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  1. Article ; Online: Recent progress in NIR-II fluorescence imaging-guided drug delivery for cancer theranostics.

    Roy, Shubham / Bag, Neelanjana / Bardhan, Souravi / Hasan, Ikram / Guo, Bing

    Advanced drug delivery reviews

    2023  Volume 197, Page(s) 114821

    Abstract: Fluorescence imaging in the second near-infrared window (NIR-II) has become a prevalent choice owing to its appealing advantages like deep penetration depth, low autofluorescence, decent spatiotemporal resolution, and a high signal-to-background ratio. ... ...

    Abstract Fluorescence imaging in the second near-infrared window (NIR-II) has become a prevalent choice owing to its appealing advantages like deep penetration depth, low autofluorescence, decent spatiotemporal resolution, and a high signal-to-background ratio. This would expedite the innovation of NIR-II imaging-guided drug delivery (IGDD) paradigms for the improvement of the prognosis of patients with tumors. This work systematically reviews the recent progress of such NIR-II IGDD-mediated cancer therapeutics and collectively brings its essence to the readers. Special care has been taken to assess their performances based on their design approach, such as enhancing their drug loading and triggering release, designing intrinsic and extrinsic fluorophores, and/ or overcoming biological barriers. Besides, the state-of-the-art NIR-II IGDD platforms for different therapies like chemo-, photodynamic, photothermal, chemodynamic, immuno-, ion channel, gas-therapies, and multiple functions such as stimulus-responsive imaging and therapy, and monitoring of drug release and therapeutic response, have been updated. In addition, for boosting theranostic outcomes and clinical translation, the innovation directions of NIR-II IGDD platforms are summarized, including renal-clearable, biodegradable, sub-cellular targeting, and/or afterglow, chemiluminescence, X-ray excitable NIR-IGDD, and even cell therapy. This review will propel new directions for safe and efficient NIR-II fluorescence-mediated anticancer drug delivery.
    MeSH term(s) Humans ; Precision Medicine ; Theranostic Nanomedicine/methods ; Neoplasms/diagnostic imaging ; Neoplasms/drug therapy ; Neoplasms/pathology ; Antineoplastic Agents/therapeutic use ; Optical Imaging/methods ; Nanoparticles/therapeutic use
    Chemical Substances Antineoplastic Agents
    Language English
    Publishing date 2023-04-08
    Publishing country Netherlands
    Document type Journal Article ; Review ; Research Support, Non-U.S. Gov't
    ZDB-ID 639113-8
    ISSN 1872-8294 ; 0169-409X
    ISSN (online) 1872-8294
    ISSN 0169-409X
    DOI 10.1016/j.addr.2023.114821
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Natural Clay-Modified Piezocatalytic Membrane for Efficient Removal of Coliform Bacteria from Wastewater.

    Mondal, Dhananjoy / Bag, Neelanjana / Roy, Jhilik / Ghosh, Saheli / Roy, Shubham / Sarkar, Monisha / Bardhan, Souravi / Sutradhar, Soumyaditya / Das, Sukhen

    Langmuir : the ACS journal of surfaces and colloids

    2024  Volume 40, Issue 11, Page(s) 5785–5798

    Abstract: In the modern era, water pollution, especially from industries, agricultural farms, and residential areas, is caused by the release of a large scale of heavy metals, organic pollutants, chemicals, etc., into the environment, posing a serious threat to ... ...

    Abstract In the modern era, water pollution, especially from industries, agricultural farms, and residential areas, is caused by the release of a large scale of heavy metals, organic pollutants, chemicals, etc., into the environment, posing a serious threat to aquatic ecosystems and nature. Moreover, untreated sewage waste discharged directly into nearby water bodies can cause various diseases to mankind due to the high load of fecal coliform bacteria. This work demonstrates the development of a biocompatible, cost-effective, highly robust, efficient, flexible, freestanding, and reusable membrane using naturally formed biocompatible kaolinite clay-doped poly(vinylidene fluoride-hexafluoropropylene) (PVDF-HFP) for effective piezodynamic destruction of coliform bacteria. In this study,
    MeSH term(s) Wastewater ; Clay ; Escherichia coli ; Ecosystem ; Anti-Bacterial Agents/pharmacology ; Bacteria
    Chemical Substances Wastewater ; Clay (T1FAD4SS2M) ; Anti-Bacterial Agents
    Language English
    Publishing date 2024-03-06
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2005937-1
    ISSN 1520-5827 ; 0743-7463
    ISSN (online) 1520-5827
    ISSN 0743-7463
    DOI 10.1021/acs.langmuir.3c03560
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Nanoparticle-mediated stimulus-responsive antibacterial therapy.

    Bag, Neelanjana / Bardhan, Souravi / Roy, Shubham / Roy, Jhilik / Mondal, Dhananjoy / Guo, Bing / Das, Sukhen

    Biomaterials science

    2023  Volume 11, Issue 6, Page(s) 1994–2019

    Abstract: The limitations associated with conventional antibacterial therapies and the subsequent amplification of multidrug-resistant (MDR) microorganisms have increased, necessitating the urgent development of innovative antibacterial techniques. Accordingly, ... ...

    Abstract The limitations associated with conventional antibacterial therapies and the subsequent amplification of multidrug-resistant (MDR) microorganisms have increased, necessitating the urgent development of innovative antibacterial techniques. Accordingly, nanoparticle-mediated therapeutics have emerged as potential candidates for antibacterial treatment due to their suitable dimensions, penetration capacity, and high efficiency in targeted drug delivery. However, although nanoparticle-based drug delivery systems have been demonstrated to be effective, they are limited by their overuse and unwanted side effects. Thus, to overcome these drawbacks, stimulus-responsive antibiotic delivery has been extended as a promising strategy for site-specific restricted drug exemption. Nano-formulations that are triggered by various stimuli, such as intrinsic, extrinsic, and bacterial stimuli, have been developed. Thus, by harnessing the physicochemical properties of various nanoparticles, the selective release of therapeutic cargoes can be achieved through the application of a variety of local stimuli such as light, sound, irradiation, pH, and magnetic field. In this review, we also highlight the progress and perspectives of stimulus-responsive combination therapy, with special emphasis on the eradication of MDR strains and biofilms. Hence, this review addresses the advancement and challenges in the applications of stimulus-responsive nanoparticles together with the various future prospects of this technique.
    MeSH term(s) Drug Delivery Systems/methods ; Anti-Bacterial Agents/chemistry ; Nanoparticles/chemistry ; Magnetic Fields ; Bacteria
    Chemical Substances Anti-Bacterial Agents
    Language English
    Publishing date 2023-03-14
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 2693928-9
    ISSN 2047-4849 ; 2047-4830
    ISSN (online) 2047-4849
    ISSN 2047-4830
    DOI 10.1039/d2bm01941h
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Recent advances in piezocatalytic polymer nanocomposites for wastewater remediation.

    Mondal, Dhananjoy / Roy, Shubham / Bardhan, Souravi / Roy, Jhilik / Kanungo, Ishita / Basu, Ruma / Das, Sukhen

    Dalton transactions (Cambridge, England : 2003)

    2022  Volume 51, Issue 2, Page(s) 451–462

    Abstract: Among several forms of water pollutants, common pesticides, herbicides, organic dyes and heavy metals present serious and persistent threats to human health due to their severe toxicity. Recently, piezocatalysis based removal of pollutants has become a ... ...

    Abstract Among several forms of water pollutants, common pesticides, herbicides, organic dyes and heavy metals present serious and persistent threats to human health due to their severe toxicity. Recently, piezocatalysis based removal of pollutants has become a promising field of research to combat such pollutions by virtue of the piezoelectric effect. In reality, piezoelectric materials can produce electron-hole separation upon external vibration, which greatly enhances the production of various reactive oxygen species (ROS) and further increases the pollutant degradation rate. Piezocatalysis does not alter the quality or composition of water, like several other conventional techniques (adsorption and photocatalysis), which makes this technique non-invasive. The simplicity and tremendously high efficacy of piezocatalysis have attracted researchers worldwide and thus various functional materials are employed for piezocatalytic wastewater remediation. In this frontier, we highlight and demonstrate recent developments on polymer based piezocatalytic nanocomposites to treat industrial wastewater in a facile manner that holds strong potential to be translated into a clean and green technology.
    Language English
    Publishing date 2022-01-04
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 1472887-4
    ISSN 1477-9234 ; 1364-5447 ; 0300-9246 ; 1477-9226
    ISSN (online) 1477-9234 ; 1364-5447
    ISSN 0300-9246 ; 1477-9226
    DOI 10.1039/d1dt02653d
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Flexible and reusable carbon dot decorated natural microcline membrane: a futuristic probe for multiple heavy metal induced carcinogen detection.

    Bardhan, Souravi / Roy, Shubham / Chanda, Dipak Kr / Mondal, Dhananjoy / Das, Solanky / Das, Sukhen

    Mikrochimica acta

    2021  Volume 188, Issue 4, Page(s) 134

    Abstract: A flexible nano-engineered natural mineral (carbon dot doped natural microcline) based membrane (MCPV) has been developed, which can efficiently detect the presence of hexavalent chromium ( ... ...

    Abstract A flexible nano-engineered natural mineral (carbon dot doped natural microcline) based membrane (MCPV) has been developed, which can efficiently detect the presence of hexavalent chromium (Cr
    MeSH term(s) Aluminum Compounds/chemistry ; Carbon/chemistry ; Carcinogens/analysis ; Chromium/analysis ; Density Functional Theory ; Drinking Water/analysis ; Fluorescent Dyes/chemistry ; Glutathione/chemistry ; Iron/analysis ; Limit of Detection ; Membranes, Artificial ; Models, Chemical ; Molecular Docking Simulation ; Ponds/analysis ; Quantum Dots/chemistry ; Silicates/chemistry ; Spectrometry, Fluorescence/methods ; Waste Water/analysis ; Water Pollutants, Chemical/analysis
    Chemical Substances Aluminum Compounds ; Carcinogens ; Drinking Water ; Fluorescent Dyes ; Membranes, Artificial ; Silicates ; Waste Water ; Water Pollutants, Chemical ; microcline ; Chromium (0R0008Q3JB) ; chromium hexavalent ion (18540-29-9) ; Carbon (7440-44-0) ; Iron (E1UOL152H7) ; Glutathione (GAN16C9B8O)
    Language English
    Publishing date 2021-03-23
    Publishing country Austria
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 89-9
    ISSN 1436-5073 ; 0026-3672
    ISSN (online) 1436-5073
    ISSN 0026-3672
    DOI 10.1007/s00604-021-04787-0
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article: InSitu-Grown Cdot-Wrapped Boehmite Nanoparticles for Cr(VI) Sensing in Wastewater and a Theoretical Probe for Chromium-Induced Carcinogen Detection

    Roy, Shubham / Bardhan, Souravi / Chanda, Dipak Kr / Roy, Jhilik / Mondal, Dhananjoy / Das, Sukhen

    ACS applied materials & interfaces. 2020 Sept. 07, v. 12, no. 39

    2020  

    Abstract: In modern society, massive industrialization escalates environmental degradation by liberating various contaminants into the environment. Hexavalent chromium is a heavy metal that is being discharged from tannery and other industries, resulting in ... ...

    Abstract In modern society, massive industrialization escalates environmental degradation by liberating various contaminants into the environment. Hexavalent chromium is a heavy metal that is being discharged from tannery and other industries, resulting in various carcinogenic diseases. This study reports a carbon dot (cdot)-based fluorometric probe for detecting hexavalent chromium in water. This is the very first time that cdots are tailored over the boehmite nanoparticle’s surface using an in situ approach. Validation of formation of the nanocomposite has been discussed in detail employing the Rietveld refinement-based X-ray crystallography method. Vibrational spectroscopy and electron microscopy of the sample authenticate the nucleation process and the growth mechanism. The Stern–Volmer approach and time-resolved fluorescence measurements justify the sensitivity of the sensor (∼58 nM), and selectivity is analyzed by exposing the material to different ionic environments. Density functional theory (DFT) is applied herein to analyze the origin of fluorescence and the sensing mechanism of the probe, which shows that photoinduced electron transfer is responsible for the turn-off-based sensing of Cr(VI). The molecular docking simulation is carried out to ensure the binding of cdots to the binding pocket of the glutathione enzyme, which is responsible for treating reactive oxygen species-mediated DNA damage due to elements such as hexavalent chromium. Time-dependent density functional calculations show that the fluorometric probe is capable of detecting Cr(VI) in living cells making it an early stage chromium-mediated carcinogen detector.
    Keywords DNA damage ; X-ray diffraction ; boehmite ; carbon ; carcinogenicity ; carcinogens ; chromium ; density functional theory ; electron microscopy ; electron transfer ; environmental degradation ; enzymes ; fluorescence ; fluorometry ; glutathione ; heavy metals ; industrialization ; nanocomposites ; oxygen ; phase transition ; spectroscopy ; tanneries ; wastewater
    Language English
    Dates of publication 2020-0907
    Size p. 43833-43843.
    Publishing place American Chemical Society
    Document type Article
    Note NAL-AP-2-clean
    ISSN 1944-8252
    DOI 10.1021/acsami.0c13433
    Database NAL-Catalogue (AGRICOLA)

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  7. Article ; Online: Piezo-responsive bismuth ferrite nanoparticle-mediated catalytic degradation of rhodamine B and pathogenic

    Roy, Jhilik / Mukhopadhyay, Leenia / Bardhan, Souravi / Mondal, Dhananjoy / Ghosh, Saheli / Chakraborty, Sudip / Bag, Neelanjana / Roy, Shubham / Basu, Ruma / Das, Sukhen

    Dalton transactions (Cambridge, England : 2003)

    2022  Volume 51, Issue 44, Page(s) 16926–16936

    Abstract: This work reports a solvothermal synthesis of ferromagnetic bismuth ferrite (BFO) nanoparticle and its piezo activity in the domain of catalytic degradation of carcinogenic and genotoxic rhodamine B (RhB) dye and ... ...

    Abstract This work reports a solvothermal synthesis of ferromagnetic bismuth ferrite (BFO) nanoparticle and its piezo activity in the domain of catalytic degradation of carcinogenic and genotoxic rhodamine B (RhB) dye and pathogenic
    MeSH term(s) Bismuth/chemistry ; Escherichia coli ; Nanoparticles ; Water ; Magnetic Phenomena
    Chemical Substances rhodamine B (K7G5SCF8IL) ; Bismuth (U015TT5I8H) ; ferrite (1317-54-0) ; Water (059QF0KO0R)
    Language English
    Publishing date 2022-11-15
    Publishing country England
    Document type Journal Article
    ZDB-ID 1472887-4
    ISSN 1477-9234 ; 1364-5447 ; 0300-9246 ; 1477-9226
    ISSN (online) 1477-9234 ; 1364-5447
    ISSN 0300-9246 ; 1477-9226
    DOI 10.1039/d2dt02918a
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: Biocompatible Carbon Dot Decorated α-FeOOH Nanohybrid for an Effective Fluorometric Sensing of Cr (VI) in Wastewater and Living Cells.

    Ghosh, Bidisha / Roy, Shubham / Bardhan, Souravi / Mondal, Dhananjoy / Saha, Ishita / Ghosh, Saheli / Basu, Ruma / Karmakar, Parimal / Das, Kaustuv / Das, Sukhen

    Journal of fluorescence

    2022  Volume 32, Issue 4, Page(s) 1489–1500

    Abstract: This article reports the fluorometric detection of toxic hexavalent chromium Cr (VI)) in wastewater and Cr (VI) contaminated living cells using in-situ grown carbon quantum dots into the goethite (α-FeOOH) nano-matrix. The synthesized nano-hybrid shows ... ...

    Abstract This article reports the fluorometric detection of toxic hexavalent chromium Cr (VI)) in wastewater and Cr (VI) contaminated living cells using in-situ grown carbon quantum dots into the goethite (α-FeOOH) nano-matrix. The synthesized nano-hybrid shows enormous potential in determining the chromium contamination levels in various types of water samples. This selective fluorometric probe is enormously sensitive (LOD 81 nM) toward hexavalent chromium, which makes it a dedicated chromium sensor. Moreover, the sensing mechanism has been assessed using Stern-Volmer's equation and fluorescence lifetime experiments showing the simultaneous occurrence of photoinduced electron transfer and the inner filter effect. This chromium sensor has also been employed to assess the contamination level in real-life industrial wastewater. The performance of this probe in a real-life wastewater sample is quite commendable. Further, this biocompatible fluorometric probe has been used to demonstrate the in-vitro sensing of Cr (VI) in HeLa cells. The rapid detection mechanism of hexavalent chromium in living cells has been validated using theoretical docking simulations. Henceforth, this fluorometric sensor material could open new avenues not only in wastewater monitoring but also in biomedical applications.
    MeSH term(s) Carbon ; Chromium/analysis ; HeLa Cells ; Humans ; Iron Compounds ; Minerals ; Wastewater ; Water Pollutants, Chemical/analysis
    Chemical Substances Iron Compounds ; Minerals ; Waste Water ; Water Pollutants, Chemical ; Chromium (0R0008Q3JB) ; goethite (1310-14-1) ; Carbon (7440-44-0)
    Language English
    Publishing date 2022-05-03
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 2016892-5
    ISSN 1573-4994 ; 1053-0509
    ISSN (online) 1573-4994
    ISSN 1053-0509
    DOI 10.1007/s10895-022-02962-x
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: In

    Roy, Shubham / Bardhan, Souravi / Chanda, Dipak Kr / Roy, Jhilik / Mondal, Dhananjoy / Das, Sukhen

    ACS applied materials & interfaces

    2020  Volume 12, Issue 39, Page(s) 43833–43843

    Abstract: In modern society, massive industrialization escalates environmental degradation by liberating various contaminants into the environment. Hexavalent chromium is a heavy metal that is being discharged from tannery and other industries, resulting in ... ...

    Abstract In modern society, massive industrialization escalates environmental degradation by liberating various contaminants into the environment. Hexavalent chromium is a heavy metal that is being discharged from tannery and other industries, resulting in various carcinogenic diseases. This study reports a carbon dot (cdot)-based fluorometric probe for detecting hexavalent chromium in water. This is the very first time that cdots are tailored over the boehmite nanoparticle's surface using an
    MeSH term(s) Carbon/chemistry ; Carcinogens/analysis ; Chromium/analysis ; Crystallography, X-Ray ; Density Functional Theory ; Fluorescent Dyes/chemistry ; Humans ; Molecular Docking Simulation ; Nanoparticles/chemistry ; Particle Size ; Quantum Dots/chemistry ; Surface Properties ; Waste Water/chemistry
    Chemical Substances Carcinogens ; Fluorescent Dyes ; Waste Water ; Chromium (0R0008Q3JB) ; chromium hexavalent ion (18540-29-9) ; Carbon (7440-44-0)
    Language English
    Publishing date 2020-09-17
    Publishing country United States
    Document type Journal Article
    ISSN 1944-8252
    ISSN (online) 1944-8252
    DOI 10.1021/acsami.0c13433
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: Real-time sensitive detection of Cr (VI) in industrial wastewater and living cells using carbon dot decorated natural kyanite nanoparticles.

    Bardhan, Souravi / Roy, Shubham / Das, Sanghita / Saha, Ishita / Mondal, Dhananjoy / Roy, Jhilik / Kr Chanda, Dipak / Das, Solanky / Karmakar, Parimal / Das, Sukhen

    Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy

    2022  Volume 273, Page(s) 121061

    Abstract: This article reports a facile strategy to detect hexavalent chromium (Cr (VI)) using a naturally formed mineral (kyanite) based fluorometric sensor. Nitrogenous carbon dots have been incorporated into natural kyanite (KYCD) nanoparticles causing a stable ...

    Abstract This article reports a facile strategy to detect hexavalent chromium (Cr (VI)) using a naturally formed mineral (kyanite) based fluorometric sensor. Nitrogenous carbon dots have been incorporated into natural kyanite (KYCD) nanoparticles causing a stable bright blue fluorescence compared to its pristine counterpart. This sensing probe structurally stabilizes and resists the agglomeration of carbon dots, thus retaining fluorescence quality for a longer period. The promising bright blue fluorescence has been utilized further to detect Cr (VI) in wastewater and living cells. Ease of synthesis, low cost, and stability of the system offers the benefit for large-scale production, which is convenient for industrial production the sensing probe. The sensor shows high selectivity and sensitivity (LOD and LOQ of 0.11 µM and 0.36 µM respectively in case of linear fitting, whereas 0.26 µM and 0.88 µM respectively for full range plot) towards hexavalent chromium in presence of other interfering elements. A detailed study of photoinduced electron transfer (PET) mediated rapid 'turn off' sensing mechanism was carried out using Time-Dependent Density functional (TDDFT) calculations. The sensing efficacy of the probe remains unaltered under a wide range of pH and can be effective in various water types. Onsite sampling and probing of Cr (VI) in tannery wastewater has been performed to validate its real-life efficiency that yields excellent results. The sensor can effectively detect chromium at a cellular level (HeLa cells) in a similar way as the bright blue fluorescence diminishes in presence of the quenching ion. Experimental in vitro studies along with theoretical docking analysis has been conducted to substantiate such issues and a higher possibility of fluorophore binding was found for Isoleucine (2.9 Å), Serine (2.96 Å), and Glycine (3.16 Å). This biocompatible sensor rapidly senses hexavalent chromium in living cells, which makes this efficient probe a true heavy metal-induced carcinogen sensor.
    MeSH term(s) Aluminum Silicates ; Carbon ; Chromium/analysis ; HeLa Cells ; Humans ; Nanoparticles ; Waste Water/analysis ; Water Pollutants, Chemical/analysis
    Chemical Substances Aluminum Silicates ; Waste Water ; Water Pollutants, Chemical ; Chromium (0R0008Q3JB) ; kyanite (1302-76-7) ; Carbon (7440-44-0)
    Language English
    Publishing date 2022-02-19
    Publishing country England
    Document type Journal Article
    ZDB-ID 210413-1
    ISSN 1873-3557 ; 0370-8322 ; 0584-8539 ; 1386-1425
    ISSN (online) 1873-3557
    ISSN 0370-8322 ; 0584-8539 ; 1386-1425
    DOI 10.1016/j.saa.2022.121061
    Database MEDical Literature Analysis and Retrieval System OnLINE

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