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  1. Article ; Online: Insights from Experiences on Antiplatelet Drugs in Stroke Prevention: A Review.

    Signorelli, Salvatore Santo / Platania, Ingrid / Tomasello, Salvatore Davide / Mangiafico, Marco / Barcellona, Giuliana / Di Raimondo, Domenico / Gaudio, Agostino

    International journal of environmental research and public health

    2020  Volume 17, Issue 16

    Abstract: Reduction of hazard risk of cerebral ischemic event (stroke, transient ischemic attack (TIA)) represents the hard point to be achieved from primary or secondary preventive strategy in the best clinical practice. However, results from clinical trials, ... ...

    Abstract Reduction of hazard risk of cerebral ischemic event (stroke, transient ischemic attack (TIA)) represents the hard point to be achieved from primary or secondary preventive strategy in the best clinical practice. However, results from clinical trials, recommendations, guidelines, systematic review, expert opinions, and meta-analysis debated on the optimal pharmacotherapy to achieve the objective. Aspirin and a number of antiplatelet agents, alone or in combination, have been considered from large trials focused on stroke prevention. The present review summarizes, discusses results from trials, and focuses on the benefits or disadvantages originating from antiplatelet drugs. Sections of the review were organized to show both benefits or consequences from antiplatelet pharmacotherapy. Conclusively, this review provides a potential synopsis on the most appropriate therapeutic approach for stroke prevention in clinical practice.
    MeSH term(s) Aged ; Diabetes Mellitus, Type 2/drug therapy ; Double-Blind Method ; Drug Therapy, Combination ; Female ; Humans ; Ischemic Attack, Transient/drug therapy ; Male ; Middle Aged ; Platelet Aggregation Inhibitors/therapeutic use ; Secondary Prevention ; Stroke/prevention & control
    Chemical Substances Platelet Aggregation Inhibitors
    Language English
    Publishing date 2020-08-12
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2175195-X
    ISSN 1660-4601 ; 1661-7827
    ISSN (online) 1660-4601
    ISSN 1661-7827
    DOI 10.3390/ijerph17165840
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: A Case of Acquired Factor V Deficiency in Patient with Bleeding.

    Vetri, Davide / Lumera, Giovanni / Tarascio, Salvatore / Scuto, Salvatore / Marino, Elisa / Barcellona, Giuliana / Signorelli, Salvatore Santo

    TH open : companion journal to thrombosis and haemostasis

    2020  Volume 4, Issue 2, Page(s) e77–e79

    Abstract: Low frequency of rare diseases origins from missed diagnosis addressing to poor prognosis. Acquired factor V inhibitor is a very low frequent bleeding condition (prevalence: 0.09/100,000,000-0.29/1,000,000 per year). Antibiotics, surgery, bacterial ... ...

    Abstract Low frequency of rare diseases origins from missed diagnosis addressing to poor prognosis. Acquired factor V inhibitor is a very low frequent bleeding condition (prevalence: 0.09/100,000,000-0.29/1,000,000 per year). Antibiotics, surgery, bacterial infections, malignancies, and autoimmune diseases are predisposing factors; however, no predisposing factor was found often. Authors reported a case of bleeding originating from an acquired factor V deficiency because they wish to draw attention to unfrequented or rare clinical situations rarely diagnosed in internal medicine unit.
    Language English
    Publishing date 2020-04-20
    Publishing country Germany
    Document type Case Reports
    ZDB-ID 2901738-5
    ISSN 2512-9465 ; 2567-3459
    ISSN (online) 2512-9465
    ISSN 2567-3459
    DOI 10.1055/s-0039-3402024
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 7138: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)

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  3. Article: Direct oral anticoagulant treatment of deep vein thrombosis reduces IL-6 expression in peripheral mono-nuclear blood cells.

    Candido, Saverio / Lumera, Giovanni / Barcellona, Giuliana / Vetri, Davide / Tumino, Elda / Platania, Ingrid / Frazzetto, Evelise / Privitera, Graziella / Incognito, Carmela / Gaudio, Agostino / Signorelli, Salvatore Santo

    Experimental and therapeutic medicine

    2020  Volume 20, Issue 6, Page(s) 237

    Abstract: Multiple factors play a pathophysiologic role for the venous thromboembolism (VTE) as a multi-factorial disease. Inflammation might play a peculiar role in shifting towards a pro-thrombotic state. Anticoagulant drugs are the first cure line for VTE. The ... ...

    Abstract Multiple factors play a pathophysiologic role for the venous thromboembolism (VTE) as a multi-factorial disease. Inflammation might play a peculiar role in shifting towards a pro-thrombotic state. Anticoagulant drugs are the first cure line for VTE. The low-molecular-weight heparins (LMWH) show anti-coagulant capability as well as reducing levels of inflammatory factors, including interleukin (IL)-6. The direct oral anticoagulants (DOACs) have shown efficacy in threating VTE, additionally to the anti-activated factor X these drugs seem able to reduce the abnormal release of pro-inflammatory agents. The present study evaluated the capability of DOACs in reducing plasma level of IL-6 in patients suffered from deep vein thrombosis (DVT) of the lower limbs. Our results showed reduced IL-6 expression levels in the peripheral lymphocytes of DVT compared to controls (fold-change, 2.8; P<0.05). We postulate that lowered IL-6 expression in the lymphocytes of DVT patients may mediate the anti-inflammatory action of DOACs. The present study is the first evidence concerning the anti-inflammatory properties of DOACs in specific setting of VTE patients such as DVT.
    Language English
    Publishing date 2020-10-21
    Publishing country Greece
    Document type Journal Article
    ZDB-ID 2683844-8
    ISSN 1792-1015 ; 1792-0981
    ISSN (online) 1792-1015
    ISSN 1792-0981
    DOI 10.3892/etm.2020.9367
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article: A Case of Acquired Factor V Deficiency in Patient with Bleeding

    Vetri, Davide / Lumera, Giovanni / Tarascio, Salvatore / Scuto, Salvatore / Marino, Elisa / Barcellona, Giuliana / Signorelli, Salvatore Santo

    TH Open

    2020  Volume 04, Issue 02, Page(s) e77–e79

    Abstract: Low frequency of rare diseases origins from missed diagnosis addressing to poor prognosis. Acquired factor V inhibitor is a very low frequent bleeding condition (prevalence: 0.09/100,000,000–0.29/1,000,000 per year). Antibiotics, surgery, bacterial ... ...

    Abstract Low frequency of rare diseases origins from missed diagnosis addressing to poor prognosis. Acquired factor V inhibitor is a very low frequent bleeding condition (prevalence: 0.09/100,000,000–0.29/1,000,000 per year). Antibiotics, surgery, bacterial infections, malignancies, and autoimmune diseases are predisposing factors; however, no predisposing factor was found often. Authors reported a case of bleeding originating from an acquired factor V deficiency because they wish to draw attention to unfrequented or rare clinical situations rarely diagnosed in internal medicine unit.
    Keywords coagulation ; acquired inhibitors ; factor V
    Language English
    Publishing date 2020-04-01
    Publisher Georg Thieme Verlag KG
    Publishing place Stuttgart ; New York
    Document type Article
    ZDB-ID 2901738-5
    ISSN 2512-9465 ; 2567-3459
    ISSN (online) 2512-9465
    ISSN 2567-3459
    DOI 10.1055/s-0039-3402024
    Database Thieme publisher's database

    More links

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Zs.A 7138: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

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