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Article ; Online: Urinary and renal oxygenation during dexmedetomidine infusion in critically ill adults with mechanistic insights from an ovine model.

Plummer, Mark P / Lankadeva, Yugeesh R / Finnis, Mark E / Harrois, Anatole / Harding, Charlie / Peiris, Rachel M / Okazaki, Nobuki / May, Clive N / Evans, Roger G / Macisaac, Christopher M / Barge, Deborah / Bellomo, Rinaldo / Deane, Adam M

Journal of critical care

2021 Volume 64, Page(s) 74–81

Abstract: Purpose: Examine effects of dexmedetomidine on bladder urinary oxygen tension (PuO: Materials and methods: In 12 critically ill patients: oxygen-sensing probe inserted in the bladder catheter and dexmedetomidine infusion at a mean (SD) rate of 0.9 ± ... ...

Abstract	Purpose: Examine effects of dexmedetomidine on bladder urinary oxygen tension (PuO Materials and methods: In 12 critically ill patients: oxygen-sensing probe inserted in the bladder catheter and dexmedetomidine infusion at a mean (SD) rate of 0.9 ± 0.3 μg/kg/h for 24-h. In 9 sheep: implantation of flow probes around the renal and pulmonary arteries, and oxygen-sensing probes in the renal cortex, renal medulla and bladder catheter; dexmedetomidine infusion at 0.5 μg/kg/h for 4-h and 1.0 μg/kg/h for 4-h then 16 h observation. Results: In patients, dexmedetomidine decreased bladder PuO Conclusions: Dexmedetomidine decreases PuO
MeSH term(s)	Adult ; Animals ; Critical Illness ; Dexmedetomidine ; Humans ; Kidney ; Oxygen ; Renal Circulation ; Sheep
Chemical Substances	Dexmedetomidine (67VB76HONO) ; Oxygen (S88TT14065)
Language	English
Publishing date	2021-03-24
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	632818-0
ISSN	1557-8615 ; 0883-9441
ISSN (online)	1557-8615
ISSN	0883-9441
DOI	10.1016/j.jcrc.2021.03.004
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Article ; Online: Dysnatremia and 6-Month Functional Outcomes in Critically Ill Patients With Aneurysmal Subarachnoid Hemorrhage: A Prospective Cohort Study.

Cohen, Jeremy / Delaney, Anthony / Anstey, James / Anstey, Matthew / Barge, Deborah / Bellomo, Rinaldo / Bhardwa, Vishnu / Brinkerhoff, Gail / Board, Jasmin / Campain, Anna / Cooper, D James / Di Tanna, Gian Luca / Finnis, Mark / Fitzgerald, Emily / Flower, Oliver / Healey, Paul / Hunt, Anna / Lawrence, Cassie / Merthens, Jan /

Newby, Lynette / Pearson, David / Raith, Eamon / Robertson, Yvonne / Schweikert, Sacha / Starr, Therese / Tallott, Mandy / van der Poll, Andrew / Young, Paul / Udy, Andrew

Critical care explorations

2021 Volume 3, Issue 6, Page(s) e0445

Abstract: Objectives: To investigate the association between plasma sodium concentrations and 6-month neurologic outcome in critically ill patients with aneurysmal subarachnoid hemorrhage.: Design: Prospective cohort study.: Setting: Eleven ICUs in ... ...

Abstract	Objectives: To investigate the association between plasma sodium concentrations and 6-month neurologic outcome in critically ill patients with aneurysmal subarachnoid hemorrhage. Design: Prospective cohort study. Setting: Eleven ICUs in Australia and New Zealand. Participants: Three-hundred fifty-six aneurysmal subarachnoid hemorrhage patients admitted to ICU between March 2016 and June 2018. The exposure variable was daily measured plasma sodium. Interventions: None. Measurements and main results: Six-month neurologic outcome as measured by the modified Rankin Scale. A poor outcome was defined as a modified Rankin Scale greater than or equal to 4. The mean age was 57 years (± 12.6 yr), 68% were female, and 32% ( Conclusions: In critically ill aneurysmal subarachnoid hemorrhage patients, higher mean sodium concentrations and greater variability were associated with worse neurologic outcomes at 6 months, despite adjustment for known confounders. Interventional studies would be required to demonstrate a causal relationship.
Language	English
Publishing date	2021-06-08
Publishing country	United States
Document type	Journal Article
ISSN	2639-8028
ISSN (online)	2639-8028
DOI	10.1097/CCE.0000000000000445
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Article ; Online: Erratum to "Six-month mortality and functional outcomes in aneurysmal sub-arachnoid haemorrhage patients admitted to intensive care units in Australia and New Zealand: A prospective cohort study" [J. Clin. Neurosci. 80 (2020) 92-99].

Udy, Andrew A / Finnis, Mark / Cohen, Jeremy / Delaney, Anthony / Anstey, James / Anstey, Matthew / Barge, Deborah / Bhardwa, Vishnu / Board, Jasmin / Brinkerhoff, Gail / Fitzgerald, Emily / Flower, Oliver / Healey, Paul M / Hunt, Anna / Lawrence, Cassie / Mehrtens, Jan / Newby, Lynette / Pearson, David / Raith, Eamon P /

Robertson, Yvonne / Schweikert, Sacha / Starr, Therese / Tallott, Mandy / van der Poll, Andrew / Young, Paul / Bellomo, Rinaldo / Cooper, David J

Journal of clinical neuroscience : official journal of the Neurosurgical Society of Australasia

2020 Volume 82, Issue Pt A, Page(s) 192

Language	English
Publishing date	2020-11-20
Publishing country	Scotland
Document type	Published Erratum
ZDB-ID	1193674-5
ISSN	1532-2653 ; 0967-5868
ISSN (online)	1532-2653
ISSN	0967-5868
DOI	10.1016/j.jocn.2020.11.018
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Article ; Online: Targeted therapeutic mild hypercapnia after cardiac arrest: A phase II multi-centre randomised controlled trial (the CCC trial).

Eastwood, Glenn M / Schneider, Antoine G / Suzuki, Satoshi / Peck, Leah / Young, Helen / Tanaka, Aiko / Mårtensson, Johan / Warrillow, Stephen / McGuinness, Shay / Parke, Rachael / Gilder, Eileen / Mccarthy, Lianne / Galt, Pauline / Taori, Gopal / Eliott, Suzanne / Lamac, Tammy / Bailey, Michael / Harley, Nerina / Barge, Deborah /

Hodgson, Carol L / Morganti-Kossmann, Maria Cristina / Pébay, Alice / Conquest, Alison / Archer, John S / Bernard, Stephen / Stub, Dion / Hart, Graeme K / Bellomo, Rinaldo

Resuscitation

2016 Volume 104, Page(s) 83–90

Abstract: Background: In intensive care observational studies, hypercapnia after cardiac arrest (CA) is independently associated with improved neurological outcome. However, the safety and feasibility of delivering targeted therapeutic mild hypercapnia (TTMH) for ...

Abstract	Background: In intensive care observational studies, hypercapnia after cardiac arrest (CA) is independently associated with improved neurological outcome. However, the safety and feasibility of delivering targeted therapeutic mild hypercapnia (TTMH) for such patients is untested. Methods: In a phase II safety and feasibility multi-centre, randomised controlled trial, we allocated ICU patients after CA to 24h of targeted normocapnia (TN) (PaCO2 35-45mmHg) or TTMH (PaCO2 50-55mmHg). The primary outcome was serum neuron specific enolase (NSE) and S100b protein concentrations over the first 72h assessed in the first 50 patients surviving to day three. Secondary end-points included global measure of function assessment at six months and mortality for all patients. Results: We enrolled 86 patients. Their median age was 61 years (58, 64 years) and 66 (79%) were male. Of these, 50 patients (58%) survived to day three for full biomarker assessment. NSE concentrations increased in the TTMH group (p=0.02) and TN group (p=0.005) over time, with the increase being significantly more pronounced in the TN group (p(interaction)=0.04). S100b concentrations decreased over time in the TTMH group (p<0.001) but not in the TN group (p=0.68). However, the S100b change over time did not differ between the groups (p(interaction)=0.23). At six months, 23 (59%) TTMH patients had good functional recovery compared with 18 (46%) TN patients. Hospital mortality occurred in 11 (26%) TTMH patients and 15 (37%) TN patients (p=0.31). Conclusions: In CA patients admitted to the ICU, TTMH was feasible, appeared safe and attenuated the release of NSE compared with TN. These findings justify further investigation of this novel treatment.
MeSH term(s)	Analysis of Variance ; Biomarkers/blood ; Female ; Glasgow Coma Scale ; Heart Arrest/mortality ; Heart Arrest/physiopathology ; Heart Arrest/therapy ; Humans ; Hypercapnia ; Intensive Care Units ; Length of Stay ; Male ; Middle Aged ; Phosphopyruvate Hydratase/blood ; Respiration, Artificial/methods ; S100 Calcium Binding Protein beta Subunit/blood
Chemical Substances	Biomarkers ; S100 Calcium Binding Protein beta Subunit ; S100B protein, human ; Phosphopyruvate Hydratase (EC 4.2.1.11)
Language	English
Publishing date	2016-07
Publishing country	Ireland
Document type	Clinical Trial, Phase II ; Journal Article ; Multicenter Study ; Randomized Controlled Trial
ZDB-ID	189901-6
ISSN	1873-1570 ; 0300-9572
ISSN (online)	1873-1570
ISSN	0300-9572
DOI	10.1016/j.resuscitation.2016.03.023
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Article ; Online: Effect of Hydrocortisone on Mortality and Organ Support in Patients With Severe COVID-19: The REMAP-CAP COVID-19 Corticosteroid Domain Randomized Clinical Trial.

Angus, Derek C / Derde, Lennie / Al-Beidh, Farah / Annane, Djillali / Arabi, Yaseen / Beane, Abigail / van Bentum-Puijk, Wilma / Berry, Lindsay / Bhimani, Zahra / Bonten, Marc / Bradbury, Charlotte / Brunkhorst, Frank / Buxton, Meredith / Buzgau, Adrian / Cheng, Allen C / de Jong, Menno / Detry, Michelle / Estcourt, Lise / Fitzgerald, Mark /

Goossens, Herman / Green, Cameron / Haniffa, Rashan / Higgins, Alisa M / Horvat, Christopher / Hullegie, Sebastiaan J / Kruger, Peter / Lamontagne, Francois / Lawler, Patrick R / Linstrum, Kelsey / Litton, Edward / Lorenzi, Elizabeth / Marshall, John / McAuley, Daniel / McGlothin, Anna / McGuinness, Shay / McVerry, Bryan / Montgomery, Stephanie / Mouncey, Paul / Murthy, Srinivas / Nichol, Alistair / Parke, Rachael / Parker, Jane / Rowan, Kathryn / Sanil, Ashish / Santos, Marlene / Saunders, Christina / Seymour, Christopher / Turner, Anne / van de Veerdonk, Frank / Venkatesh, Balasubramanian / Zarychanski, Ryan / Berry, Scott / Lewis, Roger J / McArthur, Colin / Webb, Steven A / Gordon, Anthony C / Angus, Derek / Cheng, Allen / De Jong, Menno / Gordon, Anthony / Lawler, Patrick / Webb, Steve / Campbell, Lewis / Forbes, Andrew / Gattas, David / Heritier, Stephane / Higgins, Lisa / Peake, Sandra / Presneill, Jeffrey / Seppelt, Ian / Trapani, Tony / Young, Paul / Bagshaw, Sean / Daneman, Nick / Ferguson, Niall / Misak, Cheryl / Hullegie, Sebastiaan / Pletz, Mathias / Rohde, Gernot / Rowan, Kathy / Alexander, Brian / Basile, Kim / Girard, Timothy / Huang, David / Vates, Jennifer / Beasley, Richard / Fowler, Robert / McGloughlin, Steve / Morpeth, Susan / Paterson, David / Venkatesh, Bala / Uyeki, Tim / Baillie, Kenneth / Duffy, Eamon / Fowler, Rob / Hills, Thomas / Orr, Katrina / Patanwala, Asad / Tong, Steve / Netea, Mihai / Bihari, Shilesh / Carrier, Marc / Fergusson, Dean / Goligher, Ewan / Haidar, Ghady / Hunt, Beverley / Kumar, Anand / Laffan, Mike / Lawless, Patrick / Lother, Sylvain / McCallum, Peter / Middeldopr, Saskia / McQuilten, Zoe / Neal, Matthew / Pasi, John / Schutgens, Roger / Stanworth, Simon / Turgeon, Alexis / Weissman, Alexandra / Adhikari, Neill / Anstey, Matthew / Brant, Emily / de Man, Angelique / Lamonagne, Francois / Masse, Marie-Helene / Udy, Andrew / Arnold, Donald / Begin, Phillipe / Charlewood, Richard / Chasse, Michael / Coyne, Mark / Cooper, Jamie / Daly, James / Gosbell, Iain / Harvala-Simmonds, Heli / Hills, Tom / MacLennan, Sheila / Menon, David / McDyer, John / Pridee, Nicole / Roberts, David / Shankar-Hari, Manu / Thomas, Helen / Tinmouth, Alan / Triulzi, Darrell / Walsh, Tim / Wood, Erica / Calfee, Carolyn / O’Kane, Cecilia / Shyamsundar, Murali / Sinha, Pratik / Thompson, Taylor / Young, Ian / Bihari, Shailesh / Hodgson, Carol / Laffey, John / McAuley, Danny / Orford, Neil / Neto, Ary / Lewis, Roger / McGlothlin, Anna / Miller, Eliza / Singh, Vanessa / Zammit, Claire / van Bentum Puijk, Wilma / Bouwman, Wietske / Mangindaan, Yara / Parker, Lorraine / Peters, Svenja / Rietveld, Ilse / Raymakers, Kik / Ganpat, Radhika / Brillinger, Nicole / Markgraf, Rene / Ainscough, Kate / Brickell, Kathy / Anjum, Aisha / Lane, Janis-Best / Richards-Belle, Alvin / Saull, Michelle / Wiley, Daisy / Bion, Julian / Connor, Jason / Gates, Simon / Manax, Victoria / van der Poll, Tom / Reynolds, John / van Beurden, Marloes / Effelaar, Evelien / Schotsman, Joost / Boyd, Craig / Harland, Cain / Shearer, Audrey / Wren, Jess / Clermont, Giles / Garrard, William / Kalchthaler, Kyle / King, Andrew / Ricketts, Daniel / Malakoutis, Salim / Marroquin, Oscar / Music, Edvin / Quinn, Kevin / Cate, Heidi / Pearson, Karen / Collins, Joanne / Hanson, Jane / Williams, Penny / Jackson, Shane / Asghar, Adeeba / Dyas, Sarah / Sutu, Mihaela / Murphy, Sheenagh / Williamson, Dawn / Mguni, Nhlanhla / Potter, Alison / Porter, David / Goodwin, Jayne / Rook, Clare / Harrison, Susie / Williams, Hannah / Campbell, Hilary / Lomme, Kaatje / Williamson, James / Sheffield, Jonathan / van’t Hoff, Willian / McCracken, Phobe / Young, Meredith / Board, Jasmin / Mart, Emma / Knott, Cameron / Smith, Julie / Boschert, Catherine / Affleck, Julia / Ramanan, Mahesh / D’Souza, Ramsy / Pateman, Kelsey / Shakih, Arif / Cheung, Winston / Kol, Mark / Wong, Helen / Shah, Asim / Wagh, Atul / Simpson, Joanne / Duke, Graeme / Chan, Peter / Cartner, Brittney / Hunter, Stephanie / Laver, Russell / Shrestha, Tapaswi / Regli, Adrian / Pellicano, Annamaria / McCullough, James / Tallott, Mandy / Kumar, Nikhil / Panwar, Rakshit / Brinkerhoff, Gail / Koppen, Cassandra / Cazzola, Federica / Brain, Matthew / Mineall, Sarah / Fischer, Roy / Biradar, Vishwanath / Soar, Natalie / White, Hayden / Estensen, Kristen / Morrison, Lynette / Smith, Joanne / Cooper, Melanie / Health, Monash / Shehabi, Yahya / Al-Bassam, Wisam / Hulley, Amanda / Whitehead, Christina / Lowrey, Julie / Gresha, Rebecca / Walsham, James / Meyer, Jason / Harward, Meg / Venz, Ellen / Williams, Patricia / Kurenda, Catherine / Smith, Kirsy / Smith, Margaret / Garcia, Rebecca / Barge, Deborah / Byrne, Deborah / Byrne, Kathleen / Driscoll, Alana / Fortune, Louise / Janin, Pierre / Yarad, Elizabeth / Hammond, Naomi / Bass, Frances / Ashelford, Angela / Waterson, Sharon / Wedd, Steve / McNamara, Robert / Buhr, Heidi / Coles, Jennifer / Schweikert, Sacha / Wibrow, Bradley / Rauniyar, Rashmi / Myers, Erina / Fysh, Ed / Dawda, Ashlish / Mevavala, Bhaumik / Litton, Ed / Ferrier, Janet / Nair, Priya / Buscher, Hergen / Reynolds, Claire / Santamaria, John / Barbazza, Leanne / Homes, Jennifer / Smith, Roger / Murray, Lauren / Brailsford, Jane / Forbes, Loretta / Maguire, Teena / Mariappa, Vasanth / Smith, Judith / Simpson, Scott / Maiden, Matthew / Bone, Allsion / Horton, Michelle / Salerno, Tania / Sterba, Martin / Geng, Wenli / Depuydt, Pieter / De Waele, Jan / De Bus, Liesbet / Fierens, Jan / Bracke, Stephanie / Reeve, Brenda / Dechert, William / Chassé, Michaël / Carrier, François Martin / Boumahni, Dounia / Benettaib, Fatna / Ghamraoui, Ali / Bellemare, David / Cloutier, Ève / Francoeur, Charles / Lamontagne, François / D’Aragon, Frédérick / Carbonneau, Elaine / Leblond, Julie / Vazquez-Grande, Gloria / Marten, Nicole / Wilson, Maggie / Albert, Martin / Serri, Karim / Cavayas, Alexandros / Duplaix, Mathilde / Williams, Virginie / Rochwerg, Bram / Karachi, Tim / Oczkowski, Simon / Centofanti, John / Millen, Tina / Duan, Erick / Tsang, Jennifer / Patterson, Lisa / English, Shane / Watpool, Irene / Porteous, Rebecca / Miezitis, Sydney / McIntyre, Lauralyn / Brochard, Laurent / Burns, Karen / Sandhu, Gyan / Khalid, Imrana / Binnie, Alexandra / Powell, Elizabeth / McMillan, Alexandra / Luk, Tracy / Aref, Noah / Andric, Zdravko / Cviljevic, Sabina / Đimoti, Renata / Zapalac, Marija / Mirković, Gordan / Baršić, Bruno / Kutleša, Marko / Kotarski, Viktor / Vujaklija Brajković, Ana / Babel, Jakša / Sever, Helena / Dragija, Lidija / Kušan, Ira / Vaara, Suvi / Pettilä, Leena / Heinonen, Jonna / Kuitunen, Anne / Karlsson, Sari / Vahtera, Annukka / Kiiski, Heikki / Ristimäki, Sanna / Azaiz, Amine / Charron, Cyril / Godement, Mathieu / Geri, Guillaume / Vieillard-Baron, Antoine / Pourcine, Franck / Monchi, Mehran / Luis, David / Mercier, Romain / Sagnier, Anne / Verrier, Nathalie / Caplin, Cecile / Siami, Shidasp / Aparicio, Christelle / Vautier, Sarah / Jeblaoui, Asma / Fartoukh, Muriel / Courtin, Laura / Labbe, Vincent / Leparco, Cécile / Muller, Grégoire / Nay, Mai-Anh / Kamel, Toufik / Benzekri, Dalila / Jacquier, Sophie / Mercier, Emmanuelle / Chartier, Delphine / Salmon, Charlotte / Dequin, PierreFrançois / Schneider, Francis / Morel, Guillaume / L’Hotellier, Sylvie / Badie, Julio / Berdaguer, Fernando Daniel / Malfroy, Sylvain / Mezher, Chaouki / Bourgoin, Charlotte / Megarbane, Bruno / Voicu, Sebastian / Deye, Nicolas / Malissin, Isabelle / Sutterlin, Laetitia / Guitton, Christophe / Darreau, Cédric / Landais, Mickaël / Chudeau, Nicolas / Robert, Alain / Moine, Pierre / Heming, Nicholas / Maxime, Virginie / Bossard, Isabelle / Nicholier, Tiphaine Barbarin / Colin, Gwenhael / Zinzoni, Vanessa / Maquigneau, Natacham / Finn, André / Kreß, Gabriele / Hoff, Uwe / Friedrich Hinrichs, Carl / Nee, Jens / Hagel, Stefan / Ankert, Juliane / Kolanos, Steffi / Bloos, Frank / Petros, Sirak / Pasieka, Bastian / Kunz, Kevin / Appelt, Peter / Schütze, Bianka / Kluge, Stefan / Nierhaus, Axel / Jarczak, Dominik / Roedl, Kevin / Weismann, Dirk / Frey, Anna / Klinikum Neukölln, Vivantes / Reill, Lorenz / Distler, Michael / Maselli, Astrid / Bélteczki, János / Magyar, István / Fazekas, Ágnes / Kovács, Sándor / Szőke, Viktória / Szigligeti, Gábor / Leszkoven, János / Collins, Daniel / Breen, Patrick / Frohlich, Stephen / Whelan, Ruth / McNicholas, Bairbre / Scully, Michael / Casey, Siobhan / Kernan, Maeve / Doran, Peter / O’Dywer, Michael / Smyth, Michelle / Hayes, Leanne / Hoiting, Oscar / Peters, Marco / Rengers, Els / Evers, Mirjam / Prinssen, Anton / Bosch Ziekenhuis, Jeroen / Simons, Koen / Rozendaal, Wim / Polderman, F / de Jager, P / Moviat, M / Paling, A / Salet, A / Rademaker, Emma / Peters, Anna Linda / de Jonge, E / Wigbers, J / Guilder, E / Butler, M / Cowdrey, Keri-Anne / Newby, Lynette / Chen, Yan / Simmonds, Catherine / McConnochie, Rachael / Ritzema Carter, Jay / Henderson, Seton / Van Der Heyden, Kym / Mehrtens, Jan / Williams, Tony / Kazemi, Alex / Song, Rima / Lai, Vivian / Girijadevi, Dinu / Everitt, Robert / Russell, Robert / Hacking, Danielle / Buehner, Ulrike / Williams, Erin / Browne, Troy / Grimwade, Kate / Goodson, Jennifer / Keet, Owen / Callender, Owen / Martynoga, Robert / Trask, Kara / Butler, Amelia / Schischka, Livia / Young, Chelsea / Lesona, Eden / Olatunji, Shaanti / Robertson, Yvonne / José, Nuno / Amaro dos Santos Catorze, Teodoro / de Lima Pereira, Tiago Nuno Alfaro / Neves Pessoa, Lucilia Maria / Castro Ferreira, Ricardo Manuel / Pereira Sousa Bastos, Joana Margarida / Aysel Florescu, Simin / Stanciu, Delia / Zaharia, Miahela Florentina / Kosa, Alma Gabriela / Codreanu, Daniel / Marabi, Yaseen / Al Qasim, Eman / Moneer Hagazy, Mohamned / Al Swaidan, Lolowa / Arishi, Hatim / Muñoz-Bermúdez, Rosana / Marin-Corral, Judith / Salazar Degracia, Anna / Parrilla Gómez, Francisco / Mateo López, Maria Isabel / Rodriguez Fernandez, Jorge / Cárcel Fernández, Sheila / 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Phoebe / Smee, Joanna / Mackay, Euan / Cort, Jon / Whileman, Amanda / Spencer, Thomas / Spittle, Nick / Kasipandian, Vidya / Patel, Amit / Allibone, Suzanne / Genetu, Roman Mary / Ramali, Mohamed / Ghosh, Alison / Bamford, Peter / London, Emily / Cawley, Kathryn / Faulkner, Maria / Jeffrey, Helen / Smith, Tim / Brewer, Chris / Gregory, Jane / Limb, James / Cowton, Amanda / O’Brien, Julie / Nikitas, Nikitas / Wells, Colin / Lankester, Liana / Pulletz, Mark / Birch, Jenny / Wiseman, Sophie / Horton, Sarah / Alegria, Ana / Turki, Salah / Elsefi, Tarek / Crisp, Nikki / Allen, Louise / McCullagh, Iain / Robinson, Philip / Hays, Carole / Babio-Galan, Maite / Stevenson, Hannah / Khare, Divya / Pinder, Meredith / Selvamoni, Selvin / Gopinath, Amitha / Pugh, Richard / Menzies, Daniel / Mackay, Callum / Allan, Elizabeth / Davies, Gwyneth / Puxty, Kathryn / McCue, Claire / Cathcart, Susanne / Hickey, Naomi / Ireland, Jane / Yusuff, Hakeem / Isgro, Graziella / Brightling, Chris / Bourne, Michelle / Craner, Michelle / Watters, Malcolm / Prout, Rachel / Davies, Louisa / Pegler, Suzannah / Kyeremeh, Lynsey / Arbane, Gill / Wilson, Karen / Gomm, Linda / Francia, Federica / Brett, Stephen / Sousa Arias, Sonia / Elin Hall, Rebecca / Budd, Joanna / Small, Charlotte / Birch, Janine / Collins, Emma / Henning, Jeremy / Bonner, Stephen / Hugill, Keith / Cirstea, Emanuel / Wilkinson, Dean / Karlikowski, Michal / Sutherland, Helen / Wilhelmsen, Elva / Woods, Jane / North, Julie / Sundaran, Dhinesh / Hollos, Laszlo / Coburn, Susan / Walsh, Joanne / Turns, Margaret / Hopkins, Phil / Smith, John / Noble, Harriet / Depante, Maria Theresa / Clarey, Emma / Laha, Shondipon / Verlander, Mark / Williams, Alexandra / Huckle, Abby / Hall, Andrew / Cooke, Jill / Gardiner-Hill, Caroline / Maloney, Carolyn / Qureshi, Hafiz / Flint, Neil / Nicholson, Sarah / Southin, Sara / Nicholson, Andrew / Borgatta, Barbara / Turner-Bone, Ian / Reddy, Amie / Wilding, Laura / Chamara Warnapura, Loku / Agno Sathianathan, Ronan / Golden, David / Hart, Ciaran / Jones, Jo / Bannard-Smith, Jonathan / Henry, Joanne / Birchall, Katie / Pomeroy, Fiona / Quayle, Rachael / Makowski, Arystarch / Misztal, Beata / Ahmed, Iram / KyereDiabour, Thyra / Naiker, Kevin / Stewart, Richard / Mwaura, Esther / Mew, Louise / Wren, Lynn / Willams, Felicity / Innes, Richard / Doble, Patricia / Hutter, Joanne / Shovelton, Charmaine / Plumb, Benjamin / Szakmany, Tamas / Hamlyn, Vincent / Hawkins, Nancy / Lewis, Sarah / Dell, Amanda / Gopal, Shameer / Ganguly, Saibal / Smallwood, Andrew / Harris, Nichola / Metherell, Stella / Lazaro, Juan Martin / Newman, Tabitha / Fletcher, Simon / Nortje, Jurgens / Fottrell-Gould, Deirdre / Randell, Georgina / Zaman, Mohsin / Elmahi, Einas / Jones, Andrea / Hall, Kathryn / Mills, Gary / Ryalls, Kim / Bowler, Helen / Sall, Jas / Bourne, Richard / Borrill, Zoe / Duncan, Tracey / Lamb, Thomas / Shaw, Joanne / Fox, Claire / Moreno Cuesta, Jeronimo / Xavier, Kugan / Purohit, Dharam / Elhassan, Munzir / Bakthavatsalam, Dhanalakshmi / Rowland, Matthew / Hutton, Paula / Bashyal, Archana / Davidson, Neil / Hird, Clare / Chhablani, Manish / Phalod, Gunjan / Kirkby, Amy / Archer, Simon / Netherton, Kimberley / Reschreiter, Henrik / Camsooksai, Julie / Patch, Sarah / Jenkins, Sarah / Pogson, David / Rose, Steve / Daly, Zoe / Brimfield, Lutece / Claridge, Helen / Parekh, Dhruv / Bergin, Colin / Bates, Michelle / Dasgin, Joanne / McGhee, Christopher / Sim, Malcolm / Hay, Sophie Kennedy / Henderson, Steven / Phull, Mandeep-Kaur / Zaidi, Abbas / Pogreban, Tatiana / Rosaroso, Lace Paulyn / Harvey, Daniel / Lowe, Benjamin / Meredith, Megan / Ryan, Lucy / Hormis, Anil / Walker, Rachel / Collier, Dawn / Kimpton, Sarah / Oakley, Susan / Rooney, Kevin / Rodden, Natalie / Hughes, Emma / Thomson, Nicola / McGlynn, Deborah / Walden, Andrew / Jacques, Nicola / Coles, Holly / Tilney, Emma / Vowell, Emma / Schuster-Bruce, Martin / Pitts, Sally / Miln, Rebecca / Purandare, Laura / Vamplew, Luke / Spivey, Michael / Bean, Sarah / Burt, Karen / Moore, Lorraine / Day, Christopher / Gibson, Charly / Gordon, Elizabeth / Zitter, Letizia / Keenan, Samantha / Baker, Evelyn / Cherian, Shiney / Cutler, Sean / Roynon-Reed, Anna / Harrington, Kate / Raithatha, Ajay / Bauchmuller, Kris / Ahmad, Norfaizan / Grecu, Irina / Trodd, Dawn / Martin, Jane / Wrey Brown, Caroline / Arias, Ana-Marie / Craven, Thomas / Hope, David / Singleton, Jo / Clark, Sarah / Rae, Nicola / Welters, Ingeborg / Hamilton, David Oliver / Williams, Karen / Waugh, Victoria / Shaw, David / Puthucheary, Zudin / Martin, Timothy / Santos, Filipa / Uddin, Ruzena / Somerville, Alastair / Tatham, Kate Colette / Jhanji, Shaman / Black, Ethel / Dela Rosa, Arnold / Howle, Ryan / Tully, Redmond / Drummond, Andrew / Dearden, Joy / Philbin, Jennifer / Munt, Sheila / Vuylsteke, Alain / Chan, Charles / Victor, Saji / Matsa, Ramprasad / Gellamucho, Minerva / Creagh-Brown, Ben / Tooley, Joe / Montague, Laura / De Beaux, 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Alistair / Rostron, Anthony / Woods, Lindsey / Cornell, Sarah / Pillai, Suresh / Harford, Rachel / Rees, Tabitha / Ivatt, Helen / Sundara Raman, Ajay / Davey, Miriam / Lee, Kelvin / Barber, Russell / Chablani, Manish / Brohi, Farooq / Jagannathan, Vijay / Clark, Michele / Purvis, Sarah / Wetherill, Bill / Dushianthan, Ahilanandan / Cusack, Rebecca / de Courcy-Golder, Kim / Smith, Simon / Jackson, Susan / Attwood, Ben / Parsons, Penny / Page, Valerie / Zhao, Xiao Bei / Oza, Deepali / Rhodes, Jonathan / Anderson, Tom / Morris, Sheila / Xia Le Tai, Charlotte / Thomas, Amy / Keen, Alexandra / Digby, Stephen / Cowley, Nicholas / Southern, David / Reddy, Harsha / Campbell, Andy / Watkins, Claire / Smuts, Sara / Touma, Omar / Barnes, Nicky / Alexander, Peter / Felton, Tim / Ferguson, Susan / Sellers, Katharine / Bradley-Potts, Joanne / Yates, David / Birkinshaw, Isobel / Kell, Kay / Marshall, Nicola / Carr-Knott, Lisa / Summers, Charlotte

JAMA

2020 Volume 324, Issue 13, Page(s) 1317–1329

Abstract: Importance: Evidence regarding corticosteroid use for severe coronavirus disease 2019 (COVID-19) is limited.: Objective: To determine whether hydrocortisone improves outcome for patients with severe COVID-19.: Design, setting, and participants: An ...

Abstract	Importance: Evidence regarding corticosteroid use for severe coronavirus disease 2019 (COVID-19) is limited. Objective: To determine whether hydrocortisone improves outcome for patients with severe COVID-19. Design, setting, and participants: An ongoing adaptive platform trial testing multiple interventions within multiple therapeutic domains, for example, antiviral agents, corticosteroids, or immunoglobulin. Between March 9 and June 17, 2020, 614 adult patients with suspected or confirmed COVID-19 were enrolled and randomized within at least 1 domain following admission to an intensive care unit (ICU) for respiratory or cardiovascular organ support at 121 sites in 8 countries. Of these, 403 were randomized to open-label interventions within the corticosteroid domain. The domain was halted after results from another trial were released. Follow-up ended August 12, 2020. Interventions: The corticosteroid domain randomized participants to a fixed 7-day course of intravenous hydrocortisone (50 mg or 100 mg every 6 hours) (n = 143), a shock-dependent course (50 mg every 6 hours when shock was clinically evident) (n = 152), or no hydrocortisone (n = 108). Main outcomes and measures: The primary end point was organ support-free days (days alive and free of ICU-based respiratory or cardiovascular support) within 21 days, where patients who died were assigned -1 day. The primary analysis was a bayesian cumulative logistic model that included all patients enrolled with severe COVID-19, adjusting for age, sex, site, region, time, assignment to interventions within other domains, and domain and intervention eligibility. Superiority was defined as the posterior probability of an odds ratio greater than 1 (threshold for trial conclusion of superiority >99%). Results: After excluding 19 participants who withdrew consent, there were 384 patients (mean age, 60 years; 29% female) randomized to the fixed-dose (n = 137), shock-dependent (n = 146), and no (n = 101) hydrocortisone groups; 379 (99%) completed the study and were included in the analysis. The mean age for the 3 groups ranged between 59.5 and 60.4 years; most patients were male (range, 70.6%-71.5%); mean body mass index ranged between 29.7 and 30.9; and patients receiving mechanical ventilation ranged between 50.0% and 63.5%. For the fixed-dose, shock-dependent, and no hydrocortisone groups, respectively, the median organ support-free days were 0 (IQR, -1 to 15), 0 (IQR, -1 to 13), and 0 (-1 to 11) days (composed of 30%, 26%, and 33% mortality rates and 11.5, 9.5, and 6 median organ support-free days among survivors). The median adjusted odds ratio and bayesian probability of superiority were 1.43 (95% credible interval, 0.91-2.27) and 93% for fixed-dose hydrocortisone, respectively, and were 1.22 (95% credible interval, 0.76-1.94) and 80% for shock-dependent hydrocortisone compared with no hydrocortisone. Serious adverse events were reported in 4 (3%), 5 (3%), and 1 (1%) patients in the fixed-dose, shock-dependent, and no hydrocortisone groups, respectively. Conclusions and relevance: Among patients with severe COVID-19, treatment with a 7-day fixed-dose course of hydrocortisone or shock-dependent dosing of hydrocortisone, compared with no hydrocortisone, resulted in 93% and 80% probabilities of superiority with regard to the odds of improvement in organ support-free days within 21 days. However, the trial was stopped early and no treatment strategy met prespecified criteria for statistical superiority, precluding definitive conclusions. Trial registration: ClinicalTrials.gov Identifier: NCT02735707.
MeSH term(s)	Adrenal Cortex Hormones/therapeutic use ; Adult ; Anti-Inflammatory Agents/administration & dosage ; Anti-Inflammatory Agents/adverse effects ; Betacoronavirus ; COVID-19 ; Coronavirus Infections/drug therapy ; Coronavirus Infections/mortality ; Coronavirus Infections/therapy ; Early Termination of Clinical Trials ; Female ; Humans ; Hydrocortisone/administration & dosage ; Hydrocortisone/adverse effects ; Intensive Care Units ; Male ; Middle Aged ; Pandemics ; Pneumonia, Viral/drug therapy ; Pneumonia, Viral/mortality ; Pneumonia, Viral/therapy ; Respiration, Artificial/statistics & numerical data ; SARS-CoV-2 ; Shock/drug therapy ; Shock/etiology ; Treatment Outcome ; COVID-19 Drug Treatment
Chemical Substances	Adrenal Cortex Hormones ; Anti-Inflammatory Agents ; Hydrocortisone (WI4X0X7BPJ)
Keywords	covid19
Language	English
Publishing date	2020-12-08
Publishing country	United States
Document type	Journal Article ; Randomized Controlled Trial ; Research Support, Non-U.S. Gov't
ZDB-ID	2958-0
ISSN	1538-3598 ; 0254-9077 ; 0002-9955 ; 0098-7484
ISSN (online)	1538-3598
ISSN	0254-9077 ; 0002-9955 ; 0098-7484
DOI	10.1001/jama.2020.17022
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Effect of Hydrocortisone on Mortality and Organ Support in Patients With Severe COVID-19

Goossens, Herman / Green, Cameron / Haniffa, Rashan / Higgins, Alisa M / Horvat, Christopher / Hullegie, Sebastiaan J / Kruger, Peter / Lamontagne, Francois / Lawler, Patrick R / Linstrum, Kelsey / Litton, Edward / Lorenzi, Elizabeth / Marshall, John / McAuley, Daniel / McGlothin, Anna / McGuinness, Shay / McVerry, Bryan / Montgomery, Stephanie / Mouncey, Paul / Murthy, Srinivas / Nichol, Alistair / Parke, Rachael / Parker, Jane / Rowan, Kathryn / Sanil, Ashish / Santos, Marlene / Saunders, Christina / Seymour, Christopher / Turner, Anne / van de Veerdonk, Frank / Venkatesh, Balasubramanian / Zarychanski, Ryan / Berry, Scott / Lewis, Roger J / McArthur, Colin / Webb, Steven A / Gordon, Anthony C / Writing Committee for the REMAP-CAP Investigators, / Angus, Derek / Cheng, Allen / De Jong, Menno / Gordon, Anthony / Lawler, Patrick / Webb, Steve / Campbell, Lewis / Forbes, Andrew / Gattas, David / Heritier, Stephane / Higgins, Lisa / Peake, Sandra / Presneill, Jeffrey / Seppelt, Ian / Trapani, Tony / Young, Paul / Bagshaw, Sean / Daneman, Nick / Ferguson, Niall / Misak, Cheryl / Hullegie, Sebastiaan / Pletz, Mathias / Rohde, Gernot / Rowan, Kathy / Alexander, Brian / Basile, Kim / Girard, Timothy / Huang, David / Vates, Jennifer / Beasley, Richard / Fowler, Robert / McGloughlin, Steve / Morpeth, Susan / Paterson, David / Venkatesh, Bala / Uyeki, Tim / Baillie, Kenneth / Duffy, Eamon / Fowler, Rob / Hills, Thomas / Orr, Katrina / Patanwala, Asad / Tong, Steve / Netea, Mihai / Bihari, Shilesh / Carrier, Marc / Fergusson, Dean / Goligher, Ewan / Haidar, Ghady / Hunt, Beverley / Kumar, Anand / Laffan, Mike / Lawless, Patrick / Lother, Sylvain / McCallum, Peter / Middeldopr, Saskia / McQuilten, Zoe / Neal, Matthew / Pasi, John / Schutgens, Roger / Stanworth, Simon / Turgeon, Alexis / Weissman, Alexandra / Adhikari, Neill / Anstey, Matthew / Brant, Emily / de Man, Angelique / Lamonagne, Francois / Masse, Marie-Helene / Udy, Andrew / Arnold, Donald / Begin, Phillipe / Charlewood, Richard / Chasse, Michael / Coyne, Mark / Cooper, Jamie / Daly, James / Gosbell, Iain / Harvala-Simmonds, Heli / Hills, Tom / MacLennan, Sheila / Menon, David / McDyer, John / Pridee, Nicole / Roberts, David / Shankar-Hari, Manu / Thomas, Helen / Tinmouth, Alan / Triulzi, Darrell / Walsh, Tim / Wood, Erica / Calfee, Carolyn / O’Kane, Cecilia / Shyamsundar, Murali / Sinha, Pratik / Thompson, Taylor / Young, Ian / Bihari, Shailesh / Hodgson, Carol / Laffey, John / McAuley, Danny / Orford, Neil / Neto, Ary / Lewis, Roger / McGlothlin, Anna / Miller, Eliza / Singh, Vanessa / Zammit, Claire / van Bentum Puijk, Wilma / Bouwman, Wietske / Mangindaan, Yara / Parker, Lorraine / Peters, Svenja / Rietveld, Ilse / Raymakers, Kik / Ganpat, Radhika / Brillinger, Nicole / Markgraf, Rene / Ainscough, Kate / Brickell, Kathy / Anjum, Aisha / Lane, Janis-Best / Richards-Belle, Alvin / Saull, Michelle / Wiley, Daisy / Bion, Julian / Connor, Jason / Gates, Simon / Manax, Victoria / van der Poll, Tom / Reynolds, John / van Beurden, Marloes / Effelaar, Evelien / Schotsman, Joost / Boyd, Craig / Harland, Cain / Shearer, Audrey / Wren, Jess / Clermont, Giles / Garrard, William / Kalchthaler, Kyle / King, Andrew / Ricketts, Daniel / Malakoutis, Salim / Marroquin, Oscar / Music, Edvin / Quinn, Kevin / Cate, Heidi / Pearson, Karen / Collins, Joanne / Hanson, Jane / Williams, Penny / Jackson, Shane / Asghar, Adeeba / Dyas, Sarah / Sutu, Mihaela / Murphy, Sheenagh / Williamson, Dawn / Mguni, Nhlanhla / Potter, Alison / Porter, David / Goodwin, Jayne / Rook, Clare / Harrison, Susie / Williams, Hannah / Campbell, Hilary / Lomme, Kaatje / Williamson, James / Sheffield, Jonathan / van’t Hoff, Willian / McCracken, Phobe / Young, Meredith / Board, Jasmin / Mart, Emma / Knott, Cameron / Smith, Julie / Boschert, Catherine / Affleck, Julia / Ramanan, Mahesh / D’Souza, Ramsy / Pateman, Kelsey / Shakih, Arif / Cheung, Winston / Kol, Mark / Wong, Helen / Shah, Asim / Wagh, Atul / Simpson, Joanne / Duke, Graeme / Chan, Peter / Cartner, Brittney / Hunter, Stephanie / Laver, Russell / Shrestha, Tapaswi / Regli, Adrian / Pellicano, Annamaria / McCullough, James / Tallott, Mandy / Kumar, Nikhil / Panwar, Rakshit / Brinkerhoff, Gail / Koppen, Cassandra / Cazzola, Federica / Brain, Matthew / Mineall, Sarah / Fischer, Roy / Biradar, Vishwanath / Soar, Natalie / White, Hayden / Estensen, Kristen / Morrison, Lynette / Smith, Joanne / Cooper, Melanie / Health, Monash / Shehabi, Yahya / Al-Bassam, Wisam / Hulley, Amanda / Whitehead, Christina / Lowrey, Julie / Gresha, Rebecca / Walsham, James / Meyer, Jason / Harward, Meg / Venz, Ellen / Williams, Patricia / Kurenda, Catherine / Smith, Kirsy / Smith, Margaret / Garcia, Rebecca / Barge, Deborah / Byrne, Deborah / Byrne, Kathleen / Driscoll, Alana / Fortune, Louise / Janin, Pierre / Yarad, Elizabeth / Hammond, Naomi / Bass, Frances / Ashelford, Angela / Waterson, Sharon / Wedd, Steve / McNamara, Robert / Buhr, Heidi / Coles, Jennifer 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Williams, Virginie / Rochwerg, Bram / Karachi, Tim / Oczkowski, Simon / Centofanti, John / Millen, Tina / Duan, Erick / Tsang, Jennifer / Patterson, Lisa / English, Shane / Watpool, Irene / Porteous, Rebecca / Miezitis, Sydney / McIntyre, Lauralyn / Brochard, Laurent / Burns, Karen / Sandhu, Gyan / Khalid, Imrana / Binnie, Alexandra / Powell, Elizabeth / McMillan, Alexandra / Luk, Tracy / Aref, Noah / Andric, Zdravko / Cviljevic, Sabina / Đimoti, Renata / Zapalac, Marija / Mirković, Gordan / Baršić, Bruno / Kutleša, Marko / Kotarski, Viktor / Vujaklija Brajković, Ana / Babel, Jakša / Sever, Helena / Dragija, Lidija / Kušan, Ira / Vaara, Suvi / Pettilä, Leena / Heinonen, Jonna / Kuitunen, Anne / Karlsson, Sari / Vahtera, Annukka / Kiiski, Heikki / Ristimäki, Sanna / Azaiz, Amine / Charron, Cyril / Godement, Mathieu / Geri, Guillaume / Vieillard-Baron, Antoine / Pourcine, Franck / Monchi, Mehran / Luis, David / Mercier, Romain / Sagnier, Anne / Verrier, Nathalie / Caplin, Cecile / Siami, Shidasp / Aparicio, Christelle / Vautier, Sarah / Jeblaoui, Asma / Fartoukh, Muriel / Courtin, Laura / Labbe, Vincent / Leparco, Cécile / Muller, Grégoire / Nay, Mai-Anh / Kamel, Toufik / Benzekri, Dalila / Jacquier, Sophie / Mercier, Emmanuelle / Chartier, Delphine / Salmon, Charlotte / Dequin, PierreFrançois / Schneider, Francis / Morel, Guillaume / L’Hotellier, Sylvie / Badie, Julio / Berdaguer, Fernando Daniel / Malfroy, Sylvain / Mezher, Chaouki / Bourgoin, Charlotte / Megarbane, Bruno / Voicu, Sebastian / Deye, Nicolas / Malissin, Isabelle / Sutterlin, Laetitia / Guitton, Christophe / Darreau, Cédric / Landais, Mickaël / Chudeau, Nicolas / Robert, Alain / Moine, Pierre / Heming, Nicholas / Maxime, Virginie / Bossard, Isabelle / Nicholier, Tiphaine Barbarin / Colin, Gwenhael / Zinzoni, Vanessa / Maquigneau, Natacham / Finn, André / Kreß, Gabriele / Hoff, Uwe / Friedrich Hinrichs, Carl / Nee, Jens / Hagel, Stefan / Ankert, Juliane / Kolanos, Steffi / Bloos, Frank / Petros, Sirak / Pasieka, Bastian / Kunz, Kevin / Appelt, Peter / Schütze, Bianka / Kluge, Stefan / Nierhaus, Axel / Jarczak, Dominik / Roedl, Kevin / Weismann, Dirk / Frey, Anna / Klinikum Neukölln, Vivantes / Reill, Lorenz / Distler, Michael / Maselli, Astrid / Bélteczki, János / Magyar, István / Fazekas, Ágnes / Kovács, Sándor / Szőke, Viktória / Szigligeti, Gábor / Leszkoven, János / Collins, Daniel / Breen, Patrick / Frohlich, Stephen / Whelan, Ruth / McNicholas, Bairbre / Scully, Michael / Casey, Siobhan / Kernan, Maeve / Doran, Peter / O’Dywer, Michael / Smyth, Michelle / Hayes, Leanne / Hoiting, Oscar / Peters, Marco / Rengers, Els / Evers, Mirjam / Prinssen, Anton / Bosch Ziekenhuis, Jeroen / Simons, Koen / Rozendaal, Wim / Polderman, F / de Jager, P / Moviat, M / Paling, A / Salet, A / Rademaker, Emma / Peters, Anna Linda / de Jonge, E / Wigbers, J / Guilder, E / Butler, M / Cowdrey, Keri-Anne / Newby, Lynette / Chen, Yan / Simmonds, Catherine / McConnochie, Rachael / Ritzema Carter, Jay / Henderson, Seton / Van Der Heyden, Kym / Mehrtens, Jan / Williams, Tony / Kazemi, Alex / Song, Rima / Lai, Vivian / Girijadevi, Dinu / Everitt, Robert / Russell, Robert / Hacking, Danielle / Buehner, Ulrike / Williams, Erin / Browne, Troy / Grimwade, Kate / Goodson, Jennifer / Keet, Owen / Callender, Owen / Martynoga, Robert / Trask, Kara / Butler, Amelia / Schischka, Livia / Young, Chelsea / Lesona, Eden / Olatunji, Shaanti / Robertson, Yvonne / José, Nuno / Amaro dos Santos Catorze, Teodoro / de Lima Pereira, Tiago Nuno Alfaro / Neves Pessoa, Lucilia Maria / Castro Ferreira, Ricardo Manuel / Pereira Sousa Bastos, Joana Margarida / Aysel Florescu, Simin / Stanciu, Delia / Zaharia, Miahela Florentina / Kosa, Alma Gabriela / Codreanu, Daniel / Marabi, Yaseen / Al Qasim, Eman / Moneer Hagazy, Mohamned / Al Swaidan, Lolowa / Arishi, Hatim / Muñoz-Bermúdez, Rosana / Marin-Corral, Judith / Salazar Degracia, Anna / Parrilla Gómez, Francisco / Mateo López, Maria Isabel / Rodriguez Fernandez, Jorge / Cárcel Fernández, Sheila / Carmona Flores, Rosario / León López, Rafael / de la Fuente Martos, Carmen / Allan, Angela / Polgarova, Petra / Farahi, Neda / McWilliam, Stephen / Hawcutt, Daniel / Rad, Laura / O’Malley, Laura / Whitbread, Jennifer / Kelsall, Olivia / Wild, Laura / Thrush, Jessica / Wood, Hannah / Austin, Karen / Donnelly, Adrian / Kelly, Martin / O’Kane, Sinéad / McClintock, Declan / Warnock, Majella / Johnston, Paul / Gallagher, Linda Jude / Mc Goldrick, Clare / Mc Master, Moyra / Strzelecka, Anna / Jha, Rajeev / Kalogirou, Michael / Ellis, Christine / Krishnamurthy, Vinodh / Deelchand, Vashish / Silversides, Jon / McGuigan, Peter / Ward, Kathryn / O’Neill, Aisling / Finn, Stephanie / Phillips, Barbara / Mullan, Dee / Oritz-Ruiz de Gordoa, Laura / Thomas, Matthew / Sweet, Katie / Grimmer, Lisa / Johnson, Rebekah / Pinnell, Jez / Robinson, Matt / Gledhill, Lisa / Wood, Tracy / Morgan, Matt / Cole, Jade / Hill, Helen / Davies, Michelle / Antcliffe, David / Templeton, Maie / Rojo, Roceld / Coghlan, Phoebe / Smee, Joanna / Mackay, Euan / Cort, Jon / Whileman, Amanda / Spencer, Thomas / Spittle, Nick / Kasipandian, Vidya / Patel, Amit / Allibone, Suzanne / Genetu, Roman Mary / Ramali, Mohamed / Ghosh, Alison / Bamford, Peter / London, Emily / Cawley, Kathryn / Faulkner, Maria / Jeffrey, Helen / Smith, Tim / Brewer, Chris / Gregory, Jane / Limb, James / Cowton, Amanda / O’Brien, Julie / Nikitas, Nikitas / Wells, Colin / Lankester, Liana / Pulletz, Mark / Birch, Jenny / Wiseman, Sophie / Horton, Sarah / Alegria, Ana / Turki, Salah / Elsefi, Tarek / Crisp, Nikki / Allen, Louise / McCullagh, Iain / Robinson, Philip / Hays, Carole / Babio-Galan, Maite / Stevenson, Hannah / Khare, Divya / Pinder, Meredith / Selvamoni, Selvin / Gopinath, Amitha / Pugh, Richard / Menzies, Daniel / Mackay, Callum / Allan, Elizabeth / Davies, Gwyneth / Puxty, Kathryn / McCue, Claire / Cathcart, Susanne / Hickey, Naomi / Ireland, Jane / Yusuff, Hakeem / Isgro, 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The REMAP-CAP COVID-19 Corticosteroid Domain Randomized Clinical Trial.

2020

Keywords	Writing Committee for the REMAP-CAP Investigators ; Humans ; Pneumonia ; Viral ; Coronavirus Infections ; Shock ; Hydrocortisone ; Adrenal Cortex Hormones ; Anti-Inflammatory Agents ; Treatment Outcome ; Respiration ; Artificial ; Adult ; Middle Aged ; Intensive Care Units ; Female ; Male ; Early Termination of Clinical Trials ; Pandemics ; Betacoronavirus ; covid19
Language	English
Publisher	JAMA
Publishing country	uk
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Effect of Hydrocortisone on Mortality and Organ Support in Patients With Severe COVID-19: The REMAP-CAP COVID-19 Corticosteroid Domain Randomized Clinical Trial.

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Article ; Online: Effect of Hydrocortisone on Mortality and Organ Support in Patients With Severe COVID-19

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