Article ; Online: Sex differences in the purinergic 2 receptor-mediated blood pressure response to treadmill exercise in rats with simulated peripheral artery disease.
American journal of physiology. Regulatory, integrative and comparative physiology
2024 Volume 326, Issue 6, Page(s) R449–R460
Abstract: We investigated the role played by ATP-sensitive purinergic 2 (P2) receptors in evoking the pressor response to treadmill exercise in male and female rats with and without femoral arteries that were ligated for ∼72 h to induce simulated peripheral artery ...
| Abstract | We investigated the role played by ATP-sensitive purinergic 2 (P2) receptors in evoking the pressor response to treadmill exercise in male and female rats with and without femoral arteries that were ligated for ∼72 h to induce simulated peripheral artery disease (PAD). We hypothesized that PPADS (P2 receptor antagonist, 10 mg iv) would reduce the pressor response to 4 min of treadmill exercise (15 m·min |
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| MeSH term(s) | Animals ; Female ; Male ; Peripheral Arterial Disease/physiopathology ; Peripheral Arterial Disease/metabolism ; Peripheral Arterial Disease/blood ; Rats, Sprague-Dawley ; Physical Conditioning, Animal/physiology ; Rats ; Disease Models, Animal ; Blood Pressure/physiology ; Femoral Artery/physiopathology ; Sex Factors ; Norepinephrine/blood ; Sex Characteristics | |||||
| Chemical Substances | Norepinephrine (X4W3ENH1CV) | |||||
| Language | English | |||||
| Publishing date | 2024-03-18 | |||||
| Publishing country | United States | |||||
| Document type | Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't ; Comparative Study | |||||
| ZDB-ID | 603839-6 | |||||
| ISSN | 1522-1490 ; 0363-6119 | |||||
| ISSN (online) | 1522-1490 | |||||
| ISSN | 0363-6119 | |||||
| DOI | 10.1152/ajpregu.00010.2024 | |||||
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| Database | MEDical Literature Analysis and Retrieval System OnLINE |
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