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  1. Article ; Online: Emergence of a Highly Fit SARS-CoV-2 Variant.

    Baric, Ralph S

    The New England journal of medicine

    2020  Volume 383, Issue 27, Page(s) 2684–2686

    MeSH term(s) COVID-19 ; Genome, Viral ; Humans ; Mutation ; SARS-CoV-2
    Language English
    Publishing date 2020-12-16
    Publishing country United States
    Document type Journal Article ; Comment
    ZDB-ID 207154-x
    ISSN 1533-4406 ; 0028-4793
    ISSN (online) 1533-4406
    ISSN 0028-4793
    DOI 10.1056/NEJMcibr2032888
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  2. Article ; Online: Developing therapeutic approaches for twenty-first-century emerging infectious viral diseases.

    Meganck, Rita M / Baric, Ralph S

    Nature medicine

    2021  Volume 27, Issue 3, Page(s) 401–410

    Abstract: The twenty-first century has already recorded more than ten major epidemic or pandemic virus emergence events, including the ongoing and devastating coronavirus disease 2019 (COVID-19) pandemic. As viral disease emergence is expected to accelerate, these ...

    Abstract The twenty-first century has already recorded more than ten major epidemic or pandemic virus emergence events, including the ongoing and devastating coronavirus disease 2019 (COVID-19) pandemic. As viral disease emergence is expected to accelerate, these data dictate a need for proactive approaches to develop broadly active family-specific and cross-family therapeutics for use in future disease outbreaks. Emphasis should focus not only on the development of broad-spectrum small-molecule and antibody direct-acting antivirals, but also on host-factor therapeutics, including repurposing previously approved or in-pipeline drugs. Another new class of therapeutics with great antiviral therapeutic potential is RNA-based therapeutics. Rather than only focusing on known risks, dedicated efforts must be made toward pre-emptive research focused on outbreak-prone virus families, ultimately offering a strategy to shorten the gap between outbreak and response. Emphasis should also focus on orally available drugs for outpatient use, if possible, and on identifying combination therapies that combat viral and immune-mediated pathologies, extend the effectiveness of therapeutic windows and reduce drug resistance. While such an undertaking will require new vision, dedicated funding and private, federal and academic partnerships, this approach offers hope that global populations need never experience future pandemics such as COVID-19.
    MeSH term(s) Antiviral Agents/therapeutic use ; COVID-19/epidemiology ; Communicable Diseases, Emerging/therapy ; Drug Development/methods ; Drug Development/trends ; Drug Repositioning ; History, 21st Century ; Humans ; Inventions/trends ; Pandemics ; SARS-CoV-2 ; Therapies, Investigational/methods ; Therapies, Investigational/trends ; Virus Diseases/therapy ; COVID-19 Drug Treatment
    Chemical Substances Antiviral Agents
    Language English
    Publishing date 2021-03-15
    Publishing country United States
    Document type Historical Article ; Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't ; Review
    ZDB-ID 1220066-9
    ISSN 1546-170X ; 1078-8956
    ISSN (online) 1546-170X
    ISSN 1078-8956
    DOI 10.1038/s41591-021-01282-0
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    Zs.A 4212: Show issues Location:
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  3. Article ; Online: Human lung organoids as a model for respiratory virus replication and countermeasure performance in human hosts.

    Edwards, Caitlin E / Tata, Aleksandra / Baric, Ralph S

    Translational research : the journal of laboratory and clinical medicine

    2022  Volume 250, Page(s) 36–45

    Abstract: Human respiratory viruses induce a wide breadth of disease phenotypes and outcomes of varying severity. Innovative models that recapitulate the human respiratory tract are needed to study such viruses, understand the virus-host interactions underlying ... ...

    Abstract Human respiratory viruses induce a wide breadth of disease phenotypes and outcomes of varying severity. Innovative models that recapitulate the human respiratory tract are needed to study such viruses, understand the virus-host interactions underlying replication and pathogenesis, and to develop effective countermeasures for prevention and treatment. Human organoid models provide a platform to study virus-host interactions in the proximal to distal lung in the absence of a human in vivo model. These cultures fill the niche of a suitable ex vivo model that represents the in vivo lung environment and encapsulates the structure and function of the native human lung.
    MeSH term(s) Humans ; Organoids/pathology ; Lung/pathology ; Virus Replication ; Viruses
    Language English
    Publishing date 2022-07-16
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 2246684-8
    ISSN 1878-1810 ; 1532-6543 ; 1931-5244
    ISSN (online) 1878-1810 ; 1532-6543
    ISSN 1931-5244
    DOI 10.1016/j.trsl.2022.07.002
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  4. Article ; Online: SARS-CoV-2: Combating Coronavirus Emergence.

    Graham, Rachel L / Baric, Ralph S

    Immunity

    2020  Volume 52, Issue 5, Page(s) 734–736

    Abstract: The emergence and rapid global spread of SARS-CoV-2 mark the third such identification of a novel coronavirus capable of causing severe, potentially fatal disease in humans in the ... ...

    Abstract The emergence and rapid global spread of SARS-CoV-2 mark the third such identification of a novel coronavirus capable of causing severe, potentially fatal disease in humans in the 21
    MeSH term(s) Betacoronavirus ; COVID-19 ; Coronavirus ; Coronavirus Infections ; Humans ; Pandemics ; Pneumonia, Viral ; SARS Virus ; SARS-CoV-2
    Keywords covid19
    Language English
    Publishing date 2020-05-08
    Publishing country United States
    Document type Journal Article ; Comment
    ZDB-ID 1217235-2
    ISSN 1097-4180 ; 1074-7613
    ISSN (online) 1097-4180
    ISSN 1074-7613
    DOI 10.1016/j.immuni.2020.04.016
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  5. Article ; Online: Stopping pandemics before they start: Lessons learned from SARS-CoV-2.

    Edwards, Aled M / Baric, Ralph S / Saphire, Erica Ollmann / Ulmer, Jeffrey B

    Science (New York, N.Y.)

    2022  Volume 375, Issue 6585, Page(s) 1133–1139

    Abstract: The vaccine and drug discovery responses to COVID-19 have worked far better than could have been imagined. Yet by the end of 2021, more than 5 million people had died, and the pandemic continues to evolve and rage globally. This Review will describe how ... ...

    Abstract The vaccine and drug discovery responses to COVID-19 have worked far better than could have been imagined. Yet by the end of 2021, more than 5 million people had died, and the pandemic continues to evolve and rage globally. This Review will describe how each of the vaccines, antibody therapies, and antiviral drugs that have been approved to date were built on decades of investment in technology and basic science. We will caution that the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) virus has so far proven a straightforward test of our pandemic preparedness, and we will recommend steps we should undertake now to prepare for, to minimize the effects of, and ideally to prevent future pandemics. Other Reviews in this series describe the interactions of SARS-CoV-2 with the immune system and those therapies that target the host response to infection.
    MeSH term(s) Antibodies, Monoclonal/therapeutic use ; Antiviral Agents/therapeutic use ; COVID-19/drug therapy ; COVID-19/prevention & control ; COVID-19/virology ; COVID-19 Vaccines/administration & dosage ; COVID-19 Vaccines/immunology ; Disease Progression ; Drug Development ; Drug Discovery ; Humans ; Pandemics/prevention & control ; SARS-CoV-2/drug effects ; SARS-CoV-2/immunology ; Vaccine Development ; Vaccinology ; Viral Vaccines/immunology ; Virus Diseases/drug therapy ; Virus Diseases/prevention & control
    Chemical Substances Antibodies, Monoclonal ; Antiviral Agents ; COVID-19 Vaccines ; Viral Vaccines
    Language English
    Publishing date 2022-03-10
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 128410-1
    ISSN 1095-9203 ; 0036-8075
    ISSN (online) 1095-9203
    ISSN 0036-8075
    DOI 10.1126/science.abn1900
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  6. Article ; Online: Dengue Vaccines: The Promise and Pitfalls of Antibody-Mediated Protection.

    Martinez, David R / Metz, Stefan W / Baric, Ralph S

    Cell host & microbe

    2021  Volume 29, Issue 1, Page(s) 13–22

    Abstract: More than 390 million human dengue virus (DENV) infections occur each year, worldwide. Dengvaxia, a live-virus tetravalent vaccine from Sanofi Pasteur, was recently approved for human clinical use, although vaccine performance against the four DENV ... ...

    Abstract More than 390 million human dengue virus (DENV) infections occur each year, worldwide. Dengvaxia, a live-virus tetravalent vaccine from Sanofi Pasteur, was recently approved for human clinical use, although vaccine performance against the four DENV serotypes is highly variable. Other dengue vaccines in advanced clinical testing also demonstrate variability in efficacy. In this review, we outline the benefits and challenges of developing a safe, effective, and balanced DENV vaccine that can provide uniform protection against all four serotypes. Even though T cell biology plays an important role in establishing protective immunity, this review focuses on B cell responses. We discuss the leading dengue vaccine candidates and review the specificity of antibody responses and the known immune correlates of protection against DENV infection. A better understanding of immune correlates of protection against DENV infection will inform the development of a vaccine that can provide long-term, uniform protection.
    MeSH term(s) Antibodies, Neutralizing/blood ; Antibodies, Neutralizing/immunology ; Antibodies, Viral/blood ; Antibodies, Viral/immunology ; Clinical Trials as Topic ; Dengue/immunology ; Dengue/prevention & control ; Dengue Vaccines/immunology ; Dengue Virus/genetics ; Dengue Virus/immunology ; Epitopes ; Genetic Variation ; Humans ; Immunogenicity, Vaccine ; Vaccines, Attenuated/immunology ; Vaccines, Inactivated/immunology ; Vaccines, Subunit/immunology ; Vaccines, Synthetic/immunology ; Viral Envelope Proteins/immunology
    Chemical Substances Antibodies, Neutralizing ; Antibodies, Viral ; CYD-TDV vaccine ; Dengue Vaccines ; Epitopes ; Vaccines, Attenuated ; Vaccines, Inactivated ; Vaccines, Subunit ; Vaccines, Synthetic ; Viral Envelope Proteins
    Language English
    Publishing date 2021-01-11
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 2278004-X
    ISSN 1934-6069 ; 1931-3128
    ISSN (online) 1934-6069
    ISSN 1931-3128
    DOI 10.1016/j.chom.2020.12.011
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    Zs.A 6578: Show issues Location:
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  7. Article: Giving the Genes a Shuffle: Using Natural Variation to Understand Host Genetic Contributions to Viral Infections.

    Leist, Sarah R / Baric, Ralph S

    Trends in genetics : TIG

    2018  Volume 34, Issue 10, Page(s) 777–789

    Abstract: The laboratory mouse has proved an invaluable model to identify host factors that regulate the progression and outcome of virus-induced disease. The paradigm is to use single-gene knockouts in inbred mouse strains or genetic mapping studies using ... ...

    Abstract The laboratory mouse has proved an invaluable model to identify host factors that regulate the progression and outcome of virus-induced disease. The paradigm is to use single-gene knockouts in inbred mouse strains or genetic mapping studies using biparental mouse populations. However, genetic variation among these mouse strains is limited compared with the diversity seen in human populations. To address this disconnect, a multiparental mouse population has been developed to specifically dissect the multigenetic regulation of complex disease traits. The Collaborative Cross (CC) population of recombinant inbred mouse strains is a well-suited systems-genetics tool to identify susceptibility alleles that control viral and microbial infection outcomes and immune responses and to test the promise of personalized medicine.
    MeSH term(s) Animals ; Chromosome Mapping ; Disease Models, Animal ; Genetic Predisposition to Disease ; Genetics, Population ; Humans ; Mice ; Mice, Inbred Strains/genetics ; Mice, Inbred Strains/virology ; Mice, Knockout ; Quantitative Trait Loci/genetics ; Virus Diseases/genetics ; Virus Diseases/virology
    Keywords covid19
    Language English
    Publishing date 2018-08-18
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 619240-3
    ISSN 1362-4555 ; 0168-9525 ; 0168-9479
    ISSN (online) 1362-4555
    ISSN 0168-9525 ; 0168-9479
    DOI 10.1016/j.tig.2018.07.005
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  8. Article: Is regulation preventing the development of therapeutics that may prevent future coronavirus pandemics?

    Sheahan, Timothy P / Baric, Ralph S

    Future virology

    2018  Volume 13, Issue 3, Page(s) 143–146

    Keywords covid19
    Language English
    Publishing date 2018-02-21
    Publishing country England
    Document type Journal Article
    ZDB-ID 2254606-6
    ISSN 1746-0808 ; 1746-0794
    ISSN (online) 1746-0808
    ISSN 1746-0794
    DOI 10.2217/fvl-2017-0143
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  9. Article: SARS-CoV-2: Combating Coronavirus Emergence

    Graham, Rachel L / Baric, Ralph S

    Immunity

    Abstract: The emergence and rapid global spread of SARS-CoV-2 mark the third such identification of a novel coronavirus capable of causing severe, potentially fatal disease in humans in the 21st century. As noted by Andersen et al. (Nature Medicine), the ... ...

    Abstract The emergence and rapid global spread of SARS-CoV-2 mark the third such identification of a novel coronavirus capable of causing severe, potentially fatal disease in humans in the 21st century. As noted by Andersen et al. (Nature Medicine), the sequencing of proximal zoonotic ancestors to SARS-CoV-2 has aided in the identification of alleles that may contribute to the virus' virulence in humans.
    Keywords covid19
    Publisher WHO
    Document type Article
    Note WHO #Covidence: #125392
    Database COVID19

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  10. Article ; Online: SARS-CoV-2

    Graham, Rachel L. / Baric, Ralph S.

    Immunity, 52(5)

    Combating Coronavirus Emergence

    2020  

    Abstract: The emergence and rapid global spread of SARS-CoV-2 mark the third such identification of a novel corona- virus capable of causing severe, potentially fatal disease in humans in the 21st century. As noted by Andersen et al. (Nature Medicine), the ... ...

    Abstract The emergence and rapid global spread of SARS-CoV-2 mark the third such identification of a novel corona- virus capable of causing severe, potentially fatal disease in humans in the 21st century. As noted by Andersen et al. (Nature Medicine), the sequencing of proximal zoonotic ancestors to SARS-CoV-2 has aided in the iden- tification of alleles that may contribute to the virus’ virulence in humans.
    Keywords covid19
    Language English
    Publishing country us
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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