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  1. Article ; Online: The epigenetic implication in coronavirus infection and therapy.

    Atlante, Sandra / Mongelli, Alessia / Barbi, Veronica / Martelli, Fabio / Farsetti, Antonella / Gaetano, Carlo

    Clinical epigenetics

    2020  Volume 12, Issue 1, Page(s) 156

    Abstract: Epigenetics is a relatively new field of science that studies the genetic and non-genetic aspects related to heritable phenotypic changes, frequently caused by environmental and metabolic factors. In the host, the epigenetic machinery can regulate gene ... ...

    Abstract Epigenetics is a relatively new field of science that studies the genetic and non-genetic aspects related to heritable phenotypic changes, frequently caused by environmental and metabolic factors. In the host, the epigenetic machinery can regulate gene expression through a series of reversible epigenetic modifications, such as histone methylation and acetylation, DNA/RNA methylation, chromatin remodeling, and non-coding RNAs. The coronavirus disease 19 (COVID-19) is a highly transmittable and pathogenic viral infection. The Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2), which emerged in Wuhan, China, and spread worldwide, causes it. COVID-19 severity and consequences largely depend on patient age and health status. In this review, we will summarize and comparatively analyze how viruses regulate the host epigenome. Mainly, we will be focusing on highly pathogenic respiratory RNA virus infections such as coronaviruses. In this context, epigenetic alterations might play an essential role in the onset of coronavirus disease complications. Although many therapeutic approaches are under study, more research is urgently needed to identify effective vaccine or safer chemotherapeutic drugs, including epigenetic drugs, to cope with this viral outbreak and to develop pre- and post-exposure prophylaxis against COVID-19.
    MeSH term(s) Antiviral Agents/pharmacology ; Betacoronavirus/physiology ; COVID-19 ; Coronavirus Infections/drug therapy ; Coronavirus Infections/genetics ; Coronavirus Infections/immunology ; Cytokines/genetics ; Cytokines/immunology ; Epigenesis, Genetic ; Gene Expression Regulation, Viral/drug effects ; Host-Pathogen Interactions ; Humans ; Inflammation/immunology ; Pandemics ; Pneumonia, Viral/drug therapy ; Pneumonia, Viral/genetics ; Pneumonia, Viral/immunology ; RNA Processing, Post-Transcriptional ; SARS-CoV-2
    Chemical Substances Antiviral Agents ; Cytokines
    Keywords covid19
    Language English
    Publishing date 2020-10-21
    Publishing country Germany
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Review
    ZDB-ID 2553921-8
    ISSN 1868-7083 ; 1868-7075
    ISSN (online) 1868-7083
    ISSN 1868-7075
    DOI 10.1186/s13148-020-00946-x
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Treating Senescence like Cancer: Novel Perspectives in Senotherapy of Chronic Diseases.

    Mongelli, Alessia / Atlante, Sandra / Barbi, Veronica / Bachetti, Tiziana / Martelli, Fabio / Farsetti, Antonella / Gaetano, Carlo

    International journal of molecular sciences

    2020  Volume 21, Issue 21

    Abstract: The WHO estimated around 41 million deaths worldwide each year for age-related non-communicable chronic diseases. Hence, developing strategies to control the accumulation of cell senescence in living organisms and the overall aging process is an urgently ...

    Abstract The WHO estimated around 41 million deaths worldwide each year for age-related non-communicable chronic diseases. Hence, developing strategies to control the accumulation of cell senescence in living organisms and the overall aging process is an urgently needed problem of social relevance. During aging, many biological processes are altered, which globally induce the dysfunction of the whole organism. Cell senescence is one of the causes of this modification. Nowadays, several drugs approved for anticancer therapy have been repurposed to treat senescence, and others are under scrutiny in vitro and in vivo to establish their senomorphic or senolytic properties. In some cases, this research led to a significant increase in cell survival or to a prolonged lifespan in animal models, at least. Senomorphics can act to interfere with a specific pathway in order to restore the appropriate cellular function, preserve viability, and to prolong the lifespan. On the other hand, senolytics induce apoptosis in senescent cells allowing the remaining non-senescent population to preserve or restore tissue function. A large number of research articles and reviews recently addressed this topic. Herein, we would like to focus attention on those chemical agents with senomorphic or senolytic properties that perspectively, according to literature, suggest a potential application as senotherapeutics for chronic diseases.
    MeSH term(s) Animals ; Antineoplastic Agents/pharmacology ; Antineoplastic Agents/therapeutic use ; Cellular Senescence ; Chronic Disease/drug therapy ; Chronic Disease/mortality ; Clinical Trials as Topic ; Global Health ; Humans ; Neoplasms/drug therapy ; Neoplasms/mortality ; Signal Transduction/drug effects
    Chemical Substances Antineoplastic Agents
    Language English
    Publishing date 2020-10-27
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2019364-6
    ISSN 1422-0067 ; 1422-0067 ; 1661-6596
    ISSN (online) 1422-0067
    ISSN 1422-0067 ; 1661-6596
    DOI 10.3390/ijms21217984
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Effects of Human LAV-BPIFB4 Gene Therapy on the Epigenetic Clock and Health of Aged Mice.

    Giuliani, Maria Elisa / Barbi, Veronica / Bigossi, Giorgia / Marcozzi, Serena / Giacconi, Robertina / Cardelli, Maurizio / Piacenza, Francesco / Orlando, Fiorenza / Ciaglia, Elena / Cattaneo, Monica / Mongelli, Alessia / Gaetano, Carlo / Provinciali, Mauro / Puca, Annibale Alessandro / Malavolta, Marco

    International journal of molecular sciences

    2023  Volume 24, Issue 7

    Abstract: The homozygous genotype of the Longevity-Associated Variant (LAV) in Bactericidal/Permeability-Increasing Fold-Containing Family B member 4 (BPIFB4) is enriched in long-living individuals of three independent populations and its genetic transfer in C57BL/ ...

    Abstract The homozygous genotype of the Longevity-Associated Variant (LAV) in Bactericidal/Permeability-Increasing Fold-Containing Family B member 4 (BPIFB4) is enriched in long-living individuals of three independent populations and its genetic transfer in C57BL/6J mice showed a delay in frailty progression and improvement of several biomarkers of aging and multiple aspects of health. The C57BL/6J strain is a suitable model for studying therapies aimed at extending healthy aging and longevity due to its relatively short lifespan and the availability of aging biomarkers. Epigenetic clocks based on DNA methylation profiles are reliable molecular biomarkers of aging, while frailty measurement tools are used to evaluate overall health during aging. In this study, we show that the systemic gene transfer of LAV-BPIFB4 in aged C57BL/6J mice was associated with a significant reduction in the epigenetic clock-based biological age, as measured by a three CpG clock method. Furthermore, LAV-BPIFB4 gene transfer resulted in an improvement of the Vitality Score with a reduction in the Frailty Index. These findings further support the use of LAV-BPIFB4 gene therapy to induce beneficial effects on epigenetic mechanisms associated with aging and frailty in aged mice, with potential implications for future therapies to prevent frailty in humans.
    MeSH term(s) Humans ; Mice ; Animals ; Aged ; Longevity/genetics ; Frailty/genetics ; Mice, Inbred C57BL ; Epigenesis, Genetic ; Biomarkers ; Genetic Therapy ; DNA Methylation ; Intercellular Signaling Peptides and Proteins/genetics
    Chemical Substances Biomarkers ; BPIFB4 protein, human ; Intercellular Signaling Peptides and Proteins
    Language English
    Publishing date 2023-03-30
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2019364-6
    ISSN 1422-0067 ; 1422-0067 ; 1661-6596
    ISSN (online) 1422-0067
    ISSN 1422-0067 ; 1661-6596
    DOI 10.3390/ijms24076464
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article: The epigenetic implication in coronavirus infection and therapy

    Atlante, Sandra / Mongelli, Alessia / Barbi, Veronica / Martelli, Fabio / Farsetti, Antonella / Gaetano, Carlo

    Clin Epigenetics

    Abstract: Epigenetics is a relatively new field of science that studies the genetic and non-genetic aspects related to heritable phenotypic changes, frequently caused by environmental and metabolic factors. In the host, the epigenetic machinery can regulate gene ... ...

    Abstract Epigenetics is a relatively new field of science that studies the genetic and non-genetic aspects related to heritable phenotypic changes, frequently caused by environmental and metabolic factors. In the host, the epigenetic machinery can regulate gene expression through a series of reversible epigenetic modifications, such as histone methylation and acetylation, DNA/RNA methylation, chromatin remodeling, and non-coding RNAs. The coronavirus disease 19 (COVID-19) is a highly transmittable and pathogenic viral infection. The Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2), which emerged in Wuhan, China, and spread worldwide, causes it. COVID-19 severity and consequences largely depend on patient age and health status. In this review, we will summarize and comparatively analyze how viruses regulate the host epigenome. Mainly, we will be focusing on highly pathogenic respiratory RNA virus infections such as coronaviruses. In this context, epigenetic alterations might play an essential role in the onset of coronavirus disease complications. Although many therapeutic approaches are under study, more research is urgently needed to identify effective vaccine or safer chemotherapeutic drugs, including epigenetic drugs, to cope with this viral outbreak and to develop pre- and post-exposure prophylaxis against COVID-19.
    Keywords covid19
    Publisher WHO
    Document type Article
    Note WHO #Covidence: #883596
    Database COVID19

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  5. Article ; Online: Evidence for Biological Age Acceleration and Telomere Shortening in COVID-19 Survivors.

    Mongelli, Alessia / Barbi, Veronica / Gottardi Zamperla, Michela / Atlante, Sandra / Forleo, Luana / Nesta, Marialisa / Massetti, Massimo / Pontecorvi, Alfredo / Nanni, Simona / Farsetti, Antonella / Catalano, Oronzo / Bussotti, Maurizio / Dalla Vecchia, Laura Adelaide / Bachetti, Tiziana / Martelli, Fabio / La Rovere, Maria Teresa / Gaetano, Carlo

    International journal of molecular sciences

    2021  Volume 22, Issue 11

    Abstract: The SARS-CoV-2 infection determines the COVID-19 syndrome characterized, in the worst cases, by severe respiratory distress, pulmonary and cardiac fibrosis, inflammatory cytokine release, and immunosuppression. This condition has led to the death of ... ...

    Abstract The SARS-CoV-2 infection determines the COVID-19 syndrome characterized, in the worst cases, by severe respiratory distress, pulmonary and cardiac fibrosis, inflammatory cytokine release, and immunosuppression. This condition has led to the death of about 2.15% of the total infected world population so far. Among survivors, the presence of the so-called persistent post-COVID-19 syndrome (PPCS) is a common finding. In COVID-19 survivors, PPCS presents one or more symptoms: fatigue, dyspnea, memory loss, sleep disorders, and difficulty concentrating. In this study, a cohort of 117 COVID-19 survivors (post-COVID-19) and 144 non-infected volunteers (COVID-19-free) was analyzed using pyrosequencing of defined CpG islands previously identified as suitable for biological age determination. The results show a consistent biological age increase in the post-COVID-19 population, determining a DeltaAge acceleration of 10.45 ± 7.29 years (+5.25 years above the range of normality) compared with 3.68 ± 8.17 years for the COVID-19-free population (
    Language English
    Publishing date 2021-06-07
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2019364-6
    ISSN 1422-0067 ; 1422-0067 ; 1661-6596
    ISSN (online) 1422-0067
    ISSN 1422-0067 ; 1661-6596
    DOI 10.3390/ijms22116151
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: EVIDENCE FOR BIOLOGICAL AGE ACCELERATION AND TELOMERE 2 SHORTENING IN COVID-19 SURVIVORS

    Mongelli, Alessia / gaetano, carlo / gottardi zamperla, michela / barbi, veronica / atlante, sandra / la rovere, maria teresa / bachetti, tiziana / catalano, oronzo / bussotti, maurizio / della vecchia, laura / nanni, simona / farsetti, antonella / martelli, fabio

    medRxiv

    Abstract: Introduction & Background: the SARS-CoV-2 infection determines the COVID-19 syndrome characterized, in the worst cases, by severe respiratory distress, pulmonary and cardiac fibrosis,inflammatory cytokines release, and immunodepression. This condition ... ...

    Abstract Introduction & Background: the SARS-CoV-2 infection determines the COVID-19 syndrome characterized, in the worst cases, by severe respiratory distress, pulmonary and cardiac fibrosis,inflammatory cytokines release, and immunodepression. This condition has led to the death of about 2.15% of the total infected world population so far. Among survivors, the presence of the so-called post-COVID19 syndrome (PPCS) is a common finding. In patients who survived the SARS-CoV-2 infection, overt PPCS presents one or more symptoms such as fatigue, dyspnea, memory loss, sleep disorders, and difficulty concentrating. The pathophysiology of PPCS is currently poorly understood, and whether epigenetic mechanisms are involved in this process is unexplored. Methods & Results: In this study, a cohort of 117 COVID19 survivors (post-COVID19) and 144 non-infected volunteers (COVID19-free) were analyzed using pyrosequencing of defined CpG islands previously identified as suitable for biological age determination. Besides, telomere length (TL) and ACE2 and DPP4 receptor expression were determined. The results show a consistent biological age increase in the post-covid population (mean 58,44 DS 14,66 ChronoAge Vs. mean 67,18 DS 10,86 BioAge, P<0,0001), determining a DeltaAge acceleration of 10,45 DS 7,29 years (+5.25 years above range of normality) compared to 3,68 DS 8,17 years for the COVID19-free population (P<0,0001). A significant telomere shortening parallels this finding in the post-COVID19 cohort compared to COVID19-free subjects (post-COVID19 TL: 3,03 DS 2,39 Kb vs. COVID19-free: 10,67 DS 11,69 Kb; P<0,0001). Additionally, ACE2 expression was decreased in post-COVID19 patients compare to COVID19-free, while DPP-4 did not change. Conclusion: In light of these observations, we hypothesize that some epigenetic alterations are associated with the post-COVID19 condition, particularly in the younger (<60 years). Although the consequences of such modifications on the long-term clinical outcome remain unclear, they might 46 indicate a direction to investigate the pathophysiological basis of the post-COVID19 syndrome
    Keywords covid19
    Language English
    Publishing date 2021-04-27
    Publisher Cold Spring Harbor Laboratory Press
    Document type Article ; Online
    DOI 10.1101/2021.04.23.21255973
    Database COVID19

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  7. Article ; Online: Morphological description and morphometric analyses of the Upper Palaeolithic human remains from Dzudzuana and Satsurblia caves, western Georgia.

    Margherita, Cristiana / Oxilia, Gregorio / Barbi, Veronica / Panetta, Daniele / Hublin, Jean-Jacques / Lordkipanidze, David / Meshveliani, Tengiz / Jakeli, Nino / Matskevich, Zinovi / Bar-Yosef, Ofer / Belfer-Cohen, Anna / Pinhasi, Ron / Benazzi, Stefano

    Journal of human evolution

    2017  Volume 113, Page(s) 83–90

    MeSH term(s) Body Remains/anatomy & histology ; Body Remains/diagnostic imaging ; Caves ; Georgia ; Humans ; Paleodontology ; Tomography, X-Ray Computed/methods ; Tooth/anatomy & histology ; Tooth/diagnostic imaging
    Language English
    Publishing date 2017-09-03
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 120141-4
    ISSN 1095-8606 ; 0047-2484
    ISSN (online) 1095-8606
    ISSN 0047-2484
    DOI 10.1016/j.jhevol.2017.07.011
    Database MEDical Literature Analysis and Retrieval System OnLINE

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