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  1. Book ; Online: Bisphenols and Male Reproductive Health

    Barbonetti, Arcangelo / D'Andrea, Settimio / Bernabò, Nicola / Volle, David H.

    2020  

    Keywords Medicine ; Endocrinology ; bisphenol ; endocrine disruptors ; male fertility ; spermatozoa ; spermatogenesis
    Size 1 electronic resource (103 pages)
    Publisher Frontiers Media SA
    Document type Book ; Online
    Note English ; Open Access
    HBZ-ID HT021230641
    ISBN 9782889662036 ; 2889662039
    Database ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

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  2. Article ; Online: Relationship between male aging and semen quality: a retrospective study on over 2500 men.

    Castellini, Chiara / Cordeschi, Giuliana / Tienforti, Daniele / Barbonetti, Arcangelo

    Archives of gynecology and obstetrics

    2024  

    Abstract: Purpose: We aimed to evaluate whether and to what extent an association exists between male aging and worsening of semen parameters and to determine whether a threshold age can be identified above which the decline in semen quality becomes statistically ...

    Abstract Purpose: We aimed to evaluate whether and to what extent an association exists between male aging and worsening of semen parameters and to determine whether a threshold age can be identified above which the decline in semen quality becomes statistically significant.
    Methods: 2612 men (age: 16-56 years) attending an andrology outpatient clinic for semen analysis and clinical evaluation were studied. Semen analyses were performed according to the ongoing WHO-recommended procedures. Total motile count (TMC) and total progressive motile count (TPMC) were calculated by multiplying total sperm number by total motility and progressive motility, respectively.
    Results: Significant negative correlations were found between age and total motility (r = - 0.131, p < 0.0001), progressive motility (r = - 0.112, p < 0.0001), TPMC (r = - 0.042, p = 0.037), and normal sperm morphology (r = - 0.053, p = 0.007). All these associations persisted in multivariate regression models adjusted for abstinence time, smoking, history of male accessory gland infections, varicocele and the year in which semen analysis was performed. When comparisons were performed among quartiles of increasing age, the fourth quartile, corresponding to the age group > 40 years, was associated with a significant decrease in total and progressive motility. An earlier decline in the TPMC and percentage of normal forms was also observed.
    Conclusion: Advancing male age exhibits an independent association with a decrease in the percentage of motile and morphologically normal spermatozoa, with greater evidence from the age of > 40 years. Further studies are warranted to elucidate the mechanisms and clinical reflections of these associations.
    Language English
    Publishing date 2024-03-29
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 896455-5
    ISSN 1432-0711 ; 0932-0067
    ISSN (online) 1432-0711
    ISSN 0932-0067
    DOI 10.1007/s00404-024-07448-8
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Effects of gender affirming hormone therapy with testosterone on coagulation and hematological parameters in transgender people assigned female at birth: A systematic review and meta-analysis.

    Tienforti, Daniele / Pastori, Daniele / Barbonetti, Arcangelo

    Thrombosis research

    2024  Volume 236, Page(s) 170–178

    Abstract: Background: Hormone replacement therapy is associated with an increased thromboembolic risk. The effects of testosterone (T) on coagulation markers in people assigned female at birth (AFAB) under gender affirming hormone therapy (GAHT) are not well ... ...

    Abstract Background: Hormone replacement therapy is associated with an increased thromboembolic risk. The effects of testosterone (T) on coagulation markers in people assigned female at birth (AFAB) under gender affirming hormone therapy (GAHT) are not well described.
    Methods: Systematic review and meta-analysis on English-language articles retrieved from PubMed, Scopus and Cochrane Library up to April 2023 investigating T therapy in AFAB people. Coagulation parameters included international normalized ratio (INR), fibrinogen, activated partial thromboplastin clotting time (aPTT), plasminogen activator inhibitor-1 (PAI-1); hematological variables included hemoglobin (Hb) and hematocrit (HCT). We also reported the rate of thromboembolic events. Data were combined as mean differences (MD) with a 95 % confidence interval (CI) of pre- vs post-follow-up values, using random-effects models.
    Results: We included 7 studies (6 prospective and 1 retrospective) providing information on 312 subjects (mean age: 23 to 30 years) who underwent GAHT with variable T preparation. T therapy was associated with a significant increase in INR values [MD: 0.02, 95 % confidence interval (CI): 0.01-0.03; p = 0.0001], with negligible heterogeneity (I
    Conclusion: Therapy with T increased blood viscosity in AFAB men. A slight increase in INR values was also found, but the clinical relevance and mechanism(s) of this finding needs to be clarified.
    MeSH term(s) Adult ; Female ; Humans ; Male ; Young Adult ; Fibrinogen/analysis ; Plasminogen Activator Inhibitor 1 ; Prospective Studies ; Retrospective Studies ; Testosterone/adverse effects ; Thromboembolism ; Transgender Persons
    Chemical Substances Fibrinogen (9001-32-5) ; Plasminogen Activator Inhibitor 1 ; Testosterone (3XMK78S47O)
    Language English
    Publishing date 2024-03-04
    Publishing country United States
    Document type Meta-Analysis ; Systematic Review ; Journal Article
    ZDB-ID 121852-9
    ISSN 1879-2472 ; 0049-3848
    ISSN (online) 1879-2472
    ISSN 0049-3848
    DOI 10.1016/j.thromres.2024.02.029
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Which PDE5 inhibitor is the most effective in the treatment of erectile dysfunction in men with spinal cord injury? A systematic review and network meta-analysis.

    Tienforti, Daniele / Felzani, Giorgio / Di Pasquale, Alfonso Boris / Barbonetti, Arcangelo

    Andrology

    2024  

    Abstract: Background: Phosphodiesterase 5 inhibitors (PDE5i) are the first-line drugs for erectile dysfunction (ED) but differences among available molecules should drive therapy personalization. Choosing one PDE5i over another is a challenge in men with spinal ... ...

    Abstract Background: Phosphodiesterase 5 inhibitors (PDE5i) are the first-line drugs for erectile dysfunction (ED) but differences among available molecules should drive therapy personalization. Choosing one PDE5i over another is a challenge in men with spinal cord injury (SCI), as the evidence of efficacy for each molecule is derived from few studies and comparative "head-to-head" trials are lacking.
    Objective: To assess the efficacy of the different PDE5i for SCI-related ED with a network meta-analysis (NMA) approach.
    Materials and methods: Databases from PubMed, Web of Science, Scopus, and Cochrane Library were checked for randomized controlled trials (RCTs) comparing any PDE5i to each other or placebo in men with traumatic SCI lasting ≥6 months. Data were incorporated in a random-effect NMA, where treatments' efficacy was ranked using the surface under the cumulative ranking curve (SUCRA).
    Results: The 10 RCTs included provided information about 1,492 men with ED due to traumatic SCI. Intervention arms included sildenafil, tadalafil, and/or vardenafil. Overall, at the pairwise meta-analysis, PDE5i were four times more effective than placebo in improving erectile function (risk ratio: 4.13, 95% CI: 2.76, 6.19). The comparative analysis from NMA revealed that tadalafil was associated with the highest SUCRA value (81%), followed by vardenafil (68%) and sildenafil (49%).
    Discussion and conclusion: Within the grading of comparison network, tadalafil appeared to be the best PDE5i in the treatment of SCI-related ED. Further focused studies are warranted to confirm these findings and define optimal doses and duration of therapy.
    Language English
    Publishing date 2024-03-30
    Publishing country England
    Document type Journal Article
    ZDB-ID 2696108-8
    ISSN 2047-2927 ; 2047-2919
    ISSN (online) 2047-2927
    ISSN 2047-2919
    DOI 10.1111/andr.13642
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Arachidonic Acid Pathways and Male Fertility: A Systematic Review.

    Hoxha, Malvina / Barbonetti, Arcangelo / Zappacosta, Bruno

    International journal of molecular sciences

    2023  Volume 24, Issue 9

    Abstract: Arachidonic acid (AA) is a polyunsaturated fatty acid that is involved in male fertility. Human seminal fluid contains different prostaglandins: PGE ( ... ...

    Abstract Arachidonic acid (AA) is a polyunsaturated fatty acid that is involved in male fertility. Human seminal fluid contains different prostaglandins: PGE (PGE
    MeSH term(s) Animals ; Male ; Humans ; Semen/metabolism ; Arachidonic Acid/metabolism ; Prostaglandins E/metabolism ; Prostaglandins/metabolism ; Fertility
    Chemical Substances Arachidonic Acid (27YG812J1I) ; Prostaglandins E ; Prostaglandins
    Language English
    Publishing date 2023-05-03
    Publishing country Switzerland
    Document type Systematic Review ; Journal Article ; Review
    ZDB-ID 2019364-6
    ISSN 1422-0067 ; 1422-0067 ; 1661-6596
    ISSN (online) 1422-0067
    ISSN 1422-0067 ; 1661-6596
    DOI 10.3390/ijms24098207
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Is marijuana a foe of male sexuality? Data from a large cohort of men with sexual dysfunction.

    Barbonetti, Arcangelo / Rastrelli, Giulia / Sparano, Clotilde / Castellini, Chiara / Vignozzi, Linda / Maggi, Mario / Corona, Giovanni

    Andrology

    2023  Volume 12, Issue 1, Page(s) 9–19

    Abstract: Background: Although it has been assumed that chronic cannabis use may have an unfavorable impact on male sexual function and its metabolic correlates, evidence from clinical studies remains inconclusive.: Objective: To investigate the relationship ... ...

    Abstract Background: Although it has been assumed that chronic cannabis use may have an unfavorable impact on male sexual function and its metabolic correlates, evidence from clinical studies remains inconclusive.
    Objective: To investigate the relationship between cannabis use and sexual behavior, anthropometrics and metabolic/vascular profiles in a large series of men evaluated for sexual dysfunction.
    Methods: A total of 4800 men (mean age 50.8 years) attending an andrology outpatient clinic for sexual dysfunction were studied. Sexual symptoms, hormonal, metabolic, and instrumental (penile color Doppler ultrasound, PCDU) parameters were evaluated according to the reported habitual use of recreational substances (no use, 1-2 joints/week, >2 joints/week, and use of illicit drugs other than cannabis).
    Results: When compared with non-users, cannabis users were younger and exhibited a lower prevalence of comorbidities as well as better PCDU parameters, despite reporting higher alcohol and tobacco consumption. After adjustment for confounders, cannabis use was associated with a greater instability in the couple's relationship and a higher frequency of masturbation. In addition, the group smoking >2 joints/week showed a significantly lower body mass index than both controls and users of substances other than cannabis. Men who reported using recreational drugs (either cannabis or other) exhibited significantly lower levels of both total and low-density lipoprotein cholesterol than non-users. At the PCDU, smoking 1-2 joints/week was associated with significantly higher dynamic peak systolic velocity than both non-drug use and use of >2 joints/week. Prolactin levels were significantly higher in individuals smoking 1-2 joints/week and in those who used substances other than cannabis when compared with controls, whereas no difference in total testosterone levels was observed.
    Discussion: In men with sexual dysfunction, mild cannabis consumption may be associated with a more favorable anthropometric and lipid profile and with a better penile arterial vascular response to intracavernous prostaglandin injection.
    MeSH term(s) Humans ; Male ; Middle Aged ; Cannabis ; Erectile Dysfunction ; Sexual Dysfunction, Physiological ; Penis/blood supply ; Sexuality
    Language English
    Publishing date 2023-01-20
    Publishing country England
    Document type Journal Article
    ZDB-ID 2696108-8
    ISSN 2047-2927 ; 2047-2919
    ISSN (online) 2047-2927
    ISSN 2047-2919
    DOI 10.1111/andr.13382
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: Cannabinoid signalling and effects of cannabis on the male reproductive system.

    Maccarrone, Mauro / Rapino, Cinzia / Francavilla, Felice / Barbonetti, Arcangelo

    Nature reviews. Urology

    2020  Volume 18, Issue 1, Page(s) 19–32

    Abstract: Marijuana is the most widely consumed recreational drug worldwide, which raises concerns for its potential effects on fertility. Many aspects of human male reproduction can be modulated by cannabis-derived extracts (cannabinoids) and their endogenous ... ...

    Abstract Marijuana is the most widely consumed recreational drug worldwide, which raises concerns for its potential effects on fertility. Many aspects of human male reproduction can be modulated by cannabis-derived extracts (cannabinoids) and their endogenous counterparts, known as endocannabinoids (eCBs). These latter molecules act as critical signals in a variety of physiological processes through receptors, enzymes and transporters collectively termed the endocannabinoid system (ECS). Increasing evidence suggests a role for eCBs, as well as cannabinoids, in various aspects of male sexual and reproductive health. Although preclinical studies have clearly shown that ECS is involved in negative modulation of testosterone secretion by acting both at central and testicular levels in animal models, the effect of in vivo exposure to cannabinoids on spermatogenesis remains a matter of debate. Furthermore, inconclusive clinical evidence does not seem to support the notion that plant-derived cannabinoids have harmful effects on human sexual and reproductive health. An improved understanding of the complex crosstalk between cannabinoids and eCBs is required before targeting of ECS for modulation of human fertility becomes a reality.
    MeSH term(s) Animals ; Cannabinoids/administration & dosage ; Cannabinoids/metabolism ; Endocannabinoids/administration & dosage ; Endocannabinoids/metabolism ; Genitalia, Male/drug effects ; Genitalia, Male/metabolism ; Humans ; Male ; Receptors, Cannabinoid/metabolism ; Signal Transduction/drug effects ; Signal Transduction/physiology ; Testosterone/antagonists & inhibitors ; Testosterone/metabolism
    Chemical Substances Cannabinoids ; Endocannabinoids ; Receptors, Cannabinoid ; Testosterone (3XMK78S47O)
    Language English
    Publishing date 2020-11-19
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 2493737-X
    ISSN 1759-4820 ; 1759-4812
    ISSN (online) 1759-4820
    ISSN 1759-4812
    DOI 10.1038/s41585-020-00391-8
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: Testosterone replacement therapy.

    Barbonetti, Arcangelo / D'Andrea, Settimio / Francavilla, Sandro

    Andrology

    2020  Volume 8, Issue 6, Page(s) 1551–1566

    Abstract: Background: The aim of testosterone replacement therapy (TRT) is to improve symptoms and signs of testosterone deficiency including decreased libido, erectile dysfunction, depressed mood, anaemia, loss of muscle and bone mass, by increasing serum ... ...

    Abstract Background: The aim of testosterone replacement therapy (TRT) is to improve symptoms and signs of testosterone deficiency including decreased libido, erectile dysfunction, depressed mood, anaemia, loss of muscle and bone mass, by increasing serum testosterone levels to physiologic range. TRT has been used in the last 70 years, and overtime, numerous preparations and formulations have been developed to improve pharmacokinetics (PKs) and patient compliance. The routes of delivery approved for use in the Western world include buccal, nasal, subdermal, transdermal and intramuscular (IM).
    Objectives: The aim of this narrative review was to describe and compare all available and approved testosterone preparations according to pharmacology, PKs and adverse effects.
    Materials and methods: We have performed an extensive PubMed review of the literature on TRT in clinical practice. Contraindications and monitoring of TRT were analyzed by comparing available guidelines released in the last five years. We provide a review of advantages and disadvantages of different modalities of TRT and how to monitor treatment to minimize the risks.
    Results: TRT is associated with multiple benefits highly relevant to the patient. However, the recommendations given in different guidelines on TRT are based on data from a limited number of randomized controlled trials (RCTs), as well as non-randomized clinical studies and observational studies. This is the case for the safety of a long-term TRT in late-onset hypogonadism (LOH). No evidence is provided indeed on the effects of TRT on endpoints such as deterioration of heart failure suggesting a cautious approach to T replacement in older men with a history of heart failure.
    Conclusion: Clinicians must consider the unique characteristics of each patient and make the necessary adjustments in the management of LOH in order to provide the safest and most beneficial results.
    MeSH term(s) Clinical Decision-Making ; Dosage Forms ; Drug Administration Routes ; Drug Compounding ; Eunuchism/blood ; Eunuchism/diagnosis ; Eunuchism/drug therapy ; Hormone Replacement Therapy/adverse effects ; Humans ; Male ; Risk Assessment ; Risk Factors ; Testosterone/administration & dosage ; Testosterone/adverse effects ; Testosterone/deficiency ; Testosterone/pharmacokinetics ; Treatment Outcome
    Chemical Substances Dosage Forms ; Testosterone (3XMK78S47O)
    Language English
    Publishing date 2020-03-09
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Review
    ZDB-ID 2696108-8
    ISSN 2047-2927 ; 2047-2919
    ISSN (online) 2047-2927
    ISSN 2047-2919
    DOI 10.1111/andr.12774
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: Iodine Intake and Testosterone.

    Barbonetti, Arcangelo / Castellini, Chiara / Di Giulio, Francesca / Antolini, Federica / Tienforti, Daniele / Muselli, Mario / Baroni, Marco Giorgio

    JAMA network open

    2023  Volume 6, Issue 12, Page(s) e2348573

    MeSH term(s) Humans ; Testosterone ; Testosterone Congeners ; Nutritional Status ; Iodine
    Chemical Substances Testosterone (3XMK78S47O) ; Testosterone Congeners ; Iodine (9679TC07X4)
    Language English
    Publishing date 2023-12-01
    Publishing country United States
    Document type Journal Article
    ISSN 2574-3805
    ISSN (online) 2574-3805
    DOI 10.1001/jamanetworkopen.2023.48573
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article: Editorial: Bisphenols and Male Reproductive Health.

    Barbonetti, Arcangelo / D'Andrea, Settimio / Bernabò, Nicola / Volle, David H

    Frontiers in endocrinology

    2020  Volume 11, Page(s) 597609

    MeSH term(s) Benzhydryl Compounds/adverse effects ; Endocrine Disruptors/adverse effects ; Humans ; Infertility, Male/etiology ; Infertility, Male/pathology ; Male ; Phenols/adverse effects ; Reproductive Health/standards ; Testis/drug effects ; Testis/pathology
    Chemical Substances Benzhydryl Compounds ; Endocrine Disruptors ; Phenols ; bisphenol A (MLT3645I99)
    Language English
    Publishing date 2020-10-08
    Publishing country Switzerland
    Document type Editorial ; Introductory Journal Article
    ZDB-ID 2592084-4
    ISSN 1664-2392
    ISSN 1664-2392
    DOI 10.3389/fendo.2020.597609
    Database MEDical Literature Analysis and Retrieval System OnLINE

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