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Article ; Online: Functional exploration of copy number alterations in a Drosophila model of triple negative breast cancer.

Diaz, Jennifer E L / Barcessat, Vanessa / Bahamon, Christian / Hecht, Chana / Das, Tirtha K / Cagan, Ross L

2024

Abstract: Accounting for 10-20% of breast cancer cases, TNBC is associated with a disproportionate number of breast cancer deaths. One challenge in studying TNBC is its genomic profile: outside of TP53 loss, most cases are characterized by copy number alterations ( ...

Abstract	Accounting for 10-20% of breast cancer cases, TNBC is associated with a disproportionate number of breast cancer deaths. One challenge in studying TNBC is its genomic profile: outside of TP53 loss, most cases are characterized by copy number alterations (CNAs), making modeling the disease in whole animals challenging. We computationally analyzed 186 previously identified CNA regions in breast cancer to rank genes within each region by likelihood of acting as a tumor driver. We then used a Drosophila p53-Myc TNBC model to identify 48 genes as functional drivers. To demonstrate the utility of this functional database, we established six 3-hit models; altering candidates led to increased aspects of transformation as well as resistance to the chemotherapeutic drug fluorouracil. Our work provides a functional database of CNA-associated TNBC drivers, and a template for an integrated computational/whole animal approach to identify functional drivers of transformation and drug resistance within CNAs for other tumor types.
Language	English
Publishing date	2024-05-09
Publishing country	England
Document type	Journal Article
ZDB-ID	2451104-3
ISSN	1754-8411 ; 1754-8403
ISSN (online)	1754-8411
ISSN	1754-8403
DOI	10.1242/dmm.050191
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Article ; Online: Autoimmunity in Down's syndrome via cytokines, CD4 T cells and CD11c

Malle, Louise / Patel, Roosheel S / Martin-Fernandez, Marta / Stewart, O Jay / Philippot, Quentin / Buta, Sofija / Richardson, Ashley / Barcessat, Vanessa / Taft, Justin / Bastard, Paul / Samuels, Julie / Mircher, Clotilde / Rebillat, Anne-Sophie / Maillebouis, Louise / Vilaire-Meunier, Marie / Tuballes, Kevin / Rosenberg, Brad R / Trachtman, Rebecca / Casanova, Jean-Laurent /

Notarangelo, Luigi D / Gnjatic, Sacha / Bush, Douglas / Bogunovic, Dusan

Nature

2023 Volume 615, Issue 7951, Page(s) 305–314

Abstract: Down's syndrome (DS) presents with a constellation of cardiac, neurocognitive and growth impairments. Individuals with DS are also prone to severe infections and autoimmunity including thyroiditis, type 1 diabetes, coeliac disease and alopecia ... ...

Abstract	Down's syndrome (DS) presents with a constellation of cardiac, neurocognitive and growth impairments. Individuals with DS are also prone to severe infections and autoimmunity including thyroiditis, type 1 diabetes, coeliac disease and alopecia areata
MeSH term(s)	Humans ; Autoantibodies/immunology ; Autoimmunity ; B-Lymphocytes/cytology ; B-Lymphocytes/immunology ; B-Lymphocytes/metabolism ; CD4-Positive T-Lymphocytes/cytology ; CD4-Positive T-Lymphocytes/immunology ; Cytokines/analysis ; Cytokines/immunology ; Disease Susceptibility ; Down Syndrome/immunology ; Down Syndrome/physiopathology ; Interleukin-6/immunology ; Receptors, Complement 3d
Chemical Substances	Autoantibodies ; Cytokines ; IGHV1-69 protein, human ; Interleukin-6 ; ITGAX protein, human ; Receptors, Complement 3d ; T-box transcription factor TBX21 ; IGHV4-34 protein, human
Language	English
Publishing date	2023-02-22
Publishing country	England
Document type	Journal Article ; Research Support, N.I.H., Extramural
ZDB-ID	120714-3
ISSN	1476-4687 ; 0028-0836
ISSN (online)	1476-4687
ISSN	0028-0836
DOI	10.1038/s41586-023-05736-y
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Article ; Online: Mapping Systemic Inflammation and Antibody Responses in Multisystem Inflammatory Syndrome in Children (MIS-C).

Gruber, Conor N / Patel, Roosheel S / Trachtman, Rebecca / Lepow, Lauren / Amanat, Fatima / Krammer, Florian / Wilson, Karen M / Onel, Kenan / Geanon, Daniel / Tuballes, Kevin / Patel, Manishkumar / Mouskas, Konstantinos / O'Donnell, Timothy / Merritt, Elliot / Simons, Nicole W / Barcessat, Vanessa / Del Valle, Diane M / Udondem, Samantha / Kang, Gurpawan /

Agashe, Charuta / Karekar, Neha / Grabowska, Joanna / Nie, Kai / Le Berichel, Jessica / Xie, Hui / Beckmann, Noam / Gangadharan, Sandeep / Ofori-Amanfo, George / Laserson, Uri / Rahman, Adeeb / Kim-Schulze, Seunghee / Charney, Alexander W / Gnjatic, Sacha / Gelb, Bruce D / Merad, Miriam / Bogunovic, Dusan

Cell

2023 Volume 186, Issue 15, Page(s) 3325

Language	English
Publishing date	2023-07-19
Publishing country	United States
Document type	Published Erratum
ZDB-ID	187009-9
ISSN	1097-4172 ; 0092-8674
ISSN (online)	1097-4172
ISSN	0092-8674
DOI	10.1016/j.cell.2023.06.012
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Article ; Online: Variable cellular responses to SARS-CoV-2 in fully vaccinated patients with multiple myeloma.

Cancer cell

2021 Volume 39, Issue 11, Page(s) 1442–1444

MeSH term(s)	2019-nCoV Vaccine mRNA-1273 ; Antibodies, Viral/blood ; B-Lymphocytes/drug effects ; B-Lymphocytes/immunology ; B-Lymphocytes/virology ; BNT162 Vaccine ; COVID-19/diagnosis ; COVID-19/immunology ; COVID-19/prevention & control ; COVID-19/virology ; COVID-19 Vaccines/administration & dosage ; Case-Control Studies ; Cytokines/blood ; Host-Pathogen Interactions ; Humans ; Immunity, Cellular/drug effects ; Immunogenicity, Vaccine ; Immunoglobulin G/blood ; Lymphocyte Activation/drug effects ; Multiple Myeloma/diagnosis ; Multiple Myeloma/immunology ; SARS-CoV-2/drug effects ; SARS-CoV-2/immunology ; SARS-CoV-2/pathogenicity ; Spike Glycoprotein, Coronavirus/immunology ; T-Lymphocytes/drug effects ; T-Lymphocytes/immunology ; T-Lymphocytes/virology ; Treatment Outcome ; Vaccination
Chemical Substances	Antibodies, Viral ; COVID-19 Vaccines ; Cytokines ; Immunoglobulin G ; Spike Glycoprotein, Coronavirus ; spike protein, SARS-CoV-2 ; 2019-nCoV Vaccine mRNA-1273 (EPK39PL4R4) ; BNT162 Vaccine (N38TVC63NU)
Language	English
Publishing date	2021-10-19
Publishing country	United States
Document type	Letter ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
ZDB-ID	2078448-X
ISSN	1878-3686 ; 1535-6108
ISSN (online)	1878-3686
ISSN	1535-6108
DOI	10.1016/j.ccell.2021.09.015
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Article ; Online: Neutralizing Anti-Granulocyte Macrophage-Colony Stimulating Factor Autoantibodies Recognize Post-Translational Glycosylations on Granulocyte Macrophage-Colony Stimulating Factor Years Before Diagnosis and Predict Complicated Crohn's Disease.

Mortha, Arthur / Remark, Romain / Del Valle, Diane Marie / Chuang, Ling-Shiang / Chai, Zhi / Alves, Inês / Azevedo, Catarina / Gaifem, Joana / Martin, Jerome / Petralia, Francesca / Tuballes, Kevin / Barcessat, Vanessa / Tai, Siu Ling / Huang, Hsin-Hui / Laface, Ilaria / Jerez, Yeray Arteaga / Boschetti, Gilles / Villaverde, Nicole / Wang, Mona D /

Korie, Ujunwa M / Murray, Joseph / Choung, Rok-Seon / Sato, Takahiro / Laird, Renee M / Plevy, Scott / Rahman, Adeeb / Torres, Joana / Porter, Chad / Riddle, Mark S / Kenigsberg, Ephraim / Pinho, Salomé S / Cho, Judy H / Merad, Miriam / Colombel, Jean-Frederic / Gnjatic, Sacha

Gastroenterology

2022 Volume 163, Issue 3, Page(s) 659–670

Abstract: Background & aims: Anti-granulocyte macrophage-colony stimulating factor autoantibodies (aGMAbs) are detected in patients with ileal Crohn's disease (CD). Their induction and mode of action during or before disease are not well understood. We aimed to ... ...

Abstract	Background & aims: Anti-granulocyte macrophage-colony stimulating factor autoantibodies (aGMAbs) are detected in patients with ileal Crohn's disease (CD). Their induction and mode of action during or before disease are not well understood. We aimed to investigate the underlying mechanisms associated with aGMAb induction, from functional orientation to recognized epitopes, for their impact on intestinal immune homeostasis and use as a predictive biomarker for complicated CD. Methods: We characterized using enzyme-linked immunosorbent assay naturally occurring aGMAbs in longitudinal serum samples from patients archived before the diagnosis of CD (n = 220) as well as from 400 healthy individuals (matched controls) as part of the US Defense Medical Surveillance System. We used biochemical, cellular, and transcriptional analysis to uncover a mechanism that governs the impaired immune balance in CD mucosa after diagnosis. Results: Neutralizing aGMAbs were found to be specific for post-translational glycosylation on granulocyte macrophage-colony stimulating factor (GM-CSF), detectable years before diagnosis, and associated with complicated CD at presentation. Glycosylation of GM-CSF was altered in patients with CD, and aGMAb affected myeloid homeostasis and promoted group 1 innate lymphoid cells. Perturbations in immune homeostasis preceded the diagnosis in the serum of patients with CD presenting with aGMAb and were detectable in the noninflamed CD mucosa. Conclusions: Anti-GMAbs predict the diagnosis of complicated CD long before the diagnosis of disease, recognize uniquely glycosylated epitopes, and impair myeloid cell and innate lymphoid cell balance associated with altered intestinal immune homeostasis.
MeSH term(s)	Autoantibodies ; Crohn Disease/complications ; Epitopes ; Glycosylation ; Granulocyte-Macrophage Colony-Stimulating Factor/metabolism ; Humans ; Ileal Diseases/complications ; Immunity, Innate ; Lymphocytes ; Macrophages
Chemical Substances	Autoantibodies ; Epitopes ; Granulocyte-Macrophage Colony-Stimulating Factor (83869-56-1)
Language	English
Publishing date	2022-05-24
Publishing country	United States
Document type	Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
ZDB-ID	80112-4
ISSN	1528-0012 ; 0016-5085
ISSN (online)	1528-0012
ISSN	0016-5085
DOI	10.1053/j.gastro.2022.05.029
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Article: Mapping Systemic Inflammation and Antibody Responses in Multisystem Inflammatory Syndrome in Children (MIS-C).

Gruber, Conor / Patel, Roosheel / Trachman, Rebecca / Lepow, Lauren / Amanat, Fatima / Krammer, Florian / Wilson, Karen M / Onel, Kenan / Geanon, Daniel / Tuballes, Kevin / Patel, Manishkumar / Mouskas, Konstantinos / Simons, Nicole / Barcessat, Vanessa / Valle, Diane Del / Udondem, Samantha / Kang, Gurpawan / Gangadharan, Sandeep / Ofori-Amanfo, George /

Rahman, Adeeb / Kim-Schulze, Seunghee / Charney, Alexander / Gnjatic, Sacha / Gelb, Bruce D / Merad, Miriam / Bogunovic, Dusan

medRxiv : the preprint server for health sciences

2020

Abstract: Initially, the global outbreak of COVID-19 caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) spared children from severe disease. However, after the initial wave of infections, clusters of a novel hyperinflammatory disease have been ... ...

Abstract	Initially, the global outbreak of COVID-19 caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) spared children from severe disease. However, after the initial wave of infections, clusters of a novel hyperinflammatory disease have been reported in regions with ongoing SARS-CoV-2 epidemics. While the characteristic clinical features are becoming clear, the pathophysiology remains unknown. Herein, we report on the immune profiles of eight Multisystem Inflammatory Syndrome in Children (MIS-C) cases. We document that all MIS-C patients had evidence of prior SARS-CoV-2 exposure, mounting an antibody response with normal isotype-switching and neutralization capability. We further profiled the secreted immune response by high-dimensional cytokine assays, which identified elevated signatures of inflammation (IL-18 and IL-6), lymphocytic and myeloid chemotaxis and activation (CCL3, CCL4, and CDCP1) and mucosal immune dysregulation (IL-17A, CCL20, CCL28). Mass cytometry immunophenotyping of peripheral blood revealed reductions of mDC1 and non-classical monocytes, as well as both NK- and T- lymphocytes, suggesting extravasation to affected tissues. Markers of activated myeloid function were also evident, including upregulation of ICAM1 and FcγR1 in neutrophil and non-classical monocytes, well-documented markers in autoinflammation and autoimmunity that indicate enhanced antigen presentation and Fc-mediated responses. Finally, to assess the role for autoimmunity secondary to infection, we profiled the auto-antigen reactivity of MIS-C plasma, which revealed both known disease-associated autoantibodies (anti-La) and novel candidates that recognize endothelial, gastrointestinal and immune-cell antigens. All patients were treated with anti-IL6R antibody or IVIG, which led to rapid disease resolution tracking with normalization of inflammatory markers.
Keywords	covid19
Language	English
Publishing date	2020-07-06
Publishing country	United States
Document type	Preprint
DOI	10.1101/2020.07.04.20142752
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Article: Mapping Systemic Inflammation and Antibody Responses in Multisystem Inflammatory Syndrome in Children (MIS-C)

Gruber, Conor N / Patel, Roosheel S / Trachtman, Rebecca / Lepow, Lauren / Amanat, Fatima / Krammer, Florian / Wilson, Karen M / Onel, Kenan / Geanon, Daniel / Tuballes, Kevin / Patel, Manishkumar / Mouskas, Konstantinos / O’Donnell, Timothy / Merritt, Elliot / Simons, Nicole W / Barcessat, Vanessa / Del Valle, Diane M / Udondem, Samantha / Kang, Gurpawan /

Gangadharan, Sandeep / Ofori-Amanfo, George / Laserson, Uri / Rahman, Adeeb / Kim-Schulze, Seunghee / Charney, Alexander W / Gnjatic, Sacha / Gelb, Bruce D / Merad, Miriam / Bogunovic, Dusan

Cell. 2020 Nov. 12, v. 183, no. 4

2020

Abstract: Initially, children were thought to be spared from disease caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). However, a month into the epidemic, a novel multisystem inflammatory syndrome in children (MIS-C) emerged. Herein, we ... ...

Abstract	Initially, children were thought to be spared from disease caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). However, a month into the epidemic, a novel multisystem inflammatory syndrome in children (MIS-C) emerged. Herein, we report on the immune profiles of nine MIS-C cases. All MIS-C patients had evidence of prior SARS-CoV-2 exposure, mounting an antibody response with intact neutralization capability. Cytokine profiling identified elevated signatures of inflammation (IL-18 and IL-6), lymphocytic and myeloid chemotaxis and activation (CCL3, CCL4, and CDCP1), and mucosal immune dysregulation (IL-17A, CCL20, and CCL28). Immunophenotyping of peripheral blood revealed reductions of non-classical monocytes, and subsets of NK and T lymphocytes, suggesting extravasation to affected tissues. Finally, profiling the autoantigen reactivity of MIS-C plasma revealed both known disease-associated autoantibodies (anti-La) and novel candidates that recognize endothelial, gastrointestinal, and immune-cell antigens. All patients were treated with anti-IL-6R antibody and/or IVIG, which led to rapid disease resolution.
Keywords	Severe acute respiratory syndrome coronavirus 2 ; antibody formation ; autoantibodies ; chemotaxis ; gastrointestinal system ; immunophenotyping ; inflammation ; interleukin-17 ; interleukin-18 ; interleukin-6 ; monocytes ; mucosal immunity ; neutralization
Language	English
Dates of publication	2020-1112
Size	p. 982-995.e14.
Publishing place	Elsevier Inc.
Document type	Article
Note	NAL-AP-2-clean
ZDB-ID	187009-9
ISSN	1097-4172 ; 0092-8674
ISSN (online)	1097-4172
ISSN	0092-8674
DOI	10.1016/j.cell.2020.09.034
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Article: Acute COVID-19 gene-expression profiles show multiple etiologies of long-term sequelae.

Thompson, Ryan C / Simons, Nicole W / Wilkins, Lillian / Cheng, Esther / Del Valle, Diane Marie / Hoffman, Gabriel E / Fennessy, Brian / Mouskas, Konstantinos / Francoeur, Nancy J / Johnson, Jessica S / Lepow, Lauren / Le Berichel, Jessica / Chang, Christie / Beckmann, Aviva G / Wang, Ying-Chih / Nie, Kai / Zaki, Nicholas / Tuballes, Kevin / Barcessat, Vanessa /

Cedillo, Mario A / Huckins, Laura / Roussos, Panagiotis / Marron, Thomas U / Glicksberg, Benjamin S / Nadkarni, Girish / Gonzalez-Kozlova, Edgar / Kim-Schulze, Seunghee / Sebra, Robert / Merad, Miriam / Gnjatic, Sacha / Schadt, Eric E / Charney, Alexander W / Beckmann, Noam D

medRxiv : the preprint server for health sciences

2021

Abstract: Two years into the SARS-CoV-2 pandemic, the post-acute sequelae of infection are compounding the global health crisis. Often debilitating, these sequelae are clinically heterogeneous and of unknown molecular etiology. Here, a transcriptome-wide ... ...

Abstract	Two years into the SARS-CoV-2 pandemic, the post-acute sequelae of infection are compounding the global health crisis. Often debilitating, these sequelae are clinically heterogeneous and of unknown molecular etiology. Here, a transcriptome-wide investigation of this new condition was performed in a large cohort of acutely infected patients followed clinically into the post-acute period. Gene expression signatures of post-acute sequelae were already present in whole blood during the acute phase of infection, with both innate and adaptive immune cells involved. Plasma cells stood out as driving at least two distinct clusters of sequelae, one largely dependent on circulating antibodies against the SARS-CoV-2 spike protein and the other antibody-independent. Altogether, multiple etiologies of post-acute sequelae were found concomitant with SARS-CoV-2 infection, directly linking the emergence of these sequelae with the host response to the virus.
Language	English
Publishing date	2021-10-05
Publishing country	United States
Document type	Preprint
DOI	10.1101/2021.10.04.21264434
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Article ; Online: Rapid, scalable assessment of SARS-CoV-2 cellular immunity by whole-blood PCR.

Schwarz, Megan / Torre, Denis / Lozano-Ojalvo, Daniel / Tan, Anthony T / Tabaglio, Tommaso / Mzoughi, Slim / Sanchez-Tarjuelo, Rodrigo / Le Bert, Nina / Lim, Joey Ming Er / Hatem, Sandra / Tuballes, Kevin / Camara, Carmen / Lopez-Granados, Eduardo / Paz-Artal, Estela / Correa-Rocha, Rafael / Ortiz, Alberto / Lopez-Hoyos, Marcos / Portoles, Jose / Cervera, Isabel /

Gonzalez-Perez, Maria / Bodega-Mayor, Irene / Conde, Patricia / Oteo-Iglesias, Jesús / Borobia, Alberto M / Carcas, Antonio J / Frías, Jesús / Belda-Iniesta, Cristóbal / Ho, Jessica S Y / Nunez, Kemuel / Hekmaty, Saboor / Mohammed, Kevin / Marsiglia, William M / Carreño, Juan Manuel / Dar, Arvin C / Berin, Cecilia / Nicoletti, Giuseppe / Della Noce, Isabella / Colombo, Lorenzo / Lapucci, Cristina / Santoro, Graziano / Ferrari, Maurizio / Nie, Kai / Patel, Manishkumar / Barcessat, Vanessa / Gnjatic, Sacha / Harris, Jocelyn / Sebra, Robert / Merad, Miriam / Krammer, Florian / Kim-Schulze, Seunghee / Marazzi, Ivan / Bertoletti, Antonio / Ochando, Jordi / Guccione, Ernesto

Nature biotechnology

2022 Volume 40, Issue 11, Page(s) 1680–1689

Abstract: Fast, high-throughput methods for measuring the level and duration of protective immune responses to SARS-CoV-2 are needed to anticipate the risk of breakthrough infections. Here we report the development of two quantitative PCR assays for SARS-CoV-2- ... ...

Abstract	Fast, high-throughput methods for measuring the level and duration of protective immune responses to SARS-CoV-2 are needed to anticipate the risk of breakthrough infections. Here we report the development of two quantitative PCR assays for SARS-CoV-2-specific T cell activation. The assays are rapid, internally normalized and probe-based: qTACT requires RNA extraction and dqTACT avoids sample preparation steps. Both assays rely on the quantification of CXCL10 messenger RNA, a chemokine whose expression is strongly correlated with activation of antigen-specific T cells. On restimulation of whole-blood cells with SARS-CoV-2 viral antigens, viral-specific T cells secrete IFN-γ, which stimulates monocytes to produce CXCL10. CXCL10 mRNA can thus serve as a proxy to quantify cellular immunity. Our assays may allow large-scale monitoring of the magnitude and duration of functional T cell immunity to SARS-CoV-2, thus helping to prioritize revaccination strategies in vulnerable populations.
MeSH term(s)	Humans ; SARS-CoV-2/genetics ; COVID-19 ; Immunity, Cellular ; Polymerase Chain Reaction ; T-Lymphocytes
Language	English
Publishing date	2022-06-13
Publishing country	United States
Document type	Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
ZDB-ID	1311932-1
ISSN	1546-1696 ; 1087-0156
ISSN (online)	1546-1696
ISSN	1087-0156
DOI	10.1038/s41587-022-01347-6
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Article ; Online: Molecular states during acute COVID-19 reveal distinct etiologies of long-term sequelae.

Thompson, Ryan C / Simons, Nicole W / Wilkins, Lillian / Cheng, Esther / Del Valle, Diane Marie / Hoffman, Gabriel E / Cervia, Carlo / Fennessy, Brian / Mouskas, Konstantinos / Francoeur, Nancy J / Johnson, Jessica S / Lepow, Lauren / Le Berichel, Jessica / Chang, Christie / Beckmann, Aviva G / Wang, Ying-Chih / Nie, Kai / Zaki, Nicholas / Tuballes, Kevin /

Barcessat, Vanessa / Cedillo, Mario A / Yuan, Dan / Huckins, Laura / Roussos, Panos / Marron, Thomas U / Glicksberg, Benjamin S / Nadkarni, Girish / Heath, James R / Gonzalez-Kozlova, Edgar / Boyman, Onur / Kim-Schulze, Seunghee / Sebra, Robert / Merad, Miriam / Gnjatic, Sacha / Schadt, Eric E / Charney, Alexander W / Beckmann, Noam D

Nature medicine

2022 Volume 29, Issue 1, Page(s) 236–246

Abstract: Post-acute sequelae of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection are debilitating, clinically heterogeneous and of unknown molecular etiology. A transcriptome-wide investigation was performed in 165 acutely infected ... ...

Abstract	Post-acute sequelae of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection are debilitating, clinically heterogeneous and of unknown molecular etiology. A transcriptome-wide investigation was performed in 165 acutely infected hospitalized individuals who were followed clinically into the post-acute period. Distinct gene expression signatures of post-acute sequelae were already present in whole blood during acute infection, with innate and adaptive immune cells implicated in different symptoms. Two clusters of sequelae exhibited divergent plasma-cell-associated gene expression patterns. In one cluster, sequelae associated with higher expression of immunoglobulin-related genes in an anti-spike antibody titer-dependent manner. In the other, sequelae associated independently of these titers with lower expression of immunoglobulin-related genes, indicating lower non-specific antibody production in individuals with these sequelae. This relationship between lower total immunoglobulins and sequelae was validated in an external cohort. Altogether, multiple etiologies of post-acute sequelae were already detectable during SARS-CoV-2 infection, directly linking these sequelae with the acute host response to the virus and providing early insights into their development.
MeSH term(s)	Humans ; COVID-19/genetics ; SARS-CoV-2 ; Antibodies, Viral
Chemical Substances	Antibodies, Viral
Language	English
Publishing date	2022-12-08
Publishing country	United States
Document type	Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
ZDB-ID	1220066-9
ISSN	1546-170X ; 1078-8956
ISSN (online)	1546-170X
ISSN	1078-8956
DOI	10.1038/s41591-022-02107-4
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