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  1. Article ; Online: Pediatric Plastic Surgery Under Local Anesthesia.

    LaGuardia, Jonnby S / Ali-Khan, Safi / LaBarge, Dalton / Morrison, Clinton

    Annals of plastic surgery

    2024  Volume 92, Issue 5S Suppl 3, Page(s) S352–S354

    Abstract: Background: Increasing research has shown that select surgical procedures can be performed in an office-based environment with low complication rates. Within the field of plastic surgery, these findings have mainly been studied in adult populations. ... ...

    Abstract Background: Increasing research has shown that select surgical procedures can be performed in an office-based environment with low complication rates. Within the field of plastic surgery, these findings have mainly been studied in adult populations. However, studies regarding the safety and efficacy of office-based plastic surgery in the pediatric population are lacking. In the present study, we demonstrate that appropriately selected office-based pediatric plastic surgery procedures can be performed under local anesthesia for a variety of common surgical indications with low complication rates.
    Methods: A retrospective case series of pediatric plastic surgery patients who underwent in-office procedures under local anesthesia at a single academic institution from September 2014 to June 2020 was performed.
    Results: Five hundred nine patients were treated in an office setting for various etiologies over the study period. A total of 48.9% of the patients were male and 51.1% were female. Patient age at time of procedure ranged from 24 days to 17 years of age with a median age of 13 years. A total of 778 lesions were treated. There were 10 total complications (1.29%) over the study period with only one surgical site infection that resolved with antibiotic treatment.
    Conclusions: Our work indicates that select pediatric plastic surgery procedures can be performed under local anesthesia with low complication rates.
    MeSH term(s) Humans ; Female ; Anesthesia, Local/methods ; Male ; Retrospective Studies ; Child ; Adolescent ; Child, Preschool ; Infant ; Plastic Surgery Procedures/methods ; Ambulatory Surgical Procedures/methods ; Infant, Newborn ; Postoperative Complications/epidemiology
    Language English
    Publishing date 2024-04-30
    Publishing country United States
    Document type Journal Article
    ZDB-ID 423835-7
    ISSN 1536-3708 ; 0148-7043
    ISSN (online) 1536-3708
    ISSN 0148-7043
    DOI 10.1097/SAP.0000000000003798
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    Zs.A 1419: Show issues Location:
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  2. Article ; Online: Evaluation of peripheral nerve regeneration in Murphy Roths Large mouse strain following transection injury.

    Milek, David / Echternacht, Scott R / LaGuardia, Jonnby / LaBarge, Dalton / Turpin, Loel / Grobbelaar, Adriaan / Leckenby, Jonathan I

    Regenerative medicine

    2022  Volume 18, Issue 1, Page(s) 37–53

    Abstract: Aim: ...

    Abstract Aim:
    MeSH term(s) Male ; Mice ; Animals ; Mice, Inbred C57BL ; Nerve Regeneration
    Language English
    Publishing date 2022-10-18
    Publishing country England
    Document type Journal Article ; Research Support, N.I.H., Extramural
    ZDB-ID 2274500-2
    ISSN 1746-076X ; 1746-0751
    ISSN (online) 1746-076X
    ISSN 1746-0751
    DOI 10.2217/rme-2022-0098
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  3. Article ; Online: Dendritic cell analysis in primary immunodeficiency.

    Bigley, Venetia / Barge, Dawn / Collin, Matthew

    Current opinion in allergy and clinical immunology

    2016  Volume 16, Issue 6, Page(s) 530–540

    Abstract: Purpose of review: Dendritic cells are specialized antigen-presenting cells which link innate and adaptive immunity, through recognition and presentation of antigen to T cells. Although the importance of dendritic cells has been demonstrated in many ... ...

    Abstract Purpose of review: Dendritic cells are specialized antigen-presenting cells which link innate and adaptive immunity, through recognition and presentation of antigen to T cells. Although the importance of dendritic cells has been demonstrated in many animal models, their contribution to human immunity remains relatively unexplored in vivo.Given their central role in infection, autoimmunity, and malignancy, dendritic cell deficiency or dysfunction would be expected to have clinical consequences.
    Recent findings: Human dendritic cell deficiency disorders, related to GATA binding protein 2 (GATA2) and interferon regulatory factor 8 (IRF8) mutations, have highlighted the importance of dendritic cells and monocytes in primary immunodeficiency diseases and begun to shed light on their nonredundant roles in host defense and immune regulation in vivo. The contribution of dendritic cell and monocyte dysfunction to the pathogenesis of primary immunodeficiency disease phenotypes is becoming increasingly apparent. However, dendritic cell analysis is not yet a routine part of primary immunodeficiency disease workup.
    Summary: Widespread uptake of dendritic cell/monocyte screening in clinical practice will facilitate the discovery of novel dendritic cell and monocyte disorders as well as advancing our understanding of human dendritic cell biology in health and disease.
    MeSH term(s) Adaptive Immunity ; Animals ; Antigen Presentation ; Autoimmunity ; Dendritic Cells/physiology ; GATA2 Transcription Factor/genetics ; Humans ; Immunologic Deficiency Syndromes/genetics ; Immunologic Deficiency Syndromes/immunology ; Interferon Regulatory Factors/genetics ; Monocytes/physiology ; Mutation/genetics ; T-Lymphocytes/immunology
    Chemical Substances GATA2 Transcription Factor ; GATA2 protein, human ; Interferon Regulatory Factors ; interferon regulatory factor-8
    Language English
    Publishing date 2016-10-20
    Publishing country United States
    Document type Journal Article ; Review ; Research Support, Non-U.S. Gov't
    ZDB-ID 2088710-3
    ISSN 1473-6322 ; 1528-4050
    ISSN (online) 1473-6322
    ISSN 1528-4050
    DOI 10.1097/ACI.0000000000000322
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  4. Article ; Online: Urinary and renal oxygenation during dexmedetomidine infusion in critically ill adults with mechanistic insights from an ovine model.

    Plummer, Mark P / Lankadeva, Yugeesh R / Finnis, Mark E / Harrois, Anatole / Harding, Charlie / Peiris, Rachel M / Okazaki, Nobuki / May, Clive N / Evans, Roger G / Macisaac, Christopher M / Barge, Deborah / Bellomo, Rinaldo / Deane, Adam M

    Journal of critical care

    2021  Volume 64, Page(s) 74–81

    Abstract: Purpose: Examine effects of dexmedetomidine on bladder urinary oxygen tension (PuO: Materials and methods: In 12 critically ill patients: oxygen-sensing probe inserted in the bladder catheter and dexmedetomidine infusion at a mean (SD) rate of 0.9 ± ... ...

    Abstract Purpose: Examine effects of dexmedetomidine on bladder urinary oxygen tension (PuO
    Materials and methods: In 12 critically ill patients: oxygen-sensing probe inserted in the bladder catheter and dexmedetomidine infusion at a mean (SD) rate of 0.9 ± 0.3 μg/kg/h for 24-h. In 9 sheep: implantation of flow probes around the renal and pulmonary arteries, and oxygen-sensing probes in the renal cortex, renal medulla and bladder catheter; dexmedetomidine infusion at 0.5 μg/kg/h for 4-h and 1.0 μg/kg/h for 4-h then 16 h observation.
    Results: In patients, dexmedetomidine decreased bladder PuO
    Conclusions: Dexmedetomidine decreases PuO
    MeSH term(s) Adult ; Animals ; Critical Illness ; Dexmedetomidine ; Humans ; Kidney ; Oxygen ; Renal Circulation ; Sheep
    Chemical Substances Dexmedetomidine (67VB76HONO) ; Oxygen (S88TT14065)
    Language English
    Publishing date 2021-03-24
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 632818-0
    ISSN 1557-8615 ; 0883-9441
    ISSN (online) 1557-8615
    ISSN 0883-9441
    DOI 10.1016/j.jcrc.2021.03.004
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  5. Article ; Online: Flow cytometric analysis of TCR Vβ repertoire in patients with 22q11.2 deletion syndrome.

    McLean-Tooke, A / Barge, D / Spickett, G P / Gennery, A R

    Scandinavian journal of immunology

    2011  Volume 73, Issue 6, Page(s) 577–585

    Abstract: In 22q11.2 deletion patients, the normal decrease in T lymphocyte counts after 1-2 years is blunted such that relatively T lymphocyte numbers increase over early childhood, probably via post-thymic expansion of peripheral lymphocytes. This may leave less ...

    Abstract In 22q11.2 deletion patients, the normal decrease in T lymphocyte counts after 1-2 years is blunted such that relatively T lymphocyte numbers increase over early childhood, probably via post-thymic expansion of peripheral lymphocytes. This may leave less T lymphocyte receptor (TCR) diversity than when derived from naive thymic emigrants. We analysed TCR Vβ repertoire on 27 22q11.2 chromosome deletion patients. No patient had infection at sampling. CD3(+) CD4(+) recent thymic emigrants (RTEs) were identified by CD45RA and CD31 expression. TCR Vβ repertoire was determined using four-colour flow cytometry. Patients and controls showed significant TCR Vβ family usage differences between CD3(+) CD4(+) and CD3(+) CD4(-) T lymphocyte subpopulations. Vβ family abnormalities (±3 SD of controls) were identified in 18/27 (67%) patients and 12/47 (25%) controls. In patients, the magnitude of expansions was increased, with some Vβ families representing 37% of the cells present in the subpopulations. There was a significant increase in frequency of abnormalities in CD3(+) CD4(+) (P < 0.001) and CD3(+) CD4(-) T lymphocytes (P < 0.05) in patients. A total of 11/16 patients had an abnormal CD4(+) CD25(Bright) TCR Vβ repertoire. There was no difference in expansions/contractions between CD4(+) CD25(Bright) and CD4(+) T lymphocyte repertoires (P = 0.575) for individual patients but significant differences in expansions/contractions between CD4(+) CD25(Bright) and CD8(+) T lymphocytes repertoires (P = 0.011). There was bias in Vβ usage between CD3(+) CD4(+) and CD3(+) CD4(-) T lymphocyte subsets. A total of 67% patients had TCR Vβ repertoire abnormalities, with a trend towards increased repertoire abnormalities with fewer RTEs, suggesting thymic output plays an important role in TCR repertoire diversity. There was no correlation between skewed repertoire and symptoms of infection or autoimmunity.
    MeSH term(s) Adolescent ; CD4-Positive T-Lymphocytes/immunology ; CD8-Positive T-Lymphocytes/immunology ; Child ; Child, Preschool ; DiGeorge Syndrome/genetics ; DiGeorge Syndrome/immunology ; Flow Cytometry ; Humans ; Immunophenotyping/methods ; Infant ; Receptors, Antigen, T-Cell, alpha-beta/genetics ; Receptors, Antigen, T-Cell, alpha-beta/immunology ; Statistics, Nonparametric
    Chemical Substances Receptors, Antigen, T-Cell, alpha-beta
    Language English
    Publishing date 2011-06
    Publishing country England
    Document type Journal Article
    ZDB-ID 120476-2
    ISSN 1365-3083 ; 0300-9475
    ISSN (online) 1365-3083
    ISSN 0300-9475
    DOI 10.1111/j.1365-3083.2011.02527.x
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    Zs.A 806: Show issues Location:
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  6. Article ; Online: Testing an mHealth momentary assessment Routine Outcome Monitoring application: a focus on restoration of daily life positive mood states.

    van Os, Jim / Delespaul, Philippe / Barge, Daniela / Bakker, Roberto P

    PloS one

    2014  Volume 9, Issue 12, Page(s) e115254

    Abstract: Background: Routine Outcome Monitoring (ROM) is used as a means to enrich the process of treatment with feedback on patient outcomes, facilitating patient involvement and shared decision making. While traditional ROM measures focus on retrospective ... ...

    Abstract Background: Routine Outcome Monitoring (ROM) is used as a means to enrich the process of treatment with feedback on patient outcomes, facilitating patient involvement and shared decision making. While traditional ROM measures focus on retrospective accounts of symptoms, novel mHealth technology makes it possible to collect real life, in-the-moment ambulatory data that allow for an ecologically valid assessment of personalized and contextualized emotional and behavioural adjustment in the flow daily life (mROM).
    Method: In a sample of 34 patients with major depressive disorder, treated with antidepressants, the combined effect of treatment and natural course was examined over a period of 18 weeks with Ecological Momentary Assessment (EMA). EMA consisted of repeated, within-subject, mini-measurements of experience (eg positive affect, negative affect, medication side effects) and context (eg stressors, situations, activities) at 10 unselected semi-random moments per day, for a period of six days, repeated three times over the 18-week period (baseline, week 6 and week 18).
    Results: EMA measures of emotional and behavioural adjustment were sensitive to the effects of treatment and natural course over the 18-week period, particularly EMA measures focussing on positive mood states and the ability to use natural rewards (impact of positive events on positive mood states), with standardized effect sizes of 0.4-0.5. EMA measures of activities, social interaction, stress-sensitivity and negative mood states were also sensitive to change over time.
    Conclusion: This study supports the use of mROM as a means to involve the patient in the process of needs assessment and treatment. EMA data are meaningful to the patient, as they reflect daily life circumstances. Assessment of treatment response with mROM data allows for an interpretation of the effect of treatment at the level of daily life emotional and social adjustment--as an index of health, obviating the need for an exclusive focus on traditional measures of 'sickness'.
    MeSH term(s) Adult ; Affect/physiology ; Antidepressive Agents/therapeutic use ; Computer Systems ; Depressive Disorder, Major/drug therapy ; Humans ; Imipramine ; Middle Aged ; Netherlands ; Patient Outcome Assessment ; Patient Participation/methods ; Time Factors
    Chemical Substances Antidepressive Agents ; Imipramine (OGG85SX4E4)
    Language English
    Publishing date 2014-12-16
    Publishing country United States
    Document type Journal Article ; Randomized Controlled Trial
    ZDB-ID 2267670-3
    ISSN 1932-6203 ; 1932-6203
    ISSN (online) 1932-6203
    ISSN 1932-6203
    DOI 10.1371/journal.pone.0115254
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  7. Article ; Online: Efficiency and Health Economic Evaluations of BD OneFlow™ Flow Cytometry Reagents for Diagnosing Chronic Lymphoid Leukemia.

    Moloney, Eoin / Watson, Helen / Barge, Dawn / Allen, A Joy / Carey, Peter / Hislop, Jennifer / Johnston, Louise / Lorrison, Kate / McGregor, Andrew / O'Leary, Rachel A / Power, Michael H / Wallis, Jonathan / Simpson, A John / Greystoke, Brigit

    Cytometry. Part B, Clinical cytometry

    2019  Volume 96, Issue 6, Page(s) 514–520

    Abstract: Reason for the study: To standardize the use of flow cytometry for classifying hematological malignancies and make the results reliable and reproducible across laboratories, the EuroFlow™ Consortium published a comprehensive specification of antibody- ... ...

    Abstract Reason for the study: To standardize the use of flow cytometry for classifying hematological malignancies and make the results reliable and reproducible across laboratories, the EuroFlow™ Consortium published a comprehensive specification of antibody-fluorochrome conjugates, standard protocols, and algorithms for analysis. The BD OneFlow™ system builds on, and further standardizes, the EuroFlow protocols. We aimed to assess the effects on safety, efficiency, and costs for laboratories of adopting the BD OneFlow reagent tubes (LST and B-CLPD T1) for diagnosing chronic lymphocytic leukemia.
    Methods: We compared in-house laboratory processes and results with those using the LST and B-CLPD T1 reagent tubes with, and without, blood film morphology. Outcome measures included concordance in classification results, and efficiency within the laboratory, that is, resource usage, staff time, unwanted events, and cost-consequences.
    Results: There was 100% concordance between the classifications made with in-house flow cytometry and those with the BD OneFlow reagent tubes. Using BD OneFlow tubes required 13 hours less staff time per month (i.e. for 100 samples) than the in-house process. Sensitivity analyses explored the effects of uncertainties in the price of the BD OneFlow tubes and the prevalence of CLL and identified the thresholds at which laboratories might expect cost-savings from adopting the BD OneFlow system. Laboratory and clinical staff considered the BD OneFlow system to be safe and effective.
    Conclusions: Laboratories adopting the BD OneFlow system for classifying patients with suspected CLL can expect safe, efficient processes that can be cost saving if the discount on the list price, and prevalence of CLL (which will both vary between sites and countries), is within the thresholds suggested by the health economics sensitivity analysis. © 2019 International Clinical Cytometry Society.
    MeSH term(s) Flow Cytometry/economics ; Humans ; Immunophenotyping/economics ; Indicators and Reagents/chemistry ; Leukemia, Lymphocytic, Chronic, B-Cell/diagnosis
    Chemical Substances Indicators and Reagents
    Language English
    Publishing date 2019-04-02
    Publishing country United States
    Document type Evaluation Study ; Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2099657-3
    ISSN 1552-4957 ; 1552-4949 ; 0196-4763
    ISSN (online) 1552-4957
    ISSN 1552-4949 ; 0196-4763
    DOI 10.1002/cyto.b.21779
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    Zs.A 1688: Show issues Location:
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  8. Article ; Online: T cell receptor Vbeta repertoire of T lymphocytes and T regulatory cells by flow cytometric analysis in healthy children.

    McLean-Tooke, A / Barge, D / Spickett, G P / Gennery, A R

    Clinical and experimental immunology

    2007  Volume 151, Issue 1, Page(s) 190–198

    Abstract: Evaluation of the T cell receptor (TCR) Vbeta repertoire by flow cytometric analysis has been used for studying the T cell compartments for diseases in which T cells are implicated in the pathogenesis. For the interpretation of these studies information ... ...

    Abstract Evaluation of the T cell receptor (TCR) Vbeta repertoire by flow cytometric analysis has been used for studying the T cell compartments for diseases in which T cells are implicated in the pathogenesis. For the interpretation of these studies information is needed about Vbeta usage in healthy individuals and there are few data for normal usage in paediatric populations. We examined the T lymphocyte (sub)populations in 47 healthy controls (age range: 3 months-16 years). We found non-random Vbeta usage with skewed reactivity of some families towards CD4+ or CD4- T cells. Importantly, there appeared to be no significant change in Vbeta usage according to age group. Some controls showed expansions in some Vbeta families, although incidence of such expansions was low. We went on to examine the repertoire of CD4+CD25(Bright) T regulatory cells in 25 healthy controls. We found overlapping quantitative usage for each of the Vbeta families between CD4+CD25- and CD4+CD25(Bright) T cells. However, there was a significant preferential usage for five Vbeta families and decreased usage of two Vbeta families in the CD4+CD25(Bright) T cells, suggesting that although they overlap there may be subtle but important differences in the TCR repertoire of T regulatory cells.
    MeSH term(s) Adolescent ; Aging/immunology ; CD3 Complex/immunology ; Child ; Child, Preschool ; Female ; Flow Cytometry ; Humans ; Infant ; Interleukin-2 Receptor alpha Subunit/immunology ; Male ; Receptors, Antigen, T-Cell, alpha-beta/analysis ; T-Lymphocyte Subsets/immunology ; T-Lymphocyte Subsets/metabolism ; T-Lymphocytes/immunology ; T-Lymphocytes/metabolism ; T-Lymphocytes, Regulatory/immunology ; T-Lymphocytes, Regulatory/metabolism
    Chemical Substances CD3 Complex ; Interleukin-2 Receptor alpha Subunit ; Receptors, Antigen, T-Cell, alpha-beta
    Language English
    Publishing date 2007-11-05
    Publishing country England
    Document type Journal Article
    ZDB-ID 218531-3
    ISSN 1365-2249 ; 0009-9104 ; 0964-2536
    ISSN (online) 1365-2249
    ISSN 0009-9104 ; 0964-2536
    DOI 10.1111/j.1365-2249.2007.03536.x
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  9. Article ; Online: Graves' immune reconstitution inflammatory syndrome in childhood.

    Sinha, Akash / Abinun, Mario / Gennery, Andrew R / Barge, Dawn / Slatter, Mary / Cheetham, Tim

    Thyroid : official journal of the American Thyroid Association

    2013  Volume 23, Issue 8, Page(s) 1010–1014

    Abstract: Background: The use of hematopoietic stem cell transplantations (HSCTs) as a curative therapy for life-threatening immunodeficiencies has had a profound impact on clinical outcomes. A subset of patients may experience immune reconstitution inflammatory ... ...

    Abstract Background: The use of hematopoietic stem cell transplantations (HSCTs) as a curative therapy for life-threatening immunodeficiencies has had a profound impact on clinical outcomes. A subset of patients may experience immune reconstitution inflammatory syndrome (IRIS) post-transplant affecting the thyroid gland, but this has received little attention in the pediatric literature. We present the clinical, biochemical, and cytological course of patients with Graves' disease after HSCT in the pediatric population.
    Patients and methods: Four children (median age 1.5 years, range 2 months-9 years) underwent HSCT. The conditioning regimen included chemotherapy but not radiotherapy. None of the children or their donors had evidence of thyroid disease pre-HSCT or during the follow-up period. Engraftment was uneventful in all, with stable donor T-cell chimerism, and none had evidence of graft-versus-host disease.
    Results: Patients developed Graves' disease soon after undergoing HSCT, with a median time interval between HSCT and Graves' disease of 22 months (range 16-28 months). Graves' disease was diagnosed on the basis of clinical and biochemical parameters, including a suppressed thyrotropin, raised free thyroxine, and raised thyrotropin receptor antibodies. Three patients were hypothyroid initially (suggestive of a Th1 profile) before Graves' disease (suggestive of a Th2 profile). In three patients, the clinical picture changed rapidly with hypothyroidism abruptly followed by profound thyroid hormone excess. The onset of Graves' IRIS coincided with a rapid expansion in naïve and total CD4.
    Conclusions: Immunological dysregulation during T-cell engraftment is the most likely mechanism for developing Graves' IRIS after allogenic HSTC. Clinicians need to be aware that HSCT-engendered immune recovery may result in a particularly aggressive form of autoimmune thyroid disease in children with implications for the developing central nervous system. Careful surveillance of thyroid function post-HSCT is essential.
    MeSH term(s) Child ; Child, Preschool ; Female ; Graves Disease/etiology ; Graves Disease/immunology ; Hematopoietic Stem Cell Transplantation/adverse effects ; Humans ; Immune Reconstitution Inflammatory Syndrome/etiology ; Immune Reconstitution Inflammatory Syndrome/immunology ; Infant ; Male ; Young Adult
    Language English
    Publishing date 2013-08
    Publishing country United States
    Document type Case Reports ; Journal Article
    ZDB-ID 1086044-7
    ISSN 1557-9077 ; 1050-7256
    ISSN (online) 1557-9077
    ISSN 1050-7256
    DOI 10.1089/thy.2012.0618
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  10. Article: Lymphocyte subset populations in children with polysaccharide antibody deficiency following cardiac transplantation.

    Gennery, A R / Barge, D / Spickett, G P / Cant, A J

    Journal of clinical immunology

    2001  Volume 21, Issue 1, Page(s) 37–42

    Abstract: Pneumococcal polysaccharide (PPS) antibody deficiency occurs in some children immunosuppressed following cardiac transplantation in early childhood. We studied lymphocyte subset populations in these children to identify patterns associated with antibody ... ...

    Abstract Pneumococcal polysaccharide (PPS) antibody deficiency occurs in some children immunosuppressed following cardiac transplantation in early childhood. We studied lymphocyte subset populations in these children to identify patterns associated with antibody deficiency, particularly in CD21 + B cells. Lymphocyte surface markers CD3, CD4, CD8, CD19, and CD21 were measured on whole blood by FACS analysis in four patient groups: cardiac transplant patients who did and did not respond to PPS, nontransplanted cardiac patients, and normal controls. Absolute cell numbers were compared with age-related normal ranges. The proportion of children with values below the age-related 25th percentile in each group was compared. Normal controls had significantly more CD3+, CD8+, and CD19+ cells, even when age-related differences were accounted for. Control groups had significantly more CD19 cells than transplant patients and transplanted PPS responders and cardiac controls had more mature B cells (CD21+) than transplanted PPS nonresponders. PPS antibody deficiency following pediatric cardiac transplantation may be related to an immaturity in B cells due to immunosuppression commenced in early childhood.
    MeSH term(s) Adolescent ; Antibodies, Bacterial/analysis ; B-Lymphocytes/physiology ; Child ; Child, Preschool ; Female ; Heart Transplantation ; Humans ; Immune Tolerance ; Lymphocyte Subsets/immunology ; Male ; Polysaccharides, Bacterial/immunology ; Streptococcus pneumoniae/immunology
    Chemical Substances Antibodies, Bacterial ; Polysaccharides, Bacterial
    Language English
    Publishing date 2001-01
    Publishing country Netherlands
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 779361-3
    ISSN 1573-2592 ; 0271-9142
    ISSN (online) 1573-2592
    ISSN 0271-9142
    DOI 10.1023/a:1006741015452
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