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  1. Article ; Online: Global burden of acute lower respiratory infection associated with human metapneumovirus in children under 5 years in 2018

    Xin Wang, PhD / You Li, PhD / Maria Deloria-Knoll, PhD / Shabir A Madhi, ProfPhD / Cheryl Cohen, MD / Asad Ali, MD / Sudha Basnet, ProfMD / Quique Bassat, ProfMD / W Abdullah Brooks, MD / Malinee Chittaganpitch, MSc / Marcela Echavarria, PhD / Rodrigo A Fasce, BSc / Doli Goswami, MSc / Siddhivinayak Hirve, PhD / Nusrat Homaira, PhD / Stephen R C Howie, PhD / Karen L Kotloff, ProfMD / Najwa Khuri-Bulos, ProfMD / Anand Krishnan, ProfMD /
    Marilla G Lucero, MD / Socorro Lupisan, MD / Ainara Mira-Iglesias, MSc / David P Moore, PhD / Cinta Moraleda, PhD / Marta Nunes, PhD / Histoshi Oshitani, ProfMD / Betty E Owor, PhD / Fernando P Polack, ProfMD / Katherine L O'Brien, ProfMD / Zeba A Rasmussen, MD / Barbara A Rath, ProfMD / Vahid Salimi, PhD / J Anthony G Scott, ProfFRCP / Eric A F Simões, ProfMD / Tor A Strand, ProfPhD / Donald M Thea, ProfMD / Florette K Treurnicht, PhD / Linda C Vaccari, MbChB / Lay-Myint Yoshida, ProfPhD / Heather J Zar, ProfPhD / Harry Campbell, ProfMD / Harish Nair, ProfPhD / Romina Libster / Grieven Otieno / Imane Joundi / Shobha Broor / Mark Nicol / Ritvik Amarchand / Ting Shi / F. Xavier López-Labrador

    The Lancet Global Health, Vol 9, Iss 1, Pp e33-e

    a systematic review and modelling study

    2021  Volume 43

    Abstract: Summary: Background: Human metapneumovirus is a common virus associated with acute lower respiratory infections (ALRIs) in children. No global burden estimates are available for ALRIs associated with human metapneumovirus in children, and no licensed ... ...

    Abstract Summary: Background: Human metapneumovirus is a common virus associated with acute lower respiratory infections (ALRIs) in children. No global burden estimates are available for ALRIs associated with human metapneumovirus in children, and no licensed vaccines or drugs exist for human metapneumovirus infections. We aimed to estimate the age-stratified human metapneumovirus-associated ALRI global incidence, hospital admissions, and mortality burden in children younger than 5 years. Methods: We estimated the global burden of human metapneumovirus-associated ALRIs in children younger than 5 years from a systematic review of 119 studies published between Jan 1, 2001, and Dec 31, 2019, and a further 40 high quality unpublished studies. We assessed risk of bias using a modified Newcastle-Ottawa Scale. We estimated incidence, hospital admission rates, and in-hospital case-fatality ratios (hCFRs) of human metapneumovirus-associated ALRI using a generalised linear mixed model. We applied incidence and hospital admission rates of human metapneumovirus–associated ALRI to population estimates to yield the morbidity burden estimates by age bands and World Bank income levels. We also estimated human metapneumovirus-associated ALRI in-hospital deaths and overall human metapneumovirus-associated ALRI deaths (both in-hospital and non-hospital deaths). Additionally, we estimated human metapneumovirus-attributable ALRI cases, hospital admissions, and deaths by combining human metapneumovirus-associated burden estimates and attributable fractions of human metapneumovirus in laboratory-confirmed human metapneumovirus cases and deaths. Findings: In 2018, among children younger than 5 years globally, there were an estimated 14·2 million human metapneumovirus-associated ALRI cases (uncertainty range [UR] 10·2 million to 20·1 million), 643 000 human metapneumovirus-associated hospital admissions (UR 425 000 to 977 000), 7700 human metapneumovirus-associated in-hospital deaths (2600 to 48 800), and 16 100 overall (hospital and community) ...
    Keywords Public aspects of medicine ; RA1-1270
    Subject code 360
    Language English
    Publishing date 2021-01-01T00:00:00Z
    Publisher Elsevier
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  2. Article ; Online: Global burden of respiratory infections associated with seasonal influenza in children under 5 years in 2018

    Xin Wang, MSc / You Li, PhD / Katherine L O'Brien, ProfMD / Shabir A Madhi, ProfPhD / Marc-Alain Widdowson, VetMB / Peter Byass, ProfPhD / Saad B Omer, ProfPhD / Qalab Abbas, MBBS / Asad Ali, MD / Alberta Amu, MD / Eduardo Azziz-Baumgartner, MD / Quique Bassat, ProfMD / W Abdullah Brooks, MD / Sandra S Chaves, MD / Alexandria Chung, BMedSci(H) / Cheryl Cohen, MD / Marcela Echavarria, PhD / Rodrigo A Fasce, BSc / Angela Gentile, ProfMD /
    Aubree Gordon, PhD / Michelle Groome, PhD / Terho Heikkinen, ProfMD / Siddhivinayak Hirve, PhD / Jorge H Jara, MD / Mark A Katz, MD / Najwa Khuri-Bulos, ProfMD / Anand Krishnan, ProfMD / Oscar de Leon, BSc / Marilla G Lucero, MD / John P McCracken, ScD / Ainara Mira-Iglesias, MSc / Jennifer C Moïsi, PhD / Patrick K Munywoki, PhD / Millogo Ourohiré, MD / Fernando P Polack, ProfMD / Manveer Rahi, MBChB / Zeba A Rasmussen, MD / Barbara A Rath, ProfMD / Samir K Saha, ProfPhD / Eric AF Simões, ProfMD / Viviana Sotomayor, MPH / Somsak Thamthitiwat, MD / Florette K Treurnicht, PhD / Marylene Wamukoya, MPH / Lay-Myint Yoshida, ProfPhD / Heather J Zar, ProfPhD / Harry Campbell, ProfMD / Harish Nair, ProfPhD

    The Lancet Global Health, Vol 8, Iss 4, Pp e497-e

    a systematic review and modelling study

    2020  Volume 510

    Abstract: Summary: Background: Seasonal influenza virus is a common cause of acute lower respiratory infection (ALRI) in young children. In 2008, we estimated that 20 million influenza-virus-associated ALRI and 1 million influenza-virus-associated severe ALRI ... ...

    Abstract Summary: Background: Seasonal influenza virus is a common cause of acute lower respiratory infection (ALRI) in young children. In 2008, we estimated that 20 million influenza-virus-associated ALRI and 1 million influenza-virus-associated severe ALRI occurred in children under 5 years globally. Despite this substantial burden, only a few low-income and middle-income countries have adopted routine influenza vaccination policies for children and, where present, these have achieved only low or unknown levels of vaccine uptake. Moreover, the influenza burden might have changed due to the emergence and circulation of influenza A/H1N1pdm09. We aimed to incorporate new data to update estimates of the global number of cases, hospital admissions, and mortality from influenza-virus-associated respiratory infections in children under 5 years in 2018. Methods: We estimated the regional and global burden of influenza-associated respiratory infections in children under 5 years from a systematic review of 100 studies published between Jan 1, 1995, and Dec 31, 2018, and a further 57 high-quality unpublished studies. We adapted the Newcastle-Ottawa Scale to assess the risk of bias. We estimated incidence and hospitalisation rates of influenza-virus-associated respiratory infections by severity, case ascertainment, region, and age. We estimated in-hospital deaths from influenza virus ALRI by combining hospital admissions and in-hospital case-fatality ratios of influenza virus ALRI. We estimated the upper bound of influenza virus-associated ALRI deaths based on the number of in-hospital deaths, US paediatric influenza-associated death data, and population-based childhood all-cause pneumonia mortality data in six sites in low-income and lower-middle-income countries. Findings: In 2018, among children under 5 years globally, there were an estimated 109·5 million influenza virus episodes (uncertainty range [UR] 63·1–190·6), 10·1 million influenza-virus-associated ALRI cases (6·8–15·1); 870 000 influenza-virus-associated ALRI hospital ...
    Keywords Public aspects of medicine ; RA1-1270
    Subject code 360
    Language English
    Publishing date 2020-04-01T00:00:00Z
    Publisher Elsevier
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

    Full text online

    More links

    Kategorien

    Inter-library loan at ZB MED

    Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

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