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Article: MRI Tumor Regression Grade Combined with T2-Weighted Volumetry May Predict Histopathological Response in Locally Advanced Rectal Cancer following Neoadjuvant Chemoradiotherapy-A New Scoring System Proposal.

Jankovic, Aleksandra / Kovac, Jelena Djokic / Dakovic, Marko / Mitrovic, Milica / Saponjski, Dusan / Milicevic, Ognjen / Djuric-Stefanovic, Aleksandra / Barisic, Goran

Diagnostics (Basel, Switzerland)

2023 Volume 13, Issue 20

Abstract: Modern studies focus on the discovery of innovative methods to improve the value of post-treatment magnetic resonance imaging (MRI) in the prediction of pathological responses to preoperative neoadjuvant chemoradiotherapy (nCRT) in locally advanced ... ...

Abstract	Modern studies focus on the discovery of innovative methods to improve the value of post-treatment magnetic resonance imaging (MRI) in the prediction of pathological responses to preoperative neoadjuvant chemoradiotherapy (nCRT) in locally advanced rectal cancer (LARC)
Language	English
Publishing date	2023-10-17
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2662336-5
ISSN	2075-4418
ISSN	2075-4418
DOI	10.3390/diagnostics13203226
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Article ; Online: Analysis of the Prognostic Potential of Schlafen 11, Programmed Death Ligand 1, and Redox Status in Colorectal Cancer Patients.

Miladinov, Marko / Rosic, Jovana / Eric, Katarina / Guzonjic, Azra / Jelenkovic, Jelenko / Bogavac-Stanojevic, Natasa / Dimitrijevic, Ivan / Kotur-Stevuljevic, Jelena / Barisic, Goran

International journal of molecular sciences

2023 Volume 24, Issue 20

Abstract: The Schlafen 11 (SLFN11) protein has recently emerged as pivotal in DNA damage conditions, with predictive potential for tumor response to cytotoxic chemotherapies. Recent discoveries also showed that the programmed death ligand 1 (PD-L1) protein can be ... ...

Abstract	The Schlafen 11 (SLFN11) protein has recently emerged as pivotal in DNA damage conditions, with predictive potential for tumor response to cytotoxic chemotherapies. Recent discoveries also showed that the programmed death ligand 1 (PD-L1) protein can be found on malignant cells, providing an immune evasion mechanism exploited by different tumors. Additionally, excessive generation of free radicals, redox imbalance, and consequential DNA damage can affect intestinal cell homeostasis and lead to neoplastic transformation. Therefore, our study aimed to investigate the significance of SLFN11 and PD-L1 proteins and redox status parameters as prognostic biomarkers in CRC patients. This study included a total of 155 CRC patients. SLFN11 and PD-L1 serum levels were measured with ELISA and evaluated based on redox status parameters, sociodemographic and clinical characteristics, and survival. The following redox status parameters were investigated: spectrophotometrically measured superoxide dismutase (SOD), sulfhydryl (SH) groups, advanced oxidation protein products (AOPP), malondialdehyde (MDA), pro-oxidant-antioxidant balance (PAB), and superoxide anion (O
MeSH term(s)	Humans ; B7-H1 Antigen/metabolism ; Prognosis ; Oxidation-Reduction ; Antioxidants/metabolism ; Colorectal Neoplasms/pathology ; Nuclear Proteins/genetics
Chemical Substances	CD274 protein, human ; B7-H1 Antigen ; Antioxidants ; SLFN11 protein, human ; Nuclear Proteins
Language	English
Publishing date	2023-10-11
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2019364-6
ISSN	1422-0067 ; 1422-0067 ; 1661-6596
ISSN (online)	1422-0067
ISSN	1422-0067 ; 1661-6596
DOI	10.3390/ijms242015083
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Article: Insights into treatment of complex Crohn's perianal fistulas.

Norčič, Gregor / Smrekar, Nataša / Marković, Srđan / Barišić, Goran / Kiudelis, Gediminas / Paužas, Henrikas / Molnár, Tamás / Szijarto, Attila / Šerclová, Zuzana / Roblek, Tina / Uršič, Viktor / White, Ian

BMC proceedings

2024 Volume 18, Issue Suppl 7, Page(s) 7

Abstract: Complex perianal fistula is a common complication of Crohn's disease (CD) which leads to negative impact on patient's quality of life. Successful management of the disease requires a multidisciplinary approach, including a gastroenterologist and a ... ...

Abstract	Complex perianal fistula is a common complication of Crohn's disease (CD) which leads to negative impact on patient's quality of life. Successful management of the disease requires a multidisciplinary approach, including a gastroenterologist and a colorectal surgeon, applying combined surgical and medical therapy. One of frequently practiced surgical procedures is seton placement in the fistula tract, which is used to control perianal sepsis and drain the fistula, while preventing recurrent abscess formation.Darvadstrocel, a suspension of expanded, allogeneic, adipose-derived, mesenchymal stem cells, is safe and effective for treatment-refractory complex perianal fistulas in patients with Crohn's disease. Following approval of darvadstrocel, the INSPIRE registry is being conducted in order to evaluate long-term safety and effectiveness of the drug on a large, heterogenous population.An online expert meeting was held from March 20 to March 30, 2023, which provided relevant insights into the decision-making process regarding seton use and obtained feedback on the first experiences with darvadstrocel. The aim of this article is to present the perspectives from gastroenterologists and colorectal surgeons practicing in Czechia, Hungary, Israel, Lithuania, Serbia, and Slovenia in topics such as diagnosis and treatment options for patients with complex Crohn's perianal fistulas (CPF), specifically focusing on the use of setons and darvadstrocel.During this virtual session, unavailability of comprehensive data on safety and efficacy of available treatment procedures was emphasized as an important obstacle towards development of standardized recommendations and improvement of outcomes in treatment of (CPF). Furthermore, achieving consensus in seton use, duration of its placement, and frequency of change is recognized as one of CPF treatments major challenges. Despite these issues, it is important to promote better understanding and treatment of complex perianal fistulas in order to improve the quality of life of those affected by this condition.
Language	English
Publishing date	2024-04-25
Publishing country	England
Document type	Journal Article
ZDB-ID	2411867-9
ISSN	1753-6561
ISSN	1753-6561
DOI	10.1186/s12919-024-00291-4
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Article ; Online: Application of nanofat for treatment of traumatic faecal incontinence after sphincteroplasty - A pilot study.

Barisic, Goran / Andjelkov, Katarina / Rosic, Jovana / Miladinov, Marko / Kotur-Stеvuljevic, Jelena / Dinic, Tanja / Jelenkovic, Jelenko / Krivokapic, Zoran

Colorectal disease : the official journal of the Association of Coloproctology of Great Britain and Ireland

2022 Volume 24, Issue 9, Page(s) 1054–1062

Abstract: Aim: The aim of this study was to investigate whether the application of nanofat containing stem cells improves continence in women who had previously undergone anal sphincteroplasty with unsatisfactory long-term outcomes.: Method: This prospective ... ...

Abstract	Aim: The aim of this study was to investigate whether the application of nanofat containing stem cells improves continence in women who had previously undergone anal sphincteroplasty with unsatisfactory long-term outcomes. Method: This prospective pilot study included nine women with various degrees of anal incontinence who had previously undergone anal sphincteroplasty due to obstetric trauma. In all patients, the Wexner Incontinence Score (WS) and Faecal Incontinence Quality of Life Score (FIQLS), as well as anal manometry and endoanal ultrasound measurements, were performed before the procedure and during follow-up. In all patients, liposuction was performed and 50 ml of raw lipoaspirate was obtained and processed using a NanoFat Kit device. Approximately 20 ml of the mechanically emulsified and filtrated fat was obtained and the anal sphincter complex was infiltrated with it. Patient follow-up was conducted in person or via telephone 6 and 12 months after the procedure. Results: The squeeze pressure was significantly increased 6 months after the procedure (p = 0.01). The external anal sphincter measured at the 12 o'clock position was significantly thicker (p = 0.04). A significant decrease in the WS was observed both 6 and 12 months after the procedure compared with baseline values (p < 0.05 for both). Conclusion: This study is the first to show that the application of nanofat as an injectable product improves continence in patients with unsatisfactory results after sphincteroplasty, suggesting it to be a promising and effective therapeutic tool. The procedure is safe and can be easily performed as an ambulatory procedure.
MeSH term(s)	Anal Canal/injuries ; Anal Canal/surgery ; Fecal Incontinence/etiology ; Fecal Incontinence/surgery ; Female ; Humans ; Pilot Projects ; Pregnancy ; Prospective Studies ; Quality of Life ; Treatment Outcome
Language	English
Publishing date	2022-04-24
Publishing country	England
Document type	Journal Article
ZDB-ID	1440017-0
ISSN	1463-1318 ; 1462-8910
ISSN (online)	1463-1318
ISSN	1462-8910
DOI	10.1111/codi.16148
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Article ; Online: A novel method for treatment of chronic anal fissure: adipose-derived regenerative cells - a pilot study.

Andjelkov, K / Sforza, M / Barisic, G / Soldatovic, I / Hiranyakas, A / Krivokapic, Z

Colorectal disease : the official journal of the Association of Coloproctology of Great Britain and Ireland

2017 Volume 19, Issue 6, Page(s) 570–575

Abstract: Aim: The purpose of this study was to investigate the safety and feasibility of autologous adipose-derived regenerative cells (ADRC) in the treatment of chronic anal fissure.: Method: A prospective pilot study was conducted in six patients with ... ...

Abstract	Aim: The purpose of this study was to investigate the safety and feasibility of autologous adipose-derived regenerative cells (ADRC) in the treatment of chronic anal fissure. Method: A prospective pilot study was conducted in six patients with chronic anal fissures at the First Surgical Clinic, Clinical Center of Serbia and at the BelPrime Clinic, Belgrade, Serbia. All patients were candidates for surgical treatment. The average duration of symptoms was 24 months. Pain assessment was quantified using a visual analogue scale and bowel continence was assessed using the Wexner incontinence score. Both were assessed before treatment and during each postoperative outpatient visit. Liposuction was performed under local or general anaesthesia. Extraction of ADRC was achieved with a closed automated medical device. The fat and ADRC were injected subcutaneously into the edge of the fissure. The rest of the pellet was infiltrated into the internal anal sphincter. The study has been registered at ClinicalTrials.gov (NCT02628522). Results: Complete healing of the anal fissure and the disappearance of symptoms was achieved in all patients. The average time to complete pain cessation was 33.7 ± 15.0 days. All fissures healed after 3 months and remained healed 12 months after the procedure. There were no complications related to the procedure. Conclusion: The application of ADRC may be an alternative to lateral sphincterotomy and a reliable procedure which avoids faecal incontinence.
Language	English
Publishing date	2017-06
Publishing country	England
Document type	Journal Article
ZDB-ID	1440017-0
ISSN	1463-1318 ; 1462-8910
ISSN (online)	1463-1318
ISSN	1462-8910
DOI	10.1111/codi.13555
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Article: Adynamic and dynamic muscle transposition techniques for anal incontinence.

Barišić, Goran / Krivokapić, Zoran

Gastroenterology report

2014 Volume 2, Issue 2, Page(s) 98–105

Abstract: Gracilis muscle transposition is well established in general surgery and has been the main muscle transposition technique for anal incontinence. Dynamization, through a schedule of continuous electrical stimulation, converts the fatigue-prone muscle ... ...

Abstract	Gracilis muscle transposition is well established in general surgery and has been the main muscle transposition technique for anal incontinence. Dynamization, through a schedule of continuous electrical stimulation, converts the fatigue-prone muscle fibres to a tonic fatigue-resistant morphology with acceptable results in those cases where there is limited sphincter muscle mass. The differences between gluteoplasty and graciloplasty, as well as the techniques and complications of both procedures, are outlined in this review. Overall, these techniques are rarely carried out in specialized units with experience, as there is a high revision and explantation rate.
Language	English
Publishing date	2014-03-19
Publishing country	England
Document type	Journal Article
ZDB-ID	2710871-5
ISSN	2052-0034
ISSN	2052-0034
DOI	10.1093/gastro/gou014
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Article: Mucinous adenocarcinoma of the urinary bladder after long-term duodeno-renal and colovesical fistula--case report.

Petrovic, J / Barisic, G / Krivokapic, Z / Krivokapic, B

Chirurgia (Bucharest, Romania : 1990)

2012 Volume 107, Issue 4, Page(s) 534–536

Abstract: Primary adenocarcinoma of the urinary bladder is a rare neoplasm. It accounts for 1-2% of all bladder carcinomas and sometimes may be found in the bladder diverticula. Fistula between duodenum and renal pelvis is another rarity while colovesical fistula ... ...

Abstract	Primary adenocarcinoma of the urinary bladder is a rare neoplasm. It accounts for 1-2% of all bladder carcinomas and sometimes may be found in the bladder diverticula. Fistula between duodenum and renal pelvis is another rarity while colovesical fistula is not so uncommon. We present a case of a 40 years old man who had surgery for colovesical and duodenorenal fistula and subsequently developed adenocarcinoma of the urinary bladder.
MeSH term(s)	Adenocarcinoma, Mucinous/diagnosis ; Adenocarcinoma, Mucinous/surgery ; Adult ; Colon, Sigmoid/diagnostic imaging ; Colon, Sigmoid/surgery ; Duodenal Diseases/surgery ; Humans ; Intestinal Fistula/diagnostic imaging ; Intestinal Fistula/surgery ; Male ; Radiography ; Risk Factors ; Time Factors ; Treatment Outcome ; Urinary Bladder Fistula/diagnostic imaging ; Urinary Bladder Fistula/surgery ; Urinary Bladder Neoplasms/diagnosis ; Urinary Bladder Neoplasms/surgery ; Urinary Fistula/surgery
Language	English
Publishing date	2012-07
Publishing country	Romania
Document type	Case Reports ; Journal Article
ZDB-ID	419244-8
ISSN	1842-368X ; 1221-9118 ; 0009-4730 ; 0377-5003
ISSN (online)	1842-368X
ISSN	1221-9118 ; 0009-4730 ; 0377-5003
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Zs.B 1352: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular ab Jg. 2022: Lesesaal (EG)
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Article: Sacral schwannoma found incidentally--report of a case.

Petrovic, J / Barisic, G / Krivokapic, Z

Chirurgia (Bucharest, Romania : 1990)

2012 Volume 107, Issue 3, Page(s) 412–414

Abstract: Sacral schwannoma is a rare retrorectal tumor in adults. Postoperative sacral neurological deficit is difficult to avoid. Currently, there is no established consensus regarding best treatment options. We present a case of a 33 years old patient with ... ...

Abstract	Sacral schwannoma is a rare retrorectal tumor in adults. Postoperative sacral neurological deficit is difficult to avoid. Currently, there is no established consensus regarding best treatment options. We present a case of a 33 years old patient with atypical discomfort in lower abdomen and no neurological complaints who was diagnosed with a pelvic mass by abdominal ultrasound. CT, MRI and MSCT showed an inhomogeneous presacral mass involving right S1 sacral foramen. Although there were no neurological complaints, EMG and ENG showed a minor chronic lesion of L5 root bilaterally, more on the right side, affecting the fibers to the small muscles of the feet. We treated this patient with total extirpation of the mass without additional curretage. No radiotherapy was applied and postoperative neurological functions were preserved.
MeSH term(s)	Adult ; Humans ; Incidental Findings ; Male ; Neurilemmoma/diagnosis ; Neurilemmoma/surgery ; Pelvic Neoplasms/diagnosis ; Pelvic Neoplasms/surgery ; Sacrum/pathology ; Sacrum/surgery ; Surgical Procedures, Operative/methods ; Treatment Outcome
Language	English
Publishing date	2012-05
Publishing country	Romania
Document type	Case Reports ; Journal Article
ZDB-ID	419244-8
ISSN	1842-368X ; 1221-9118 ; 0009-4730 ; 0377-5003
ISSN (online)	1842-368X
ISSN	1221-9118 ; 0009-4730 ; 0377-5003
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Zs.B 1352: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular ab Jg. 2022: Lesesaal (EG)
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Article: Comparison of functional outcome of colonic J-pouch and latero-terminal anastomosis in low anterior resection for rectal cancer.

Marković, Velimir / Dimitrijević, Ivan / Barišić, Goran / Krivokapić, Zoran

Srpski arhiv za celokupno lekarstvo

2015 Volume 143, Issue 3-4, Page(s) 158–161

Abstract: Introduction: Functional results after low anterior resection for rectal cancer are an issue of increasing attention among colorectal surgeons and others interested in this subject. The consensus on ideal reconstruction type has not been achieved to ... ...

Abstract	Introduction: Functional results after low anterior resection for rectal cancer are an issue of increasing attention among colorectal surgeons and others interested in this subject. The consensus on ideal reconstruction type has not been achieved to date, although the number of papers on this subject has been published in recent years. Objective: We conducted a prospective, parallel group study comparing latero-terminal with colonic J-pouch anastomosis in terms of defecatory function in patients undergoing stapled low colorectal/ coloanal anastomosis. Methods: A total of 80 patients were included in this study with either latero-terminal or colonic J-pouch anastomosis. Defecatory function was evaluated using the modified version of MSKCC questionnaire 6, 12 and 24 months after the operation. Fecal continence was evaluated using the Wexner continence score. Results: In both groups, trend towards improvement was registered in all measured variables in all three control intervals. This can apply to bowel frequency, urgency, night soiling, fragmentation and incomplete evacuation. However, the difference was not statistically significant, and when reviewing the trend of results we can note that in the J-pouch group steady state has not been reached even after 24 month control. Conclusion: This trial did not reveal any significant differences in defecatory function 6, 12 and 24 months after low anterior resection (LAR) between patients with a latero-terminal anastomosis and those with colonic J-pouch anastomosis. Our results did not confirm superiority of colonic J-pouch over the latero-terminal anastomosis
MeSH term(s)	Adult ; Aged ; Anastomosis, Surgical ; Colon/surgery ; Colonic Pouches ; Defecation/physiology ; Female ; Humans ; Male ; Middle Aged ; Prospective Studies ; Reconstructive Surgical Procedures/methods ; Rectal Neoplasms/physiopathology ; Rectal Neoplasms/surgery ; Rectum/surgery ; Treatment Outcome
Language	English
Publishing date	2015-05-25
Publishing country	Serbia
Document type	Comparative Study ; Journal Article
ZDB-ID	128567-1
ISSN	0370-8179 ; 0354-2793 ; 0049-0210
ISSN	0370-8179 ; 0354-2793 ; 0049-0210
DOI	10.2298/sarh1504158m
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Zs.B 248: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular ab Jg. 2022: Lesesaal (EG)
Zs.MO 556: Show issues

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Article: Isolated splenic metastases of colorectal carcinoma--case report and review of literature.

Popović, M / Barisić, G / Krivokapić, Z

Acta chirurgica Iugoslavica

2008 Volume 55, Issue 3, Page(s) 73–76

Abstract: It is very rare situation when surgeon can virtually expect a curative operation after revealing distal metastases of colorectal carcinoma. In case of isolated splenic metastases, splenectomy can result with good five year survival rate. There are no ... ...

Abstract	It is very rare situation when surgeon can virtually expect a curative operation after revealing distal metastases of colorectal carcinoma. In case of isolated splenic metastases, splenectomy can result with good five year survival rate. There are no more than 15 cases of isolated splenic metastases publish in English speaking literature. This article reveals our case along with a literature review and brief discussion of diagnostic and therapeutic options.
MeSH term(s)	Adenocarcinoma/secondary ; Adenocarcinoma/surgery ; Aged ; Colorectal Neoplasms/pathology ; Humans ; Male ; Splenectomy ; Splenic Neoplasms/secondary ; Splenic Neoplasms/surgery
Language	English
Publishing date	2008-08-19
Publishing country	Serbia
Document type	Case Reports ; Journal Article
ZDB-ID	428721-6
ISSN	0354-950X ; 0001-5474
ISSN	0354-950X ; 0001-5474
DOI	10.2298/aci0803073p
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