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  1. Article: An intriguing case of anemia and renal failure.

    Baradhi, Krishna M

    Proceedings (Baylor University. Medical Center)

    2019  Volume 32, Issue 1, Page(s) 78–79

    Abstract: Hydralazine-induced vasculitis is an established autoimmune entity but widely underdiagnosed despite its initial description in 1953. Hydralazine-induced lupus occurs in 5% to 10% of patients and is characterized by fever, arthralgias, rash, anemia, ... ...

    Abstract Hydralazine-induced vasculitis is an established autoimmune entity but widely underdiagnosed despite its initial description in 1953. Hydralazine-induced lupus occurs in 5% to 10% of patients and is characterized by fever, arthralgias, rash, anemia, leukopenia, and positive antinuclear antibodies. Renal involvement is rare in drug-induced systemic lupus erythematosus but can occur. Hydralazine may also be associated with an antineutrophil cytoplasmic antibody to complicate the diagnostic evaluation. There are no definitive diagnostic criteria for hydralazine-induced lupus, and diagnosis relies on chronic exposure to high doses of hydralazine with positive antinuclear and antihistone antibodies and classical histopathological findings. We describe a 48-year-old man with fatigue, anemia, and renal failure from hydralazine-mediated lupus with concomitant antineutrophil cytoplasmic antibodies and highlight the importance of medication history and scrupulous interpretation of serologies and biopsy for diagnosis and management of this familiar yet underrecognized disease. Clinicians should analyze the risk of hydralazine-induced adverse effects before initiating therapy and continue clinical vigilance while patients are on hydralazine.
    Language English
    Publishing date 2019-01-24
    Publishing country United States
    Document type Case Reports
    ZDB-ID 2703932-8
    ISSN 1525-3252 ; 0899-8280
    ISSN (online) 1525-3252
    ISSN 0899-8280
    DOI 10.1080/08998280.2018.1540824
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article: Scurvy in 2017 in the USA.

    Baradhi, Krishna M / Vallabhaneni, Shobana / Koya, Supriya

    Proceedings (Baylor University. Medical Center)

    2018  Volume 31, Issue 2, Page(s) 227–228

    Abstract: Vitamin C deficiency may be common in third-world countries due to malnutrition, but it is currently rare in the USA. Initially, nonspecific symptoms like exhaustion and depression may make this disease difficult to diagnose until classical ... ...

    Abstract Vitamin C deficiency may be common in third-world countries due to malnutrition, but it is currently rare in the USA. Initially, nonspecific symptoms like exhaustion and depression may make this disease difficult to diagnose until classical dermatological manifestations appear. Diagnosis mainly relies on clinical presentation, dietary history to identify risk factors, and dramatic recession of symptoms and signs following vitamin C therapy. Human beings cannot synthesize vitamin C and hence need 90% of vitamin C intake from fruits and vegetables. As a processed carbohydrate-rich diet becomes the staple food, scurvy must be recognized before it becomes potentially fatal. We describe a 65-year-old man with dyspnea, fatigue, anemia, and bleeding diathesis from scurvy and emphasize the importance of dietary history and the critical role of vitamin C in diagnosis and management of this forgotten entity.
    Language English
    Publishing date 2018-03-12
    Publishing country United States
    Document type Case Reports
    ZDB-ID 2703932-8
    ISSN 1525-3252 ; 0899-8280
    ISSN (online) 1525-3252
    ISSN 0899-8280
    DOI 10.1080/08998280.2018.1435115
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Seizures, renal failure and acute respiratory failure: not your typical case of Henoch-Schonlein purpura.

    Bose, Subhasish / Pathireddy, Samata / Baradhi, Krishna M / Aeddula, Narothama Reddy

    BMJ case reports

    2019  Volume 12, Issue 7

    Abstract: A 30-year-old Caucasian woman with no prior medical history presented with pedal oedema, arthralgias and abdominal pain with diarrhoea, following a respiratory infection. She had mild abdominal tenderness along with a purpuric rash on the extremities and ...

    Abstract A 30-year-old Caucasian woman with no prior medical history presented with pedal oedema, arthralgias and abdominal pain with diarrhoea, following a respiratory infection. She had mild abdominal tenderness along with a purpuric rash on the extremities and was anaemic. Following initial workup for anaemia and rash, her condition deteriorated with renal impairment, respiratory failure and seizures necessitating ventilatory support, dialysis and steroids. Serologies were negative, and skin biopsy showed leucocytoclastic vasculitis without vascular IgA deposition, and renal biopsy showed subendothelial, mesangial deposits of IgA with C3 indicative of Henoch-Schonlein purpura (HSP). She was treated with steroids, haemodialysis and on 6-month follow-up recovered renal function. We present the case to illustrate that HSP, though rare in adults, can present with multiorgan failure, with renal, pulmonary and central nervous system involvement, and the need for early diagnosis and prompt treatment for rapid clinical recovery.
    MeSH term(s) Acute Kidney Injury/diagnosis ; Acute Kidney Injury/etiology ; Acute Kidney Injury/pathology ; Acute Kidney Injury/therapy ; Adrenal Cortex Hormones/therapeutic use ; Adult ; Anticonvulsants/therapeutic use ; Biopsy ; Electroencephalography ; Female ; Glomerulonephritis/etiology ; Glomerulonephritis/pathology ; Glomerulonephritis/therapy ; Humans ; Magnetic Resonance Imaging ; Purpura, Schoenlein-Henoch/complications ; Purpura, Schoenlein-Henoch/diagnosis ; Purpura, Schoenlein-Henoch/pathology ; Purpura, Schoenlein-Henoch/therapy ; Renal Dialysis ; Respiration, Artificial ; Respiratory Distress Syndrome/etiology ; Respiratory Distress Syndrome/therapy ; Seizures/diagnosis ; Seizures/drug therapy ; Seizures/etiology
    Chemical Substances Adrenal Cortex Hormones ; Anticonvulsants
    Language English
    Publishing date 2019-07-17
    Publishing country England
    Document type Case Reports ; Journal Article
    ISSN 1757-790X
    ISSN (online) 1757-790X
    DOI 10.1136/bcr-2019-229939
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Alport's syndrome and intracranial aneurysm: mere coincidence or undiscovered causal relationship.

    Bose, Subhasish / Pathireddy, Samata / Baradhi, Krishna M / Aeddula, Narothama Reddy

    BMJ case reports

    2019  Volume 12, Issue 1

    Abstract: A 44-year-old Caucasian man with a history of deceased donor renal transplant for end-stage renal disease from Alport's syndrome (AS), presented with a spontaneous subarachnoid haemorrhage and hydrocephalus. Following an external ventricular drain for ... ...

    Abstract A 44-year-old Caucasian man with a history of deceased donor renal transplant for end-stage renal disease from Alport's syndrome (AS), presented with a spontaneous subarachnoid haemorrhage and hydrocephalus. Following an external ventricular drain for the hydrocephalus, a CT angiography revealed a dissection of the left vertebral artery extending into vertebro-basilar junction necessitating a bypass between left occipital artery to left posterior inferior cerebellar artery. He had a posterior fossa Craniectomy, C1 laminectomy and coiling off, of the left vertebral artery. Postprocedure course was prolonged but uneventful with complete recovery and normal renal function 18 months postpresentation. AS, a disease caused by abnormalities in the synthesis of type IV collagen, can cause aneurysms with severe and permanent neurological sequalae. We present a case of AS with intracranial arterial dissection with potential life-threatening consequences and discuss the genetic and molecular basis of AS along with review of the relevant literature.
    MeSH term(s) Adult ; Diagnosis, Differential ; Humans ; Intracranial Aneurysm/complications ; Intracranial Aneurysm/diagnostic imaging ; Intracranial Aneurysm/surgery ; Male ; Nephritis, Hereditary/complications ; Nephritis, Hereditary/physiopathology ; Tomography, X-Ray Computed
    Language English
    Publishing date 2019-01-29
    Publishing country England
    Document type Case Reports ; Journal Article
    ISSN 1757-790X
    ISSN (online) 1757-790X
    DOI 10.1136/bcr-2018-228175
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Methamphetamine (

    Baradhi, Krishna M / Pathireddy, Samata / Bose, Subhasish / Aeddula, Narothama Reddy

    BMJ case reports

    2019  Volume 12, Issue 9

    Abstract: A 26-year-old Caucasian man with no medical history, except years of oral and intravenous drug abuse, presented with fatigue, shortness of breath, epistaxis and uncontrolled hypertension. He was pale with skin ecchymosis over his thighs and was anaemic, ... ...

    Abstract A 26-year-old Caucasian man with no medical history, except years of oral and intravenous drug abuse, presented with fatigue, shortness of breath, epistaxis and uncontrolled hypertension. He was pale with skin ecchymosis over his thighs and was anaemic, with severe renal failure and metabolic acidosis. Following initial clinical stabilisation of the patient, a renal biopsy was obtained, which showed vascular and glomerular changes consistent with thrombotic microangiopathic injury and advanced glomerulosclerosis. He was treated with antihypertensives and required haemodialysis. He admitted using 'crystal meth' regularly for many years, which is likely responsible for his renal failure. We present the case to illustrate methamphetamine-induced renal disease leading to end-stage renal disease and to bring awareness among practising clinicians, ancillary healthcare workers and public health professionals of this often undervalued cause of renal failure, which can be prevented.
    MeSH term(s) Acidosis/complications ; Adult ; Disease Progression ; Humans ; Hypertension/complications ; Kidney Failure, Chronic/chemically induced ; Kidney Failure, Chronic/pathology ; Male ; Methamphetamine/adverse effects ; Substance Abuse, Intravenous ; Substance Abuse, Oral
    Chemical Substances Methamphetamine (44RAL3456C)
    Language English
    Publishing date 2019-09-19
    Publishing country England
    Document type Case Reports
    ISSN 1757-790X
    ISSN (online) 1757-790X
    DOI 10.1136/bcr-2019-230288
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Unilateral renal cystic disease.

    Baradhi, Krishna M / Abuelo, Gary J

    Kidney international

    2012  Volume 81, Issue 2, Page(s) 220

    MeSH term(s) Adult ; Female ; Humans ; Kidney Diseases, Cystic/diagnosis ; Kidney Diseases, Cystic/diagnostic imaging ; Radiography
    Language English
    Publishing date 2012-01
    Publishing country United States
    Document type Case Reports ; Journal Article
    ZDB-ID 120573-0
    ISSN 1523-1755 ; 0085-2538
    ISSN (online) 1523-1755
    ISSN 0085-2538
    DOI 10.1038/ki.2011.343
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: The Case | Acute renal failure after antibiotic treatment for bronchitis. Diagnosis: Pigment nephropathy from cephalexin-induced immune hemolytic anemia.

    Baradhi, Krishna M / Ahmed, Subhan / Buford, Malcolm L

    Kidney international

    2015  Volume 87, Issue 6, Page(s) 1269–1270

    MeSH term(s) Acute Kidney Injury/chemically induced ; Anemia, Hemolytic/chemically induced ; Anemia, Hemolytic/complications ; Anti-Bacterial Agents/adverse effects ; Bronchitis/drug therapy ; Cephalexin/adverse effects ; Female ; Humans ; Middle Aged
    Chemical Substances Anti-Bacterial Agents ; Cephalexin (OBN7UDS42Y)
    Language English
    Publishing date 2015-06
    Publishing country United States
    Document type Case Reports ; Journal Article
    ZDB-ID 120573-0
    ISSN 1523-1755 ; 0085-2538
    ISSN (online) 1523-1755
    ISSN 0085-2538
    DOI 10.1038/ki.2014.152
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: The Case: diabetic nephropathy in a nondiabetic smoker?

    Baradhi, Krishna M / Gary Abuelo, J / Stillman, Isaac E

    Kidney international

    2012  Volume 82, Issue 10, Page(s) 1141–1142

    MeSH term(s) Biomarkers/blood ; Biomarkers/urine ; Biopsy ; Complement C3/analysis ; Diabetic Nephropathies/diagnosis ; Diabetic Nephropathies/immunology ; Diabetic Nephropathies/pathology ; Diagnosis, Differential ; Fluorescent Antibody Technique ; Glomerulonephritis/diagnosis ; Glomerulonephritis/immunology ; Glomerulonephritis/pathology ; Humans ; Kidney/immunology ; Kidney/pathology ; Kidney/ultrastructure ; Male ; Microscopy, Electron ; Middle Aged ; Predictive Value of Tests ; Smoking/adverse effects
    Chemical Substances Biomarkers ; Complement C3
    Language English
    Publishing date 2012-11
    Publishing country United States
    Document type Case Reports ; Journal Article
    ZDB-ID 120573-0
    ISSN 1523-1755 ; 0085-2538
    ISSN (online) 1523-1755
    ISSN 0085-2538
    DOI 10.1038/ki.2012.333
    Database MEDical Literature Analysis and Retrieval System OnLINE

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