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  1. AU="Barbara Mognetti"
  2. AU="Gibb, Jonathan"
  3. AU="Garg, Priya S"
  4. AU="Van Driessche, Veroniek"
  5. AU="Solianova, Veronika"
  6. AU="Strauss, Sarah"
  7. AU="Messemaker, Tobias C"
  8. AU="Daniel, Maria Urszula"
  9. AU=Edwards Robert J AU=Edwards Robert J
  10. AU="Shriver, Craig D"
  11. AU="Huang, Xiang-Zhong"
  12. AU=Cabanne Eglantine
  13. AU="Bernal, A"
  14. AU="Malorie Perry"
  15. AU="Oppenheim, Alan"
  16. AU="Ozcan, Muhit"
  17. AU="Zhang, Cissy"
  18. AU="Blaize, Justin L"
  19. AU="R, Ram Babu"
  20. AU="Khalili Arash"
  21. AU="Bhatia, Sandeep"
  22. AU="Ticha, Johnson M"
  23. AU="Aranzabal Barrio, N"

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  1. Artikel ; Online: Reviving a Classic Antigen with a Cutting-Edge Approach

    Chiara Castrignano / Federica Di Scipio / Francesco Franco / Barbara Mognetti / Giovanni Nicolao Berta

    Pharmaceuticals, Vol 16, Iss 794, p

    Nanobodies for HER2+ Breast Cancer

    2023  Band 794

    Abstract: The serendipitous discovery of nanobodies (NBs) around two decades ago opened the door to new possibilities for innovative strategies, particularly in cancer treatment. These antigen-binding fragments are derived from heavy-chain-only antibodies ... ...

    Abstract The serendipitous discovery of nanobodies (NBs) around two decades ago opened the door to new possibilities for innovative strategies, particularly in cancer treatment. These antigen-binding fragments are derived from heavy-chain-only antibodies naturally found in the serum of camelids and sharks. NBs are an appealing agent for the progress of innovative therapeutic strategies because they combine the advantageous assets of smaller molecules and conventional monoclonal antibodies (mAbs). Moreover, the possibility to produce NBs using bacterial systems reduces manufacturing expenses and speeds up the production process, making them a feasible option for the development of new bio-drugs. Several NBs have been developed over the past 10 years and are currently being tested in clinical trials for various human targets. Here, we provide an overview of the notable structural and biochemical characteristics of NBs, particularly in their application against HER2, an extracellular receptor that often gets aberrantly activated during breast cancer tumorigenesis. The focus is on the recent advancements in diagnostic and therapeutic research up to the present date.
    Schlagwörter nanobody ; target therapy ; HER2 ; breast cancer ; Medicine ; R ; Pharmacy and materia medica ; RS1-441
    Thema/Rubrik (Code) 610
    Sprache Englisch
    Erscheinungsdatum 2023-05-01T00:00:00Z
    Verlag MDPI AG
    Dokumenttyp Artikel ; Online
    Datenquelle BASE - Bielefeld Academic Search Engine (Lebenswissenschaftliche Auswahl)

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  2. Artikel ; Online: Glucocorticoid Receptor Polymorphism A3669G Is Associated with Airflow Obstruction in Mild-to-Severe Asthma

    Barbara Mognetti / Daniela Francesca Giachino / Francesca Bertolini / Vitina Carriero / Andrea Elio Sprio / Fabio Luigi Massimo Ricciardolo

    Applied Sciences, Vol 13, Iss 7450, p

    2023  Band 7450

    Abstract: Background: Glucocorticoids (GCs) represent the mainstay therapy for asthmatics. A subset of severe asthmatics fails to respond to steroid-based therapies, leading to important healthcare costs. Single nucleotide polymorphisms (SNPs) of glucocorticoid ... ...

    Abstract Background: Glucocorticoids (GCs) represent the mainstay therapy for asthmatics. A subset of severe asthmatics fails to respond to steroid-based therapies, leading to important healthcare costs. Single nucleotide polymorphisms (SNPs) of glucocorticoid receptor genes were associated with a response to GC. We evaluate the possible relation of BclI and A3669G SNPs to clinical, biological and functional characteristics of asthmatics. Methods: We recruited 172 mild-to-severe asthmatic outpatients referring to the Severe Asthma and Rare Lung Disease Unit at San Luigi University Hospital. Clinical data were obtained at recruitment when spirometry tests and peripheral blood sampling were performed. Patients were genotyped for BclI and A3669G through the pyrosequencing assay results. Results: Patients with the A3669G AG genotype were younger, allergic and had higher IgE levels compared to AA genotype ( p < 0.05). Moreover, asthmatics with the AA genotype had a lower post-bronchodilator FEV 1 /FVC ratio than the GG genotype ( p < 0.05), and a higher RV/TLC ratio than the AG genotype ( p < 0.05). Conclusions: The A3669G AG genotype might be related to type-2 allergic asthma; in particular, allele A of A3669G SNP was associated with GC response in our asthmatics. In conclusion, this observational cross-sectional study suggests a possible role of A3669G SNP as a predictor of asthma severity and phenotype.
    Schlagwörter asthma ; glucocorticoid receptor gene ; airflow obstruction ; air trapping ; SNP ; Technology ; T ; Engineering (General). Civil engineering (General) ; TA1-2040 ; Biology (General) ; QH301-705.5 ; Physics ; QC1-999 ; Chemistry ; QD1-999
    Thema/Rubrik (Code) 610
    Sprache Englisch
    Erscheinungsdatum 2023-06-01T00:00:00Z
    Verlag MDPI AG
    Dokumenttyp Artikel ; Online
    Datenquelle BASE - Bielefeld Academic Search Engine (Lebenswissenschaftliche Auswahl)

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  3. Artikel ; Online: Sexual Violence and Alcohol Intake

    Barbara Mognetti / Federica Di Scipio / Giuliana Abbadessa / Giulia Carnino / Antonella Canavese / Paola Castagna / Federica Romano / Sarah Gino / Giovanni N. Berta

    Medicina, Vol 59, Iss 12, p

    A Population-Based Explorative Study in a Northwestern Italian Area

    2023  Band 2098

    Abstract: Background and Objectives : Sexual violence (SV) is a major global public health concern. While socioeconomic factors and familial relationships have been widely reported to contribute to SV, the role of alcohol consumption should not be ignored. Indeed, ...

    Abstract Background and Objectives : Sexual violence (SV) is a major global public health concern. While socioeconomic factors and familial relationships have been widely reported to contribute to SV, the role of alcohol consumption should not be ignored. Indeed, alcohol can impair cognition, distort reality, increase aggression, and ease drug-facilitated sexual assault. This retrospective study aims to explore the relationship between alcohol consumption and SV by examining the prevalence, characteristics, and consequences of violence episodes. Materials and Methods : A total of 1481 women accessed the Rape Centre “Centro Soccorso Violenza Sessuale” in Turin, Italy between 2008 and 2019, with 223 reporting alcohol consumption before the assault. Results : The alcohol group had a younger age profile, predominantly within the 18–25-year-old category. SV incidents involving alcohol consumers were more likely to occur in public places or in someone else’s home, while the non-alcohol-consuming group experienced more violence in their own homes. Acquaintances and unknown individuals were primarily responsible, whereas partners were the most common perpetrators of violence against non-alcohol-consuming women. Alcohol consumers sought medical attention sooner after the assault and exhibited more symptoms and injuries, particularly of neurological origin. Concurrent use of recreational drugs was higher among alcohol consumers. The logistic regression analysis revealed higher odds of injury for Italian women and those in the 18–35 age groups after consuming alcohol. Conclusions : This study contributes to the understanding of the relationship between alcohol consumption and SV. The prevalence of alcohol-related sexual aggression is lower compared to that shown in previous studies. Nationality, age, and assailant identity influence SV dynamics. These findings can guide well-targeted interventions and prevention strategies to address SV and inform communities facing similar challenges.
    Schlagwörter sexual violence ; rape ; alcohol intake ; risk factors ; Medicine (General) ; R5-920
    Thema/Rubrik (Code) 360
    Sprache Englisch
    Erscheinungsdatum 2023-11-01T00:00:00Z
    Verlag MDPI AG
    Dokumenttyp Artikel ; Online
    Datenquelle BASE - Bielefeld Academic Search Engine (Lebenswissenschaftliche Auswahl)

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  4. Artikel ; Online: Profile of Bacterial Infections in COVID-19 Patients

    Irene Stefanini / Giuseppe De Renzi / Elisa Foddai / Elisa Cordani / Barbara Mognetti

    Biology, Vol 10, Iss 822, p

    Antimicrobial Resistance in the Time of SARS-CoV-2

    2021  Band 822

    Abstract: The global onset of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) virus infections happened suddenly, hence imposing a rapid definition of effective therapeutic approaches. Antibiotics were included among the prophylactic agents because of ...

    Abstract The global onset of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) virus infections happened suddenly, hence imposing a rapid definition of effective therapeutic approaches. Antibiotics were included among the prophylactic agents because of both the similarity between SARS-CoV-2 and atypical pneumonia symptoms, and the immune-modulating and anti-inflammatory properties of such drugs. Although, this approach could exacerbate the emergence of antimicrobial resistance. To evaluate the impact of the COVID-19 pandemic on the spread and characteristics of bacterial infections, as well as on the frequency of antimicrobial resistance, we investigated and compared clinical bacterial strains isolated in an Italian hospital from COVID-19 patients and non-COVID-19 patients during and before the COVID-19 outbreak. Data clearly indicate the impact of the COVID-19 pandemic on bacterial infections: not only some bacterial species were found in either COVID-19 positive or in COVID-19 negative patients, but isolates from COVID-19 patients also showed higher levels of antimicrobial resistance. Nevertheless, despite some bacterial species were isolated only before or over the pandemic, no differences were observed among the antimicrobial resistance levels. Overall, these results recapitulate the current situation of microbial infections and could also provide an overview of the impact of COVID-19 on bacterial pathogens spread and resistance.
    Schlagwörter bacterial infections ; AMR ; SARS-CoV-2 ; COVID-19 ; Biology (General) ; QH301-705.5
    Thema/Rubrik (Code) 610
    Sprache Englisch
    Erscheinungsdatum 2021-08-01T00:00:00Z
    Verlag MDPI AG
    Dokumenttyp Artikel ; Online
    Datenquelle BASE - Bielefeld Academic Search Engine (Lebenswissenschaftliche Auswahl)

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  5. Artikel ; Online: Pseudo-Dipeptide Bearing α,α -Difluoromethyl Ketone Moiety as Electrophilic Warhead with Activity against Coronaviruses

    Andrea Citarella / Davide Gentile / Antonio Rescifina / Anna Piperno / Barbara Mognetti / Giorgio Gribaudo / Maria Teresa Sciortino / Wolfgang Holzer / Vittorio Pace / Nicola Micale

    International Journal of Molecular Sciences, Vol 22, Iss 3, p

    2021  Band 1398

    Abstract: The synthesis of α-fluorinated methyl ketones has always been challenging. New methods based on the homologation chemistry via nucleophilic halocarbenoid transfer, carried out recently in our labs, allowed us to design and synthesize a target-directed ... ...

    Abstract The synthesis of α-fluorinated methyl ketones has always been challenging. New methods based on the homologation chemistry via nucleophilic halocarbenoid transfer, carried out recently in our labs, allowed us to design and synthesize a target-directed dipeptidyl α,α-difluoromethyl ketone (DFMK) 8 as a potential antiviral agent with activity against human coronaviruses. The ability of the newly synthesized compound to inhibit viral replication was evaluated by a viral cytopathic effect (CPE)-based assay performed on MCR5 cells infected with one of the four human coronaviruses associated with respiratory distress, i.e., hCoV-229E, showing antiproliferative activity in the micromolar range (EC 50 = 12.9 ± 1.22 µM), with a very low cytotoxicity profile (CC 50 = 170 ± 3.79 µM, 307 ± 11.63 µM, and 174 ± 7.6 µM for A549, human embryonic lung fibroblasts (HELFs), and MRC5 cells, respectively). Docking and molecular dynamics simulations studies indicated that 8 efficaciously binds to the intended target hCoV-229E main protease (M pro ). Moreover, due to the high similarity between hCoV-229E M pro and SARS-CoV-2 M pro , we also performed the in silico analysis towards the second target, which showed results comparable to those obtained for hCoV-229E M pro and promising in terms of energy of binding and docking pose.
    Schlagwörter coronavirus ; cysteine proteases ; hCoV-229E ; SARS-CoV-2 M pro ; difluoromethyl ketone ; Biology (General) ; QH301-705.5 ; Chemistry ; QD1-999
    Thema/Rubrik (Code) 333
    Sprache Englisch
    Erscheinungsdatum 2021-01-01T00:00:00Z
    Verlag MDPI AG
    Dokumenttyp Artikel ; Online
    Datenquelle BASE - Bielefeld Academic Search Engine (Lebenswissenschaftliche Auswahl)

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  6. Artikel ; Online: Human renal angiomyolipoma cells of male and female origin can migrate and are influenced by microenvironmental factors.

    Francesca Bertolini / Giulia Casarotti / Luisella Righi / Enrico Bollito / Carlo Albera / Silvia Anna Racca / Donato Colangelo / Barbara Mognetti

    PLoS ONE, Vol 13, Iss 6, p e

    2018  Band 0199371

    Abstract: BACKGROUND:Improving the knowledge of angiomyolipoma physiopathology might help in refining its pharmacological treatment. We investigated if angiomyolipoma cells have migratory properties, how their growth and motility can be influenced by the hormonal ... ...

    Abstract BACKGROUND:Improving the knowledge of angiomyolipoma physiopathology might help in refining its pharmacological treatment. We investigated if angiomyolipoma cells have migratory properties, how their growth and motility can be influenced by the hormonal milieu, and if this can be related to a specific gender. METHODS:Primary cells were isolated from angiomyolipomas surgically resected for therapeutical reasons in a female and in a male patient. The genetic control demonstrated no TSC2 deletion. Bi- (wound healing) and three-dimensional (transwell assay) migration were analyzed in vitro in basal conditions and under the influence of 17- β-estradiol and SDF-1α. RESULTS:Treatment up to 72 hours with 17-β-estradiol (0.1-100 nM), tamoxifen (0.2-20 μM) or with both, does not modify angiomyolipoma cells proliferation. On the other hand, SDF-1α and 17-β-estradiol treatment induce a significant motility increase (both bi- and three-dimensional) which becomes evident already after 2 hours of incubation. Angiomyolipoma cells express mRNA coding for SDF-1α and 17-β-estradiol receptors and secrete both the metalloproteases principally involved in malignant phenotype acquisition, i.e. MMP-2 and MMP-9. CONCLUSION:Angiomyolipoma cells behave similarly, despite their different source. Primary angiomyolipoma cells migrate in response to hormonal milieu and soluble factors, and produce active metalloproteases, both aspects being consistent with the theory claiming they can migrate to the lungs (and/or other organs) and colonizing them. No main feature, among the aspects we analyzed, seems to be referable to the gender of origin.
    Schlagwörter Medicine ; R ; Science ; Q
    Sprache Englisch
    Erscheinungsdatum 2018-01-01T00:00:00Z
    Verlag Public Library of Science (PLoS)
    Dokumenttyp Artikel ; Online
    Datenquelle BASE - Bielefeld Academic Search Engine (Lebenswissenschaftliche Auswahl)

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  7. Artikel ; Online: Immunopathology of Early Pregnancy

    Gérard Chaouat / Elisabeth Menu / Barbara Mognetti / Marléne Moussa / Véronique Cayol / Yakoute Mostefaoui / Sylvie Dubanchet / Philippe Khadel / Jean Luc Voluménie / Catherine Bertrand Rongiéres / Geneviéve Lapprée Delage

    Infectious Diseases in Obstetrics & Gynecology, Vol 5, Iss 2, Pp 73-

    1997  Band 92

    Schlagwörter Gynecology and obstetrics ; RG1-991 ; Medicine ; R ; Immunologic diseases. Allergy ; RC581-607 ; Specialties of internal medicine ; RC581-951 ; Internal medicine ; RC31-1245
    Sprache Englisch
    Erscheinungsdatum 1997-01-01T00:00:00Z
    Verlag Hindawi Publishing Corporation
    Dokumenttyp Artikel ; Online
    Datenquelle BASE - Bielefeld Academic Search Engine (Lebenswissenschaftliche Auswahl)

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