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  1. Article ; Online: Acute coronary syndrome in a patient with acquired immunodeficiency syndrome and non-bacterial thrombotic endocarditis.

    Jedlinski, Ireneusz / Baralkiewicz, Grazyna / Poprawski, Kajetan

    European heart journal

    2010  Volume 31, Issue 8, Page(s) 935

    MeSH term(s) Acquired Immunodeficiency Syndrome/complications ; Acute Coronary Syndrome/complications ; Acute Coronary Syndrome/diagnostic imaging ; Adult ; Coronary Thrombosis/complications ; Coronary Thrombosis/diagnostic imaging ; Echocardiography, Transesophageal ; Endocarditis/complications ; Endocarditis/diagnostic imaging ; Humans ; Male
    Language English
    Publishing date 2010-04
    Publishing country England
    Document type Case Reports ; Journal Article
    ZDB-ID 603098-1
    ISSN 1522-9645 ; 0195-668X
    ISSN (online) 1522-9645
    ISSN 0195-668X
    DOI 10.1093/eurheartj/ehp580
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  2. Article ; Online: Expanding HIV-1 subtype B transmission networks among men who have sex with men in Poland.

    Parczewski, Miłosz / Leszczyszyn-Pynka, Magdalena / Witak-Jędra, Magdalena / Szetela, Bartosz / Gąsiorowski, Jacek / Knysz, Brygida / Bociąga-Jasik, Monika / Skwara, Paweł / Grzeszczuk, Anna / Jankowska, Maria / Barałkiewicz, Grażyna / Mozer-Lisewska, Iwona / Łojewski, Władysław / Kozieł, Katarzyna / Grąbczewska, Edyta / Jabłonowska, Elżbieta / Urbańska, Anna

    PloS one

    2017  Volume 12, Issue 2, Page(s) e0172473

    Abstract: Introduction: Reconstruction of HIV transmission links allows to trace the spread and dynamics of infection and guide epidemiological interventions. The aim of this study was to characterize transmission networks among subtype B infected patients from ... ...

    Abstract Introduction: Reconstruction of HIV transmission links allows to trace the spread and dynamics of infection and guide epidemiological interventions. The aim of this study was to characterize transmission networks among subtype B infected patients from Poland.
    Material and methods: Maximum likelihood phylogenenetic trees were inferred from 966 HIV-1 subtype B protease/reverse transcriptase sequences from patients followed up in nine Polish HIV centers. Monophyletic clusters were identified using 3% within-cluster distance and 0.9 bootstrap values. Interregional links for the clusters were investigated and time from infection to onward transmission estimated using Bayesian dated MCMC phylogeny.
    Results: Three hundred twenty one (33.2%) sequences formed 109 clusters, including ten clusters of ≥5 sequences (n = 81, 8.4%). Transmission networks were more common among MSM (234 sequences, 68.6%) compared to other infection routes (injection drug use: 28 (8.2%) and heterosexual transmissions: 59 (17.3%) cases, respectively [OR:3.5 (95%CI:2.6-4.6),p<0.001]. Frequency of clustering increased from 26.92% in 2009 to 50.6% in 2014 [OR:1.18 (95%CI:1.06-1.31),p = 0.0026; slope +2.8%/year] with median time to onward transmission within clusters of 1.38 (IQR:0.59-2.52) years. In multivariate models clustering was associated with both MSM transmission route [OR:2.24 (95%CI:1.38-3.65),p<0.001] and asymptomatic stage of HIV infection [OR:1.93 (95%CI:1.4-2.64),p<0.0001]. Additionally, interregional networks were linked to MSM transmissions [OR:4.7 (95%CI:2.55-8.96),p<0.001].
    Conclusions: Reconstruction of the HIV-1 subtype B transmission patterns reveals increasing degree of clustering and existence of interregional networks among Polish MSM. Dated phylogeny confirms the association between onward transmission and recent infections. High transmission dynamics among Polish MSM emphasizes the necessity for active testing and early treatment in this group.
    MeSH term(s) Adult ; Bayes Theorem ; Cluster Analysis ; Contact Tracing/statistics & numerical data ; Female ; Genotype ; HIV Infections/epidemiology ; HIV Infections/transmission ; HIV Infections/virology ; HIV Protease/genetics ; HIV-1/classification ; HIV-1/genetics ; HIV-1/isolation & purification ; Heterosexuality ; Homosexuality, Male ; Humans ; Male ; Phylogeny ; Poland/epidemiology ; Public Health Surveillance ; Substance Abuse, Intravenous/epidemiology ; Substance Abuse, Intravenous/virology
    Chemical Substances HIV Protease (EC 3.4.23.-) ; p16 protease, Human immunodeficiency virus 1 (EC 3.4.23.-)
    Language English
    Publishing date 2017-02-24
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2267670-3
    ISSN 1932-6203 ; 1932-6203
    ISSN (online) 1932-6203
    ISSN 1932-6203
    DOI 10.1371/journal.pone.0172473
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  3. Article: The Spectrum of Malignancies among Adult HIV Cohort in Poland between 1995 and 2012: A Retrospective Analysis of 288 Cases.

    Kowalski, Jacek / Cholewińska, Grażyna / Pyziak-Kowalska, Karolina / Jabłonowska, Elżbieta / Barałkiewicz, Grażyna / Grzeszczuk, Anna / Leszczyszyn-Pynka, Magdalena / Olczak, Anita / Jankowska, Maria / Mikuła, Tomasz / Bociąga-Jasik, Monika / Firląg-Burkacka, Ewa / Horban, Andrzej

    Contemporary oncology (Poznan, Poland)

    2015  Volume 19, Issue 3, Page(s) 226–235

    Abstract: The aim of the study: The aim of the study was to evaluate the spectrum of AIDS-defining malignancies (ADMs) and non-AIDS-defining malignancies (NADMs) in HIV-infected patients in Poland.: Material and methods: A retrospective observational study was ...

    Abstract The aim of the study: The aim of the study was to evaluate the spectrum of AIDS-defining malignancies (ADMs) and non-AIDS-defining malignancies (NADMs) in HIV-infected patients in Poland.
    Material and methods: A retrospective observational study was conducted among HIV-infected adult patients who developed a malignancy between 1995 and 2012 in a Polish cohort. Malignancies were divided into ADMs and NADMs. Non-AIDS-defining malignancies were further categorised as virus-related (NADMs-VR) and unrelated (NADMs-VUR). Epidemiological data was analysed according to demographic data, medical history, and HIV-related information. Results were analysed by OR, EPITools package parameters and Fisher's exact test.
    Results: In this study 288 malignancies were discovered. The mean age at diagnosis was 41.25 years (IQR20-81); for ADMs 38.05 years, and for NADMs-VURs 46.42 years; 72.22% were male, 40.28% were co-infected with HCV. The risk behaviours were: 37.85% IDU, 33.33% MSM, and 24.31% heterosexual. Mean CD4+ at the diagnosis was 282 cells/mm(3) (for ADMs 232 and for NADMs-VUR 395). Average duration of HIV infection at diagnosis was 5.69 years. There were 159 (55.2%) ADMs and 129 (44.8%) NADMs, among whom 58 (44.96%) NADMs-VR and 71 (55.04%) NADMs-VUR. The most frequent malignancies were: NHL (n = 76; 26.39%), KS (n = 49; 17.01%), ICC (n = 34; 11.81%), HD (n = 23; 7.99%), lung cancer (n = 18; 6.25%) and HCC (n = 14; 4.86%). The amount of NADMs, NADMs-VURs in particular, is increasing at present. Male gender (OR = 1.889; 95% CI: 1.104-3.233; p = 0.024), advanced age: 50-60 years (OR = 3.022; 95% CI: 1.359-6.720; p = 0.01) and ≥ 60 years (OR = 15.111; 95% CI: 3.122-73.151; p < 0.001), longer duration of HIV-infection and successful HAART (OR = 2.769; 95% CI: 1.675-4.577; p = 0) were independent predictors of NADMs overall, respectively.
    Conclusions: In a Polish cohort NHL was the most frequent malignancy among ADMs, whereas HD was the most frequent among NADMs. Increased incidence of NADMs appearing in elderly men with longer duration of HIV-infection and with better virological and immunological control was confirmed. As HIV-infected individuals live longer, better screening strategies, especially for NADMs-VUR, are needed. The spectrum of cancer diagnoses in Poland currently does not appear dissimilar to that observed in other European populations.
    Language English
    Publishing date 2015-07-08
    Publishing country Poland
    Document type Journal Article
    ISSN 1428-2526
    ISSN 1428-2526
    DOI 10.5114/wo.2015.52658
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  4. Article ; Online: Distribution and time trends of HIV-1 variants in Poland: Characteristics of non-B clades and recombinant viruses.

    Parczewski, Miłosz / Leszczyszyn-Pynka, Magdalena / Witak-Jędra, Magdalena / Rymer, Weronika / Zalewska, Małgorzata / Gąsiorowski, Jacek / Bociąga-Jasik, Monika / Kalinowska-Nowak, Anna / Garlicki, Aleksander / Grzeszczuk, Anna / Jankowska, Maria / Lemańska, Małgorzata / Barałkiewicz, Grażyna / Mozer-Lisewska, Iwona / Łojewski, Władysław / Grąbczewska, Edyta / Olczak, Anita / Jabłonowska, Elżbieta / Urbańska, Anna

    Infection, genetics and evolution : journal of molecular epidemiology and evolutionary genetics in infectious diseases

    2016  Volume 39, Page(s) 232–240

    Abstract: The spread of HIV-1 subtypes varies considerably both worldwide and within Europe, with non-B variants commonly found across various exposure groups. This study aimed to analyse the distribution and temporal trends in HIV-1 subtype variability across ... ...

    Abstract The spread of HIV-1 subtypes varies considerably both worldwide and within Europe, with non-B variants commonly found across various exposure groups. This study aimed to analyse the distribution and temporal trends in HIV-1 subtype variability across Poland. For analysis of the subtype distribution, 1219 partial pol sequences obtained from patients followed up in 9 of 17 Polish HIV treatment centres were used. Subtyping was inferred using the maximum likelihood method; recombination was assessed using the bootscanning and jumping profile hidden Markov model methods. Subtype B dominated in the studied group (n=1059, 86.9%); in 160 (13.1%) sequences, non-B variants were present [A1 (n=63, 5.2%), D (n=43, 3.5%), C (n=22, 1.8%), and F1 (n=2, 0.2%)]. In 25 (2.1%) cases circulating recombinant forms (CRFs) were found. Five A1 variants (0.4%) were unique AB recombinant forms (URF) not previously identified in Poland. Non-B clades were notably more common among females (n=73, 45.6%, p<0.001) and heterosexual individuals (n=103, 66.5%, p<0.001) and less frequent among men who have sex with men (MSM) (n=27, 17.42%, p<0.001). HIV-1 viral load at diagnosis was higher among non-B cases [median: 5.0 (IQR: 4.4-5.6)] vs. [median: 4.8 (IQR: 4.3-5.4) log copies/ml for subtype B (p<0.001)] with a lower CD4(+) lymphocyte count at baseline [median: 248 (IQR: 75-503) for non-B vs. median: 320 (IQR: 125-497) cells/μl for subtype B; p<0.001]. The frequency of the non-B subtypes proved stable from 2008 (11.5%) to 2014 (8.0%) [OR: 0.95 (95% CI: 0.84-1.07), p=0.4], with no temporal differences for exposure groups, gender, age and AIDS. Despite the predominance of subtype B, the variability of HIV in Poland is notable; both CRFs and URFs are present in the analysed population. Non-B variants are associated with heterosexual transmission, more advanced HIV disease and have stable temporal frequencies.
    MeSH term(s) Adult ; CD4 Lymphocyte Count ; Female ; Genetic Variation ; Genotype ; HIV Infections/epidemiology ; HIV Infections/immunology ; HIV Infections/virology ; HIV-1/genetics ; Humans ; Male ; Middle Aged ; Odds Ratio ; Phylogeny ; Poland/epidemiology ; Recombination, Genetic ; Viral Load
    Language English
    Publishing date 2016-04
    Publishing country Netherlands
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2037068-4
    ISSN 1567-7257 ; 1567-1348
    ISSN (online) 1567-7257
    ISSN 1567-1348
    DOI 10.1016/j.meegid.2016.02.001
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  5. Article ; Online: Transmitted HIV drug resistance in antiretroviral-treatment-naive patients from Poland differs by transmission category and subtype.

    Parczewski, Miłosz / Leszczyszyn-Pynka, Magdalena / Witak-Jędra, Magdalena / Maciejewska, Katarzyna / Rymer, Weronika / Szymczak, Aleksandra / Szetela, Bartosz / Gąsiorowski, Jacek / Bociąga-Jasik, Monika / Skwara, Paweł / Garlicki, Aleksander / Grzeszczuk, Anna / Rogalska, Magdalena / Jankowska, Maria / Lemańska, Małgorzata / Hlebowicz, Maria / Barałkiewicz, Grażyna / Mozer-Lisewska, Iwona / Mazurek, Renata /
    Lojewski, Władyslaw / Grąbczewska, Edyta / Olczak, Anita / Jabłonowska, Elżbieta / Clark, Jeremy / Urbańska, Anna

    The Journal of antimicrobial chemotherapy

    2015  Volume 70, Issue 1, Page(s) 233–242

    Abstract: Objectives: The surveillance of HIV-transmitted drug resistance mutations (t-DRMs), including temporal trends across subtypes and exposure groups, remains a priority in the current management of the epidemic worldwide.: Methods: A cross-sectional ... ...

    Abstract Objectives: The surveillance of HIV-transmitted drug resistance mutations (t-DRMs), including temporal trends across subtypes and exposure groups, remains a priority in the current management of the epidemic worldwide.
    Methods: A cross-sectional analysis of 833 treatment-naive patients from 9 of 17 Polish HIV treatment centres. Partial pol sequences were used to analyse drug resistance with a general time reversible (GTR)-based maximum likelihood algorithm used for cluster/pair identification. Mutation frequencies and temporal trends were investigated.
    Results: t-DRMs were observed in 9% of cases (5.8% for NRTI, 1.2% NNRTI and 2.0% PI mutations) and were more common among heterosexually infected (HET) individuals (13.4%) compared with MSM (8.3%, P = 0.03) or injection drug users (IDUs; 2.9%, P = 0.001) and in MSM compared with IDUs (P = 0.046). t-DRMs were more frequent in cases infected with the non-B variant (21.6%) compared with subtype B (6.6%, P < 0.001). With subtype B a higher mutation frequency was found in MSM compared with non-MSM cases (8.3% versus 1.8% for IDU + HET, P = 0.038), while non-B variants were associated with heterosexual exposure (30.4% for HET versus 4.8% for MSM, P = 0.019; versus 0 for IDU, P = 0.016). Trends in t-DRM frequencies were stable over time except for a decrease in NNRTI t-DRMs among MSM (P = 0.0662) and an NRTI t-DRM decrease in HET individuals (P = 0.077). With subtype B a higher frequency of sequence pairs/clusters in MSM (50.4%) was found compared with HET (P < 0.001) and IDUs (P = 0.015).
    Conclusions: Despite stable trends over time, patterns of t-DRMs differed notably between transmission categories and subtypes: subtype B was associated with MSM transmission and clustering while in non-B clades t-DRMs were more common and were associated with heterosexual infections.
    MeSH term(s) Adult ; Anti-HIV Agents/pharmacology ; Cross-Sectional Studies ; Drug Resistance, Viral ; Female ; Genotype ; HIV/classification ; HIV/drug effects ; HIV/genetics ; HIV Infections/epidemiology ; HIV Infections/transmission ; HIV Infections/virology ; Humans ; Male ; Middle Aged ; Mutation Rate ; Poland/epidemiology ; Prevalence ; Sequence Analysis, DNA ; pol Gene Products, Human Immunodeficiency Virus/genetics
    Chemical Substances Anti-HIV Agents ; pol Gene Products, Human Immunodeficiency Virus
    Language English
    Publishing date 2015-01
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 191709-2
    ISSN 1460-2091 ; 0305-7453
    ISSN (online) 1460-2091
    ISSN 0305-7453
    DOI 10.1093/jac/dku372
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  6. Article ; Online: Time trends in HIV-1 transmitted drug resistance mutation frequency in Poland.

    Parczewski, Milosz / Witak-Jedra, Magdalena / Maciejewska, Katarzyna / Bociaga-Jasik, Monika / Skwara, Pawel / Garlicki, Aleksander / Grzeszczuk, Anna / Rogalska, Magdalena / Jankowska, Maria / Lemanska, Malgorzata / Hlebowicz, Maria / Baralkiewicz, Grazyna / Mozer-Lisewska, Iwona / Mazurek, Renata / Lojewski, Wladyslaw / Grabczewska, Edyta / Olczak, Anita / Jablonowska, Elzbieta / Rymer, Weronika /
    Szymczak, Aleksandra / Szetela, Bartosz / Gasiorowski, Jacek / Knysz, Brygida / Urbanska, Anna / Leszczyszyn-Pynka, Magdalena

    Journal of the International AIDS Society

    2014  Volume 17, Issue 4 Suppl 3, Page(s) 19753

    Abstract: Introduction: In Poland, the HIV epidemic has shifted recently from being predominantly related to injection drug use (IDU) to being driven by transmissions among men-who-have-sex-with-men (MSM). The number of new HIV cases has increased in the recent ... ...

    Abstract Introduction: In Poland, the HIV epidemic has shifted recently from being predominantly related to injection drug use (IDU) to being driven by transmissions among men-who-have-sex-with-men (MSM). The number of new HIV cases has increased in the recent years, while no current data on the transmitted drug resistance associated mutations (tDRM) frequency trend over time are available from 2010. In this study, we analyze the temporal trends in the spread of tDRM from 2008 to 2013.
    Materials and methods: Partial pol sequences from 833 antiretroviral treatment-naive individuals of European descent (Polish origin) linked to care in 9 of 17 Polish HIV treatment centres were analyzed. Drug resistance interpretation was performed according to WHO surveillance recommendations, subtyping with REGA genotyping 2.0 tool. Time trends were examined for the frequency of t-DRM across subtypes and transmission groups using logistic regression (R statistical platform, v. 3.1.0).
    Results: Frequency of tDRM proved stable over time, with mutation frequency change from 11.3% in 2008 to 8.3% in 2013 [OR: 0.91 (95% CI 0.80-1,05), p=0.202] (Figure 1a). Also, no significant differences over time were noted for the subtype B (decrease from 8.4% 2008 to 6.2% in 2013 [OR: 0.94 (95% CI 0.79-1.11), p=0.45] and across non-B variants [change from 22.6% 2008 to 23.1% in 2013, OR: 0.94 (95% CI 0.75-1.19), p=0.62]. When patient groups were stratified according to transmission route, in MSM there was a trend for a NNRTI t-DRM decrease (from 6.8% 2008 to 1% in 2013, OR: 0.61 (95% CI 0.34-1.02), p=0.0655, slope -0.74%/year) (Figure 1b), related to the subtype B infected MSM (decrease from 7% 2008 to 1% in 2013, OR: 0.61 (95% CI 0.34-1.03), p=0.0662, slope -0.75%/year). Overall tDRM frequency decrease was also noted for the heterosexually infected patients [from 17.6% 2008 to 10.3% in 2013, OR: 0.83 (95% CI 0.67-1.02, p=0.077, slope -2.041%/year)] but did not associate with drug class (Figure 1c). In IDUs, the trends in t-DRM frequency were not significant over time (change from 1.9% in 2008 to 0 in 2013 [OR:1.24 (95% CI 0.73-2.26), p=0.4)].
    Conclusions: The frequency of t-DRM in Poland is generally stable over time. Decrease in the overall tDRM frequency in heterosexual infected cases and NNRTI resistance in subtype B infected MSM may be related to the higher treatment efficacy of current cART.
    Language English
    Publishing date 2014
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2467110-1
    ISSN 1758-2652 ; 1758-2652
    ISSN (online) 1758-2652
    ISSN 1758-2652
    DOI 10.7448/IAS.17.4.19753
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