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  1. Article: Gradual dosing of ursodeoxycholic acid in mothers with intrahepatic cholestasis of pregnancy may improve composite neonatal outcome.

    Hamud, Amir / Cohen, Matan J / Hochner-Celnikier, Drorith / Bar-Oz, Benjamin / Ackerman, Zvi

    Annals of hepatology

    2024  Volume 29, Issue 3, Page(s) 101490

    Abstract: Introduction and objectives: Intrahepatic cholestasis of pregnancy (ICP) is often accompanied by fetal and maternal complications.: Materials and methods: Retrospective review of the clinical course of women with ICP and their neonates treated at our ...

    Abstract Introduction and objectives: Intrahepatic cholestasis of pregnancy (ICP) is often accompanied by fetal and maternal complications.
    Materials and methods: Retrospective review of the clinical course of women with ICP and their neonates treated at our medical center over a 10-year period. Special attention was paid to the maternal and neonatal response to 2 different modes of ursodeoxycholic acid (UDCA) administration.
    Results: Neonates of mothers with high total bile acid levels had a poorer composite neonatal outcome. Twenty-seven women who presented at an advanced stage of their pregnancies did not receive UDCA. UDCA was administered in 2 modes: either a full dose at admission (76 women) or a gradually increasing dose until the desired dosage was reached (25 women). The mean gestational age at delivery for the 94 neonates that were exposed to full UDCA dose was the lowest (36±2.3 weeks for the full dose, 37±1.4 weeks for the 30 neonates from the gradually increasing dose, 38±1.6 weeks for the 29 neonates from the no treatment group, p<0.001). The group of neonates that were exposed to full UDCA dose had the highest rate of unfavorable composite neonatal outcome (53% for full dose, 30% for gradually increasing dose, 24% for the no treatment group, p=0.006).
    Conclusions: Compared to the administration of a full UDCA dose, the administration of a gradually increasing dose of UDCA may be associated with a greater gestational age at delivery and fewer events of unfavorable composite neonatal outcomes. These novel findings should be retested prospectively in a large cohort of patients.
    MeSH term(s) Humans ; Ursodeoxycholic Acid/administration & dosage ; Ursodeoxycholic Acid/therapeutic use ; Female ; Pregnancy ; Cholestasis, Intrahepatic/drug therapy ; Cholestasis, Intrahepatic/diagnosis ; Cholestasis, Intrahepatic/blood ; Retrospective Studies ; Pregnancy Complications/drug therapy ; Pregnancy Complications/blood ; Infant, Newborn ; Cholagogues and Choleretics/administration & dosage ; Cholagogues and Choleretics/adverse effects ; Cholagogues and Choleretics/therapeutic use ; Adult ; Gestational Age ; Treatment Outcome ; Pregnancy Outcome
    Chemical Substances Ursodeoxycholic Acid (724L30Y2QR) ; Cholagogues and Choleretics
    Language English
    Publishing date 2024-02-23
    Publishing country Mexico
    Document type Journal Article
    ZDB-ID 2188733-0
    ISSN 1665-2681
    ISSN 1665-2681
    DOI 10.1016/j.aohep.2024.101490
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  2. Article ; Online: Using a safe taxi service to transport newborn babies home from hospital.

    Eventov-Friedman, S / Bar-Oz, B / Zisk-Rony, R Y

    Acta paediatrica (Oslo, Norway : 1992)

    2014  Volume 103, Issue 1, Page(s) 57–61

    Abstract: Aim: To evaluate an intervention to enhance parents' use of car safety seats (CSSs) for their newborn baby's first journey home from the hospital in a population not usually exposed to television, internet and mainstream printed media.: Methods: ... ...

    Abstract Aim: To evaluate an intervention to enhance parents' use of car safety seats (CSSs) for their newborn baby's first journey home from the hospital in a population not usually exposed to television, internet and mainstream printed media.
    Methods: Parents of newborn babies who did not bring a CSS to the hospital before their baby was discharged were lent a CSS to use in a 'safe taxi' service. All taxi drivers were trained to install the CSS safely. The intervention was evaluated using preprogramme questionnaires and follow-up interviews 4-8 weeks after discharge.
    Results: Twelve parents participated in the intervention during the study period (January to April 2011) and in the evaluation process. Eleven couples were Jewish and one was Muslim. Most (75%) reported that they had not previously used CSS routinely and the reason was not financial. Following the 'safe taxi' intervention, 83% reported the use of CSS when travelling in all vehicles (excluding buses). On follow-up, most participants reported that the intervention increased their awareness and the use of CSS.
    Conclusion: The intervention, targeted at this specific population, was well received by the parents, increased awareness, changed practices and assured that more newborns travelled home safely in a CSS.
    MeSH term(s) Adult ; Child Restraint Systems ; Female ; Hospitals ; Humans ; Infant, Newborn ; Transportation ; Young Adult
    Language English
    Publishing date 2014-01
    Publishing country Norway
    Document type Journal Article
    ZDB-ID 203487-6
    ISSN 1651-2227 ; 0365-1436 ; 0803-5253
    ISSN (online) 1651-2227
    ISSN 0365-1436 ; 0803-5253
    DOI 10.1111/apa.12431
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  3. Article ; Online: Oral propranolol for prevention of threshold retinopathy of prematurity (ROPROP): protocol of a randomised controlled trial.

    Bührer, Christoph / Erdeve, Ömer / Bassler, Dirk / Bar-Oz, Benjamin

    BMJ open

    2018  Volume 8, Issue 7, Page(s) e021749

    Abstract: Introduction: Retinopathy of prematurity (ROP) is a disease observed in extremely premature infants characterised by visioning-threatening retinal vessel proliferation. Propranolol, a drug used for decades in newborn infants with heart diseases, ... ...

    Abstract Introduction: Retinopathy of prematurity (ROP) is a disease observed in extremely premature infants characterised by visioning-threatening retinal vessel proliferation. Propranolol, a drug used for decades in newborn infants with heart diseases, hypertension and thyrotoxicosis and licenced for infantile haemangiomas, may be effective in halting progression of ROP to severe stages, as suggested by preliminary data from small studies.
    Methods and analysis: ROPROP is an investigator-initiated, multicentre, placebo-controlled double-blind, randomised controlled trial aiming to assess the safety and efficacy of orally administered propranolol to reduce the risk of threshold ROP (stage 3) in extremely preterm infants at 48 weeks postmenstrual age (primary objective) and the rate of infants requiring local interventions for severe ROP (secondary objective). Key inclusion criteria: gestational age <28 weeks, birth weight <1250 g, postmenstrual age ≥31 and <37 weeks, incipient ROP (stage 1 or 2, with or without plus disease) and written informed consent by parents or legal guardian. Key exclusion criteria: requirement for open-label propranolol treatment, major congenital malformations (including those with cerebrovascular malformations), known chromosomal anomalies, colobomas and other eye malformations, atrioventricular block grade 2 or 3 and comedication with antiarrhythmics, clonidine, insulin (pharmacodynamic interaction), phenobarbital or rifampicin (pharmacokinetic interaction). The intervention consists of oral propranolol-hydrochloride (1.6 mg/kg/day in three to four divided dosages) or placebo until discharge, for a maximum of 10 weeks. Analysis is by intention to treat.
    Ethics and dissemination: The protocol has received ethical and regulatory approval. Results will be published after peer review irrespective of the study outcome.
    Trial registration numbers: NCT03083431 , EudraCT# 2017-002124-24 (EUCTR), 00013730 (DRKS); Pre-results.
    MeSH term(s) Administration, Oral ; Adrenergic beta-Antagonists/administration & dosage ; Disease Progression ; Double-Blind Method ; Gestational Age ; Humans ; Infant ; Infant, Extremely Premature ; Infant, Newborn ; Infant, Very Low Birth Weight ; Propranolol/administration & dosage ; Randomized Controlled Trials as Topic ; Retinopathy of Prematurity/prevention & control ; Treatment Outcome
    Chemical Substances Adrenergic beta-Antagonists ; Propranolol (9Y8NXQ24VQ)
    Language English
    Publishing date 2018-07-06
    Publishing country England
    Document type Clinical Trial Protocol ; Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2747269-3
    ISSN 2044-6055 ; 2044-6055 ; 2053-3624
    ISSN (online) 2044-6055
    ISSN 2044-6055 ; 2053-3624
    DOI 10.1136/bmjopen-2018-021749
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  4. Article ; Online: Selective Serotonin Reuptake Inhibitors (SSRIs) and Serotonin Norepinephrine Reuptake Inhibitors (SNRIs) During Pregnancy and the Risk for Autism spectrum disorder (ASD) and Attention deficit hyperactivity disorder (ADHD) in the Offspring: A True Effect or a Bias? A Systematic Review & Meta-Analysis.

    Leshem, Regina / Bar-Oz, Benjamin / Diav-Citrin, Orna / Gbaly, Siham / Soliman, Jessica / Renoux, Christel / Matok, Ilan

    Current neuropharmacology

    2021  Volume 19, Issue 6, Page(s) 896–906

    Abstract: Background and objective: An inconsistent association between exposure to SSRIs and SNRIs and the risk for ASD and ADHD in the Offspring was observed in observational studies. Some suggest that the reported association might be due to unmeasured ... ...

    Abstract Background and objective: An inconsistent association between exposure to SSRIs and SNRIs and the risk for ASD and ADHD in the Offspring was observed in observational studies. Some suggest that the reported association might be due to unmeasured confounding. We aimed to study this association and to look for sources of bias by performing a systematic review and meta-analysis.
    Methods: Medline, Embase, and the Cochrane Library were searched up to June 2019 for studies reporting on ASD and ADHD in the Offspring following exposure during pregnancy. We followed the PRISMA 2009 guidelines for data selection and extraction. Outcomes were pooled using random- effects models and odds ratios (OR), and 95% confidence intervals (CI) were calculated for each outcome using the adjusted point estimate of each study.
    Results: Eighteen studies were included in the meta-analysis. We found an association between SSRIs/ SNRIs prenatal use and the risk for ASD and ADHD (OR=1.42, 95% CI: 1.23-1.65, I
    Conclusions: Although we found an association between exposure to SSRIs/SNRIs during pregnancy and the risk for ASD and ADHD, an association with those disorders was also present for exposure pre-pregnancy, suggesting that the association might be due to unmeasured confounding. We are aiming to further assess the role of potential unmeasured confounding in the estimation of the association and perform a network meta-analysis.
    MeSH term(s) Attention Deficit Disorder with Hyperactivity/epidemiology ; Autism Spectrum Disorder/chemically induced ; Female ; Humans ; Norepinephrine ; Pregnancy ; Prenatal Exposure Delayed Effects ; Serotonin ; Selective Serotonin Reuptake Inhibitors/adverse effects ; Serotonin and Noradrenaline Reuptake Inhibitors
    Chemical Substances Serotonin Uptake Inhibitors ; Serotonin and Noradrenaline Reuptake Inhibitors ; Serotonin (333DO1RDJY) ; Norepinephrine (X4W3ENH1CV)
    Language English
    Publishing date 2021-02-12
    Publishing country United Arab Emirates
    Document type Journal Article ; Meta-Analysis ; Systematic Review
    ZDB-ID 2192352-8
    ISSN 1875-6190 ; 1570-159X
    ISSN (online) 1875-6190
    ISSN 1570-159X
    DOI 10.2174/1570159X19666210303121059
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  5. Article ; Online: Do developmental and temperamental characteristics mediate the association between preterm birth and the quality of mother-child interaction?

    Harel-Gadassi, Ayelet / Friedlander, Edwa / Yaari, Maya / Bar-Oz, Benjamin / Eventov-Friedman, Smadar / Mankuta, David / Yirmiya, Nurit

    Infant behavior & development

    2020  Volume 58, Page(s) 101421

    Abstract: Background: The current study aims to evaluate the association between preterm birth and the quality of mother-child interaction of very preterm-, moderate preterm-, and full-term-born children at 18 and 36 months and to determine whether developmental ... ...

    Abstract Background: The current study aims to evaluate the association between preterm birth and the quality of mother-child interaction of very preterm-, moderate preterm-, and full-term-born children at 18 and 36 months and to determine whether developmental and behavioral characteristics mediate the association between preterm birth and the quality of mother-child interaction.
    Method: Participants included 110 preterm-born children and 39 full-term-born children assessed at ages 18 and 36 months. Mother-child free play interactions, the Mullen Scales of Early Learning, the Infant Behavior Questionnaire, and the Early Childhood Behavior Questionnaire were administered.
    Results: Significant associations between preterm birth and the quality of mother-child interaction were found at 18 and 36 months. The mother-child interaction quality was less optimal for the preterm-born children compared with the full-term-born children, mainly so for the very preterm-born children. Unlike behavioral characteristics, cognitive development was found to mediate the association between the gestational age-based group and the quality of mother-child interaction.
    Conclusions: Intervention programs for preterm-born children and their families, should consider maternal and children's behaviors during mother-child interactions, in addition to cognitive, language, motor and emotional regulation abilities, and particularly so with very preterm-born children, who exhibit slower cognitive development.
    MeSH term(s) Adult ; Child Development/physiology ; Child, Preschool ; Female ; Humans ; Infant ; Infant Behavior/physiology ; Infant Behavior/psychology ; Infant, Newborn ; Infant, Premature/physiology ; Infant, Premature/psychology ; Male ; Middle Aged ; Mother-Child Relations/psychology ; Surveys and Questionnaires ; Temperament/physiology ; Young Adult
    Language English
    Publishing date 2020-03-02
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 224510-3
    ISSN 1934-8800 ; 1879-0453 ; 0163-6383
    ISSN (online) 1934-8800 ; 1879-0453
    ISSN 0163-6383
    DOI 10.1016/j.infbeh.2020.101421
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  6. Article ; Online: Prenatal exposure to selective serotonin reuptake inhibitors and serotonin norepinephrine reuptake inhibitors and risk for persistent pulmonary hypertension of the newborn: a systematic review, meta-analysis, and network meta-analysis.

    Masarwa, Reem / Bar-Oz, Benjamin / Gorelik, Einat / Reif, Shimon / Perlman, Amichai / Matok, Ilan

    American journal of obstetrics and gynecology

    2018  Volume 220, Issue 1, Page(s) 57.e1–57.e13

    Abstract: Background: There is a marked increase in the use of selective serotonin reuptake inhibitors and serotonin norepinephrine reuptake inhibitors in the last decade. Many newborns are likely to be exposed during pregnancy and labor.: Objective: We aimed ... ...

    Abstract Background: There is a marked increase in the use of selective serotonin reuptake inhibitors and serotonin norepinephrine reuptake inhibitors in the last decade. Many newborns are likely to be exposed during pregnancy and labor.
    Objective: We aimed to evaluate the association between exposure to selective serotonin reuptake inhibitors and serotonin norepinephrine reuptake inhibitors during pregnancy and the risk for persistent pulmonary hypertension of the newborn. We sought to compare the risk for persistent pulmonary hypertension of the newborn between specific selective serotonin reuptake inhibitor agents.
    Study design: MEDLINE, Embase, and Cochrane were searched up to July 2017. No language restrictions were applied. Search key words included: "SSRI," "SNRI," "pregnancy," "risk," "new-born," and "pulmonary hypertension." Retrospective cohort studies and case-control studies reporting the risk for persistent pulmonary hypertension of the newborn in the offspring of women exposed to selective serotonin reuptake inhibitors or serotonin norepinephrine reuptake inhibitors during pregnancy, were extracted. Two independent researchers identified relevant data. Random effects meta-analysis was used to pool results. Odds ratios were calculated with subsequent 95% confidence intervals. Network meta-analysis was conducted, incorporating direct and indirect comparisons among different selective serotonin reuptake inhibitors. The primary outcome was risk for persistent pulmonary hypertension of the newborn after exposure to selective serotonin reuptake inhibitors or serotonin norepinephrine reuptake inhibitors during pregnancy.
    Results: A total of 11 studies were identified. A total of 156,978 women and their offspring were exposed to selective serotonin reuptake inhibitors or serotonin norepinephrine reuptake inhibitors during pregnancy. Persistent pulmonary hypertension of the newborn was detected among 452 exposed offspring, representing an incidence rate of 2.9 cases per 1000 live births and a number needed to harm of 1000. The risk for persistent pulmonary hypertension of the newborn was significantly increased in the analysis of exposure to selective serotonin reuptake inhibitor/serotonin norepinephrine reuptake inhibitor in any trimester (odds ratio, 1.82; 95% confidence interval, 1.31-2.54; I
    Conclusion: Exposure to selective serotonin reuptake inhibitors or serotonin norepinephrine reuptake inhibitors during pregnancy is associated with an increased risk for persistent pulmonary hypertension of the newborn. According to our findings, sertraline ranked as most likely to have the lowest risk for persistent pulmonary hypertension of the newborn compared to other selective serotonin reuptake inhibitors, suggesting it may have the best safety profile for use in pregnancy in this regard. Further studies are needed to fully establish these results.
    MeSH term(s) Depressive Disorder/diagnosis ; Depressive Disorder/drug therapy ; Female ; Follow-Up Studies ; Gestational Age ; Humans ; Incidence ; Infant, Newborn ; Network Meta-Analysis ; Norepinephrine/administration & dosage ; Norepinephrine/antagonists & inhibitors ; Persistent Fetal Circulation Syndrome/chemically induced ; Persistent Fetal Circulation Syndrome/epidemiology ; Persistent Fetal Circulation Syndrome/physiopathology ; Pregnancy ; Pregnancy Complications/diagnosis ; Pregnancy Complications/drug therapy ; Pregnancy Trimester, Third ; Prenatal Exposure Delayed Effects/chemically induced ; Prenatal Exposure Delayed Effects/physiopathology ; Risk Assessment ; Serotonin Uptake Inhibitors/administration & dosage ; Serotonin Uptake Inhibitors/adverse effects
    Chemical Substances Serotonin Uptake Inhibitors ; Norepinephrine (X4W3ENH1CV)
    Language English
    Publishing date 2018-08-28
    Publishing country United States
    Document type Journal Article ; Meta-Analysis ; Systematic Review
    ZDB-ID 80016-8
    ISSN 1097-6868 ; 0002-9378
    ISSN (online) 1097-6868
    ISSN 0002-9378
    DOI 10.1016/j.ajog.2018.08.030
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  7. Article ; Online: Saliva Real-Time Polymerase Chain Reaction for Targeted Screening of Congenital Cytomegalovirus Infection.

    Eventov-Friedman, Smadar / Manor, Hili / Bar-Oz, Benjamin / Averbuch, Diana / Caplan, Orit / Lifshitz, Aliza / Bdolah-Abram, Tali / Wolf, Dana G

    The Journal of infectious diseases

    2019  Volume 220, Issue 11, Page(s) 1790–1796

    Abstract: Background: Saliva real-time polymerase chain reaction (PCR) was shown to be sensitive and specific for the detection of congenital cytomegalovirus (cCMV) in universal screening studies. In the current study, we assessed the performance of saliva real- ... ...

    Abstract Background: Saliva real-time polymerase chain reaction (PCR) was shown to be sensitive and specific for the detection of congenital cytomegalovirus (cCMV) in universal screening studies. In the current study, we assessed the performance of saliva real-time PCR in newborns undergoing targeted cCMV screening.
    Methods: Saliva real-time PCR results were prospectively correlated with reference-standard urine detection in newborns undergoing targeted cCMV screening over a 3-year period, in successive validation (concurrent testing of all saliva and urine specimens) and routine-screening (confirmatory urine testing of positive saliva results) implementation phases.
    Results: The sensitivity, specificity, and positive and negative predictive values of saliva real-time PCR were 98.3% (95% confidence interval, 90.8%-99.9%), 91.5% (89.3%-93.3%), 45.6% (36.7%-54.7%), and 99.9% (99.2%-99.9%), respectively, in 856 concurrently tested newborns. True-positive saliva real-time PCR detection (defined in relation to urine detection) was associated with earlier saliva sampling (P = .002) and a higher saliva viral load (P < .001). We further identified a saliva viral load cutoff value that reliably distinguished between true-positive and false-positive saliva results.
    Conclusions: In newborns undergoing targeted screening for cCMV, saliva real-time PCR is highly sensitive yet has a low positive predictive value, necessitating confirmatory testing. Early sampling and application of a validated viral load cutoff could improve the assay performance and support its large-scale implementation in this growing clinical setting.
    MeSH term(s) Cytomegalovirus/isolation & purification ; Cytomegalovirus Infections/congenital ; Cytomegalovirus Infections/diagnosis ; Female ; Humans ; Infant, Newborn ; Male ; Mass Screening/methods ; Molecular Diagnostic Techniques/methods ; Predictive Value of Tests ; Prospective Studies ; Real-Time Polymerase Chain Reaction/methods ; Saliva/virology ; Sensitivity and Specificity
    Language English
    Publishing date 2019-08-07
    Publishing country United States
    Document type Evaluation Study ; Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 3019-3
    ISSN 1537-6613 ; 0022-1899
    ISSN (online) 1537-6613
    ISSN 0022-1899
    DOI 10.1093/infdis/jiz373
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  8. Article ; Online: Neonatal end-of-life care: a single-center NICU experience in Israel over a decade.

    Eventov-Friedman, Smadar / Kanevsky, Hana / Bar-Oz, Benjamin

    Pediatrics

    2013  Volume 131, Issue 6, Page(s) e1889–96

    Abstract: Objectives: To follow changes in the causes of neonatal deaths in the NICU at Hadassah Medical Center, Jerusalem, Israel, over a decade; to examine trends regarding types of end-of-life-care provided (primary nonintervention, maximal intensive, and ... ...

    Abstract Objectives: To follow changes in the causes of neonatal deaths in the NICU at Hadassah Medical Center, Jerusalem, Israel, over a decade; to examine trends regarding types of end-of-life-care provided (primary nonintervention, maximal intensive, and redirection of intensive care, including limitation of care and withdrawal of life-sustaining treatment); and to assess the parental role in the decision-making process given that the majority of the population is religious.
    Methods: All neonates who died between 2000 and 2009 were identified. The causes and circumstances of death were abstracted from the medical records. Trends in end-of-life decisions were compared between 2 time periods: 2000-2004 versus 2005-2009.
    Results: Overall, 239 neonates died. The leading cause of death in both study periods was prematurity and its complications (76%). Among term infants, the leading cause of death was congenital anomalies (48%). Fifty-six percent of the infants received maximal intensive care; 28% had redirection of intensive care, of whom 10% had withdrawal of life-sustaining treatment; and 16% had primary nonintervention care. Over the years, maximal intensive care decreased from 65% to 46% (P < .02), whereas redirection of care increased from 19.2% to 37.5% (P < .0005). An active parental role in the end-of-life decision process increased from 38% to 84%.
    Conclusions: Even among religious families of extremely sick neonates, redirection of care is a feasible treatment option, suggesting that apart from survival, quality-of-life considerations emerge as an important factor in the decision-making process for the infant, parents, and caregivers.
    MeSH term(s) Cause of Death/trends ; Decision Making ; Female ; Humans ; Infant Mortality/trends ; Infant, Newborn ; Intensive Care Units, Neonatal/statistics & numerical data ; Israel ; Male ; Parents ; Terminal Care/statistics & numerical data
    Language English
    Publishing date 2013-06
    Publishing country United States
    Document type Journal Article
    ZDB-ID 207677-9
    ISSN 1098-4275 ; 0031-4005
    ISSN (online) 1098-4275
    ISSN 0031-4005
    DOI 10.1542/peds.2012-0981
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  9. Article ; Online: The proportion of errors in medical prescriptions and their executions among hospitalized children before and during accreditation.

    Mekory, Tal Margalit / Bahat, Hilla / Bar-Oz, Benjamin / Tal, Orna / Berkovitch, Matitiahu / Kozer, Eran

    International journal for quality in health care : journal of the International Society for Quality in Health Care

    2017  Volume 29, Issue 3, Page(s) 366–370

    Abstract: Objective: To evaluate the rate of medication related errors in the pediatric ward and pediatric emergency department (PED), before and after implementing intervention strategies according to the Joint Commission International (JCI) accreditation ... ...

    Abstract Objective: To evaluate the rate of medication related errors in the pediatric ward and pediatric emergency department (PED), before and after implementing intervention strategies according to the Joint Commission International (JCI) accreditation program.
    Design: A retrospective cross-sectional study that included chart review.
    Setting: A university affiliated pediatric ward and PED.
    Participants: Children 0-18 years old admitted on February 2013 (before the JCI program) and February 2014 (during implementation of the JCI program).
    Intervention(s): A training program designed to meet the JCI official standards on medication prescribing.
    Main outcome measure(s): The number of prescribing and medication administration errors in the 2 years.
    Results: We collected 937 valid prescription orders and 924 administration orders (1861 medical orders) from February 2013, and 961 valid prescription orders and 958 administration orders (1919 medical orders) from February 2014. There was a significant reduction in prescribing errors from 6.5 to 4.2% between years 2013 and 2014 (P = 0.03). There was no significant difference in administration error rates between the two periods (104 (11.3%) in the first period and 114 (11.9%) in the second; P = 0.61).
    Conclusions: The errors rate we found was within the range described in the literature. Quality assurance interventions can significantly reduce medication prescribing errors.
    MeSH term(s) Academic Medical Centers ; Accreditation ; Adolescent ; Child ; Child, Preschool ; Cross-Sectional Studies ; Emergency Service, Hospital/standards ; Humans ; Infant ; Infant, Newborn ; Israel ; Medication Errors/statistics & numerical data ; Pharmacy Service, Hospital/standards ; Retrospective Studies
    Language English
    Publishing date 2017-03-20
    Publishing country England
    Document type Journal Article
    ZDB-ID 1194150-9
    ISSN 1464-3677 ; 1353-4505
    ISSN (online) 1464-3677
    ISSN 1353-4505
    DOI 10.1093/intqhc/mzx031
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  10. Article ; Online: National Evidence in Israel Supporting Reevaluation of Respiratory Syncytial Virus Prophylactic Guidelines.

    Gross, Itai / Siedner-Weintraub, Yael / Abu Ahmad, Wiessam / Bar-Oz, Benjamin / Eventov-Friedman, Smadar

    Neonatology

    2017  Volume 111, Issue 3, Page(s) 240–246

    Abstract: Background: The American Academy of Pediatrics (AAP) recently narrowed the indications for respiratory syncytial virus (RSV) prophylaxis, while in Israel the guidelines have not changed.: Objective: To compare the prevalence and severity of RSV ... ...

    Abstract Background: The American Academy of Pediatrics (AAP) recently narrowed the indications for respiratory syncytial virus (RSV) prophylaxis, while in Israel the guidelines have not changed.
    Objective: To compare the prevalence and severity of RSV infection among preterm infants born earlier than 340/7 weeks of gestation (PI), late preterm infants born at 340/7-366/7 weeks (LPTI), and term infants born after 370/7 weeks of gestation (TI) and to determine whether the results support a change in local policy.
    Methods: Data of all children aged 0-14 years hospitalized with PCR-positive RSV in a single tertiary center from 2010 to 2014 were collected. A total of 793 children were included and divided into 3 groups: 637 were TI, 105 were LPTI, and 50 were PI. These groups were compared regarding incidence of hospitalization due to RSV infection, intensive care unit (ICU) hospitalization, and length of hospitalization.
    Results: The hospitalization rate due to RSV infection was 5.2, 3.5, and 1.3% among PI, LPTI, and TI, respectively (p < 0.01). The hospitalization rate in the ICU was 24, 7.6, and 3% among PI, LPTI, and TI, respectively (p < 0.001). The length (days) of hospitalization was significantly longer among PI compared with LPTI and TI (p < 0.001). Overall, the hospitalization rate and disease severity were significantly higher for infants born earlier than 35 weeks of gestation compared with more maturely born infants.
    Conclusion: RSV infection remains a major cause of morbidity among children born prematurely even after RSV prophylaxis and would probably be greater were prophylaxis curtailed. Our results do not support applying the current AAP guidelines in Israel. Further local studies are needed to optimize prophylaxis for both PI and LPTI.
    Language English
    Publishing date 2017
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2266911-5
    ISSN 1661-7819 ; 1661-7800
    ISSN (online) 1661-7819
    ISSN 1661-7800
    DOI 10.1159/000452196
    Database MEDical Literature Analysis and Retrieval System OnLINE

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