LIVIVO - Search results -

Search results

Result 1 - 10 of total 90

Search options

Article ; Online: COVID-19 imparted immune manifestation can be combated by NLGP: Lessons from cancer research.

Bose, Anamika / Baral, Rathindranath

2022 Volume 158, Page(s) 155980

Abstract: SARS-CoV-2 easily infects human monocytes, macrophages and possibly dendritic cells (DCs), causing dysfunctions of these important antigen presenting cells (APCs). Observed DC dysfunctions facilitate improper antigen presentation, which obviously results ...

Abstract	SARS-CoV-2 easily infects human monocytes, macrophages and possibly dendritic cells (DCs), causing dysfunctions of these important antigen presenting cells (APCs). Observed DC dysfunctions facilitate improper antigen presentation, which obviously results T cell anergy, exhaustion and apoptosis, thus, may be contributing significantly in SARS-CoV-2 infection associated lymphopenia. Neem Leaf Glycoprotein or NLGP has enormous role in altered DC functions, thereby, offering optimum T cell mediated cytotoxicity, as experienced from cancer system. Such NLGP guided correction of altered DCs might also be effective to generate proper SARS-CoV-2-specific effector and central memory T cells.
MeSH term(s)	Azadirachta ; CD8-Positive T-Lymphocytes ; COVID-19 ; Dendritic Cells ; Humans ; Neoplasms ; Plant Leaves ; Plant Proteins ; SARS-CoV-2
Chemical Substances	Plant Proteins
Language	English
Publishing date	2022-07-31
Publishing country	England
Document type	Journal Article
ZDB-ID	1018055-2
ISSN	1096-0023 ; 1043-4666
ISSN (online)	1096-0023
ISSN	1043-4666
DOI	10.1016/j.cyto.2022.155980
Database	MEDical Literature Analysis and Retrieval System OnLINE

Full text online

Accessible to users with ZB MED library card

In stock of ZB MED Cologne/Königswinter

Zs.A 2840: Show issues

Location:
Je nach Verfügbarkeit (siehe Angabe bei Bestand)
bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
Jg. 1995 - 2021: Lesesall (2.OG)
ab Jg. 2022: Lesesaal (EG)

Order via subito

This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

Details ▾

Article ; Online: Macrophages in tumor: An inflammatory perspective.

Goswami, Kuntal Kanti / Bose, Anamika / Baral, Rathindranath

Clinical immunology (Orlando, Fla.)

2021 Volume 232, Page(s) 108875

Abstract: Inflammation is a part of carefully co-ordinated healing immune exercise to eliminate injurious stimuli. However, in substantial number of cancer types, it contributes in shaping up of robust tumor microenvironment (TME). Solid TME promotes infiltration ... ...

Abstract	Inflammation is a part of carefully co-ordinated healing immune exercise to eliminate injurious stimuli. However, in substantial number of cancer types, it contributes in shaping up of robust tumor microenvironment (TME). Solid TME promotes infiltration of tumor associated macrophages (TAMs) that contributes to cancer promotion. TAMs are functionally heterogeneous and display an extraordinary degree of plasticity, which allow 'Switching' of macrophages into an 'M2', phenotype, linked with immunosuppression, advancement of tumor angiogenesis with metastatic consequences. In contrary to the classical M1 macrophages, these M2 TAMs are high-IL-10, TGF-β secreting-'anti-inflammatory'. In this review, we will discuss the modes of infiltration and switching of TAMs into M2 anti-inflammatory state in the TME to promote immunosuppression and inflammation-driven cancer.
MeSH term(s)	Animals ; Humans ; Neoplasms/immunology ; Tumor Microenvironment/immunology ; Tumor-Associated Macrophages/immunology
Language	English
Publishing date	2021-11-02
Publishing country	United States
Document type	Journal Article ; Review
ZDB-ID	1459903-x
ISSN	1521-7035 ; 1521-6616
ISSN (online)	1521-7035
ISSN	1521-6616
DOI	10.1016/j.clim.2021.108875
Database	MEDical Literature Analysis and Retrieval System OnLINE

Full text online

Accessible to users with ZB MED library card

In stock of ZB MED Cologne/Königswinter

Zs.A 880: Show issues

Location:
Je nach Verfügbarkeit (siehe Angabe bei Bestand)
bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
Jg. 1995 - 2021: Lesesall (1.OG)
ab Jg. 2022: Lesesaal (EG)

Order via subito

Details ▾

Article ; Online: Evolvability and emergence of tumor heterogeneity as a space-time function.

Saha, Bhaskar / Vannucci, Luca / Saha, Baibaswata / Tenti, Paolo / Baral, Rathindranath

Cytokine

2022 Volume 161, Page(s) 156061

Abstract: The loss of control of cell proliferation, apoptosis regulation and contact inhibition leads to tumor development. While benign tumors are restricted to their primary space, i.e. where these tumors first originate, the metastatic tumors not only ... ...

Abstract	The loss of control of cell proliferation, apoptosis regulation and contact inhibition leads to tumor development. While benign tumors are restricted to their primary space, i.e. where these tumors first originate, the metastatic tumors not only disseminate- facilitated by hypoxia-driven neovascularization- to distant secondary sites but also show substantial changes in metabolism, tissue architectures, gene expression profiles and immune phenotypes. All these alterations result in radio-, chemo- and immune-resistance rendering these metastatic tumor cells refractory to therapy. Since the beginning of the transformation, these factors- which influence each other- are incorporated to the developing and metastasizing tumor. As a result, the complexities in the heterogeneity of tumor progressively increase. This space-time function in the heterogeneity of tumors is generated by various conditions and factors at the genetic as well as microenvironmental levels, for example, endogenous retroviruses, methylation and epigenetic dysregulation that may be etiology-specific, cancer associated inflammation, remodeling of the extracellular matrix and mesenchymal cell shifted functions. On the one hand, these factors may cause de-differentiation of the tumor cells leading to cancer stem cells that contribute to radio-, chemo- and immune-resistance and recurrence of tumors. On the other hand, they may also enhance the heterogeneity under specific microenvironment-driven proliferation. In this editorial, we intend to underline the importance of heterogeneity in cancer progress, its evaluation and its use in correlation with the tumor evolution in a specific patient as a field of research for achieving precise patient-tailored treatments and amelioration of diagnostic (monitoring) tools and prognostic capacity.
MeSH term(s)	Humans ; Neoplasms/genetics ; Neovascularization, Pathologic ; Cell Proliferation/genetics ; Neoplastic Stem Cells ; Extracellular Matrix ; Tumor Microenvironment/genetics
Language	English
Publishing date	2022-10-15
Publishing country	England
Document type	Editorial ; Research Support, Non-U.S. Gov't
ZDB-ID	1018055-2
ISSN	1096-0023 ; 1043-4666
ISSN (online)	1096-0023
ISSN	1043-4666
DOI	10.1016/j.cyto.2022.156061
Database	MEDical Literature Analysis and Retrieval System OnLINE

Full text online

Accessible to users with ZB MED library card

In stock of ZB MED Cologne/Königswinter

Zs.A 2840: Show issues

Location:
Je nach Verfügbarkeit (siehe Angabe bei Bestand)
bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
Jg. 1995 - 2021: Lesesall (2.OG)
ab Jg. 2022: Lesesaal (EG)

Order via subito

Details ▾

Article ; Online: Lactic acid in alternative polarization and function of macrophages in tumor microenvironment.

Goswami, Kuntal Kanti / Banerjee, Saptak / Bose, Anamika / Baral, Rathindranath

Human immunology

2022 Volume 83, Issue 5, Page(s) 409–417

Abstract: In developing tumor, macrophages are one major immune infiltrate that not only contributes in shaping up of tumor microenvironment (TME) but also have the potential of determining the fate of tumor in terms of its progression. Phenotypic plasticity of ... ...

Abstract	In developing tumor, macrophages are one major immune infiltrate that not only contributes in shaping up of tumor microenvironment (TME) but also have the potential of determining the fate of tumor in terms of its progression. Phenotypic plasticity of macrophages primarily channelizes them to alternative (M2) form of tumor associated macrophages (TAM) in the TME. One of the key tumor derived components that plays a crucial role in TAM polarization from M1 to M2 form is lactic acid and has prominent role in progression of malignancy. The role of lactic acid as signalling molecule as well as an immunomodulator has recently been recognized. This review focuses on the mechanism and signalling that are involved in lactic acid induced M2 polarization and possible therapeutic strategies for regulating lactic acidosis in TME.
MeSH term(s)	Humans ; Lactic Acid ; Macrophages ; Neoplasms ; Tumor Microenvironment ; Tumor-Associated Macrophages
Chemical Substances	Lactic Acid (33X04XA5AT)
Language	English
Publishing date	2022-03-15
Publishing country	United States
Document type	Journal Article ; Review
ZDB-ID	801524-7
ISSN	1879-1166 ; 0198-8859
ISSN (online)	1879-1166
ISSN	0198-8859
DOI	10.1016/j.humimm.2022.02.007
Database	MEDical Literature Analysis and Retrieval System OnLINE

Full text online

Accessible to users with ZB MED library card

In stock of ZB MED Cologne/Königswinter

Zs.A 1597: Show issues

Location:
Je nach Verfügbarkeit (siehe Angabe bei Bestand)
bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
Jg. 1995 - 2021: Lesesall (1.OG)
ab Jg. 2022: Lesesaal (EG)

Order via subito

Details ▾

Article ; Online: The immunomodulatory impact of naturally derived neem leaf glycoprotein on the initiation progression model of 4NQO induced murine oral carcinogenesis: a preclinical study.

Das, Juhina / Bera, Saurav / Ganguly, Nilanjan / Guha, Ipsita / Ghosh Halder, Tithi / Bhuniya, Avishek / Nandi, Partha / Chakravarti, Mohona / Dhar, Sukanya / Sarkar, Anirban / Das, Tapasi / Banerjee, Saptak / Ghose, Sandip / Bose, Anamika / Baral, Rathindranath

Frontiers in immunology

2024 Volume 15, Page(s) 1325161

Abstract: Introduction: Murine tumor growth restriction by neem leaf glycoprotein (NLGP) was established in various transplanted models of murine sarcoma, melanoma and carcinoma. However, the role of NLGP in the sequential carcinogenic steps has not been explored. ...

Abstract	Introduction: Murine tumor growth restriction by neem leaf glycoprotein (NLGP) was established in various transplanted models of murine sarcoma, melanoma and carcinoma. However, the role of NLGP in the sequential carcinogenic steps has not been explored. Thus, tongue carcinogenesis in Swiss mice was induced by 4-nitroquinoline-1-oxide (4NQO), which has close resemblance to human carcinogenesis process. Interventional role of NLGP in initiation-promotion protocol established during 4NQO mediated tongue carcinogenesis in relation to systemic immune alteration and epithelial-mesenchymal transition (EMT) is investigated. Methods: 4NQO was painted on tongue of Swiss mice every third day at a dose of 25µl of 5mg/ml stock solution. After five consecutive treatment with 4NQO (starting Day7), one group of mice was treated with NLGP (s.c., 25µg/mice/week), keeping a group as PBS control. Mice were sacrificed in different time-intervals to harvest tongues and studied using histology, immunohistochemistry, flow-cytometry and RT-PCR on different immune cells and EMT markers (e-cadherin, vimentin) to elucidate their phenotypic and secretory status. Results: Local administration of 4NQO for consecutive 300 days promotes significant alteration in tongue mucosa including erosion in papillae and migration of malignant epithelial cells to the underlying connective tissue stroma with the formation of cell nests (exophytic-hyperkeratosis with mild dysplasia). Therapeutic NLGP treatment delayed pre-neoplastic changes promoting normalization of mucosa by maintaining normal structure. Flow-cytometric evidences suggest that NLGP treatment upregulated CD8 Discussion: Efficacy of NLGP was tested first time in sequential carcinogenesis model and proved effective in delaying the initial progression. NLGP normalizes type 1 immunity including activation of the CD8
MeSH term(s)	Mice ; Animals ; Humans ; Vimentin ; Glycoproteins ; Carcinogenesis ; Carcinogens/analysis ; Plant Leaves/chemistry ; Cadherins
Chemical Substances	Vimentin ; Glycoproteins ; Carcinogens ; Cadherins
Language	English
Publishing date	2024-03-22
Publishing country	Switzerland
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2606827-8
ISSN	1664-3224 ; 1664-3224
ISSN (online)	1664-3224
ISSN	1664-3224
DOI	10.3389/fimmu.2024.1325161
Database	MEDical Literature Analysis and Retrieval System OnLINE

Order via subito

Article ; Online: Neem Leaf Glycoprotein disrupts exhausted CD8+ T cell-mediated cancer stem cell aggression.

Chakravarti, Mohona / Bera, Saurav / Dhar, Sukanya / Sarkar, Anirban / Choudhury, Pritha Roy / Ganguly, Nilanjan / Das, Juhina / Sultana, Jasmine / Guha, Aishwarya / Biswas, Souradeep / Das, Tapasi / Hajra, Subhadip / Banerjee, Saptak / Baral, Rathindranath / Bose, Anamika

Molecular cancer research : MCR

2024

Abstract: Targeting exhausted CD8+T cell (TEX) induced aggravated cancer stem cells (CSC) holds immense therapeutic potential. In this regard, immunomodulation via Neem Leaf Glycoprotein (NLGP), a plant-derived glycoprotein immunomodulator is explored. Since ... ...

Abstract	Targeting exhausted CD8+T cell (TEX) induced aggravated cancer stem cells (CSC) holds immense therapeutic potential. In this regard, immunomodulation via Neem Leaf Glycoprotein (NLGP), a plant-derived glycoprotein immunomodulator is explored. Since former reports have proven immune-dependent tumor restriction of NLGP across multiple tumor models, we hypothesized that NLGP might reprogram and rectify TEX to target CSCs successfully. Here we report that NLGP's therapeutic administration significantly reduced TEX -associated CSC virulence in in vivo B16-F10 melanoma tumor model. Similar trend was observed in in vitro generated TEX and B16-F10/MCF7 co-culture setups. NLGP rewired CSCs by downregulating clonogenicity, multidrug resistance phenotypes and PDL1, OCT4, SOX2 expression. Cell cycle analysis revealed that NLGP-educated TEX efficiently pushed CSCs out of quiescent-phase (G0G1) into synthesis-phase (S), supported by hyper-phosphorylation of G0G1-S transitory cyclins and Rb-proteins. This rendered quiescent CSCs susceptible to s-phase targeting chemotherapeutic drugs like 5-Fluorouracil (5FU). Consequently combinatorial treatment of NLGP and 5FU brought optimal CSC targeting efficiency with increase in apoptotic bodies and pro-apoptotic BID expression. Notably a strong nephron-protective effect of NLGP was also observed, which prevented 5FU associated toxicity. Furthermore, Dectin-1 mediated NLGP uptake and subsequent alteration of Notch1 and mTOR axis was deciphered as the involved signalling network. This observation unveiled Dectin-1 as a potent immunotherapeutic drug-target to counter T cell exhaustion. Cumulatively, NLGP immunotherapy alleviated exhausted CD8+T cell induced CSC aggravation. Implications: Our study recommends that NLGP-immunotherapy can be utilized to counter ramifications of T cell exhaustion and to target therapy elusive aggressive CSCs without evoking toxicity.
Language	English
Publishing date	2024-05-14
Publishing country	United States
Document type	Journal Article
ZDB-ID	2098788-2
ISSN	1557-3125 ; 1541-7786
ISSN (online)	1557-3125
ISSN	1541-7786
DOI	10.1158/1541-7786.MCR-23-0993
Database	MEDical Literature Analysis and Retrieval System OnLINE

In stock of ZB MED Cologne/Königswinter

Zs.A 5744: Show issues

Location:
Je nach Verfügbarkeit (siehe Angabe bei Bestand)
bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
Jg. 1995 - 2021: Lesesall (2.OG)
ab Jg. 2022: Lesesaal (EG)

Order via subito

Details ▾
- See ZB MED holdings
- Order with fees

Article: Use of selenium as micronutrients and for future anticancer drug: a review

Patra, Arup Ranjan / Hajra, Subhadip / Baral, Rathindranath / Bhattacharya, Sudin

Nucleus. 2020 Aug., v. 63, no. 2

2020

Abstract: The inherent duality of selenium can be the stepping stone to generate selenium based front line chemotherapeutic drug against ever evolving disease landscape of cancer. Not only as a therapeutic agent, but also in supportive care this essential ... ...

Abstract	The inherent duality of selenium can be the stepping stone to generate selenium based front line chemotherapeutic drug against ever evolving disease landscape of cancer. Not only as a therapeutic agent, but also in supportive care this essential micronutrient may be a good supplement to balance redox homeostasis and boost up patients immunity. Many in vitro, in vivo and clinical studies have generated a lot of useful information about anticancer properties of this trace element, which can be used as backbone in these aspects. The knowledge about speciation, distribution and compartmentalization of selenium metabolites, their pharmacokinetics, regulation of selenogenome and selenoproteome function, genomic variants and epigenetic effects are to be integrated to achieve the novel target. Advancement of bioinformatics and new technologies can be very much helpful in this regard.
Keywords	antineoplastic agents ; bioinformatics ; drug therapy ; epigenetics ; genomics ; homeostasis ; immunity ; landscapes ; metabolites ; pharmacokinetics ; selenium
Language	English
Dates of publication	2020-08
Size	p. 107-118.
Publishing place	Springer India
Document type	Article
Note	NAL-AP-2-clean ; Review
ZDB-ID	2589081-5
ISSN	0976-7975 ; 0029-568X
ISSN (online)	0976-7975
ISSN	0029-568X
DOI	10.1007/s13237-019-00306-y
Database	NAL-Catalogue (AGRICOLA)

Full text online

Accessible to users with ZB MED library card

Order via subito

Details ▾
- Full text online
- Order with fees

Article ; Online: High monocytic MDSC signature predicts multi-drug resistance and cancer relapse in non-Hodgkin lymphoma patients treated with R-CHOP.

Dhar, Sukanya / Chakravarti, Mohona / Ganguly, Nilanjan / Saha, Akata / Dasgupta, Shayani / Bera, Saurav / Sarkar, Anirban / Roy, Kamalika / Das, Juhina / Bhuniya, Avishek / Ghosh, Sarbari / Sarkar, Madhurima / Hajra, Srabanti / Banerjee, Saptak / Pal, Chiranjib / Saha, Bhaskar / Mukherjee, Kalyan Kusum / Baral, Rathindranath / Bose, Anamika

Frontiers in immunology

2024 Volume 14, Page(s) 1303959

Abstract: Introduction: Non-Hodgkin Lymphoma (NHL) is a heterogeneous lymphoproliferative malignancy with B cell origin. Combinatorial treatment of rituximab, cyclophsphamide, hydroxydaunorubicin, oncovin, prednisone (R-CHOP) is the standard treatment regimen for ...

Abstract	Introduction: Non-Hodgkin Lymphoma (NHL) is a heterogeneous lymphoproliferative malignancy with B cell origin. Combinatorial treatment of rituximab, cyclophsphamide, hydroxydaunorubicin, oncovin, prednisone (R-CHOP) is the standard treatment regimen for NHL, yielding a complete remission (CR) rate of 40-50%. Unfortunately, considerable patients undergo relapse after CR or initial treatment, resulting in poor clinical implications. Patient's response to chemotherapy varies widely from static disease to cancer recurrence and later is primarily associated with the development of multi-drug resistance (MDR). The immunosuppressive cells within the tumor microenvironment (TME) have become a crucial target for improving the therapy efficacy. However, a better understanding of their involvement is needed for distinctive response of NHL patients after receiving chemotherapy to design more effective front-line treatment algorithms based on reliable predictive biomarkers. Methods: Peripheral blood from 61 CD20 Results: We observed a strong positive correlation between elevated level of CD33 Conclusion: Our data suggests that screening patients for high titre of M-MDSCs might be considered as a new potential biomarker and treatment modality in overcoming chemo-resistance in NHL patients.
MeSH term(s)	Humans ; Animals ; Mice ; Myeloid-Derived Suppressor Cells/metabolism ; Rituximab/pharmacology ; Rituximab/therapeutic use ; Rituximab/metabolism ; Vincristine/pharmacology ; Vincristine/therapeutic use ; Interleukin-10/metabolism ; Prednisone/pharmacology ; Prednisone/therapeutic use ; Interleukin-6/metabolism ; Neoplasm Recurrence, Local/metabolism ; Lymphoma, Non-Hodgkin/drug therapy ; Lymphoma, Non-Hodgkin/metabolism ; Cyclophosphamide/pharmacology ; Cyclophosphamide/therapeutic use ; Doxorubicin/pharmacology ; Doxorubicin/therapeutic use ; Doxorubicin/metabolism ; Lymphoma/metabolism ; Biomarkers/metabolism ; Drug Resistance, Multiple ; Tumor Microenvironment/physiology
Chemical Substances	Rituximab (4F4X42SYQ6) ; Vincristine (5J49Q6B70F) ; Interleukin-10 (130068-27-8) ; Prednisone (VB0R961HZT) ; Interleukin-6 ; Cyclophosphamide (8N3DW7272P) ; Doxorubicin (80168379AG) ; Biomarkers
Language	English
Publishing date	2024-01-18
Publishing country	Switzerland
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2606827-8
ISSN	1664-3224 ; 1664-3224
ISSN (online)	1664-3224
ISSN	1664-3224
DOI	10.3389/fimmu.2023.1303959
Database	MEDical Literature Analysis and Retrieval System OnLINE

Order via subito

Article ; Online: Neem leaf glycoprotein binding to Dectin-1 receptors on dendritic cell induces type-1 immunity through CARD9 mediated intracellular signal to NFκB.

Ganguly, Nilanjan / Das, Tapasi / Bhuniya, Avishek / Guha, Ipsita / Chakravarti, Mohona / Dhar, Sukanya / Sarkar, Anirban / Bera, Saurav / Dhar, Jesmita / Dasgupta, Shayani / Saha, Akata / Ghosh, Tithi / Das, Juhina / Sk, Ugir Hossain / Banerjee, Saptak / Laskar, Subrata / Bose, Anamika / Baral, Rathindranath

Cell communication and signaling : CCS

2024 Volume 22, Issue 1, Page(s) 237

Abstract: Background: A water-soluble ingredient of mature leaves of the tropical mahogany 'Neem' (Azadirachta indica), was identified as glycoprotein, thus being named as 'Neem Leaf Glycoprotein' (NLGP). This non-toxic leaf-component regressed cancerous murine ... ...

Abstract	Background: A water-soluble ingredient of mature leaves of the tropical mahogany 'Neem' (Azadirachta indica), was identified as glycoprotein, thus being named as 'Neem Leaf Glycoprotein' (NLGP). This non-toxic leaf-component regressed cancerous murine tumors (melanoma, carcinoma, sarcoma) recurrently in different experimental circumstances by boosting prime antitumor immune attributes. Such antitumor immunomodulation, aid cytotoxic T cell (T Methods: Six glycoprotein-binding C-type lectins found on APCs, namely, MBR, Dectin-1, Dectin-2, DC-SIGN, DEC205 and DNGR-1 were screened on bone marrow-derived dendritic cells from C57BL/6 J mice. Fluorescence microscopy, RT-PCR, flow cytometry and ELISA revealed Dectin-1 as the NLGP-binding receptor, followed by verifications through RNAi. Following detection of β-Glucans in NLGP, their interactions with Dectin-1 were explored in silico. Roles of second messengers and transcription factors in the downstream signal were studied by co-immunoprecipitation, western blotting, and chromatin-immunoprecipitation. Intracellularization of FITC-coupled NLGP was observed by processing confocal micrographs of DCs. Results: Considering extents of hindrance in NLGP-driven transcription rates of the cytokines IL-10 and IL-12p35 by receptor-neutralization, Dectin-1 receptors on dendritic cells were found to bind NLGP through the ligand's peripheral β-Glucan chains. The resulting signal phosphorylates PKCδ, forming a trimolecular complex of CARD9, Bcl10 and MALT1, which in turn activates the canonical NFκB-pathway of transcription-regulation. Consequently, the NFκB-heterodimer p65:p50 enhances Il12a transcription and the p50:p50 homodimer represses Il10 transcription, bringing about a cytokine-based systemic-bias towards type-1 immune environment. Further, NLGP gets engulfed within dendritic cells, possibly through endocytic activities of Dectin-1. Conclusion: NLGP's binding to Dectin-1 receptors on murine dendritic cells, followed by the intracellular signal, lead to NFκB-mediated contrasting regulation of cytokine-transcriptions, initiating a pro-inflammatory immunopolarization, which amplifies further by the responding immune cells including T
MeSH term(s)	Animals ; Lectins, C-Type/metabolism ; Lectins, C-Type/genetics ; Dendritic Cells/immunology ; Dendritic Cells/metabolism ; Plant Leaves ; Signal Transduction ; Azadirachta/chemistry ; Mice, Inbred C57BL ; Mice ; CARD Signaling Adaptor Proteins/metabolism ; NF-kappa B/metabolism ; Protein Binding
Chemical Substances	Lectins, C-Type ; dectin 1 ; CARD Signaling Adaptor Proteins ; NF-kappa B ; Card9 protein, mouse
Language	English
Publishing date	2024-04-23
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2126315-2
ISSN	1478-811X ; 1478-811X
ISSN (online)	1478-811X
ISSN	1478-811X
DOI	10.1186/s12964-024-01576-z
Database	MEDical Literature Analysis and Retrieval System OnLINE

Order via subito

Article ; Online: Cancer stem cell-immune cell crosstalk in breast tumor microenvironment: a determinant of therapeutic facet.

Guha, Aishwarya / Goswami, Kuntal Kanti / Sultana, Jasmine / Ganguly, Nilanjan / Choudhury, Pritha Roy / Chakravarti, Mohona / Bhuniya, Avishek / Sarkar, Anirban / Bera, Saurav / Dhar, Sukanya / Das, Juhina / Das, Tapasi / Baral, Rathindranath / Bose, Anamika / Banerjee, Saptak

Frontiers in immunology

2023 Volume 14, Page(s) 1245421

Abstract: Breast cancer (BC) is globally one of the leading killers among women. Within a breast tumor, a minor population of transformed cells accountable for drug resistance, survival, and metastasis is known as breast cancer stem cells (BCSCs). Several ... ...

Abstract	Breast cancer (BC) is globally one of the leading killers among women. Within a breast tumor, a minor population of transformed cells accountable for drug resistance, survival, and metastasis is known as breast cancer stem cells (BCSCs). Several experimental lines of evidence have indicated that BCSCs influence the functionality of immune cells. They evade immune surveillance by altering the characteristics of immune cells and modulate the tumor landscape to an immune-suppressive type. They are proficient in switching from a quiescent phase (slowly cycling) to an actively proliferating phenotype with a high degree of plasticity. This review confers the relevance and impact of crosstalk between immune cells and BCSCs as a fate determinant for BC prognosis. It also focuses on current strategies for targeting these aberrant BCSCs that could open avenues for the treatment of breast carcinoma.
MeSH term(s)	Animals ; Female ; Humans ; Breast Neoplasms/pathology ; Mammary Neoplasms, Animal/pathology ; Cell Line, Tumor ; Prognosis ; Neoplastic Stem Cells/metabolism
Language	English
Publishing date	2023-11-27
Publishing country	Switzerland
Document type	Journal Article ; Review ; Research Support, Non-U.S. Gov't
ZDB-ID	2606827-8
ISSN	1664-3224 ; 1664-3224
ISSN (online)	1664-3224
ISSN	1664-3224
DOI	10.3389/fimmu.2023.1245421
Database	MEDical Literature Analysis and Retrieval System OnLINE

Order via subito

To top

Full text online

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

Full text online

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

Full text online

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

Full text online

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

More links

Kategorien

Order via subito

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

Full text online

More links

Kategorien

Order via subito

More links

Kategorien

Order via subito

More links

Kategorien

Order via subito

More links

Kategorien

Order via subito