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  1. Article ; Online: What assessment of the liver before resection for hepatocellular carcinoma?

    Barbier, Louise / Cauchy, François

    Clinics and research in hepatology and gastroenterology

    2022  Volume 46, Issue 6, Page(s) 101916

    MeSH term(s) Carcinoma, Hepatocellular/pathology ; Carcinoma, Hepatocellular/surgery ; Hepatectomy ; Humans ; Liver Neoplasms/pathology ; Liver Neoplasms/surgery ; Neoplasm Recurrence, Local/surgery ; Retrospective Studies
    Language English
    Publishing date 2022-04-07
    Publishing country France
    Document type Editorial
    ZDB-ID 2594333-9
    ISSN 2210-741X ; 2210-7401
    ISSN (online) 2210-741X
    ISSN 2210-7401
    DOI 10.1016/j.clinre.2022.101916
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  2. Article ; Online: Preoperative DLCO predicts severe early complications after liver transplantation.

    Li, Xing / Barbier, Louise / Ferrandière, Martine / Remerand, Francis / Salamé, Ephrem / Plantier, Laurent

    Respiratory medicine and research

    2024  Volume 85, Page(s) 101089

    Abstract: Background: Severe early complications are common after liver transplantation (LT) and are a key determinant of LT-related morbidity and mortality. The aim of this study was to assess whether lung function measured in the pre-operative period predicted ... ...

    Abstract Background: Severe early complications are common after liver transplantation (LT) and are a key determinant of LT-related morbidity and mortality. The aim of this study was to assess whether lung function measured in the pre-operative period predicted complicated outcomes in the first month after LT.
    Material and methods: Patients with mild-to-moderate liver disease (Model for End stage Liver Disease-MELD score≤30) who underwent LT between October 2015 and May 2020 in a single centre were retrospectively included. The primary endpoint was the occurrence of severe early complications after LT defined by mechanical ventilation duration > 2 days or length of ICU stay > 7 days or reintubation or death < 1 month after LT.
    Results: One hundred and twenty patients were included (age 59 [53-64] years, 72 % men). Forty patients (33 %) had early complications after LT. Measured and%predicted hemoglobin-corrected lung transfer capacity for carbon monoxide (DLCOc) were significantly lower in patients with severe early complications after LT. DLCOc was the only variable that associated independently with severe early complications by multivariate analysis. DLCOc under 16.3 ml.min
    Conclusion: A decrease in DLCOc indicated an increased risk of severe early complications after LT.
    Language English
    Publishing date 2024-02-07
    Publishing country France
    Document type Journal Article
    ISSN 2590-0412
    ISSN (online) 2590-0412
    DOI 10.1016/j.resmer.2024.101089
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  3. Article ; Online: "Hors Tour" Liver Grafts: A Step Towards Optimal Donor and Recipient Matching?

    Barbier, Louise / Cauchy, François

    World journal of surgery

    2019  Volume 44, Issue 3, Page(s) 925–926

    MeSH term(s) France ; Humans ; Liver ; Liver Transplantation ; Living Donors ; Tissue Donors
    Language English
    Publishing date 2019-12-24
    Publishing country United States
    Document type Journal Article ; Comment
    ZDB-ID 224043-9
    ISSN 1432-2323 ; 0364-2313
    ISSN (online) 1432-2323
    ISSN 0364-2313
    DOI 10.1007/s00268-019-05341-z
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    Zs.A 1336: Show issues Location:
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  4. Article: What are the Specifics of Biliary Surgery in Cirrhotic Patients?

    Cauchy, François / Vibert, Eric / Barbier, Louise

    Chirurgia (Bucharest, Romania : 1990)

    2020  Volume 115, Issue 2, Page(s) 191–207

    Abstract: This work's objective was to review the literature on biliary surgery in order to best define the surgical indications and the specifics of their management. A review of the literature from 1995 to August 2015 was conducted in Pubmed and Google Scholar. ...

    Abstract This work's objective was to review the literature on biliary surgery in order to best define the surgical indications and the specifics of their management. A review of the literature from 1995 to August 2015 was conducted in Pubmed and Google Scholar.
    MeSH term(s) Biliary Tract Diseases/complications ; Biliary Tract Diseases/surgery ; Biliary Tract Surgical Procedures/methods ; Humans ; Liver Cirrhosis/complications
    Language English
    Publishing date 2020-05-05
    Publishing country Romania
    Document type Journal Article ; Review
    ZDB-ID 419244-8
    ISSN 1842-368X ; 1221-9118 ; 0009-4730 ; 0377-5003
    ISSN (online) 1842-368X
    ISSN 1221-9118 ; 0009-4730 ; 0377-5003
    DOI 10.21614/chirurgia.115.2.191
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    Zs.B 1352: Show issues Location:
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    Zs.MO 620: Show issues

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  5. Article ; Online: A Long Graft Artery is a Safe and Reproducible Procedure for Arterial Reconstruction In Liver Transplantation.

    Blondeau, Marc / Barbier, Louise A / Gil, Camille / Peyrafort, Pierre / Salamé, Ephrem

    Transplantation proceedings

    2022  Volume 54, Issue 3, Page(s) 731–733

    Abstract: Background: Although a short and nonredundant anastomosis is most often performed in liver transplantation, there is no strong evidence in the literature about the ideal arterial reconstruction. We describe here the "long-artery" technique that enables ... ...

    Abstract Background: Although a short and nonredundant anastomosis is most often performed in liver transplantation, there is no strong evidence in the literature about the ideal arterial reconstruction. We describe here the "long-artery" technique that enables a wide side-to-end anastomosis and preserves arterial length.
    Methods: We present the results between 2011 and 2019 of the "long-artery" technique performed in our center. Patients with a split liver transplantation or aortohepatic conduits were not included. This technique uses the whole arterial axis of the graft. A side-to-end anastomosis is performed between the common and/or proper hepatic artery of the recipient, and the celiac trunk with an aortic patch of the graft, while the gastroduodenal artery of the recipient is preserved. An omental flap is positioned under the graft artery to prevent kinking.
    Results: Eight hundred thirty-two transplant patients were included in the analysis. Early hepatic artery thrombosis was diagnosed in 22 (2.6%) patients and occurred within the first 10 days after the procedure. A thrombectomy was performed in 7 patients, which was successful in 4 patients, and 18 patients were retransplanted. Seven patients (0.8%) developed a late hepatic artery thrombosis, including 2 patients who were retransplanted.
    Conclusions: The "long-artery" technique is a safe and efficient technique for arterial reconstruction in liver transplantation and does not seem to increase the rate of early hepatic artery thrombosis.
    MeSH term(s) Anastomosis, Surgical/methods ; Celiac Artery/surgery ; Hepatic Artery/surgery ; Humans ; Liver Transplantation/adverse effects ; Liver Transplantation/methods ; Thrombosis/surgery ; Vascular Surgical Procedures/adverse effects ; Vascular Surgical Procedures/methods
    Language English
    Publishing date 2022-03-10
    Publishing country United States
    Document type Journal Article
    ZDB-ID 82046-5
    ISSN 1873-2623 ; 0041-1345
    ISSN (online) 1873-2623
    ISSN 0041-1345
    DOI 10.1016/j.transproceed.2022.01.015
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    Zs.A 835: Show issues Location:
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  6. Article ; Online: The Authors' Reply.

    Barbier, Louise / Bucur, Petru / Salamé, Ephrem

    Transplantation

    2018  Volume 102, Issue 10, Page(s) e457

    MeSH term(s) Liver ; Liver Transplantation
    Language English
    Publishing date 2018-09-24
    Publishing country United States
    Document type Letter ; Comment
    ZDB-ID 208424-7
    ISSN 1534-6080 ; 0041-1337
    ISSN (online) 1534-6080
    ISSN 0041-1337
    DOI 10.1097/TP.0000000000002365
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    Zs.A 488: Show issues Location:
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    Zs.MO 509: Show issues

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  7. Article ; Online: Somatostatin vs. Octreotide for Prevention of Postoperative Pancreatic Fistula The PREFIPS Randomized Clinical Trial A FRENCH 007 - ACHBT Study.

    Gaujoux, Sébastien / Regimbeau, Jean-Marc / Piessen, Guillaume / Truant, Stéphanie / Foissac, Frantz / Barbier, Louise / Buc, Emmanuel / Adham, Mustapha / Fuks, David / Deguelte, Sophie / Muscari, Fabrice / Sulpice, Laurent / Vaillant, Jean-Christophe / Schwarz, Lilian / Sa Cunha, Antonio / Muzzolini, Milena / Dousset, Bertrand / Sauvanet, Alain

    Annals of surgery

    2024  

    Abstract: Objective: Pharmacological prevention of postoperative pancreatic fistula (POPF) after pancreatectomy is open to debate. The present study compares clinically significant POPF rates in patients randomized between somatostatin versus octreotide as ... ...

    Abstract Objective: Pharmacological prevention of postoperative pancreatic fistula (POPF) after pancreatectomy is open to debate. The present study compares clinically significant POPF rates in patients randomized between somatostatin versus octreotide as prophylactic treatment.
    Patients and methods: Multicentric randomized controlled open study in patient's candidate for pancreaticoduodenectomy (PD) or distal pancreatectomy (DP) comparing somatostatin continuous intravenous infusion for 7 days versus octreotid 100 μg, every 8 hours subcutaneous injection for 7 days, stratified by procedure (PD vs. DP) and size of the main pancreatic duct (>4 mm) on grade B/C POPF rates at 90 days based on an intention-to-treat analysis.
    Results: Of 763 eligible patients, 651 were randomized: 327 in the octreotide arm and 324 in the somatostatin arm, with comparable the stratification criteria - type of surgery and main pancreatic duct dilatation. Most patients had PD (n=480; 73.8%), on soft/normal pancreas (n=367; 63.2%) with a non-dilated main pancreatic duct (n=472; 72.5%), most often for pancreatic adenocarcinoma (n=311; 47.8%). Almost all patients had abdominal drainage (n=621; 96.1%) and 121 (19.5%) left the hospital with the drain in place (median length of stay=16 d). A total of 153 patients (23.5%) developed a grade B/C POPF with no difference between both groups: 24.1%: somatostatin arm and 22.9%: octreotide arm (Chi-2 test, P=0.73, ITT analysis). Absence of statistically significant difference persisted after adjustment for stratification variables and in per-protocol analysis.
    Conclusions: Continuous intravenous somatostatin is not statistically different from subcutaneous octreotide in the prevention of grade B/C POPF after pancreatectomy.
    Language English
    Publishing date 2024-04-25
    Publishing country United States
    Document type Journal Article
    ZDB-ID 340-2
    ISSN 1528-1140 ; 0003-4932
    ISSN (online) 1528-1140
    ISSN 0003-4932
    DOI 10.1097/SLA.0000000000006313
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  8. Article ; Online: Early activation and recruitment of invariant natural killer T cells during liver ischemia-reperfusion: the major role of the alarmin interleukin-33.

    Robin, Aurélie / Mackowiak, Claire / Bost, Romain / Dujardin, Fanny / Barbarin, Alice / Thierry, Antoine / Hauet, Thierry / Pellerin, Luc / Gombert, Jean-Marc / Salamé, Ephrem / Herbelin, André / Barbier, Louise

    Frontiers in immunology

    2023  Volume 14, Page(s) 1099529

    Abstract: Over the past thirty years, the complexity of the αβ-T cell compartment has been enriched by the identification of innate-like T cells (ITCs), which are composed mainly of invariant natural killer T (iNKT) cells and mucosal-associated invariant T (MAIT) ... ...

    Abstract Over the past thirty years, the complexity of the αβ-T cell compartment has been enriched by the identification of innate-like T cells (ITCs), which are composed mainly of invariant natural killer T (iNKT) cells and mucosal-associated invariant T (MAIT) cells. Based on animal studies using ischemia-reperfusion (IR) models, a key role has been attributed to iNKT cells in close connection with the alarmin/cytokine interleukin (IL)-33, as early sensors of cell-stress in the initiation of acute sterile inflammation. Here we have investigated whether the new concept of a biological axis of circulating iNKT cells and IL-33 applies to humans, and may be extended to other ITC subsets, namely MAIT and γδ-T cells, in the acute sterile inflammation sequence occurring during liver transplant (LT). From a prospective biological collection of recipients, we reported that LT was accompanied by an early and preferential activation of iNKT cells, as attested by almost 40% of cells having acquired the expression of CD69 at the end of LT (i.e. 1-3 hours after portal reperfusion), as opposed to only 3-4% of conventional T cells. Early activation of iNKT cells was positively correlated with the systemic release of the alarmin IL-33 at graft reperfusion. Moreover, in a mouse model of hepatic IR, iNKT cells were activated in the periphery (spleen), and recruited in the liver in WT mice, as early as the first hour after reperfusion, whereas this phenomenon was virtually missing in IL-33-deficient mice. Although to a lesser degree than iNKT cells, MAIT and γδ-T cells also seemed targeted during LT, as attested by 30% and 10% of them acquiring CD69 expression, respectively. Like iNKT cells, and in clear contrast to γδ-T cells, activation of MAIT cells during LT was closely associated with both release of IL-33 immediately after graft reperfusion and severity of liver dysfunction occurring during the first three post-operative days. All in all, this study identifies iNKT and MAIT cells in connection with IL-33 as new key cellular factors and mechanisms of acute sterile inflammation in humans. Further investigations are required to confirm the implication of MAIT and iNKT cell subsets, and to precisely assess their functions, in the clinical course of sterile inflammation accompanying LT.
    MeSH term(s) Animals ; Humans ; Mice ; Alarmins/metabolism ; Inflammation/metabolism ; Interleukin-33/metabolism ; Ischemia/metabolism ; Liver Diseases/metabolism ; Natural Killer T-Cells/metabolism ; Prospective Studies ; Reperfusion
    Chemical Substances Alarmins ; Interleukin-33
    Language English
    Publishing date 2023-05-09
    Publishing country Switzerland
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2606827-8
    ISSN 1664-3224 ; 1664-3224
    ISSN (online) 1664-3224
    ISSN 1664-3224
    DOI 10.3389/fimmu.2023.1099529
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  9. Article: Adénocarcinome pancréatique: quelle prise en charge?

    Barbier, Louise / Delpero, Jean-Robert

    La Revue du praticien

    2014  Volume 64, Issue 9, Page(s) 1297–1298

    Title translation Pancreatic adenocarcinoma: what treatment?.
    MeSH term(s) Adenocarcinoma/diagnosis ; Adenocarcinoma/pathology ; Adenocarcinoma/therapy ; Cholangiopancreatography, Endoscopic Retrograde ; Contraindications ; Humans ; Magnetic Resonance Imaging ; Neoplasm Metastasis ; Pancreatectomy/utilization ; Pancreatic Neoplasms/diagnosis ; Pancreatic Neoplasms/pathology ; Pancreatic Neoplasms/therapy ; Patient Care Team
    Language French
    Publishing date 2014-11
    Publishing country France
    Document type Journal Article
    ZDB-ID 205365-2
    ISSN 2101-017X ; 0035-2640
    ISSN (online) 2101-017X
    ISSN 0035-2640
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    Ua VI Zs.433: Show issues Location:
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  10. Article: Tumeurs du pancreas.

    Barbier, Louise / Delpero, Jean-Robert

    La Revue du praticien

    2014  Volume 64, Issue 9, Page(s) 1307–1312

    Title translation Pancreatic tumours.
    MeSH term(s) Adenocarcinoma, Mucinous/diagnosis ; Adenocarcinoma, Mucinous/therapy ; Adenoma/diagnosis ; Adenoma/pathology ; Adenoma/therapy ; Carcinoma, Pancreatic Ductal/diagnosis ; Carcinoma, Pancreatic Ductal/therapy ; Carcinoma, Papillary/diagnosis ; Carcinoma, Papillary/therapy ; Diagnosis, Differential ; Diagnostic Imaging/methods ; Humans ; Neuroendocrine Tumors/diagnosis ; Neuroendocrine Tumors/genetics ; Neuroendocrine Tumors/therapy ; Pancreatic Neoplasms/diagnosis ; Pancreatic Neoplasms/pathology ; Pancreatic Neoplasms/therapy
    Language French
    Publishing date 2014-11
    Publishing country France
    Document type Journal Article ; Review
    ZDB-ID 205365-2
    ISSN 2101-017X ; 0035-2640
    ISSN (online) 2101-017X
    ISSN 0035-2640
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