cells construct a dense apical actin cortex to carry out their barrier and exchange functions. The apical cortex assembles in response to three-dimensional (3D) extracellular cues, but the regulation of this process during epithelial morphogenesis remains unknown. Here, we describe the function of Smoothelin-like 2 (SMTNL2), a member of the smooth-muscle-related Smoothelin protein family, in apical cortex maturation. SMTNL2 is induced during development in multiple epithelial tissues and localizes to the apical and junctional actin cortex in intestinal and kidney epithelial cells. SMTNL2 deficiency leads to membrane herniations in the apical domain of epithelial cells, indicative of cortex abnormalities. We find that SMTNL2 binds to actin filaments and is required to slow down the turnover of apical actin. We also characterize the SMTNL2 proximal interactome and find that SMTNL2 executes its functions partly through inhibition of coronin-1B. Although coronin-1B-mediated actin dynamics are required for early morphogenesis, its sustained activity is detrimental for the mature apical shape. SMTNL2 binds to coronin-1B through its N-terminal coiled-coil region and negates its function to stabilize the apical cortex. In sum, our results unveil a mechanism for regulating actin dynamics during epithelial morphogenesis, providing critical insights on the developmental control of the cellular cortex.
    MeSH term(s) Actin Cytoskeleton/metabolism ; Actins/metabolism ; Animals ; Dogs ; Epithelial Cells/cytology ; Epithelial Cells/metabolism ; Epithelium ; Female ; HEK293 Cells ; Humans ; Madin Darby Canine Kidney Cells ; Microfilament Proteins/antagonists & inhibitors ; Morphogenesis ; Phosphoproteins/metabolism ; Zebrafish
    Chemical Substances Actins ; Microfilament Proteins ; Phosphoproteins ; SMTNL2 protein, human ; coronin proteins (145420-64-0)
    Language English
    Publishing date 2020-12-03
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 1071731-6
    ISSN 1879-0445 ; 0960-9822
    ISSN (online) 1879-0445
    ISSN 0960-9822
    DOI 10.1016/j.cub.2020.11.010
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    Zs.A 3208: Show issues Location:
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