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  1. AU="Baoting He"
  2. AU="Yang, Shuihua"
  3. AU="Chubanov, Vladimir"
  4. AU="Alessandro Pedretti"
  5. AU="Daniel Krewski"
  6. AU="Benhamida, Myriam"
  7. AU="Bérubé, Caterina"
  8. AU=Shaykh Ramzi
  9. AU="Chaker, A M"
  10. AU="Connor, Ashton A"
  11. AU="Pruscini, Ilaria"
  12. AU="Diane M. Pascoe"
  13. AU="Hartner, G"
  14. AU="Özgür Akgül"
  15. AU="Paryani, Mohammad Reza"
  16. AU="Lutin, Florence"
  17. AU="Cheung, D Y T"
  18. AU="Shaishta, Naghma"
  19. AU=Zhao Mengyi
  20. AU="Liang, Dejin"
  21. AU="Yeşim YENİ"
  22. AU="Sivlér, Tobias"
  23. AU=Datta Srayan
  24. AU="Masoud Behzadifar"
  25. AU="Jonathan Fuld"
  26. AU="López-Caballero, María Guadalupe"
  27. AU="Rawlinson, Jennifer R"
  28. AU="Priti N Mody-Pan"
  29. AU="Yunusov, Marat S"
  30. AU=Peever John
  31. AU="Khosravi, Majid"
  32. AU="Xiang, La"
  33. AU="Sag, Duygu"
  34. AU="Khatiri Yanehsari, M."
  35. AU="Cooke, Georga"
  36. AU="Stefanello, Bianca"
  37. AU="Cummings, Brian J"
  38. AU=Yu Xiongwu
  39. AU=Greenland Sander
  40. AU=Deanfield John
  41. AU="Vu, Hung"
  42. AU="Soucek, Alexander"
  43. AU="Rihui Su"
  44. AU="Campbell, Steve"

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  1. Artikel ; Online: Assessing the safety of lipid-modifying medications among Chinese adolescents

    Shan Luo / Hugh Simon Lam / Yap Hang Chan / Clara Sze Man Tang / Baoting He / Man Ki Kwok / Gabriel M. Leung / C Mary Schooling / Shiu Lun Au Yeung

    BMC Medicine, Vol 21, Iss 1, Pp 1-

    a drug-target Mendelian randomization study

    2023  Band 11

    Abstract: Abstract Background With increasing hypercholesterolemia prevalence in East Asian adolescents, pharmacologic interventions (e.g., HMGCR inhibitors (statins) and PCSK9 inhibitors) may have to be considered although their longer-term safety in the general ... ...

    Abstract Abstract Background With increasing hypercholesterolemia prevalence in East Asian adolescents, pharmacologic interventions (e.g., HMGCR inhibitors (statins) and PCSK9 inhibitors) may have to be considered although their longer-term safety in the general adolescent population is unclear. This study aims to investigate the longer-term safety of HMGCR inhibitors and PCSK9 inhibitors among East Asian adolescents using genetics. Methods A drug-target Mendelian randomization study leveraging the Global Lipid Genetics Consortium (East Asian, n = 146,492) and individual-level data from Chinese participants in the Biobank clinical follow-up of Hong Kong’s “Children of 1997” birth cohort (n = 3443, aged ~ 17.6 years). Safety outcomes (n = 100) included anthropometric and hematological traits, renal, liver, lung function, and other nuclear magnetic resonance metabolomics. Positive control outcomes were cholesterol markers from the “Children of 1997” birth cohort and coronary artery disease from Biobank Japan. Results Genetic inhibition of HMGCR and PCSK9 were associated with reduction in cholesterol-related NMR metabolomics, e.g., apolipoprotein B (HMGCR: beta [95% CI], − 1.06 [− 1.52 to − 0.60]; PCSK9: − 0.93 [− 1.56 to − 0.31]) and had the expected effect on the positive control outcomes. After correcting for multiple comparisons (p-value < 0.006), genetic inhibition of HMGCR was associated with lower linoleic acid − 0.79 [− 1.25 to − 0.35]. Genetic inhibition of PCSK9 was not associated with the safety outcomes assessed. Conclusions Statins and PCSK9 inhibitors in East Asian adolescents appeared to be safe based on the outcomes concerned. Larger studies were warranted to verify these findings. This study serves as a proof of principle study to inform the medication safety among adolescents via genetics.
    Schlagwörter HMGCR inhibitors ; PCSK9 inhibitors ; Safety ; Adolescents ; Drug-target Mendelian randomization ; Medicine ; R
    Sprache Englisch
    Erscheinungsdatum 2023-10-01T00:00:00Z
    Verlag BMC
    Dokumenttyp Artikel ; Online
    Datenquelle BASE - Bielefeld Academic Search Engine (Lebenswissenschaftliche Auswahl)

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  2. Artikel ; Online: The effect of birth weight on body composition

    Junxi Liu / Shiu Lun Au Yeung / Baoting He / Man Ki Kwok / Gabriel Matthew Leung / C Mary Schooling

    PLoS ONE, Vol 14, Iss 9, p e

    Evidence from a birth cohort and a Mendelian randomization study.

    2019  Band 0222141

    Abstract: Background Lower birth weight is associated with diabetes although the underlying mechanisms are unclear. Muscle mass could be a modifiable link and hence a target of intervention. We assessed the associations of birth weight with muscle and fat mass ... ...

    Abstract Background Lower birth weight is associated with diabetes although the underlying mechanisms are unclear. Muscle mass could be a modifiable link and hence a target of intervention. We assessed the associations of birth weight with muscle and fat mass observationally in a population with little socio-economic patterning of birth weight and using Mendelian randomization (MR) for validation. Methods In the population-representative "Children of 1997" birth cohort (n = 8,327), we used multivariable linear regression to assess the adjusted associations of birth weight (kg) with muscle mass (kg) and body fat (%) at ~17.5 years. Genetically predicted birth weight (effect size) was applied to summary genetic associations with fat-free mass and fat mass (kg) from the UK Biobank (n = ~331,000) to obtain unconfounded estimates using inverse-variance weighting. Results Observationally, birth weight was positively associated with muscle mass (3.29 kg per kg birth weight, 95% confidence interval (CI) 2.83 to 3.75) and body fat (1.09% per kg birth weight, 95% CI 0.54 to 1.65). Stronger associations with muscle mass were observed in boys than in girls (p for interaction 0.004). Using MR, birth weight was positively associated with fat-free mass (0.77 kg per birth weight z-score, 95% CI 0.22 to 1.33) and fat mass (0.58, 95% CI 0.01 to 1.15). No difference by sex was evident. Conclusion Higher birth weight increasing muscle mass may be relevant to lower birth weight increasing the risk of diabetes and suggests post-natal muscle mass as a potential target of intervention.
    Schlagwörter Medicine ; R ; Science ; Q
    Sprache Englisch
    Erscheinungsdatum 2019-01-01T00:00:00Z
    Verlag Public Library of Science (PLoS)
    Dokumenttyp Artikel ; Online
    Datenquelle BASE - Bielefeld Academic Search Engine (Lebenswissenschaftliche Auswahl)

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  3. Artikel ; Online: Birth weight and prematurity with lung function at ~17.5 years

    Baoting He / Man Ki Kwok / Shiu Lun Au Yeung / Shi Lin Lin / June Yue Yan Leung / Lai Ling Hui / Albert M. Li / Gabriel M. Leung / C. Mary Schooling

    Scientific Reports, Vol 10, Iss 1, Pp 1-

    “Children of 1997” birth cohort

    2020  Band 12

    Abstract: Abstract We aimed to determine if prematurity and lower birth weight are associated with poorer lung function in a non-western developed setting with less marked confounding by socioeconomic position. Using multivariable linear regression in Hong Kong’s “ ...

    Abstract Abstract We aimed to determine if prematurity and lower birth weight are associated with poorer lung function in a non-western developed setting with less marked confounding by socioeconomic position. Using multivariable linear regression in Hong Kong’s “Children of 1997” birth cohort, adjusted associations of prematurity and birth weight with forced expiratory volume in 1 second (FEV1), forced vital capacity (FVC), and forced expiratory flow at 25–75% of the pulmonary volume (FEF25–75%) at ~17.5 years were assessed. Associations for birth weight were stronger in boys for FEV1 (boys: 0.31 L, 95% confidence interval (CI) 0.24 to 0.38, girls: 0.18 L, 95% CI 0.12 to 0.25), FVC (boys: 0.36 L, 95% CI 0.27 to 0.44, girls: 0.22 L, 95% CI 0.15 to 0.28) and FEF25–75% (boys: 0.35 L, 95% CI 0.21 to 0.49, girls: 0.22 L, 95% CI 0.09 to 0.34) adjusted for age, socioeconomic position and infant and maternal characteristics. Similarly adjusted, preterm birth (compared to full-term birth) was associated with lower FEV1/FVC and FEF25–75%. Thus, associations of lower birth weight, especially in boys, and prematurity with poorer lung function at 17.5 years were found. Identifying underlying mechanism might contribute to the improvement of pulmonary health and the prevention of adult respiratory illness.
    Schlagwörter Medicine ; R ; Science ; Q
    Thema/Rubrik (Code) 360
    Sprache Englisch
    Erscheinungsdatum 2020-01-01T00:00:00Z
    Verlag Nature Publishing Group
    Dokumenttyp Artikel ; Online
    Datenquelle BASE - Bielefeld Academic Search Engine (Lebenswissenschaftliche Auswahl)

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  4. Artikel ; Online: The association of early-life exposure to air pollution with lung function at ~17.5 years in the “Children of 1997” Hong Kong Chinese Birth Cohort

    Baoting He / Jian V. Huang / Man Ki Kwok / Shiu Lun Au Yeung / Lai Ling Hui / Albert M. Li / Gabriel M. Leung / C. Mary Schooling

    Environment International, Vol 123, Iss , Pp 444-

    2019  Band 450

    Abstract: Background: Early-life air pollution exposure is associated with lung function in children and adolescents. However, whether the association of prenatal and early postnatal exposure to air pollution with lung function continues into adulthood remains ... ...

    Abstract Background: Early-life air pollution exposure is associated with lung function in children and adolescents. However, whether the association of prenatal and early postnatal exposure to air pollution with lung function continues into adulthood remains unclear. Objective: To investigate the associations of early exposure to air pollution with lung function at ~17.5 years in a non-western developed setting with more concentrated air pollutants. Methods: We examined the associations of exposure to particular matter with an aerodynamic diameter of <10 μm (PM10), nitrogen dioxides (NO2), nitric oxide (NO), sulfur dioxide (SO2) in standard deviations (SD)) at different early life stages with lung function (indicated by forced vital capacity (FVC), forced expiratory volume in 1 s (FEV1) and forced expiratory flow at 25%–75% of the pulmonary volume (FEF25%–75%)) in SD at ~17.5 years, personal history of wheezing and asthma in the population-representative Hong Kong Chinese birth cohort “Children of 1997”(n = 2942). Results: Higher in utero and infancy and toddlerhood NO2 were associated with lower FEV1 (−0.022, 95% confidence interval (CI) –0.029 to −0.015 and − 0.026, 95% CI –0.033 to −0.019), FEV1/FVC (−0.035, 95% CI –0.050 to −0.021 and –0.052, 95% CI –0.066 to −0.038) and FEF25%–75% (−0.031, 95% CI –0.040 to −0.022 and –0.043, 95% CI –0.051 to −0.035). A similar association was observed for NO. Weak associations of NO2 and NO with FVC were observed (–0.011, 95% CI –0.018 to −0.003 and –0.010, 95% CI –0.020 to −0.001). NOx was associated with higher risk of wheezing (1.08, 95% CI 1.03 to 1.14) but not asthma (1.02, 95% CI 0.94 to 1.11). SO2 and PM10 were not clearly associated with lung function, wheezing or asthma. Conclusion: Our findings suggest that early exposure to air pollution from NO2 may have long-term effects on lung function, which could affect respiratory health throughout life.
    Schlagwörter Environmental sciences ; GE1-350
    Thema/Rubrik (Code) 333
    Sprache Englisch
    Erscheinungsdatum 2019-02-01T00:00:00Z
    Verlag Elsevier
    Dokumenttyp Artikel ; Online
    Datenquelle BASE - Bielefeld Academic Search Engine (Lebenswissenschaftliche Auswahl)

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