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  1. Article ; Online: Correction to: Adipose‑derived stem cells applied to ankle pathologies: a systematic review.

    Arceri, A / Mazzotti, A / Artioli, E / Zielli, S O / Barile, F / Manzetti, M / Viroli, G / Ruffilli, A / Faldini, C

    Musculoskeletal surgery

    2024  

    Language English
    Publishing date 2024-04-06
    Publishing country Italy
    Document type Published Erratum
    ZDB-ID 2495458-5
    ISSN 2035-5114 ; 2035-5106
    ISSN (online) 2035-5114
    ISSN 2035-5106
    DOI 10.1007/s12306-023-00809-7
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article: Pedicle Dysplasia in Proximal Thoracic Adolescent Idiopathic Scoliosis Curves: What are We Missing and What are its Possible Surgical Implications? An Observational Retrospective Study on 104 Patients.

    Viroli, Giovanni / Ruffilli, Alberto / Barile, Francesca / Manzetti, Marco / Traversari, Matteo / Faldini, Cesare

    Global spine journal

    2024  , Page(s) 21925682241230964

    Abstract: Study design: Retrospective cohort study.: Objectives: To assess if pedicle dysplasia is present in proximal thoracic (PT), both structural and nonstructural, compared to main thoracic (MT) curves; and to assess if it is predictive of radiographic ... ...

    Abstract Study design: Retrospective cohort study.
    Objectives: To assess if pedicle dysplasia is present in proximal thoracic (PT), both structural and nonstructural, compared to main thoracic (MT) curves; and to assess if it is predictive of radiographic outcomes at minimum 2 years of follow-up.
    Methods: A retrospective review of surgically-treated Adolescent Idiopathic Scoliosis (AIS) patients with Lenke 1-2-3-4 curves was performed. On preoperative CT-scan, at the apical vertebra, pedicle width on the concavity (PWc) and on the convexity (PWv) and Pedicle Dysplasia Index (PDI, defined as PWc/PWv) were measured. Preoperative and last follow-up (at least 2 years) x-rays were reviewed.
    Results: 104 patients meeting the inclusion criteria were divided into Structural-PT (S-PT) and Nonstructural-PT (NS-PT) groups based on Lenke criteria. PWc (
    Conclusion: S-PT and NS-PT curves show significant pedicle dysplasia on the concavity. Pedicle dysplasia significantly correlated with shoulder balance at follow-up, for NS-PT patterns. Patients with a PWc <1 mm or PDI <.30 are at particular risk of postoperative shoulder imbalance.
    Language English
    Publishing date 2024-02-06
    Publishing country England
    Document type Journal Article
    ZDB-ID 2648287-3
    ISSN 2192-5690 ; 2192-5682
    ISSN (online) 2192-5690
    ISSN 2192-5682
    DOI 10.1177/21925682241230964
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Diagnosis and treatment of acute inflammatory sacroiliitis in pregnant or post-partum women: a systematic review of the current literature.

    Viroli, G / Cerasoli, T / Barile, F / Modeo, M / Manzetti, M / Traversari, M / Ruffilli, A / Faldini, C

    Musculoskeletal surgery

    2023  

    Abstract: The aim of the present study is to systematically review the current literature about diagnosis and treatment of acute inflammatory sacroiliitis in pregnant or post-partum women. A systematic search was carried out according to the Preferred Reporting ... ...

    Abstract The aim of the present study is to systematically review the current literature about diagnosis and treatment of acute inflammatory sacroiliitis in pregnant or post-partum women. A systematic search was carried out according to the Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines. Data about clinical presentation, diagnosis methods and treatment strategies were retrieved from included studies and reported in a table. After screening, five studies on 34 women were included; they were all affected by acute inflammatory sacroiliitis. Clinical examination and magnetic resonance imaging were used to confirm diagnosis. In four studies, patients were treated with ultrasound-guided sacroiliac injections of steroids and local anesthetics, while one study used only manual mobilization. Clinical scores improved in all patients. Ultrasound-guided injections proved to be a safe and effective strategy for inflammatory sacroiliitis treatment during pregnancy or post-partum.
    Language English
    Publishing date 2023-06-20
    Publishing country Italy
    Document type Journal Article ; Review
    ZDB-ID 2495458-5
    ISSN 2035-5114 ; 2035-5106
    ISSN (online) 2035-5114
    ISSN 2035-5106
    DOI 10.1007/s12306-023-00786-x
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Adipose-derived stem cells applied to ankle pathologies: a systematic review.

    Arceri, A / Mazzotti, A / Artioli, E / Zielli, S O / Barile, F / Manzetti, M / Viroli, G / Ruffilli, A / Faldini, C

    Musculoskeletal surgery

    2023  Volume 108, Issue 1, Page(s) 1–9

    Abstract: The purpose of this systematic review was to analyze the current use of adipose-derived mesenchymal stem cells (ADMSCs) and present the available evidence on their therapeutic potential in the treatment of ankle orthopedic issues, evaluating the ... ...

    Abstract The purpose of this systematic review was to analyze the current use of adipose-derived mesenchymal stem cells (ADMSCs) and present the available evidence on their therapeutic potential in the treatment of ankle orthopedic issues, evaluating the applications and results. A literature search of PubMed, Google Scholar, EMBASE and Cochrane Library database was performed. The review was conducted following PRISMA guidelines. Risk of bias assessment was conducted through the Methodological Index for Non-Randomized Studies (MINORS) criteria. Initial search results yielded 4348 articles. A total of 8 articles were included in the review process. No clinical evidence has demonstrated the effectiveness of one isolation method over the other, but nonenzymatic mechanical method has more advantages. In all studies included significant clinical outcomes improvement were recorded in patients affected by osteochondral lesion and osteoarthritis of ankle. All studies performed a concomitant procedure. No serious complications were reported. ADMSC injection, especially through the nonenzymatic mechanical methods, looks to be simple and promising treatment for osteochondral lesions and osteoarthritis of the ankle, with no severe complications. The current scarcity of studies and their low-quality level preclude definitive conclusions presently. LEVEL OF EVIDENCE: III.
    MeSH term(s) Humans ; Ankle ; Ankle Joint ; Osteoarthritis/therapy ; Stem Cells ; Treatment Outcome ; Talus
    Language English
    Publishing date 2023-11-09
    Publishing country Italy
    Document type Systematic Review ; Journal Article ; Review
    ZDB-ID 2495458-5
    ISSN 2035-5114 ; 2035-5106
    ISSN (online) 2035-5114
    ISSN 2035-5106
    DOI 10.1007/s12306-023-00798-7
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: A novel retrograde technique for ankle osteochodral lesions: the sub-endo-chondral regenerative treatment (secret).

    Faldini, C / Mazzotti, A / Artioli, E / Ruffilli, A / Barile, F / Zielli, S O / Geraci, G

    Musculoskeletal surgery

    2022  Volume 107, Issue 3, Page(s) 337–343

    Abstract: Purpose: To describe a new surgical technique for osteochondral lesions of the ankle, using bone marrow concentrate on a scaffold and homologous bone graft positioned through a retrograde approach. Many surgical options for ankle osteochondral lesions ... ...

    Abstract Purpose: To describe a new surgical technique for osteochondral lesions of the ankle, using bone marrow concentrate on a scaffold and homologous bone graft positioned through a retrograde approach. Many surgical options for ankle osteochondral lesions have been described, and the ideal treatment is still debated. Bone marrow stimulating techniques are recommended for cystic lesions, with some concerns regarding the healing potential of the subchondral bone. In case of wide osteochondral defects, regenerative solutions are preferred but a massive chondral debridement is usually required. To overcome these problems, a novel technique is proposed.
    Methods: The proposed technique was performed on patients affected by osteochondral lesions of the talus, either cysts with intact cartilage or wide osteochondral defects. A preoperative magnetic resonance imaging was obtained to localize the lesion. A 6-mm tarsal tunnel was retrogradely created toward the lesion, to allow a complete sub-endo-chondral debridement preserving the healthy cartilage. A hyaluronan scaffold soaked with a previously prepared bone marrow concentrate was retrogradely positioned under the cartilage surface and the tunnel was filled with homologous bone graft. Preoperative clinical scores and postoperative x-rays were registered.
    Results: Four patients were treated using this technique. No intraoperative and postoperative complications occurred. Good bone remodeling was observed at 12-week postoperative x-rays.
    Conclusions: This technique combines the mini-invasiveness of retrograde drilling with the regenerative properties of biological scaffold soaked with bone marrow concentrate. Despite further research being needed, it seems a new viable solution to treat both subchondral cysts and large osteochondral defects of the ankle, whose management is still controversial.
    MeSH term(s) Humans ; Ankle ; Arthroscopy/methods ; Ankle Joint/diagnostic imaging ; Ankle Joint/surgery ; Talus/surgery ; Radiography ; Magnetic Resonance Imaging ; Cartilage, Articular/diagnostic imaging ; Cartilage, Articular/surgery ; Treatment Outcome
    Language English
    Publishing date 2022-11-14
    Publishing country Italy
    Document type Journal Article
    ZDB-ID 2495458-5
    ISSN 2035-5114 ; 2035-5106
    ISSN (online) 2035-5114
    ISSN 2035-5106
    DOI 10.1007/s12306-022-00767-6
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Are there gender-specific differences in hip and knee cartilage composition and degeneration? A systematic literature review.

    Di Martino, Alberto / Barile, Francesca / D'Agostino, Claudio / Castafaro, Vanita / Cerasoli, Tosca / Mora, Paolo / Ruffilli, Alberto / Traina, Francesco / Faldini, Cesare

    European journal of orthopaedic surgery & traumatology : orthopedie traumatologie

    2024  

    Abstract: The aim of the present review is to systematically analyse the current literature about gender differences in hip or knee cartilage composition and degeneration, to help explaining how and why osteoarthritis affects women more often and more severely ... ...

    Abstract The aim of the present review is to systematically analyse the current literature about gender differences in hip or knee cartilage composition and degeneration, to help explaining how and why osteoarthritis affects women more often and more severely than men. A systematic review of the literature in English was performed. Eleven studies on 1962 patients (905 females and 787 males) that reported differences on cartilage composition between males and females were included. Nine evaluated the knee, one the hip, and one both. They were heterogeneous in their methods: one conducted histological analyses, and all the others evaluated cartilage characteristics (volume, width, and composition) through magnetic resonance imaging. All authors reported gender differences in both volume and morphology of the cartilage, from infancy to menopause. In fact, a study on 92 healthy children statistically showed significant gender differences in cartilage thickness at all sites, even after adjustment for age, body, and bone size. Gender differences become more evident after menopause, when women have a lower cartilage volume and a higher cartilage loss. Men show significantly higher knee and hip cartilage volumes than women, and women carry a significantly greater risk to develop osteoarthritis. This is in part due to body and bone size, but also depends on qualitative and quantitative differences in the composition of cartilage and its degeneration rate after menopause. Structural changes in cartilage that occur between genders during ageing have significance in the development of osteoarthritis.
    Language English
    Publishing date 2024-03-08
    Publishing country France
    Document type Journal Article
    ZDB-ID 1231084-0
    ISSN 1432-1068 ; 1633-8065 ; 0948-4817 ; 0940-3264
    ISSN (online) 1432-1068
    ISSN 1633-8065 ; 0948-4817 ; 0940-3264
    DOI 10.1007/s00590-024-03871-4
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 3479: Show issues Location:
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    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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  7. Article ; Online: Restoration of Spinopelvic Alignment After Reduction of High-grade Spondylolisthesis: Myth or Reality? A Systematic Review of the literature and Meta-analysis.

    Viroli, Giovanni / Ruffilli, Alberto / Ialuna, Marco / Barile, Francesca / Manzetti, Marco / Traversari, Matteo / Vita, Fabio / Faldini, Cesare

    Clinical spine surgery

    2024  

    Abstract: Study design: Systematic review and meta-analysis of literature.: Objective: The aim of the presented study is to assess whether the reduction of high-grade spondylolisthesis (HGS) through the correction of lumbosacral kyphosis leads to a decrease in ...

    Abstract Study design: Systematic review and meta-analysis of literature.
    Objective: The aim of the presented study is to assess whether the reduction of high-grade spondylolisthesis (HGS) through the correction of lumbosacral kyphosis leads to a decrease in the sagittal spinopelvic compensatory mechanisms.
    Summary of background data: HGS is as an anterior translation of a vertebra, >50%. It is also characterized by a kyphotic deformity of the affected level. This combination of translation and kyphosis leads to compensatory mechanisms on the sagittal plane [pelvic retroversion, increased lumbar lordosis (LL), reduction in thoracic kyphosis (TK)].
    Methods: A systematic search of electronic databases was conducted. Inclusion criteria were diagnosis of HGS (Meyerding >II, Slip% >50%), partial or complete reduction surgery (with a significant decrease in Slip%), and report of spinopelvic parameters (pelvic incidence, pelvic tilt, or sacral slope). Clinical and radiographic outcomes were extracted and summarized. Meta-analyses were performed to estimate the differences between preoperative and postoperative spinopelvic alignment measures. P<0.05 was considered significant.
    Results: Eighteen studies were included. PT showed a statistically significant decrease of -2.1217 (95% CI: -3.4803 to -0.7630), while SS showed a significant increase of 4.8349 (95% CI: 2.7462-6.9236). Conversely, both LL and TK showed nonsignificant changes, -4.7043 (95% CI: -10.4535 to 1.0449) and 6.3881 (95% CI: -0.8344 to 13.6106), respectively. VAS significantly decreased by -3.1950 (95% CI: -4.9462 to -1.4439).
    Conclusions: The meta-analysis showed mild, yet statistically significant, decrease of PT and an increase in SS after HGS reduction. Conversely, nonstatically significant decrease in LL and an increase in TK occurred. The clinical significance of these results remains questionable.
    Level of evidence: Level IV.
    Language English
    Publishing date 2024-03-27
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2849646-2
    ISSN 2380-0194 ; 2380-0186
    ISSN (online) 2380-0194
    ISSN 2380-0186
    DOI 10.1097/BSD.0000000000001593
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 2427: Show issues Location:
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    Jg. 1995 - 2021: Lesesall (2.OG)
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  8. Article ; Online: Mental Health Issues as a Consequence of the Pandemic: Group Psycho-Educational Intervention to Support Patients Recovered from COVID-19 Infection.

    Vagnini, Denise / Lamperti, Nicolò / Molgora, Sara / Barile, Francesca / Facchin, Federica / Mazza, Umberto / Saita, Emanuela

    International journal of environmental research and public health

    2023  Volume 20, Issue 12

    Abstract: Common psycho-physical symptoms have emerged in patients who were previously recovered for COVID-19 infection, including traumatic experience and enduring emotional disturbances. A group psycho-educational intervention of seven weekly sessions and a ... ...

    Abstract Common psycho-physical symptoms have emerged in patients who were previously recovered for COVID-19 infection, including traumatic experience and enduring emotional disturbances. A group psycho-educational intervention of seven weekly sessions and a follow-up after three months was proposed to all Italian-speaking patients formally discharged from a public hospital in northern Italy and physically recovered from infection. Eighteen patients were recruited and divided into four age-homogenous groups, each led by two facilitators (psychologists and psychotherapists). The group sessions followed a structured format with thematic modules, including main topics, tasks, and homework assignments. Data were collected through recordings and verbatim transcripts. The objectives of the study were twofold: (1) to analyze the emerging themes and gain insight into the significant aspects of the participants' lived experience of COVID-19, and (2) to examine changes in how participants approached these themes throughout the intervention process. Semantic-pragmatic text analyses, specifically thematic analysis of elementary context and correspondence analysis, were conducted using T-LAB software. Linguistic analysis revealed a congruence between the intervention's objectives and the participants' experiences. The study highlighted an evolution in the narratives, as participants transitioned from a passive and concrete perspective on the disease to a more comprehensive cognitive and emotional elaboration of their personal illness stories. These findings hold potential relevance for healthcare services and professionals working in this field.
    MeSH term(s) Humans ; COVID-19/epidemiology ; Pandemics ; Mental Health ; Emotions ; Italy/epidemiology
    Language English
    Publishing date 2023-06-12
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2175195-X
    ISSN 1660-4601 ; 1661-7827
    ISSN (online) 1660-4601
    ISSN 1661-7827
    DOI 10.3390/ijerph20126105
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  9. Article ; Online: Unicompartmental knee arthroplasty has higher revisions than total knee arthroplasty at long term follow-up: a registry study on 6453 prostheses.

    Di Martino, A / Bordini, B / Barile, F / Ancarani, C / Digennaro, V / Faldini, C

    Knee surgery, sports traumatology, arthroscopy : official journal of the ESSKA

    2020  Volume 29, Issue 10, Page(s) 3323–3329

    Abstract: Purpose: The purpose of this study is to analyse long-term unicompartmental knee arthroplasty (UKA) focusing on survivorship, causes of failure and revision strategy.: Methods: This study is a retrospective analysis of data from a regional ... ...

    Abstract Purpose: The purpose of this study is to analyse long-term unicompartmental knee arthroplasty (UKA) focusing on survivorship, causes of failure and revision strategy.
    Methods: This study is a retrospective analysis of data from a regional arthroplasty registry for cases performed between 2000 and 2017. A total of 6453 UKAs were identified and the following information was analysed: demographic data, diagnosis leading to primary implant, survivorship, complication rate, causes of failure, revision strategies. UKA registry data were compared with total knee arthroplasty (TKA) registry data of 54,012 prostheses, which were implanted in the same time period.
    Results: 6453 UKAs were included in the study: the vast majority of them (84.4%) were implanted due to primary osteoarthritis followed by deformity (7.1%) and necrosis of the condyle (5.1%). When compared to TKA, UKA showed lower perioperative complication rate (0.3% compared to 0.6%) but higher revision rate (18.2% at 15 years, compared to 6.2% for TKA). No correlation was found between diagnosis leading to primary implant and prosthesis survival. The most frequent cause of failure was total aseptic loosening (37.4%), followed by pain without loosening (19.8%). Of the 620 UKAs requiring revision, 485 were revised with a TKA and 61 of them required a re-revision; on the other hand, of the 35 cases where another UKA was implanted, 16 required a re-revision.
    Conclusion: UKA is associated with fewer perioperative complications but higher revision rates when compared to TKA. Its survivorship is not affected by the diagnosis leading to primary implant. Revision surgery of a failed UKA should be performed implanting a TKA, which is associated with a lower re-revision rate when compared to another UKA.
    Level of evidence: Level 3, therapeutic study.
    MeSH term(s) Arthroplasty, Replacement, Knee/adverse effects ; Humans ; Knee Prosthesis ; Osteoarthritis, Knee/surgery ; Prosthesis Failure ; Registries ; Reoperation ; Retrospective Studies ; Treatment Outcome
    Language English
    Publishing date 2020-08-01
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 1159064-6
    ISSN 1433-7347 ; 0942-2056
    ISSN (online) 1433-7347
    ISSN 0942-2056
    DOI 10.1007/s00167-020-06184-1
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    Zs.A 3742: Show issues Location:
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  10. Article ; Online: Incidental dural tears do not affect the overall patients' reported outcome of spine surgery at long-term follow-up: results of a systematic review.

    Faldini, C / Barile, F / D'Antonio, G / Rinaldi, A / Manzetti, M / Viroli, G / Vita, F / Traversari, M / Cerasoli, T / Ruffilli, A

    Musculoskeletal surgery

    2023  Volume 108, Issue 1, Page(s) 47–61

    Abstract: To conduct a systematic review of the literature in order to establish if there is an overall adverse effect of accidental durotomy on the long-term patients' reported outcome after elective spine surgery. A systematic literature search was carried out ... ...

    Abstract To conduct a systematic review of the literature in order to establish if there is an overall adverse effect of accidental durotomy on the long-term patients' reported outcome after elective spine surgery. A systematic literature search was carried out according to the Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines. Data about pre- and postoperative clinical outcomes of patients with accidental durotomy and patients without were extracted and analysed. After screening, eleven studies were included with a total of 80,541 patients. About 4112 of these patients (5.10%) had incidental dural tear. When comparing patients with dural tear to patients without, 9/11 authors found no patients' reported differences at last follow-up. One author found a slightly worse VAS back pain in dural tear patients, and another author found inferior SF-36 and ODI scores in dural tear patients (both below minimal clinically important difference). Accidental dural tear did not have a significant adverse effect on clinical outcome of elective spine surgery. More studies are needed to better demonstrate this result.
    MeSH term(s) Humans ; Spine/surgery ; Orthopedic Procedures/adverse effects
    Language English
    Publishing date 2023-03-06
    Publishing country Italy
    Document type Journal Article ; Systematic Review
    ZDB-ID 2495458-5
    ISSN 2035-5114 ; 2035-5106
    ISSN (online) 2035-5114
    ISSN 2035-5106
    DOI 10.1007/s12306-023-00777-y
    Database MEDical Literature Analysis and Retrieval System OnLINE

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